{"id":"https://openalex.org/W4410970679","doi":"https://doi.org/10.1158/1940-6207.c.7851704","title":"Data from Deriving a Mammogram-Based Risk Score from Screening Digital Breast Tomosynthesis for 5-Year Breast Cancer Risk Prediction","display_name":"Data from Deriving a Mammogram-Based Risk Score from Screening Digital Breast Tomosynthesis for 5-Year Breast Cancer Risk Prediction","publication_year":2025,"publication_date":"2025-06-02","ids":{"openalex":"https://openalex.org/W4410970679","doi":"https://doi.org/10.1158/1940-6207.c.7851704"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.c.7851704","doi":"https://doi.org/10.1158/1940-6207.c.7851704","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.7851704","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1940-6207.c.7851704","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050572872","display_name":"Shu Jiang","orcid":"https://orcid.org/0000-0003-1464-4838","observed_orcids":["https://orcid.org/0000-0003-1464-4838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shu Jiang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1464-4838","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036192458","display_name":"Debbie Lee Bennett","orcid":"https://orcid.org/0000-0003-1898-0361","observed_orcids":["https://orcid.org/0000-0003-1898-0361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debbie L. Bennett","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1898-0361","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5031201037","display_name":"Graham A. Colditz","orcid":"https://orcid.org/0000-0002-7307-0291","observed_orcids":["https://orcid.org/0000-0002-7307-0291"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Graham A. Colditz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7307-0291","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-risk-prediction","display_name":"breast cancer risk prediction","score":0.9020000100135803},{"id":"https://openalex.org/keywords/digital-breast-tomosynthesis","display_name":"digital breast tomosynthesis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mammography","display_name":"mammography","score":0.5899999737739563},{"id":"https://openalex.org/keywords/synthetic-images","display_name":"synthetic images","score":0.4560000002384186},{"id":"https://openalex.org/keywords/transfer-learning","display_name":"transfer learning","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tyrer-cuzick-model","display_name":"Tyrer-Cuzick model","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.843999981880188},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.765999972820282},{"id":"https://openalex.org/keywords/breast-cancer-screening","display_name":"breast cancer screening","score":0.6909999847412109},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2909182381","wikidata":"https://www.wikidata.org/wiki/Q7820316","display_name":"Digital Breast Tomosynthesis","level":5,"score":0.7509462833404541},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7363374829292297},{"id":"https://openalex.org/C147454874","wikidata":"https://www.wikidata.org/wiki/Q7820316","display_name":"Tomosynthesis","level":5,"score":0.709937334060669},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5611560940742493},{"id":"https://openalex.org/C2780472235","wikidata":"https://www.wikidata.org/wiki/Q324634","display_name":"Mammography","level":4,"score":0.4935840368270874},{"id":"https://openalex.org/C2778491387","wikidata":"https://www.wikidata.org/wiki/Q17011492","display_name":"Breast cancer screening","level":5,"score":0.4888007342815399},{"id":"https://openalex.org/C2777432617","wikidata":"https://www.wikidata.org/wiki/Q22905905","display_name":"Breast imaging","level":5,"score":0.4768472909927368},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.4573719799518585},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3998814523220062},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3538037836551666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29546216130256653},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26266300678253174},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22760862112045288},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1940-6207.c.7851704","doi":"https://doi.org/10.1158/1940-6207.c.7851704","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.7851704","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1940-6207.c.7851704","doi":"https://doi.org/10.1158/1940-6207.c.7851704","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.7851704","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408301994","https://openalex.org/W4402655163","https://openalex.org/W4280581942","https://openalex.org/W4220970294","https://openalex.org/W4280559251","https://openalex.org/W7140191557","https://openalex.org/W4414521601","https://openalex.org/W4411290780","https://openalex.org/W4393093467","https://openalex.org/W4417460470"],"abstract_inverted_index":{"Abstract":[0],"Screening":[1],"digital":[2,234],"breast":[3,9,76,111,250,269],"tomosynthesis":[4],"(DBT)":[5],"aims":[6],"to":[7,18,23,87,173,205,216,261],"identify":[8],"cancer":[10,77,103,112,251,270],"early":[11,24],"when":[12,162],"treatment":[13],"is":[14,213],"most":[15],"effective,":[16],"leading":[17],"reduced":[19],"mortality.":[20],"In":[21],"addition":[22],"detection,":[25],"the":[26,50,85,91,141,174,184,262],"information":[27],"contained":[28],"within":[29,232],"DBT":[30,65,122,178,254],"images":[31],"may":[32],"also":[33],"inform":[34],"subsequent":[35],"risk":[36,202,210,218,225,246,264,271],"stratification":[37],"and":[38,164,167,212,223,241,255],"guide":[39],"risk-reducing":[40],"management.":[41,226],"Using":[42],"transfer":[43],"learning,":[44],"we":[45],"refined":[46],"a":[47,59,96,130,188,244],"model":[48,86,145,175,181,200,228,248],"in":[49,81,126,140,147,268],"Joanne":[51],"Knight":[52],"Breast":[53,93,165],"Health":[54],"Cohort":[55],"at":[56],"Washington":[57],"University,":[58],"cohort":[60,97],"of":[61,98,133,153,191],"5,066":[62],"women":[63,100],"with":[64,75,176,187],"screening":[66],"(mean":[67,104],"age,":[68,105],"54.6),":[69],"among":[70,107],"whom":[71,108],"105":[72],"were":[73,114,171],"diagnosed":[74,115],"(26":[78],"ductal":[79,124],"carcinoma":[80,125],"situ).":[82,127],"We":[83,128,239],"applied":[84],"external":[88,148],"data":[89,149],"from":[90,102],"Emory":[92],"Imaging":[94],"Dataset,":[95],"7,017":[99],"free":[101],"55.4),":[106],"111":[109],"pathology-confirmed":[110],"cases":[113],"more":[116],"than":[117],"6":[118],"months":[119],"after":[120],"initial":[121],"(17":[123],"obtained":[129],"5-year":[131,189,209,245],"AUC":[132,152,159,190],"0.75":[134],"[95%":[135],"confidence":[136],"interval":[137],"(CI),":[138],"0.73\u20130.78]":[139],"internal":[142],"validation.":[143],"The":[144,158,180,227],"validated":[146],"gave":[150],"an":[151],"0.72":[154],"(95%":[155,193],"CI,":[156,194],"0.69\u20130.75).":[157],"was":[160],"unchanged":[161],"age":[163],"Imaging-Reporting":[166],"Data":[168],"System":[169],"density":[170],"added":[172],"synthetic":[177,206,253],"images.":[179],"significantly":[182],"outperforms":[183],"Tyrer-Cuzick":[185],"model,":[186],"0.56":[192],"0.54\u20130.58;":[195],"P":[196],"<":[197],"0.01).":[198],"Our":[199],"extends":[201],"prediction":[203,247],"applications":[204],"DBT,":[207],"provides":[208],"estimates,":[211],"readily":[214],"calibrated":[215],"national":[217,263],"strata":[219,265],"for":[220,249],"clinical":[221,257],"translation":[222],"guideline-driven":[224],"could":[229],"be":[230],"implemented":[231],"any":[233],"mammography":[235],"program.":[236],"Prevention":[237],"Relevance:":[238],"develop":[240],"externally":[242],"validate":[243],"using":[252],"demonstrate":[256],"utility":[258],"by":[259],"calibrating":[260],"as":[266],"defined":[267],"management":[272],"guidelines.":[273]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}