{"id":"https://openalex.org/W4410957301","doi":"https://doi.org/10.1042/bcj20253033","title":"Arginine promotes the activation of human lung fibroblasts independent of its metabolism","display_name":"Arginine promotes the activation of human lung fibroblasts independent of its metabolism","publication_year":2025,"publication_date":"2025-06-01","ids":{"openalex":"https://openalex.org/W4410957301","doi":"https://doi.org/10.1042/bcj20253033","pmid":"https://pubmed.ncbi.nlm.nih.gov/39554075","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11565920"},"language":"en","primary_location":{"id":"doi:10.1042/bcj20253033","doi":"https://doi.org/10.1042/bcj20253033","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bcj20253033","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1042/bcj20253033","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066414145","display_name":"Robert B. Hamanaka","orcid":"https://orcid.org/0000-0002-8909-356X","observed_orcids":["https://orcid.org/0000-0002-8909-356X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B Hamanaka","raw_affiliation_strings":["1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A"],"raw_orcid":"https://orcid.org/0000-0002-8909-356X","affiliations":[{"raw_affiliation_string":"1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113250721","display_name":"Kun Woo D Shin","orcid":"https://orcid.org/0009-0000-0477-153X","observed_orcids":["https://orcid.org/0009-0000-0477-153X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kun Woo D Shin","raw_affiliation_strings":["1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042515589","display_name":"Volkan Atalay","orcid":"https://orcid.org/0000-0001-7850-0601","observed_orcids":["https://orcid.org/0000-0001-7850-0601"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Volkan Atalay","raw_affiliation_strings":["2Department of Information Systems and Supply Chain Management, Loyola University Chicago, Chicago, IL 60611, U.S.A"],"raw_orcid":"https://orcid.org/0000-0001-7850-0601","affiliations":[{"raw_affiliation_string":"2Department of Information Systems and Supply Chain Management, Loyola University Chicago, Chicago, IL 60611, U.S.A","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037440533","display_name":"Reng\u00fcl \u00c7etin-Atalay","orcid":"https://orcid.org/0000-0003-2408-6606","observed_orcids":["https://orcid.org/0000-0003-2408-6606"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rengul Cetin-Atalay","raw_affiliation_strings":["1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A"],"raw_orcid":"https://orcid.org/0000-0003-2408-6606","affiliations":[{"raw_affiliation_string":"1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047018273","display_name":"Hardik Shah","orcid":"https://orcid.org/0000-0001-8408-5686","observed_orcids":["https://orcid.org/0000-0001-8408-5686"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4390039251","display_name":"University of Chicago Medicine Comprehensive Cancer Center","ror":"https://ror.org/042wftp98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865","https://openalex.org/I4390039251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hardik Shah","raw_affiliation_strings":["3Metabolomics Platform, Comprehensive Cancer Center, The University of Chicago, Chicago, IL 60637, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Metabolomics Platform, Comprehensive Cancer Center, The University of Chicago, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4390039251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082102722","display_name":"Jennifer C. Houpy Szafran","orcid":"https://orcid.org/0000-0001-6154-5205","observed_orcids":["https://orcid.org/0000-0001-6154-5205"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer C Houpy Szafran","raw_affiliation_strings":["1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079814684","display_name":"Parker S. Woods","orcid":"https://orcid.org/0000-0002-9054-4196","observed_orcids":["https://orcid.org/0000-0002-9054-4196"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parker S Woods","raw_affiliation_strings":["1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112096955","display_name":"Angelo Y. Meliton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelo Y Meliton","raw_affiliation_strings":["1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045464318","display_name":"Obada R. Shamaa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Obada R Shamaa","raw_affiliation_strings":["1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030184709","display_name":"Yufeng Tian","orcid":"https://orcid.org/0000-0002-6814-7071","observed_orcids":["https://orcid.org/0000-0002-6814-7071"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yufeng Tian","raw_affiliation_strings":["1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090951343","display_name":"Takugo Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takugo Cho","raw_affiliation_strings":["1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059656427","display_name":"G\u00f6khan M. Mutlu","orcid":"https://orcid.org/0000-0002-2056-612X","observed_orcids":["https://orcid.org/0000-0002-2056-612X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G\u00f6khan M Mutlu","raw_affiliation_strings":["1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A"],"raw_orcid":"https://orcid.org/0000-0002-2056-612X","affiliations":[{"raw_affiliation_string":"1Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059656427"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":9.493,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.98757737,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"482","issue":"12","first_page":"823","last_page":"838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.2337999939918518,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.07779999822378159,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8790000081062317},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.9169999957084656},{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8569999933242798},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/arginine-metabolism","display_name":"arginine metabolism","score":0.7670000195503235},{"id":"https://openalex.org/keywords/gcn2","display_name":"GCN2","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/citrulline","display_name":"citrulline","score":0.8939999938011169},{"id":"https://openalex.org/keywords/argininosuccinate-synthetase","display_name":"argininosuccinate synthetase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/collagen-expression","display_name":"collagen expression","score":0.7540000081062317},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8600000143051147},{"id":"https://openalex.org/keywords/arginine-deprivation","display_name":"arginine deprivation","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.8176270723342896},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5723820328712463},{"id":"https://openalex.org/C2779744229","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Human lung","level":3,"score":0.5503338575363159},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5013339519500732},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49758341908454895},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4500029683113098},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3662288784980774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3178849518299103},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2700106203556061},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2120538055896759},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.20034858584403992}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1042/bcj20253033","doi":"https://doi.org/10.1042/bcj20253033","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bcj20253033","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"doi:10.1101/2024.11.01.618293","doi":"https://doi.org/10.1101/2024.11.01.618293","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.11.01.618293","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:12235046","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12235046","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:39554075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39554075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:40454944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40454944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11565920","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11565920","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11565920/pdf/nihpp-2024.11.01.618293v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1042/bcj20253033","doi":"https://doi.org/10.1042/bcj20253033","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bcj20253033","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2053708667","display_name":null,"funder_award_id":"R01HL151680 (RBH) and F32HL167569 (ORS)","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6924344760","display_name":"Glutamine Metabolism in Alveolar Macrophages following Influenza A Infection","funder_award_id":"F32HL167569","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7344412722","display_name":null,"funder_award_id":"R01ES010524","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G83920212","display_name":null,"funder_award_id":"R01HL151680 (RBH) and F32HL167569","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000892405","display_name":"ChicAgo Center for Health and EnvironmenT (CACHET)","funder_award_id":"P30ES027792","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G903082952","display_name":"Metabolic Regulation of Myofibroblast Differentiation","funder_award_id":"R01HL151680","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410957301.pdf","grobid_xml":"https://content.openalex.org/works/W4410957301.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1493142940","https://openalex.org/W1970926917","https://openalex.org/W1972933720","https://openalex.org/W1996295305","https://openalex.org/W2008239768","https://openalex.org/W2011944016","https://openalex.org/W2019431738","https://openalex.org/W2024260450","https://openalex.org/W2025029681","https://openalex.org/W2045142779","https://openalex.org/W2051994750","https://openalex.org/W2065122236","https://openalex.org/W2101960743","https://openalex.org/W2109163588","https://openalex.org/W2113127336","https://openalex.org/W2114104545","https://openalex.org/W2126960653","https://openalex.org/W2135003533","https://openalex.org/W2152550693","https://openalex.org/W2159571285","https://openalex.org/W2167700196","https://openalex.org/W2197124664","https://openalex.org/W2318614509","https://openalex.org/W2323326409","https://openalex.org/W2485649401","https://openalex.org/W2555868191","https://openalex.org/W2565062778","https://openalex.org/W2571931234","https://openalex.org/W2604353006","https://openalex.org/W2622134291","https://openalex.org/W2764000436","https://openalex.org/W2892293198","https://openalex.org/W2902994754","https://openalex.org/W2906906692","https://openalex.org/W2937049592","https://openalex.org/W2938184291","https://openalex.org/W2943664521","https://openalex.org/W2946604129","https://openalex.org/W2958340383","https://openalex.org/W2979370542","https://openalex.org/W2981640996","https://openalex.org/W3009792425","https://openalex.org/W3021543659","https://openalex.org/W3040876684","https://openalex.org/W3043103202","https://openalex.org/W3119881275","https://openalex.org/W3122854029","https://openalex.org/W3134140991","https://openalex.org/W3159234432","https://openalex.org/W3194603675","https://openalex.org/W3215946229","https://openalex.org/W3216744479","https://openalex.org/W4321611761","https://openalex.org/W4378781368","https://openalex.org/W4392239915","https://openalex.org/W4400491625","https://openalex.org/W4404026945","https://openalex.org/W4405985520"],"related_works":["https://openalex.org/W4410275819","https://openalex.org/W2126960653","https://openalex.org/W6888679320","https://openalex.org/W7161567916","https://openalex.org/W2062481948","https://openalex.org/W2312732964","https://openalex.org/W2152550693","https://openalex.org/W2325985252","https://openalex.org/W2323600853","https://openalex.org/W4380795377"],"abstract_inverted_index":{"Arginine":[0,27],"is":[1,195],"a":[2,49],"conditionally":[3],"essential":[4],"amino":[5],"acid":[6],"with":[7,84,124],"known":[8],"roles":[9,57],"in":[10,42,60,80,99,120,178,192],"protein":[11,167],"production,":[12],"nitric":[13],"oxide":[14],"synthesis,":[15],"biosynthesis":[16,28],"of":[17,23,40,45,58,63,77,93,106,115,134,149,160,175,190,198,202],"proline":[18],"and":[19,21,29,55,75,96,108,136,165,200],"polyamines,":[20],"regulation":[22,76],"intracellular":[24],"signaling":[25,56,203],"pathways.":[26],"catabolism":[30,119],"have":[31],"been":[32,68],"linked":[33],"to":[34,146],"transforming":[35],"growth":[36],"factor-\u03b2":[37],"(TGF-\u03b2)-induced":[38],"activation":[39,65,148,164],"fibroblasts":[41,82,122,194],"the":[43,53,61,73,91,147,173,187],"context":[44],"pulmonary":[46],"fibrosis;":[47],"however,":[48],"thorough":[50],"study":[51],"on":[52],"metabolic":[54,104],"arginine":[59,78,94,107,116,128,143,176,191],"process":[62],"fibroblast":[64,209],"has":[66],"not":[67],"conducted.":[69],"Here,":[70],"we":[71,111],"examined":[72],"role":[74,189],"metabolism":[79],"lung":[81,100,121,193],"activated":[83],"TGF-\u03b2.":[85,125],"We":[86,140],"found":[87,112,141],"that":[88,142,186],"TGF-\u03b2":[89],"increases":[90],"expression":[92,133],"biosynthetic":[95],"catabolic":[97],"enzymes":[98],"fibroblasts.":[101],"Surprisingly,":[102],"using":[103],"tracers":[105],"its":[109],"precursors,":[110],"little":[113],"evidence":[114],"synthesis":[117],"or":[118],"treated":[123],"Despite":[126],"this,":[127],"remained":[129],"crucial":[130],"for":[131,196,208],"TGF-\u03b2-induced":[132,157],"collagen":[135,166],"\u03b1-smooth":[137],"muscle":[138],"actin.":[139],"limitation":[144],"leads":[145],"general":[150],"control":[151],"nonderepressible":[152],"2":[153],"(GCN2),":[154],"while":[155],"inhibiting":[156],"mechanistic":[158],"target":[159],"rapamycin":[161],"complex":[162],"1":[163],"production.":[168],"Extracellular":[169],"citrulline":[170],"could":[171],"rescue":[172],"effect":[174],"deprivation":[177],"an":[179],"argininosuccinate":[180],"synthase-dependent":[181],"manner.":[182],"Our":[183],"findings":[184],"suggest":[185],"major":[188],"charging":[197],"arginyl-tRNAs":[199],"promotion":[201],"events":[204],"which":[205],"are":[206],"required":[207],"activation.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-10T00:00:00"}