{"id":"https://openalex.org/W4410940236","doi":"https://doi.org/10.1101/2025.05.29.656472","title":"Expanding the MR1 ligandome using chemical class-specific fragmentation and molecular networking","display_name":"Expanding the MR1 ligandome using chemical class-specific fragmentation and molecular networking","publication_year":2025,"publication_date":"2025-06-01","ids":{"openalex":"https://openalex.org/W4410940236","doi":"https://doi.org/10.1101/2025.05.29.656472","pmid":"https://pubmed.ncbi.nlm.nih.gov/40501914","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12154739"},"language":"en","primary_location":{"id":"doi:10.1101/2025.05.29.656472","doi":"https://doi.org/10.1101/2025.05.29.656472","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.29.656472","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/06/01/2025.05.29.656472.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/06/01/2025.05.29.656472.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5097335940","display_name":"Chiara Lecchi","orcid":"https://orcid.org/0009-0009-0345-778X","observed_orcids":["https://orcid.org/0009-0009-0345-778X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiara Lecchi","raw_affiliation_strings":["Masonic Cancer Center, University of Minnesota; Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0009-0009-0345-778X","affiliations":[{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota; Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083352550","display_name":"Alessandro Vacchini","orcid":"https://orcid.org/0000-0001-5473-9693","observed_orcids":["https://orcid.org/0000-0001-5473-9693"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alessandro Vacchini","raw_affiliation_strings":["Experimental Immunology, Department of Biomedicine, University Hospital and University of Basel, Basel 4031, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5473-9693","affiliations":[{"raw_affiliation_string":"Experimental Immunology, Department of Biomedicine, University Hospital and University of Basel, Basel 4031, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012424953","display_name":"Stefano Sainas","orcid":"https://orcid.org/0000-0001-5010-8536","observed_orcids":["https://orcid.org/0000-0001-5010-8536"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Sainas","raw_affiliation_strings":["Department of Drug Science and Technology. University of Torino, Via Pietro Giuria 9, Torino 10125, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5010-8536","affiliations":[{"raw_affiliation_string":"Department of Drug Science and Technology. University of Torino, Via Pietro Giuria 9, Torino 10125, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072049747","display_name":"Marco L. Lolli","orcid":"https://orcid.org/0000-0002-3030-3163","observed_orcids":["https://orcid.org/0000-0002-3030-3163"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco L. Lolli","raw_affiliation_strings":["Department of Drug Science and Technology. University of Torino, Via Pietro Giuria 9, Torino 10125, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3030-3163","affiliations":[{"raw_affiliation_string":"Department of Drug Science and Technology. University of Torino, Via Pietro Giuria 9, Torino 10125, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037223667","display_name":"Matthew W. Luedtke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Luedtke","raw_affiliation_strings":["Masonic Cancer Center, University of Minnesota; Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota; Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061145119","display_name":"Lucia Mori","orcid":"https://orcid.org/0000-0002-5522-4648","observed_orcids":["https://orcid.org/0000-0002-5522-4648"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lucia Mori","raw_affiliation_strings":["Experimental Immunology, Department of Biomedicine, University Hospital and University of Basel, Basel 4031, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-5522-4648","affiliations":[{"raw_affiliation_string":"Experimental Immunology, Department of Biomedicine, University Hospital and University of Basel, Basel 4031, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018674182","display_name":"Gennaro De Libero","orcid":"https://orcid.org/0000-0003-0853-7868","observed_orcids":["https://orcid.org/0000-0003-0853-7868"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gennaro De Libero","raw_affiliation_strings":["Experimental Immunology, Department of Biomedicine, University Hospital and University of Basel, Basel 4031, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-0853-7868","affiliations":[{"raw_affiliation_string":"Experimental Immunology, Department of Biomedicine, University Hospital and University of Basel, Basel 4031, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062371918","display_name":"Silvia Balbo","orcid":"https://orcid.org/0000-0002-7686-0504","observed_orcids":["https://orcid.org/0000-0002-7686-0504"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Silvia Balbo","raw_affiliation_strings":["Division of Environmental Health Sciences, School of Public Health University of Minnesota, Minneapolis, MN 55455, USA","Masonic Cancer Center, University of Minnesota; Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0002-7686-0504","affiliations":[{"raw_affiliation_string":"Division of Environmental Health Sciences, School of Public Health University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota; Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015278922","display_name":"Peter W. Villalta","orcid":"https://orcid.org/0000-0002-0067-3083","observed_orcids":["https://orcid.org/0000-0002-0067-3083"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W Villalta","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Minnesota, Minneapolis MN 55455, USA","Masonic Cancer Center, University of Minnesota; Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0002-0067-3083","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Minnesota, Minneapolis MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota; Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5062371918"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.37700000405311584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-networking","display_name":"molecular networking","score":0.9909999966621399},{"id":"https://openalex.org/keywords/riboflavin-analogs","display_name":"riboflavin analogs","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.5378313660621643},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.535514771938324},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5134199857711792},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4965968728065491},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.48126834630966187},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.45933711528778076},{"id":"https://openalex.org/C99679407","wikidata":"https://www.wikidata.org/wiki/Q56761637","display_name":"Substructure","level":2,"score":0.4164556860923767},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4082053601741791},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.13576224446296692},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09720760583877563},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2025.05.29.656472","doi":"https://doi.org/10.1101/2025.05.29.656472","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.29.656472","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/06/01/2025.05.29.656472.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40501914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40501914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12154739","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12154739","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.05.29.656472","doi":"https://doi.org/10.1101/2025.05.29.656472","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.29.656472","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/06/01/2025.05.29.656472.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410940236.pdf","grobid_xml":"https://content.openalex.org/works/W4410940236.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1543068333","https://openalex.org/W2031450946","https://openalex.org/W2035992057","https://openalex.org/W2062581107","https://openalex.org/W2065252029","https://openalex.org/W2162709457","https://openalex.org/W2260757309","https://openalex.org/W2318611331","https://openalex.org/W2399338035","https://openalex.org/W2549598671","https://openalex.org/W2614152856","https://openalex.org/W2802909948","https://openalex.org/W2883450285","https://openalex.org/W2895341279","https://openalex.org/W2945679805","https://openalex.org/W2955996460","https://openalex.org/W3009934661","https://openalex.org/W3080789666","https://openalex.org/W3092910538","https://openalex.org/W3129424480","https://openalex.org/W3147065452","https://openalex.org/W3205542661","https://openalex.org/W4307425304","https://openalex.org/W4317425811","https://openalex.org/W4387187589","https://openalex.org/W4390706650","https://openalex.org/W4390945625","https://openalex.org/W4391255793","https://openalex.org/W4396815340","https://openalex.org/W4398140932","https://openalex.org/W4399053829","https://openalex.org/W4400497912","https://openalex.org/W4401324982","https://openalex.org/W4401395804","https://openalex.org/W4402697799","https://openalex.org/W4404742165","https://openalex.org/W4407128387","https://openalex.org/W4410144981"],"related_works":["https://openalex.org/W4380576925","https://openalex.org/W2235147056","https://openalex.org/W4412630933","https://openalex.org/W2026834364","https://openalex.org/W1999426587","https://openalex.org/W3108604517","https://openalex.org/W4377565712","https://openalex.org/W4385460782","https://openalex.org/W2179948434","https://openalex.org/W2586351239"],"abstract_inverted_index":{"The":[0,173],"identification":[1],"and":[2,25,48,97,123,145,158,169,193],"subsequent":[3],"characterization":[4],"of":[5,45,55,74,119,167,175,187,208],"unknown":[6],"analytes":[7,160],"using":[8,80],"mass":[9,32,194],"spectrometry":[10],"presents":[11],"a":[12,38,83,120],"long-standing":[13],"challenge":[14],"across":[15],"many":[16],"research":[17],"fields,":[18],"particularly":[19],"when":[20],"analyte":[21],"levels":[22],"are":[23,162],"low":[24],"the":[26,53,67,77,117,133,181,185],"compound":[27,105,136],"class":[28,112,152],"is":[29],"underrepresented":[30],"in":[31,198],"spectral":[33,98,195],"databases.":[34],"We":[35,65],"have":[36],"developed":[37],"data":[39,56],"analysis":[40],"workflow":[41],"for":[42,60,71,88],"investigating":[43],"classes":[44,73,106,207],"small":[46],"molecules":[47],"demonstrated":[49],"its":[50],"application":[51,174],"through":[52],"reanalysis":[54],"collected":[57],"to":[58,69,109,130,179],"probe":[59],"modified":[61],"nucleoside":[62],"MR1-presented":[63],"antigens.":[64],"reanalyzed":[66],"datasets":[68],"screen":[70],"additional":[72,142],"compounds":[75,114],"within":[76],"MR1":[78,182],"ligandome":[79,183],"Compound":[81],"Discoverer,":[82],"commercial":[84],"software":[85],"package":[86],"designed":[87],"metabolomic":[89],"analysis,":[90],"featuring":[91],"fragmentation":[92],"filtering":[93],"nodes,":[94],"molecular":[95,124,191],"networking,":[96,192],"database":[99,196],"searching.":[100],"Our":[101],"study":[102],"identified":[103,164],"two":[104,141],"that":[107,161],"bind":[108],"MR1.":[110],"One":[111],"includes":[113],"characterized":[115],"by":[116,140],"presence":[118],"ribityl":[121],"substructure":[122],"formulas":[125],"consistent":[126],"with":[127],"structural":[128],"similarity":[129],"riboflavin,":[131],"where":[132],"most":[134],"abundant":[135],"differs":[137],"from":[138],"riboflavin":[139],"oxygen":[143],"atoms":[144],"one":[146],"fewer":[147],"carbon":[148],"atom.":[149],"A":[150],"second":[151],"comprises":[153],"an":[154],"adenosine":[155],"monophosphate":[156],"isomer":[157],"larger":[159],"putatively":[163],"as":[165],"consisting":[166],"di-":[168],"tri-covalently":[170],"bound":[171],"nucleotides.":[172],"our":[176],"analytical":[177],"approach":[178],"characterize":[180],"demonstrates":[184],"power":[186],"combining":[188],"compound-class":[189],"fragmentation,":[190],"searching":[197],"exploring":[199],"receptor":[200],"ligandomes":[201],"and,":[202],"more":[203],"generally,":[204],"identifying":[205],"novel":[206],"compounds.":[209]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-10T00:00:00"}
