{"id":"https://openalex.org/W4411031371","doi":"https://doi.org/10.47960/3029-3316.2024.2.1.41","title":"THERAPEUTIC RESPONSE AND TOXICITY OF CYCLIN- DEPENDENT KINASE 4/6 INHIBITORS IN THE TREATMENT OF HORMONE RECEPTOR-POSITIVE, HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR-2 NEGATIVE METASTATIC BREAST CANCER \u2013 A SINGLE-CENTER EXPERIENCE","display_name":"THERAPEUTIC RESPONSE AND TOXICITY OF CYCLIN- DEPENDENT KINASE 4/6 INHIBITORS IN THE TREATMENT OF HORMONE RECEPTOR-POSITIVE, HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR-2 NEGATIVE METASTATIC BREAST CANCER \u2013 A SINGLE-CENTER EXPERIENCE","publication_year":2024,"publication_date":"2024-12-20","ids":{"openalex":"https://openalex.org/W4411031371","doi":"https://doi.org/10.47960/3029-3316.2024.2.1.41"},"language":"en","primary_location":{"id":"doi:10.47960/3029-3316.2024.2.1.41","doi":"https://doi.org/10.47960/3029-3316.2024.2.1.41","is_oa":true,"landing_page_url":"https://doi.org/10.47960/3029-3316.2024.2.1.41","pdf_url":"https://pauk.sum.ba/ojs/mai/article/download/163/147/304","source":{"id":"https://openalex.org/S4404676725","display_name":"Medicina academica integrativa.","issn_l":"3029-3308","issn":["3029-3308","3029-3316"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4404676724","host_organization_name":"University of Mostar","host_organization_lineage":["https://openalex.org/P4404676724"],"host_organization_lineage_names":["University of Mostar"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina Academica Integrativa","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pauk.sum.ba/ojs/mai/article/download/163/147/304","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Martina Kova\u010d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799544919","display_name":"University Clinical Hospital Mostar","ror":"https://ror.org/05wcbg446","country_code":"BA","type":"healthcare","lineage":["https://openalex.org/I2799544919"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Martina Kova\u010d","raw_affiliation_strings":["Oncology Clinic, University Clinical Hospital Mostar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Clinic, University Clinical Hospital Mostar","institution_ids":["https://openalex.org/I2799544919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117831278","display_name":"Marija Karaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799544919","display_name":"University Clinical Hospital Mostar","ror":"https://ror.org/05wcbg446","country_code":"BA","type":"healthcare","lineage":["https://openalex.org/I2799544919"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Marija Karaga","raw_affiliation_strings":["Oncology Clinic, University Clinical Hospital Mostar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Clinic, University Clinical Hospital Mostar","institution_ids":["https://openalex.org/I2799544919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071175533","display_name":"Dragana Mileti\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799544919","display_name":"University Clinical Hospital Mostar","ror":"https://ror.org/05wcbg446","country_code":"BA","type":"healthcare","lineage":["https://openalex.org/I2799544919"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Dragana Mileti\u0107","raw_affiliation_strings":["Oncology Clinic, University Clinical Hospital Mostar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Clinic, University Clinical Hospital Mostar","institution_ids":["https://openalex.org/I2799544919"]}]},{"author_position":"last","author":{"id":null,"display_name":"Inga Marijanovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799544919","display_name":"University Clinical Hospital Mostar","ror":"https://ror.org/05wcbg446","country_code":"BA","type":"healthcare","lineage":["https://openalex.org/I2799544919"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Inga Marijanovi\u0107","raw_affiliation_strings":["Oncology Clinic, University Clinical Hospital Mostar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Clinic, University Clinical Hospital Mostar","institution_ids":["https://openalex.org/I2799544919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2799544919"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38093867,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"2","first_page":"41","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.9610000252723694},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.9520000219345093},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.7009999752044678},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.7099999785423279},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9869999885559082},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-lines","display_name":"treatment lines","score":0.6890000104904175},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5490000247955322},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.6690000295639038},{"id":"https://openalex.org/keywords/treatment-interruption","display_name":"treatment interruption","score":0.875}],"concepts":[{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.6296514272689819},{"id":"https://openalex.org/C2908728163","wikidata":"https://www.wikidata.org/wiki/Q415271","display_name":"Human Epidermal Growth Factor Receptor 2","level":4,"score":0.5839787721633911},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.554753839969635},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5523470640182495},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5101373791694641},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48372629284858704},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47828659415245056},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4751429557800293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44575217366218567},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.42306390404701233},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4185551106929779},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4164067804813385},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41087979078292847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2473360300064087},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08865061402320862}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.47960/3029-3316.2024.2.1.41","doi":"https://doi.org/10.47960/3029-3316.2024.2.1.41","is_oa":true,"landing_page_url":"https://doi.org/10.47960/3029-3316.2024.2.1.41","pdf_url":"https://pauk.sum.ba/ojs/mai/article/download/163/147/304","source":{"id":"https://openalex.org/S4404676725","display_name":"Medicina academica integrativa.","issn_l":"3029-3308","issn":["3029-3308","3029-3316"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4404676724","host_organization_name":"University of Mostar","host_organization_lineage":["https://openalex.org/P4404676724"],"host_organization_lineage_names":["University of Mostar"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina Academica Integrativa","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.47960/3029-3316.2024.2.1.41","doi":"https://doi.org/10.47960/3029-3316.2024.2.1.41","is_oa":true,"landing_page_url":"https://doi.org/10.47960/3029-3316.2024.2.1.41","pdf_url":"https://pauk.sum.ba/ojs/mai/article/download/163/147/304","source":{"id":"https://openalex.org/S4404676725","display_name":"Medicina academica integrativa.","issn_l":"3029-3308","issn":["3029-3308","3029-3316"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4404676724","host_organization_name":"University of Mostar","host_organization_lineage":["https://openalex.org/P4404676724"],"host_organization_lineage_names":["University of Mostar"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina Academica Integrativa","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411031371.pdf","grobid_xml":"https://content.openalex.org/works/W4411031371.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402561689","https://openalex.org/W4397007235","https://openalex.org/W4309486417","https://openalex.org/W4310753911","https://openalex.org/W4404026121","https://openalex.org/W4410823161","https://openalex.org/W4380150743","https://openalex.org/W4242284502","https://openalex.org/W2039815363","https://openalex.org/W4223500579"],"abstract_inverted_index":{"Background:":[0],"The":[1,70],"aim":[2],"of":[3,14,54,98,133,140,143,205,228],"the":[4,9,52,95,99,105,122,130,134,141,155,200,221,242],"study":[5,71,150],"was":[6,151,161,191],"to":[7,30,41,45,111,168,211],"determine":[8,31],"therapeutic":[10,182],"response":[11,40,167],"and":[12,39,62,66,137,145,202],"toxicity":[13],"CDK":[15,84,176,231],"4/6":[16,85,177,232],"inhibitor":[17,233],"therapy":[18,42,169,198,215,234],"in":[19,37,43,166,179,189,199,216],"patients":[20,79,173,194,229],"with":[21,83],"hormone-positive":[22],"HER2-negative":[23,90],"metastatic":[24,91],"breast":[25,92],"cancer.":[26],"Additional":[27],"aims":[28],"were":[29,81,118,127],"whether":[32],"there":[33],"is":[34],"a":[35,185],"difference":[36,165,188],"survival":[38,209],"relation":[44],"age,":[46],"ECOG":[47],"status,":[48],"other":[49],"visceral":[50],"diseases,":[51],"length":[53],"time":[55],"waiting":[56],"for":[57,77,87,116],"drug":[58],"approval,":[59],"side":[60,238],"effects,":[61,239],"consequently,":[63],"treatment":[64,206],"interruption":[65],"dose":[67],"reduction.":[68],"Methods:":[69],"analyzed":[72],"all":[73],"available":[74],"medical":[75,123],"documentation":[76],"65":[78],"who":[80,174,195,213],"treated":[82],"inhibitors":[86,178],"hormone":[88],"receptor-positive":[89],"cancer":[93],"at":[94],"Oncology":[96],"Clinic":[97],"University":[100],"Clinical":[101],"Hospital":[102],"Mostar":[103],"during":[104],"period":[106],"from":[107,129],"January":[108],"1,":[109],"2020,":[110],"December":[112],"31,":[113],"2023.":[114],"Data":[115],"analysis":[117],"obtained":[119,128,156],"by":[120],"processing":[121],"documentation.":[124],"Additionally,":[125],"data":[126],"Federal":[131],"Fund":[132],"Health":[135],"Insurance":[136],"Reinsurance":[138],"Institute":[139],"Federation":[142],"Bosnia":[144],"Herzegovina.":[146],"A":[147,224],"retrospective":[148],"cohort":[149],"conducted":[152],"based":[153],"on":[154,230],"data.":[157],"Principal":[158],"conclusion:":[159],"There":[160],"no":[162],"statistically":[163,186,225],"significant":[164,187,226],"regarding":[170],"PFS":[171],"between":[172],"received":[175,196,214],"four":[180],"different":[181],"lines.":[183],"However,":[184],"OS":[190],"found,":[192],"i.e.,":[193],"this":[197],"first":[201],"second":[203],"lines":[204],"had":[207],"longer":[208],"compared":[210],"those":[212],"later":[217],"lines,":[218],"partially":[219],"confirming":[220,241],"hypothesized":[222],"hypothesis.":[223,243],"majority":[227],"did":[235],"not":[236],"experience":[237],"thus":[240],"Keywords:":[244],"Breast":[245],"Neoplasms,":[246],"Neoplasm":[247],"Metastasis,":[248],"Cyclin-Dependent":[249],"Kinase":[250],"Inhibitor":[251]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
