{"id":"https://openalex.org/W4411036545","doi":"https://doi.org/10.1016/j.omton.2025.200998","title":"The safer effector cell? Potential of CD147 CAR NK cells to tackle tumors with lower toxicity","display_name":"The safer effector cell? Potential of CD147 CAR NK cells to tackle tumors with lower toxicity","publication_year":2025,"publication_date":"2025-06-01","ids":{"openalex":"https://openalex.org/W4411036545","doi":"https://doi.org/10.1016/j.omton.2025.200998","pmid":"https://pubmed.ncbi.nlm.nih.gov/40529619","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12171805"},"language":"en","primary_location":{"id":"doi:10.1016/j.omton.2025.200998","doi":"https://doi.org/10.1016/j.omton.2025.200998","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omton.2025.200998","pdf_url":"https://www.cell.com/action/showPdf?pii=S2950329925000670","source":{"id":"https://openalex.org/S5407037028","display_name":"Molecular Therapy Oncology","issn_l":"2950-3299","issn":["2950-3299"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","doyens","jufo-1","ki-jl-1","norway-1","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cell.com/action/showPdf?pii=S2950329925000670","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Alan Hodges","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Hodges","raw_affiliation_strings":["Center for Immunotherapy, Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA","Texas A&M University System College of Medicine, Bryan, TX 77807, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunotherapy, Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Texas A&M University System College of Medicine, Bryan, TX 77807, USA","institution_ids":["https://openalex.org/I173268674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032240853","display_name":"Shu\u2010Hsia Chen","orcid":"https://orcid.org/0000-0002-9168-5775","observed_orcids":["https://orcid.org/0000-0002-9168-5775"]},"institutions":[{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shu-Hsia Chen","raw_affiliation_strings":["Center for Immunotherapy, Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA","Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medical Science and Graduate School of Medical Sciences, New York, NY 10065, USA","Texas A&M University System College of Medicine, Bryan, TX 77807, USA"],"raw_orcid":"https://orcid.org/0000-0002-9168-5775","affiliations":[{"raw_affiliation_string":"Center for Immunotherapy, Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medical Science and Graduate School of Medical Sciences, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Texas A&M University System College of Medicine, Bryan, TX 77807, USA","institution_ids":["https://openalex.org/I173268674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027856972","display_name":"Ping\u2010Ying Pan","orcid":"https://orcid.org/0000-0002-2971-4221","observed_orcids":["https://orcid.org/0000-0002-2971-4221"]},"institutions":[{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ping-Ying Pan","raw_affiliation_strings":["Center for Immunotherapy, Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA","Texas A&M University System College of Medicine, Bryan, TX 77807, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunotherapy, Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Texas A&M University System College of Medicine, Bryan, TX 77807, USA","institution_ids":["https://openalex.org/I173268674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5027856972","https://openalex.org/A5032240853"],"corresponding_institution_ids":["https://openalex.org/I173268674","https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405286254"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14900216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"2","first_page":"200998","last_page":"200998"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.035999998450279236,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd147","display_name":"CD147","score":0.9570000171661377},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.9020000100135803},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9210000038146973},{"id":"https://openalex.org/keywords/on-target-off-tumor-toxicity","display_name":"on-target off-tumor toxicity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C2776654903","wikidata":"https://www.wikidata.org/wiki/Q2601463","display_name":"SAFER","level":2,"score":0.8294016122817993},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7726216316223145},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6102325320243835},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4562372863292694},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39620184898376465},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.342451274394989},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3316919803619385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26450732350349426},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21997177600860596},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0881468653678894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07864442467689514},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.omton.2025.200998","doi":"https://doi.org/10.1016/j.omton.2025.200998","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omton.2025.200998","pdf_url":"https://www.cell.com/action/showPdf?pii=S2950329925000670","source":{"id":"https://openalex.org/S5407037028","display_name":"Molecular Therapy Oncology","issn_l":"2950-3299","issn":["2950-3299"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","doyens","jufo-1","ki-jl-1","norway-1","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12171805","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12171805","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Oncol","raw_type":"Text"},{"id":"pmid:40529619","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40529619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Oncology","raw_type":"News"},{"id":"pmh:oai:doaj.org/article:7ef3110a612f43cea2d8b2970438bd7d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7ef3110a612f43cea2d8b2970438bd7d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy: Oncology, Vol 33, Iss 2, Pp 200998- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.omton.2025.200998","doi":"https://doi.org/10.1016/j.omton.2025.200998","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omton.2025.200998","pdf_url":"https://www.cell.com/action/showPdf?pii=S2950329925000670","source":{"id":"https://openalex.org/S5407037028","display_name":"Molecular Therapy Oncology","issn_l":"2950-3299","issn":["2950-3299"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","doyens","jufo-1","ki-jl-1","norway-1","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1529878467","display_name":"LILRB modulates tumor microenvironment and promotes tumor progression","funder_award_id":"R01CA204191","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G291981582","display_name":"Modulation of tumor inflammatory factor for immune therapy","funder_award_id":"R01CA208703","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3137273128","display_name":"Mechanism of Intratumoral Transport of Particulate Drugs","funder_award_id":"R01CA222959","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000909101","display_name":"Novel gene delivery to modulate the tumor microenvironment and antigen-specific antitumor immunity","funder_award_id":"R01CA283580","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000915301","display_name":"SPORE in Lymphoma","funder_award_id":"P50CA126752","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333841","display_name":"Houston Methodist Research Institute","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411036545.pdf","grobid_xml":"https://content.openalex.org/works/W4411036545.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2773804840","https://openalex.org/W2804159084","https://openalex.org/W2903062212","https://openalex.org/W2922879840","https://openalex.org/W3004611567","https://openalex.org/W3080714131","https://openalex.org/W3088185527","https://openalex.org/W4282923422","https://openalex.org/W4318465547","https://openalex.org/W4389046163","https://openalex.org/W4391046307","https://openalex.org/W4396903575","https://openalex.org/W4407959189","https://openalex.org/W6878210083"],"related_works":["https://openalex.org/W4407959189","https://openalex.org/W3083432359","https://openalex.org/W4313260754","https://openalex.org/W3165634478","https://openalex.org/W2989809912","https://openalex.org/W4412627527","https://openalex.org/W2913951975","https://openalex.org/W4415255388","https://openalex.org/W4253811734","https://openalex.org/W2744371465"],"abstract_inverted_index":{"In":[0],"a":[1,78],"recent":[2],"issue":[3],"of":[4,17,37,43,55],"Molecular":[5],"Therapy:":[6],"Oncology,":[7],"Saha":[8],"et":[9],"al.":[10],"explore":[11],"the":[12,35,41,47,52],"potential":[13],"advantages":[14],"in":[15,40,58],"safety":[16,82],"chimeric":[18],"antigen":[19],"receptor":[20],"(CAR)":[21],"natural":[22],"killer":[23],"(NK)":[24],"cells":[25,29,39,57,72],"over":[26],"CAR":[27],"T":[28],"with":[30,87],"maintained":[31],"anti-tumor":[32],"efficacy.1":[33],"Through":[34],"use":[36],"CD147-CAR-NK":[38,71],"context":[42],"hepatocellular":[44],"carcinoma":[45],"models,":[46],"article":[48],"aims":[49],"to":[50,62],"evaluate":[51],"toxicity":[53],"profile":[54],"CAR-NK":[56],"isolation":[59],"and":[60,84],"compared":[61,86],"CD147-CAR-T":[63,88],"cell":[64],"therapy.":[65],"The":[66],"key":[67],"findings":[68],"indicate":[69],"that":[70],"exhibit":[73],"selective":[74],"\u201con-target,":[75,80],"on-tumor\u201d":[76],"activity,":[77],"favorable":[79],"off-tumor\u201d":[81],"profile,":[83],"when":[85],"cells,":[89],"reduced":[90],"neurotoxicity.":[91]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}
