{"id":"https://openalex.org/W4411020118","doi":"https://doi.org/10.1080/29933935.2025.2508199","title":"Two-week supplementation of Bifidobacterium adolescentis iVS-1 reduces symptoms associated with lactose intolerance in lactose maldigesters","display_name":"Two-week supplementation of Bifidobacterium adolescentis iVS-1 reduces symptoms associated with lactose intolerance in lactose maldigesters","publication_year":2025,"publication_date":"2025-06-04","ids":{"openalex":"https://openalex.org/W4411020118","doi":"https://doi.org/10.1080/29933935.2025.2508199","pmid":"https://pubmed.ncbi.nlm.nih.gov/41909904","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12940102"},"language":"en","primary_location":{"id":"doi:10.1080/29933935.2025.2508199","doi":"https://doi.org/10.1080/29933935.2025.2508199","is_oa":true,"landing_page_url":"https://doi.org/10.1080/29933935.2025.2508199","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/29933935.2025.2508199?needAccess=true","source":{"id":"https://openalex.org/S4390297034","display_name":"Gut Microbes Reports","issn_l":"2993-3935","issn":["2993-3935"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/29933935.2025.2508199?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090687256","display_name":"Monica Ramakrishnan","orcid":"https://orcid.org/0000-0001-9758-6543","observed_orcids":["https://orcid.org/0000-0001-9758-6543"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Ramakrishnan","raw_affiliation_strings":["Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","Department of Nutrition Science, Purdue University, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011316965","display_name":"Tzu-Wen Cross","orcid":"https://orcid.org/0000-0002-8856-8578","observed_orcids":["https://orcid.org/0000-0002-8856-8578"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tzu-Wen L. Cross","raw_affiliation_strings":["Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","Department of Nutrition Science, Purdue University, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157812404","display_name":"Anne K. Wilcox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne K. Wilcox","raw_affiliation_strings":["Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","Department of Nutrition Science, Purdue University, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029301588","display_name":"Anna Clapp Organski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Clapp Organski","raw_affiliation_strings":["Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","Department of Nutrition Science, Purdue University, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115733181","display_name":"Robin L. Rhine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin L. Rhine","raw_affiliation_strings":["Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","Department of Ecology & Evolutionary Biology, University of California, Irvine, CA, USA","Department of Nutrition Science, Purdue University, West Lafayette, IN, USA","University of California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Ecology & Evolutionary Biology, University of California, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"University of California","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092553822","display_name":"Sindusha Mysore Saiprasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sindusha Mysore Saiprasad","raw_affiliation_strings":["Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","Department of Pediatrics, UC Davis, Sacramento, CA, USA","UC Davis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Pediatrics, UC Davis, Sacramento, CA, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"UC Davis","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009003037","display_name":"Abigayle M. R. Simpson","orcid":"https://orcid.org/0000-0003-1714-6535","observed_orcids":["https://orcid.org/0000-0003-1714-6535"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigayle M. R. Simpson","raw_affiliation_strings":["Department of Ecology & Evolutionary Biology, University of California Irvine, California, USA","Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","Synbiotic Health","Synbiotic Health, Lincoln, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology & Evolutionary Biology, University of California Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Synbiotic Health","institution_ids":[]},{"raw_affiliation_string":"Synbiotic Health, Lincoln, NE, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036896252","display_name":"Daniel Joseph Tancredi","orcid":"https://orcid.org/0000-0002-3884-7907","observed_orcids":["https://orcid.org/0000-0002-3884-7907"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Tancredi","raw_affiliation_strings":["Department of Pediatrics, UC Davis, Sacramento, California 95817, USA;","Synbiotic Health","Synbiotic Health, Lincoln, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, UC Davis, Sacramento, California 95817, USA;","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Synbiotic Health","institution_ids":[]},{"raw_affiliation_string":"Synbiotic Health, Lincoln, NE, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025788069","display_name":"Mallory J. Suhr Van Haute","orcid":"https://orcid.org/0000-0002-2106-5124","observed_orcids":["https://orcid.org/0000-0002-2106-5124"]},"institutions":[{"id":"https://openalex.org/I4405273114","display_name":"American Forests","ror":"https://ror.org/05a0b2205","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405273114"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mallory J. Van Haute","raw_affiliation_strings":["Synbiotic Health, Lincoln, Nebraska, USA","Lewpine Consulting LLC","Lewpine Consulting LLC, American Fork, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synbiotic Health, Lincoln, Nebraska, USA","institution_ids":[]},{"raw_affiliation_string":"Lewpine Consulting LLC","institution_ids":[]},{"raw_affiliation_string":"Lewpine Consulting LLC, American Fork, UT, USA","institution_ids":["https://openalex.org/I4405273114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000249078","display_name":"Chloe M. Christensen","orcid":"https://orcid.org/0000-0002-3097-539X","observed_orcids":["https://orcid.org/0000-0002-3097-539X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chloe M. Christensen","raw_affiliation_strings":["Synbiotic Health, Lincoln, Nebraska, USA","Synbiotic Health","Synbiotic Health, Lincoln, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synbiotic Health, Lincoln, Nebraska, USA","institution_ids":[]},{"raw_affiliation_string":"Synbiotic Health","institution_ids":[]},{"raw_affiliation_string":"Synbiotic Health, Lincoln, NE, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088513617","display_name":"Zachery T. Lewis","orcid":"https://orcid.org/0000-0002-7725-2869","observed_orcids":["https://orcid.org/0000-0002-7725-2869"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Zachery T. Lewis","raw_affiliation_strings":["Lewpine Consulting LLC, American Fork, Utah, USA","School of Microbiology, Department of Medicine, and APC Microbiome Ireland, University College Cork, Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewpine Consulting LLC, American Fork, Utah, USA","institution_ids":[]},{"raw_affiliation_string":"School of Microbiology, Department of Medicine, and APC Microbiome Ireland, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091072392","display_name":"Thomas A. Auchtung","orcid":"https://orcid.org/0000-0002-0135-6266","observed_orcids":["https://orcid.org/0000-0002-0135-6266"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Auchtung","raw_affiliation_strings":["Synbiotic Health, Lincoln, Nebraska, USA","Department of Food Science and Technology, Nebraska Food for Health Center, University of Nebraska, Lincoln, NE, USA","University of Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synbiotic Health, Lincoln, Nebraska, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Food Science and Technology, Nebraska Food for Health Center, University of Nebraska, Lincoln, NE, USA","institution_ids":["https://openalex.org/I114395901"]},{"raw_affiliation_string":"University of Nebraska","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157853269","display_name":"Jens Walter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE","US"],"is_corresponding":false,"raw_author_name":"Jens Walter","raw_affiliation_strings":["School of Microbiology, Department of Medicine, and APC Microbiome Ireland, University College Cork, Cork, Ireland","Department of Nutrition Science, Purdue University, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Microbiology, Department of Medicine, and APC Microbiome Ireland, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016959484","display_name":"Robert W. Hutkins","orcid":"https://orcid.org/0000-0003-1206-5947","observed_orcids":["https://orcid.org/0000-0003-1206-5947"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Hutkins","raw_affiliation_strings":["Department of Food Science and Technology, Nebraska Food for Health Center, University of Nebraska, Lincoln, NE 68502, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Technology, Nebraska Food for Health Center, University of Nebraska, Lincoln, NE 68502, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085855717","display_name":"Dennis A. Savaiano","orcid":"https://orcid.org/0000-0001-8872-6276","observed_orcids":["https://orcid.org/0000-0001-8872-6276"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dennis A. Savaiano","raw_affiliation_strings":["Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5085855717"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":2.3486,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.86494569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"2","issue":"1","first_page":"2508199","last_page":"2508199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactose-intolerance","display_name":"lactose intolerance","score":0.8960000276565552},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8019999861717224},{"id":"https://openalex.org/keywords/beta-galactosidase","display_name":"beta-galactosidase","score":0.9100000262260437},{"id":"https://openalex.org/keywords/lactose-maldigestion","display_name":"lactose maldigestion","score":0.9660000205039978},{"id":"https://openalex.org/keywords/galactooligosaccharides","display_name":"galactooligosaccharides","score":0.9589999914169312},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":0.6639999747276306},{"id":"https://openalex.org/keywords/gastrointestinal-symptoms","display_name":"gastrointestinal symptoms","score":0.6489999890327454},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.7730000019073486},{"id":"https://openalex.org/keywords/fecal-urgency","display_name":"fecal urgency","score":0.8849999904632568},{"id":"https://openalex.org/keywords/gas-formation","display_name":"gas formation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/lactose-fermentation","display_name":"lactose fermentation","score":0.5600000023841858},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2777432071","wikidata":"https://www.wikidata.org/wiki/Q219223","display_name":"Lactose intolerance","level":3,"score":0.908475399017334},{"id":"https://openalex.org/C2778724459","wikidata":"https://www.wikidata.org/wiki/Q127900","display_name":"Lactose","level":2,"score":0.8849180340766907},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.7184063196182251},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.52213054895401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44038912653923035},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3463435173034668},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.09976539015769958},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.09496745467185974}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1080/29933935.2025.2508199","doi":"https://doi.org/10.1080/29933935.2025.2508199","is_oa":true,"landing_page_url":"https://doi.org/10.1080/29933935.2025.2508199","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/29933935.2025.2508199?needAccess=true","source":{"id":"https://openalex.org/S4390297034","display_name":"Gut Microbes Reports","issn_l":"2993-3935","issn":["2993-3935"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes Reports","raw_type":"journal-article"},{"id":"doi:10.1101/2024.12.16.24319107","doi":"https://doi.org/10.1101/2024.12.16.24319107","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.12.16.24319107","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/12/16/2024.12.16.24319107.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:12940102","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12940102/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12940102/pdf/KGMR_2_2508199.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes Rep","raw_type":"Text"},{"id":"pmid:41909904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41909904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut microbes reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:355f474a67a042de9893a53b1ee9ee3d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/355f474a67a042de9893a53b1ee9ee3d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gut Microbes Reports, Vol 2, Iss 1 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/29933935.2025.2508199","doi":"https://doi.org/10.1080/29933935.2025.2508199","is_oa":true,"landing_page_url":"https://doi.org/10.1080/29933935.2025.2508199","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/29933935.2025.2508199?needAccess=true","source":{"id":"https://openalex.org/S4390297034","display_name":"Gut Microbes Reports","issn_l":"2993-3935","issn":["2993-3935"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332605","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411020118.pdf","grobid_xml":"https://content.openalex.org/works/W4411020118.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1546783991","https://openalex.org/W1978813613","https://openalex.org/W2034285706","https://openalex.org/W2055043387","https://openalex.org/W2057746244","https://openalex.org/W2061908562","https://openalex.org/W2083231447","https://openalex.org/W2084086329","https://openalex.org/W2097900169","https://openalex.org/W2117457769","https://openalex.org/W2148368648","https://openalex.org/W2170024099","https://openalex.org/W2401404581","https://openalex.org/W2408741412","https://openalex.org/W2511014725","https://openalex.org/W2528556938","https://openalex.org/W2613503171","https://openalex.org/W2616792245","https://openalex.org/W2807194798","https://openalex.org/W2809784323","https://openalex.org/W2913469559","https://openalex.org/W2938663642","https://openalex.org/W2963276645","https://openalex.org/W2969489093","https://openalex.org/W2975404032","https://openalex.org/W3015630858","https://openalex.org/W3037693413","https://openalex.org/W3090355613","https://openalex.org/W3108785720","https://openalex.org/W3122701034","https://openalex.org/W3136006140","https://openalex.org/W3207595951","https://openalex.org/W4220752769","https://openalex.org/W4296807794","https://openalex.org/W4388539984","https://openalex.org/W4392906193","https://openalex.org/W4399862981"],"related_works":["https://openalex.org/W4385812017","https://openalex.org/W2908771370","https://openalex.org/W4296807794","https://openalex.org/W134770954","https://openalex.org/W1978813613","https://openalex.org/W7065418223","https://openalex.org/W2616792245","https://openalex.org/W2408741412","https://openalex.org/W2377810711","https://openalex.org/W3122701034"],"abstract_inverted_index":{"ABSTRACT":[0],"Probiotic":[1],"supplements":[2],"containing":[3],"high":[4,63],"\u03b2-galactosidase-producing":[5],"bacteria":[6],"may":[7,193],"aid":[8],"in":[9,74],"the":[10,26,114,123,126,134,151],"management":[11],"of":[12,20,29,35,77,125,178,181,185],"lactose":[13,54,78,91,199],"intolerance.":[14,200],"We":[15],"previously":[16],"isolated":[17],"a":[18,30,38],"strain":[19],"Bifidobacterium":[21],"adolescentis":[22,98,191],",":[23],"iVS-1,":[24],"from":[25,41],"fecal":[27,71,166],"sample":[28],"human":[31],"donor":[32],"after":[33,133],"consumption":[34],"galactooligosaccharides":[36],"(GOS),":[37],"prebiotic":[39],"derived":[40],"lactose.":[42],"Therefore,":[43],"it":[44],"was":[45,86,120],"hypothesized":[46],"that":[47],"iVS-1":[48,61,99,118,143,192],"might":[49],"reduce":[50],"symptoms":[51,149,188],"associated":[52],"with":[53,89],"maldigestion.":[55],"Compared":[56,112],"to":[57,94,113,156],"other":[58],"probiotic":[59],"strains,":[60],"had":[62,162],"\u03b2-galactosidase":[64],"activity":[65],"and":[66,132,161,171,183],"reduced":[67],"gas":[68],"formation":[69],"by":[70],"communities":[72],"during":[73,150],"vitro":[75],"fermentations":[76],"or":[79,103],"milk.":[80],"A":[81],"randomized":[82,93],"placebo-controlled":[83],"clinical":[84],"trial":[85,204],"then":[87],"conducted":[88],"21":[90],"maldigesters,":[92],"receive":[95],"either":[96],"B.":[97,190],"(n":[100,105],"=":[101,106,130,140,159,169,174],"11)":[102],"placebo":[104,157],"10)":[107],"daily":[108,148],"for":[109,165,198],"two":[110,135],"weeks.":[111],"two-week":[115],"run-in":[116],"period,":[117],"abundance":[119],"higher":[121],"at":[122,207],"end":[124],"treatment":[127,152,197],"period":[128,138,153],"(p":[129,139,158,168,173],"0.0005)":[131],"week":[136],"post-treatment":[137],"0.045).":[141],"The":[142,176,203],"group":[144],"experienced":[145],"less":[146],"overall":[147],"when":[154],"compared":[155],"0.032)":[160],"significant":[163],"improvement":[164,184],"urgency":[167],"0.033)":[170],"diarrhea":[172],"0.006).":[175],"metabolism":[177],"lactose,":[179],"reduction":[180],"gas,":[182],"multiple":[186],"gastrointestinal":[187],"suggests":[189],"be":[194],"an":[195],"effective":[196],"Trial":[201],"Registration":[202],"is":[205],"registered":[206],"ClinicalTrials.gov":[208],"(":[209],"https://clinicaltrials.gov/study/NCT05668468":[210],").":[211]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2025-10-10T00:00:00"}