{"id":"https://openalex.org/W4411031398","doi":"https://doi.org/10.31083/rn36399","title":"Cerebrospinal Fluid Biomarker Profile in Atypical Alzheimer\u2019s Disease","display_name":"Cerebrospinal Fluid Biomarker Profile in Atypical Alzheimer\u2019s Disease","publication_year":2025,"publication_date":"2025-05-22","ids":{"openalex":"https://openalex.org/W4411031398","doi":"https://doi.org/10.31083/rn36399","pmid":"https://pubmed.ncbi.nlm.nih.gov/40464420"},"language":"en","primary_location":{"id":"doi:10.31083/rn36399","doi":"https://doi.org/10.31083/rn36399","is_oa":true,"landing_page_url":"https://doi.org/10.31083/rn36399","pdf_url":null,"source":{"id":"https://openalex.org/S184263677","display_name":"Revista de Neurolog\u00eda","issn_l":"0210-0010","issn":["0210-0010","1576-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4322632785","host_organization_name":"Viguera Publishers","host_organization_lineage":["https://openalex.org/P4322632785"],"host_organization_lineage_names":["Viguera Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de Neurolog\u00eda","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.31083/rn36399","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093100150","display_name":"Elisa Mart\u00ednez Campos","orcid":"https://orcid.org/0000-0002-0305-1546","observed_orcids":["https://orcid.org/0000-0002-0305-1546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisa Mart\u00ednez Campos","raw_affiliation_strings":["Servicio de Neurolog\u00eda, Hospital Universitario de Navarra, 31008 Pamplona, Espa\u00f1a"],"raw_orcid":"https://orcid.org/0000-0002-0305-1546","affiliations":[{"raw_affiliation_string":"Servicio de Neurolog\u00eda, Hospital Universitario de Navarra, 31008 Pamplona, Espa\u00f1a","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004489674","display_name":"Paula Tellechea-Aramburo","orcid":"https://orcid.org/0000-0001-8402-5712","observed_orcids":["https://orcid.org/0000-0001-8402-5712"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula Tellechea Aramburo","raw_affiliation_strings":["Servicio de Neurolog\u00eda, Hospital Universitario de Navarra, 31008 Pamplona, Espa\u00f1a"],"raw_orcid":"https://orcid.org/0000-0001-8402-5712","affiliations":[{"raw_affiliation_string":"Servicio de Neurolog\u00eda, Hospital Universitario de Navarra, 31008 Pamplona, Espa\u00f1a","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040135319","display_name":"Javier S\u00e1nchez\u2010Ruiz de Gordoa","orcid":"https://orcid.org/0000-0001-6467-5830","observed_orcids":["https://orcid.org/0000-0001-6467-5830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javier S\u00e1nchez Ruiz de Gordoa","raw_affiliation_strings":["Servicio de Neurolog\u00eda, Hospital Universitario de Navarra, 31008 Pamplona, Espa\u00f1a"],"raw_orcid":"https://orcid.org/0000-0001-6467-5830","affiliations":[{"raw_affiliation_string":"Servicio de Neurolog\u00eda, Hospital Universitario de Navarra, 31008 Pamplona, Espa\u00f1a","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105805923","display_name":"Rosa Larumbe Ilund\u00e1in","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosa Larumbe Ilundain","raw_affiliation_strings":["Servicio de Neurolog\u00eda, Hospital Universitario de Navarra, 31008 Pamplona, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Neurolog\u00eda, Hospital Universitario de Navarra, 31008 Pamplona, Espa\u00f1a","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6201,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.67067285,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"80","issue":"4","first_page":"36399","last_page":"36399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atypical-alzheimer-s-disease","display_name":"atypical Alzheimer's disease","score":0.906000018119812},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.4350000023841858},{"id":"https://openalex.org/keywords/phosphorylated-tau","display_name":"phosphorylated tau","score":0.949999988079071},{"id":"https://openalex.org/keywords/total-tau","display_name":"total tau","score":0.6980000138282776},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.902999997138977},{"id":"https://openalex.org/keywords/aphasia","display_name":"aphasia","score":0.7940000295639038},{"id":"https://openalex.org/keywords/frontal-lobe-involvement","display_name":"frontal lobe involvement","score":0.6700000166893005},{"id":"https://openalex.org/keywords/clinical-phenotype","display_name":"clinical phenotype","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cortical-injury","display_name":"cortical injury","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.7625834941864014},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7552881240844727},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6932726502418518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5772998929023743},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5575568675994873},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5551387071609497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5550228357315063},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.4381817579269409},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4158784747123718},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4155963361263275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18088364601135254},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09002909064292908},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08034351468086243}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.31083/rn36399","doi":"https://doi.org/10.31083/rn36399","is_oa":true,"landing_page_url":"https://doi.org/10.31083/rn36399","pdf_url":null,"source":{"id":"https://openalex.org/S184263677","display_name":"Revista de Neurolog\u00eda","issn_l":"0210-0010","issn":["0210-0010","1576-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4322632785","host_organization_name":"Viguera Publishers","host_organization_lineage":["https://openalex.org/P4322632785"],"host_organization_lineage_names":["Viguera Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de Neurolog\u00eda","raw_type":"journal-article"},{"id":"pmid:40464420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40464420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de neurologia","raw_type":"English Abstract"},{"id":"pmh:oai:europepmc.org:10949135","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12135633","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12135633","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12135633","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rev Neurol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.31083/rn36399","doi":"https://doi.org/10.31083/rn36399","is_oa":true,"landing_page_url":"https://doi.org/10.31083/rn36399","pdf_url":null,"source":{"id":"https://openalex.org/S184263677","display_name":"Revista de Neurolog\u00eda","issn_l":"0210-0010","issn":["0210-0010","1576-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4322632785","host_organization_name":"Viguera Publishers","host_organization_lineage":["https://openalex.org/P4322632785"],"host_organization_lineage_names":["Viguera Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de Neurolog\u00eda","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1791696956","https://openalex.org/W2075444764","https://openalex.org/W2091444239","https://openalex.org/W2111200377","https://openalex.org/W2293378393","https://openalex.org/W2343379702","https://openalex.org/W2783965729","https://openalex.org/W2798054687","https://openalex.org/W2935805765","https://openalex.org/W2962225906","https://openalex.org/W3037982876","https://openalex.org/W3131646863","https://openalex.org/W4200536910","https://openalex.org/W4311054773","https://openalex.org/W4364379972","https://openalex.org/W4385175232","https://openalex.org/W4404913872"],"related_works":["https://openalex.org/W2604464132","https://openalex.org/W3164771895","https://openalex.org/W2161088626","https://openalex.org/W3029893540","https://openalex.org/W2314682585","https://openalex.org/W2313584493","https://openalex.org/W2135667114","https://openalex.org/W2110968082","https://openalex.org/W2966053455","https://openalex.org/W3122747281"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Cerebrospinal":[1],"fluid":[2],"(CSF)":[3],"biomarkers":[4,76,196],"for":[5,11,207],"Alzheimer's":[6],"disease":[7,200],"(AD)":[8],"are":[9],"essential":[10],"the":[12,36,134,137,186,192],"early":[13],"identification":[14],"of":[15,20,42,109,164,194],"non-amnestic":[16],"phenotypes.":[17],"Increased":[18],"levels":[19],"total":[21],"tau":[22,26,176],"(t-tau)":[23],"and":[24,73,95,152,167,180,203],"phosphorylated":[25],"(p-tau)":[27],"have":[28],"been":[29],"reported":[30],"in":[31,52,83,91,197],"atypical":[32,123,138],"AD":[33,75,113],"cases,":[34],"although":[35],"specific":[37],"pattern":[38],"remains":[39],"a":[40],"subject":[41],"debate.":[43],"This":[44],"study":[45,99],"aimed":[46],"to":[47,54,69,169],"evaluate":[48],"CSF":[49,84,195],"biomarker":[50],"profiles":[51],"relation":[53],"clinical":[55,71],"phenotype.":[56,188],"MATERIALS":[57],"AND":[58],"METHODS:":[59],"A":[60],"retrospective":[61],"review":[62],"was":[63],"performed,":[64],"analyzing":[65],"demographic":[66],"data,":[67],"time":[68,168],"diagnosis,":[70],"phenotype,":[72,136],"core":[74],"(beta-amyloid":[77],"peptide":[78],"1-42":[79],"(A\u03b21-42),":[80],"t-tau,":[81],"p-tau)":[82],"from":[85],"patients":[86,102,119],"evaluated":[87],"at":[88],"University":[89],"Hospital":[90],"Navarra":[92],"between":[93],"2019":[94],"2022.":[96],"RESULTS:":[97],"The":[98],"included":[100],"57":[101],"(54%":[103],"female,":[104],"mean":[105],"age":[106],"67":[107],"years),":[108],"whom":[110],"41":[111],"met":[112],"diagnostic":[114],"criteria.":[115],"Among":[116],"these,":[117],"10":[118],"(25%)":[120],"presented":[121],"with":[122,133],"phenotypes":[124],"(50%":[125],"aphasic,":[126],"30%":[127],"frontal,":[128],"20%":[129],"mixed":[130],"non-amnestic).":[131],"Compared":[132],"amnestic":[135,187],"group":[139],"exhibited":[140],"significantly":[141],"higher":[142],"t-tau":[143],"(562.9":[144],"pg/mL":[145,155],"vs":[146,156],"320.3":[147],"pg/mL,":[148,158],"p":[149,159],"=":[150,160],"0.021)":[151],"p-tau":[153],"(81.5":[154],"37.7":[157],"0.016)":[161],"levels,":[162,177],"independent":[163],"age,":[165],"sex,":[166],"diagnosis.":[170],"CONCLUSIONS:":[171],"Atypical":[172],"cases":[173],"demonstrated":[174],"increased":[175],"suggesting":[178],"earlier":[179],"more":[181],"extensive":[182],"cortical":[183],"damage":[184],"than":[185],"These":[189],"findings":[190],"underscore":[191],"significance":[193],"phenotypic":[198],"differentiation,":[199],"course":[201],"prediction,":[202],"individualized":[204],"treatment":[205],"strategies":[206],"AD.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}
