{"id":"https://openalex.org/W4411035898","doi":"https://doi.org/10.7554/elife.107670.3","title":"Paraventricular thalamus hyperactivity mediates stress-induced sensitization of unlearned fear but not stress-enhanced fear learning (SEFL)","display_name":"Paraventricular thalamus hyperactivity mediates stress-induced sensitization of unlearned fear but not stress-enhanced fear learning (SEFL)","publication_year":2026,"publication_date":"2026-06-22","ids":{"openalex":"https://openalex.org/W4411035898","doi":"https://doi.org/10.7554/elife.107670.3","pmid":"https://pubmed.ncbi.nlm.nih.gov/40501542","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12157491"},"language":"en","primary_location":{"id":"doi:10.7554/elife.107670.3","doi":"https://doi.org/10.7554/elife.107670.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.107670.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.107670.3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kenji J. Nishimura","orcid":"https://orcid.org/0000-0002-5264-5850","observed_orcids":["https://orcid.org/0000-0002-5264-5850"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenji J. Nishimura","raw_affiliation_strings":["Center for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-5264-5850","affiliations":[{"raw_affiliation_string":"Center for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019048915","display_name":"Denisse Paredes","orcid":"https://orcid.org/0000-0002-3689-5921","observed_orcids":["https://orcid.org/0000-0002-3689-5921"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denisse Paredes","raw_affiliation_strings":["Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039188742","display_name":"Nathaniel A. Nocera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel A. Nocera","raw_affiliation_strings":["Center for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dhruv Aggarwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhruv Aggarwal","raw_affiliation_strings":["Center for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090696851","display_name":"Michael R. Drew","orcid":"https://orcid.org/0000-0002-3883-1542","observed_orcids":["https://orcid.org/0000-0002-3883-1542"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Drew","raw_affiliation_strings":["Center for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00650252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paraventricular-thalamus","display_name":"paraventricular thalamus","score":0.8980000019073486},{"id":"https://openalex.org/keywords/stress-enhanced-fear-learning","display_name":"stress-enhanced fear learning","score":0.9629999995231628},{"id":"https://openalex.org/keywords/foot-shock-stress","display_name":"footshock stress","score":0.9079999923706055},{"id":"https://openalex.org/keywords/fiber-photometry","display_name":"fiber photometry","score":0.8870000243186951},{"id":"https://openalex.org/keywords/chemogenetic-inhibition","display_name":"chemogenetic inhibition","score":0.8809999823570251},{"id":"https://openalex.org/keywords/trauma-and-stressor-related-disorders","display_name":"trauma- and stressor-related disorders","score":0.703000009059906},{"id":"https://openalex.org/keywords/fear-reactivity","display_name":"fear reactivity","score":0.39800000190734863},{"id":"https://openalex.org/keywords/freezing-behavior","display_name":"freezing behavior","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.7896633148193359},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.6107981204986572},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5585978627204895},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.5264939665794373},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5036522746086121},{"id":"https://openalex.org/C3019662062","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Behavioral sensitization","level":4,"score":0.4284589886665344},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.052334994077682495},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.7554/elife.107670.3","doi":"https://doi.org/10.7554/elife.107670.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.107670.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.1101/2025.05.30.657116","doi":"https://doi.org/10.1101/2025.05.30.657116","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.30.657116","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40501542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40501542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12157491","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12157491","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"doi:10.18738/t8/azjenk","doi":"https://doi.org/10.18738/t8/azjenk","is_oa":true,"landing_page_url":"https://doi.org/10.18738/t8/azjenk","pdf_url":null,"source":{"id":"https://openalex.org/S4306402198","display_name":"Texas Digital Library (University of Texas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86519309","host_organization_name":"The University of Texas at Austin","host_organization_lineage":["https://openalex.org/I86519309"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.7554/elife.107670.3","doi":"https://doi.org/10.7554/elife.107670.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.107670.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.66839998960495,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4009490717","display_name":"Hippocampal Mechanisms of Fear Extinction","funder_award_id":"R01MH117426","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G735527941","display_name":"Enhancing rodent behavioral phenotyping using guided ultrasonic waves","funder_award_id":"R21MH128610","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000896275","display_name":"Training in Learning and Memory","funder_award_id":"T32MH106454","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W144853063","https://openalex.org/W576234086","https://openalex.org/W1231274610","https://openalex.org/W1463791314","https://openalex.org/W1905774592","https://openalex.org/W1968714114","https://openalex.org/W1972768039","https://openalex.org/W1978054272","https://openalex.org/W1980811060","https://openalex.org/W1987795694","https://openalex.org/W1993364340","https://openalex.org/W2001158321","https://openalex.org/W2012068152","https://openalex.org/W2039051183","https://openalex.org/W2043256468","https://openalex.org/W2054498332","https://openalex.org/W2079658013","https://openalex.org/W2086976785","https://openalex.org/W2145926148","https://openalex.org/W2152156940","https://openalex.org/W2152345984","https://openalex.org/W2746196658","https://openalex.org/W2769890869","https://openalex.org/W2808086217","https://openalex.org/W2922937995","https://openalex.org/W2939750467","https://openalex.org/W2991405359","https://openalex.org/W2999103251","https://openalex.org/W3097694911","https://openalex.org/W3103747990","https://openalex.org/W3119946099","https://openalex.org/W3154021207","https://openalex.org/W4213130864","https://openalex.org/W4241043260","https://openalex.org/W4366141661","https://openalex.org/W4390607492","https://openalex.org/W4403557345","https://openalex.org/W4406658648","https://openalex.org/W7218349123"],"related_works":["https://openalex.org/W6908527515","https://openalex.org/W7211961481","https://openalex.org/W4393869670","https://openalex.org/W4297142669","https://openalex.org/W4413004195","https://openalex.org/W7152378436","https://openalex.org/W4366141661","https://openalex.org/W2991405359","https://openalex.org/W4390607492","https://openalex.org/W3158048337"],"abstract_inverted_index":{"Exposure":[0],"to":[1,32,38,107,117,135,224],"stress":[2,113,165,209],"can":[3],"cause":[4],"long-lasting":[5],"enhancement":[6,143],"of":[7,29,42,63,89,111,144,173,199,206,217,238,247,253,272,288],"fear":[8,34,64,75,91,248,255,274],"and":[9,166,210,251,275,285],"other":[10],"defensive":[11],"responses":[12,76,92],"that":[13,126,159,180,196,245],"extend":[14],"beyond":[15],"the":[16,22,52,60,70,84,151,191,200,204],"cues":[17],"or":[18,230,236],"contexts":[19],"associated":[20,140,186],"with":[21,141,170,187],"original":[23],"traumatic":[24],"event.":[25],"These":[26],"nonassociative":[27],"consequences":[28],"stress,":[30],"referred":[31],"as":[33,156,266,278],"sensitization,":[35],"are":[36,77],"thought":[37],"underlie":[39],"some":[40],"symptoms":[41,287],"trauma-related":[43],"disorders.":[44,291],"Fear":[45,54,99],"sensitization":[46,88,246,252,271],"has":[47],"been":[48],"predominately":[49],"studied":[50],"using":[51,93],"Stress-Enhanced":[53,98],"Learning":[55],"(SEFL)":[56,250],"paradigm,":[57],"which":[58,73],"models":[59],"stress-induced":[61,142,270],"amplification":[62],"learning.":[65],"Less":[66],"is":[67],"known":[68],"about":[69],"mechanisms":[71,86],"through":[72],"unlearned":[74,90,145,254,273],"sensitized":[78],"by":[79],"stress.":[80],"Here,":[81],"we":[82,96,130,178,194],"investigated":[83],"neural":[85,137,259],"for":[87,269,282],"a":[94,108,118,157,267,279],"paradigm":[95],"termed":[97],"Responding":[100],"(SEFR).":[101],"In":[102,240],"this":[103],"model,":[104],"mice":[105,221],"exposed":[106],"single":[109],"session":[110],"footshock":[112,164],"exhibit":[114],"enhanced":[115],"freezing":[116],"novel":[119],"tone":[120],"stimulus.":[121],"To":[122],"investigate":[123],"brain":[124],"regions":[125],"might":[127],"mediate":[128],"SEFR,":[129,181],"first":[131],"used":[132],"c-Fos":[133,148],"mapping":[134],"identify":[136,263],"activity":[138,168,189],"changes":[139],"fear.":[146],"Our":[147,261],"screen":[149],"identified":[150],"posterior":[152],"paraventricular":[153],"thalamus":[154],"(pPVT)":[155],"region":[158],"was":[160,185,222],"persistently":[161],"hyperactive":[162],"after":[163],"whose":[167],"correlated":[169],"behavioral":[171],"expression":[172,237],"SEFR.":[174,226],"Using":[175],"fiber":[176],"photometry,":[177],"observed":[179],"but":[182],"not":[183,233],"SEFL,":[184],"increased":[188],"in":[190,219],"pPVT.":[192],"Next,":[193],"found":[195],"chemogenetic":[197],"inhibition":[198,229],"pPVT":[201,218,228,264,277],"blocked":[202],"both":[203],"induction":[205],"SEFR":[207],"during":[208],"its":[211],"later":[212],"expression,":[213],"while":[214],"artificial":[215],"stimulation":[216,231],"stress-naive":[220],"sufficient":[223],"recapitulate":[225],"Interestingly,":[227],"did":[232],"affect":[234],"acquisition":[235],"SEFL.":[239],"conclusion,":[241],"our":[242],"results":[243,262],"indicate":[244],"learning":[249],"(SEFR)":[256],"have":[257],"distinct":[258],"mechanisms.":[260],"hyperactivity":[265],"mechanism":[268],"highlight":[276],"potential":[280],"target":[281],"treating":[283],"arousal":[284],"reactivity":[286],"traumaand":[289],"stressor-related":[290]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2025-10-10T00:00:00"}
