{"id":"https://openalex.org/W4411039223","doi":"https://doi.org/10.1158/1535-7163.29234046","title":"Supplementary Figure S4 from Targeting CDK7 Enhances the Antitumor Efficacy of Enzalutamide in Androgen Receptor\u2013Positive Triple-Negative Breast Cancer by Inhibiting c-MYC\u2013mediated Tumorigenesis","display_name":"Supplementary Figure S4 from Targeting CDK7 Enhances the Antitumor Efficacy of Enzalutamide in Androgen Receptor\u2013Positive Triple-Negative Breast Cancer by Inhibiting c-MYC\u2013mediated Tumorigenesis","publication_year":2025,"publication_date":"2025-06-04","ids":{"openalex":"https://openalex.org/W4411039223","doi":"https://doi.org/10.1158/1535-7163.29234046"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.29234046","doi":"https://doi.org/10.1158/1535-7163.29234046","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.29234046","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.29234046","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072948474","display_name":"Xuemei Xie","orcid":"https://orcid.org/0000-0002-0409-2294","observed_orcids":["https://orcid.org/0000-0002-0409-2294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuemei Xie","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0409-2294","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053679135","display_name":"Maroua Manai","orcid":"https://orcid.org/0000-0003-4037-3402","observed_orcids":["https://orcid.org/0000-0003-4037-3402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maroua Manai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4037-3402","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044884802","display_name":"Dileep Reddy Rampa","orcid":"https://orcid.org/0000-0003-3086-4822","observed_orcids":["https://orcid.org/0000-0003-3086-4822"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dileep R. Rampa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3086-4822","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003091635","display_name":"Jon A. Fuson","orcid":"https://orcid.org/0009-0000-2543-214X","observed_orcids":["https://orcid.org/0009-0000-2543-214X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jon A. Fuson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-2543-214X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090707057","display_name":"Elizabeth S. Nakasone","orcid":"https://orcid.org/0000-0002-5658-2551","observed_orcids":["https://orcid.org/0000-0002-5658-2551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth S. Nakasone","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5658-2551","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003469635","display_name":"Troy Pearson","orcid":"https://orcid.org/0009-0002-0801-6632","observed_orcids":["https://orcid.org/0009-0002-0801-6632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Troy Pearson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-0801-6632","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114798734","display_name":"Bharat S. Kuntal","orcid":"https://orcid.org/0000-0002-0833-5468","observed_orcids":["https://orcid.org/0000-0002-0833-5468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bharat S. Kuntal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0833-5468","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110083321","display_name":"Debu Tripathy","orcid":"https://orcid.org/0000-0002-5711-2404","observed_orcids":["https://orcid.org/0000-0002-5711-2404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debu Tripathy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5711-2404","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088814426","display_name":"Naoto Tada Ueno","orcid":"https://orcid.org/0000-0002-0166-7275","observed_orcids":["https://orcid.org/0000-0002-0166-7275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoto T. Ueno","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0166-7275","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025672158","display_name":"Jangsoon Lee","orcid":"https://orcid.org/0000-0002-6862-5686","observed_orcids":["https://orcid.org/0000-0002-6862-5686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jangsoon Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6862-5686","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.28220000863075256,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.1696999967098236,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzalutamide","display_name":"enzalutamide","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cdk7-inhibition","display_name":"CDK7 inhibition","score":0.8939999938011169},{"id":"https://openalex.org/keywords/c-myc-transcription","display_name":"c-myc transcription","score":0.8799999952316284},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6230000257492065},{"id":"https://openalex.org/keywords/hcc1806-cells","display_name":"HCC1806 cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.9311033487319946},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.8558736443519592},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.7774375081062317},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.523589015007019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5011770725250244},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.44963499903678894},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4422316253185272},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.42455410957336426},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4099385142326355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38740649819374084},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3525587320327759},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3356078863143921}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.29234046","doi":"https://doi.org/10.1158/1535-7163.29234046","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.29234046","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/29234046","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_S4_from_Targeting_CDK7_Enhances_the_Antitumor_Efficacy_of_Enzalutamide_in_Androgen_Receptor_Positive_Triple-Negative_Breast_Cancer_by_Inhibiting_c-MYC_mediated_Tumorigenesis/29234046","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.29234046","doi":"https://doi.org/10.1158/1535-7163.29234046","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.29234046","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4411039449","https://openalex.org/W4404723507","https://openalex.org/W4322769617","https://openalex.org/W4312097907","https://openalex.org/W2292180879","https://openalex.org/W4392812982","https://openalex.org/W2796062489","https://openalex.org/W4290960330","https://openalex.org/W2221943220","https://openalex.org/W4392722179"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"S4.":[2],"Enzalutamide":[3],"and":[4,15,19],"KRLS-017":[5,20],"had":[6],"no":[7],"synergistic":[8],"effect":[9],"in":[10,24],"AR-negative":[11],"HCC1806":[12],"TNBC":[13,27],"cells,":[14],"combination":[16],"of":[17],"enzalutamide":[18],"reduced":[21],"c-MYC":[22],"transcription":[23],"AR+":[25],"LAR":[26],"cells.":[28]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}