{"id":"https://openalex.org/W4410936973","doi":"https://doi.org/10.21608/astb.2025.354245.1016","title":"Alzheimer's disease: exploring the pathogenesis, progression, and strategies for management","display_name":"Alzheimer's disease: exploring the pathogenesis, progression, and strategies for management","publication_year":2025,"publication_date":"2025-06-01","ids":{"openalex":"https://openalex.org/W4410936973","doi":"https://doi.org/10.21608/astb.2025.354245.1016"},"language":"en","primary_location":{"id":"doi:10.21608/astb.2025.354245.1016","doi":"https://doi.org/10.21608/astb.2025.354245.1016","is_oa":true,"landing_page_url":"https://doi.org/10.21608/astb.2025.354245.1016","pdf_url":"https://astb.journals.ekb.eg/article_428772_90b55e3599e7b1507b1ce8f0d9163677.pdf","source":{"id":"https://openalex.org/S4404670085","display_name":"Aswan Science and Technology Bulletin","issn_l":"1110-0184","issn":["1110-0184","3009-7916"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aswan Science and Technology Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://astb.journals.ekb.eg/article_428772_90b55e3599e7b1507b1ce8f0d9163677.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034064913","display_name":"Safinaz E. El-Baga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86310350","display_name":"Aswan University","ror":"https://ror.org/048qnr849","country_code":"EG","type":"education","lineage":["https://openalex.org/I86310350"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"safinaz A elbaga","raw_affiliation_strings":["Zoology department, Faculty of Science, Aswan University, Aswan, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zoology department, Faculty of Science, Aswan University, Aswan, Egypt","institution_ids":["https://openalex.org/I86310350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019684856","display_name":"Eatemad Ahmed Awadalla","orcid":"https://orcid.org/0000-0002-5470-3575","observed_orcids":["https://orcid.org/0000-0002-5470-3575"]},"institutions":[{"id":"https://openalex.org/I86310350","display_name":"Aswan University","ror":"https://ror.org/048qnr849","country_code":"EG","type":"education","lineage":["https://openalex.org/I86310350"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Eatemad Awadalla","raw_affiliation_strings":["Aswan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aswan University","institution_ids":["https://openalex.org/I86310350"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mohammed Hosny Hassaan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189575948","display_name":"South Valley University","ror":"https://ror.org/00jxshx33","country_code":"EG","type":"education","lineage":["https://openalex.org/I189575948"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohammed Hosny Hassaan","raw_affiliation_strings":["Medical Biochemistry Dep., Faculty Of Medicine, South Valley University,  Qena,  Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biochemistry Dep., Faculty Of Medicine, South Valley University,  Qena,  Egypt","institution_ids":["https://openalex.org/I189575948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5117792383","display_name":"Abdelkader Mohamed Abdelkader","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86310350","display_name":"Aswan University","ror":"https://ror.org/048qnr849","country_code":"EG","type":"education","lineage":["https://openalex.org/I86310350"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Abdelkader Mohamed Abdelkader","raw_affiliation_strings":["Aswan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aswan University","institution_ids":["https://openalex.org/I86310350"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"1","first_page":"132","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.028599999845027924,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.8220000267028809},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8109999895095825},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6029999852180481},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/memory-loss","display_name":"memory loss","score":0.5260000228881836},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.6480000019073486},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.6679999828338623},{"id":"https://openalex.org/keywords/alzheimer-s-disease-drugs","display_name":"Alzheimer's disease drugs","score":0.621999979019165},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7008782029151917},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6168677806854248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46064192056655884},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4420401453971863},{"id":"https://openalex.org/C2982889124","wikidata":"https://www.wikidata.org/wiki/Q107439039","display_name":"Disease management","level":4,"score":0.41343551874160767},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2766212821006775},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18129846453666687},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.12849408388137817}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21608/astb.2025.354245.1016","doi":"https://doi.org/10.21608/astb.2025.354245.1016","is_oa":true,"landing_page_url":"https://doi.org/10.21608/astb.2025.354245.1016","pdf_url":"https://astb.journals.ekb.eg/article_428772_90b55e3599e7b1507b1ce8f0d9163677.pdf","source":{"id":"https://openalex.org/S4404670085","display_name":"Aswan Science and Technology Bulletin","issn_l":"1110-0184","issn":["1110-0184","3009-7916"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aswan Science and Technology Bulletin","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21608/astb.2025.354245.1016","doi":"https://doi.org/10.21608/astb.2025.354245.1016","is_oa":true,"landing_page_url":"https://doi.org/10.21608/astb.2025.354245.1016","pdf_url":"https://astb.journals.ekb.eg/article_428772_90b55e3599e7b1507b1ce8f0d9163677.pdf","source":{"id":"https://openalex.org/S4404670085","display_name":"Aswan Science and Technology Bulletin","issn_l":"1110-0184","issn":["1110-0184","3009-7916"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aswan Science and Technology Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410936973.pdf","grobid_xml":"https://content.openalex.org/works/W4410936973.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1524376662","https://openalex.org/W1534628288","https://openalex.org/W1566564316","https://openalex.org/W1570302318","https://openalex.org/W1841772591","https://openalex.org/W1968900405","https://openalex.org/W1972982304","https://openalex.org/W1985031521","https://openalex.org/W2002171748","https://openalex.org/W2004405731","https://openalex.org/W2007044705","https://openalex.org/W2015882290","https://openalex.org/W2018317802","https://openalex.org/W2023819682","https://openalex.org/W2028265367","https://openalex.org/W2038003980","https://openalex.org/W2039194156","https://openalex.org/W2052136081","https://openalex.org/W2052792956","https://openalex.org/W2076517751","https://openalex.org/W2119757776","https://openalex.org/W2138740149","https://openalex.org/W2153823980","https://openalex.org/W2156093068","https://openalex.org/W2159271495","https://openalex.org/W2259782685","https://openalex.org/W2358666620","https://openalex.org/W2581177196","https://openalex.org/W2738888781","https://openalex.org/W2752287204","https://openalex.org/W2795738620","https://openalex.org/W2968638119","https://openalex.org/W3014251530","https://openalex.org/W4308512354","https://openalex.org/W4361207180","https://openalex.org/W4366526189","https://openalex.org/W4380792369","https://openalex.org/W4382182816","https://openalex.org/W4388009936","https://openalex.org/W7098836794"],"related_works":["https://openalex.org/W1986309965","https://openalex.org/W7166023785","https://openalex.org/W3111129073","https://openalex.org/W3207170903","https://openalex.org/W4382919179","https://openalex.org/W6893990869","https://openalex.org/W2386258460","https://openalex.org/W7151855831","https://openalex.org/W3007245640","https://openalex.org/W6893120441"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1,6],"(AD),":[2],"a":[3,94,116],"devastating":[4],"neurodegenerative":[5,33],"with":[7,17,48,93],"many":[8],"possible":[9],"etiologies":[10],"that":[11],"have":[12,45,128],"been":[13,46,129],"explained":[14],"and":[15,22,87,105,136,139],"associated":[16],"spatial":[18],"disorientation,":[19],"memory":[20,160],"loss":[21],"the":[23,49,76,83,132,137,143,155],"gradual":[24,61],"decline":[25,84],"of":[26,51,56,78,85,97,145],"intellectual":[27],"capacity.":[28],"The":[29,54],"current":[30],"research":[31],"on":[32],"illnesses":[34],"has":[35],"put":[36],"certain":[37],"candidate":[38],"compounds":[39],"through":[40],"clinical":[41],"trials.":[42],"Many":[43],"reasons":[44],"linked":[47],"increase":[50],"AD":[52,57,119],"risk.":[53],"progression":[55],"is":[58,99,120],"marked":[59],"by":[60,131],"cognitive":[62,88,146],"decline,":[63],"brain":[64],"alterations":[65],"such":[66],"as":[67],"decreased":[68],"information":[69],"transfer":[70],"throughout":[71],"synapses,":[72],"which":[73],"results":[74],"in":[75],"death":[77],"neurons,":[79],"thus":[80],"contributive":[81],"to":[82],"functional":[86],"abilities":[89],"Early":[90],"diagnosis,":[91],"coupled":[92],"better":[95],"understanding":[96],"biomarkers,":[98],"crucial":[100],"for":[101,142],"improving":[102],"patient":[103],"outcomes":[104],"developing":[106],"targeted":[107],"therapies.":[108],"Even":[109],"though":[110],"it":[111],"was":[112],"first":[113],"recognized":[114],"over":[115],"century":[117],"ago,":[118],"still":[121],"an":[122],"incurable":[123],"disease.":[124],"Only":[125],"four":[126],"medications":[127],"accepted":[130],"European":[133],"Medicines":[134],"Agency":[135],"Food":[138],"Drug":[140],"Administration":[141],"treatment":[144],"symptoms;":[147],"these":[148],"medications,":[149],"however,":[150],"cannot":[151],"stop":[152],"or":[153,159],"slow":[154],"disease's":[156],"progression,":[157],"neurodegeneration,":[158],"loss.":[161]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}