{"id":"https://openalex.org/W4410955394","doi":"https://doi.org/10.1001/jama.2025.7398","title":"Prevalence of Artificial Sweetener Neotame in US-Marketed Disposable E-Cigarettes","display_name":"Prevalence of Artificial Sweetener Neotame in US-Marketed Disposable E-Cigarettes","publication_year":2025,"publication_date":"2025-06-02","ids":{"openalex":"https://openalex.org/W4410955394","doi":"https://doi.org/10.1001/jama.2025.7398","pmid":"https://pubmed.ncbi.nlm.nih.gov/40060039","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11888565"},"language":"en","primary_location":{"id":"doi:10.1001/jama.2025.7398","doi":"https://doi.org/10.1001/jama.2025.7398","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.2025.7398","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.21203/rs.3.rs-6074654/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005940470","display_name":"Hanno C. Erythropel","orcid":"https://orcid.org/0000-0003-3443-9794","observed_orcids":["https://orcid.org/0000-0003-3443-9794"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanno C. Erythropel","raw_affiliation_strings":["Department of Chemical and Environmental Engineering, Yale University, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Environmental Engineering, Yale University, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024237390","display_name":"Sairam V. Jabba","orcid":"https://orcid.org/0000-0003-0646-3519","observed_orcids":["https://orcid.org/0000-0003-0646-3519"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sairam V. Jabba","raw_affiliation_strings":["Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116441906","display_name":"Remi A. Mellinghoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Remi A. Mellinghoff","raw_affiliation_strings":["Department of Chemical and Environmental Engineering, Yale University, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Environmental Engineering, Yale University, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116441907","display_name":"Victor Garcia-Gallet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Garcia-Gallet","raw_affiliation_strings":["Rensselaer Polytechnic Institute, Troy, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rensselaer Polytechnic Institute, Troy, New York","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066728798","display_name":"Peter Silinski","orcid":"https://orcid.org/0000-0003-3680-3115","observed_orcids":["https://orcid.org/0000-0003-3680-3115"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Silinski","raw_affiliation_strings":["Department of Chemistry, Duke University, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Duke University, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044625101","display_name":"Julie Beth Zimmerman","orcid":"https://orcid.org/0000-0002-5392-312X","observed_orcids":["https://orcid.org/0000-0002-5392-312X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie B. Zimmerman","raw_affiliation_strings":["Department of Chemical and Environmental Engineering, Yale University, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Environmental Engineering, Yale University, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083624959","display_name":"Sven\u2010Eric Jordt","orcid":"https://orcid.org/0000-0001-6171-5622","observed_orcids":["https://orcid.org/0000-0001-6171-5622"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sven E. Jordt","raw_affiliation_strings":["Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1041,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.95875208,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"334","issue":"5","first_page":"448","last_page":"448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14396","display_name":"Healthcare Regulation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neotame","display_name":"neotame","score":0.9980000257492065},{"id":"https://openalex.org/keywords/artificial-sweeteners","display_name":"artificial sweeteners","score":0.9850000143051147},{"id":"https://openalex.org/keywords/disposable-e-cigarettes","display_name":"disposable e-cigarettes","score":0.9769999980926514},{"id":"https://openalex.org/keywords/high-intensity-sweeteners","display_name":"high-intensity sweeteners","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9156243205070496},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.8382124900817871},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.5654615759849548},{"id":"https://openalex.org/C2911055575","wikidata":"https://www.wikidata.org/wiki/Q626292","display_name":"Artificial Sweetener","level":3,"score":0.5047479867935181},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2874983549118042},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.23097312450408936},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07072219252586365},{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1001/jama.2025.7398","doi":"https://doi.org/10.1001/jama.2025.7398","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.2025.7398","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-6074654/v1","doi":"https://doi.org/10.21203/rs.3.rs-6074654/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-6074654/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:40060039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40060039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Journal Article"},{"id":"pmid:40455485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40455485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11888565","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11888565","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Res Sq","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12131167","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12131167/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JAMA","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-6074654/v1","doi":"https://doi.org/10.21203/rs.3.rs-6074654/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-6074654/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000898435","display_name":"Impact of new tobacco product design and synthetic additives on use initiation and preference behavior","funder_award_id":"R01DA060884","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000912004","display_name":"Yale Center for the Study of Tobacco Product Use and Addiction (YCSTP)","funder_award_id":"U54DA036151","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W4296793988","https://openalex.org/W4399171735","https://openalex.org/W4401390826","https://openalex.org/W4401442730","https://openalex.org/W4405836063","https://openalex.org/W4407606773"],"related_works":["https://openalex.org/W7220425539","https://openalex.org/W4394994299","https://openalex.org/W4384282127","https://openalex.org/W4396830757","https://openalex.org/W4411981350","https://openalex.org/W4285801757","https://openalex.org/W4392840481","https://openalex.org/W4407632545","https://openalex.org/W6981459137","https://openalex.org/W2397702437"],"abstract_inverted_index":{"Background:":[0],"Sweeteners":[1],"are":[2],"used":[3],"by":[4,181],"tobacco":[5],"product":[6,10,86],"manufacturers":[7],"to":[8,178,197],"improve":[9],"palatability":[11],"and":[12,25,55,69,83,102,138,161,172,200],"appeal.":[13],"Recently,":[14],"the":[15,130,147,190],"high-intensity":[16],"artificial":[17,148,188],"sweetener,":[18],"neotame,":[19],"was":[20,91,127],"detected":[21,92,128],"in":[22,35,93,108,118,129,151,168,194],"nicotine":[23,68,79,103],"analogue-containing":[24],"\"zero":[26],"nicotine\"":[27],"electronic":[28],"cigarettes":[29],"(e-cigarettes).":[30],"The":[31,123,143],"prevalence":[32,145],"of":[33,76,133,146,164,192],"neotame":[34,58,150,193],"popular":[36,97],"US-marketed":[37],"disposable":[38,44,98,115,152],"e-cigarettes":[39,153,195],"remains":[40],"unknown.":[41],"Methods:":[42],"Popular":[43],"e-cigarette":[45,99],"devices":[46],"were":[47,72,87],"chosen":[48],"based":[49],"on":[50,159],"2024":[51],"US":[52],"market":[53],"surveys":[54],"analyzed":[56],"for":[57,202],"using":[59],"Liquid":[60],"Chromatography":[61],"-":[62],"Mass":[63],"Spectrometry":[64],"(LCMS).":[65],"Nicotine,":[66],"6-methyl":[67],"cooling":[70,171],"compounds":[71],"also":[73,120],"quantified.":[74],"Contents":[75],"FDA-approved":[77,110],"e-cigarettes,":[78],"analogue-containing,":[80],"\"zero-nicotine\"":[81],"disposables":[82],"a":[84],"candy":[85],"compared.":[88],"Results:":[89],"Neotame":[90],"all":[94],"57":[95],"tested":[96,134],"devices,":[100],"zero-nicotine,":[101],"analogue":[104],"products,":[105,135,166],"but":[106],"not":[107],"13":[109],"nor":[111],"Juul":[112],"products.":[113],"2":[114],"products":[116],"marketed":[117],"2021":[119],"contained":[121],"neotame.":[122],"synthetic":[124],"coolant":[125],"WS-23":[126],"large":[131],"majority":[132],"with":[136,170],"menthol":[137],"WS-3":[139],"less":[140],"prevalent.":[141],"Conclusions:":[142],"high":[144],"sweetener":[149],"raises":[154],"concerns":[155],"about":[156],"its":[157],"effects":[158],"appeal":[160],"abuse":[162],"potential":[163,203],"these":[165],"especially":[167],"combination":[169],"sweet-associated":[173],"flavors":[174],"(fruit,":[175],"candy)":[176],"known":[177],"be":[179,198],"preferred":[180],"youth.":[182],"While":[183],"more":[184],"heat-stable":[185],"than":[186],"other":[187],"sweeteners,":[189],"degradation":[191],"needs":[196],"investigated":[199],"assessed":[201],"toxicity.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2025-10-10T00:00:00"}
