{"id":"https://openalex.org/W4410930215","doi":"https://doi.org/10.1172/jci191346","title":"Mechanism-based nonopioid analgesic targets","display_name":"Mechanism-based nonopioid analgesic targets","publication_year":2025,"publication_date":"2025-06-01","ids":{"openalex":"https://openalex.org/W4410930215","doi":"https://doi.org/10.1172/jci191346","pmid":"https://pubmed.ncbi.nlm.nih.gov/40454476","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12126239"},"language":"en","primary_location":{"id":"doi:10.1172/jci191346","doi":"https://doi.org/10.1172/jci191346","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci191346","pdf_url":"http://www.jci.org/articles/view/191346/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.jci.org/articles/view/191346/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034939866","display_name":"Xiangsunze Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangsunze Zeng","raw_affiliation_strings":["Center , Boston Children's Hospital and Department of Neurobiology , Harvard Medical School , Boston , Massachusetts , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center , Boston Children's Hospital and Department of Neurobiology , Harvard Medical School , Boston , Massachusetts , USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030898803","display_name":"Rasheen Powell","orcid":"https://orcid.org/0000-0003-4423-6413","observed_orcids":["https://orcid.org/0000-0003-4423-6413"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rasheen Powell","raw_affiliation_strings":["Center , Boston Children's Hospital and Department of Neurobiology , Harvard Medical School , Boston , Massachusetts , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center , Boston Children's Hospital and Department of Neurobiology , Harvard Medical School , Boston , Massachusetts , USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017534594","display_name":"Clifford J. Woolf","orcid":"https://orcid.org/0000-0002-6636-3897","observed_orcids":["https://orcid.org/0000-0002-6636-3897","https://orcid.org/0000-0001-9840-596X"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clifford J. Woolf","raw_affiliation_strings":["Center , Boston Children's Hospital and Department of Neurobiology , Harvard Medical School , Boston , Massachusetts , USA"],"raw_orcid":"https://orcid.org/0000-0002-6636-3897","affiliations":[{"raw_affiliation_string":"Center , Boston Children's Hospital and Department of Neurobiology , Harvard Medical School , Boston , Massachusetts , USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017534594"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":3.9981,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.95912322,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"135","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-opioid-analgesics","display_name":"non-opioid analgesics","score":0.996999979019165},{"id":"https://openalex.org/keywords/opioid-crisis","display_name":"opioid epidemic","score":0.5979999899864197},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.36899998784065247},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.6980000138282776},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.9039999842643738},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":1.0},{"id":"https://openalex.org/keywords/nociplastic-pain","display_name":"nociplastic pain","score":0.996999979019165},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.7889999747276306},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/multimodal-pain-therapy","display_name":"multimodal pain management","score":0.8399999737739563},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.7519999742507935},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pain-mechanisms","display_name":"pain mechanisms","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.7578281164169312},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.621667206287384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45010823011398315},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.4268394708633423},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42326316237449646},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci191346","doi":"https://doi.org/10.1172/jci191346","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci191346","pdf_url":"http://www.jci.org/articles/view/191346/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12126239","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12126239","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:40454476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40454476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:62a82abaa62f4a81bccb7f2f99d1cb10","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/62a82abaa62f4a81bccb7f2f99d1cb10","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Clinical Investigation, Vol 135, Iss 11 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1172/jci191346","doi":"https://doi.org/10.1172/jci191346","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci191346","pdf_url":"http://www.jci.org/articles/view/191346/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000865226","display_name":"Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain","funder_award_id":"R35NS105076","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410930215.pdf","grobid_xml":"https://content.openalex.org/works/W4410930215.grobid-xml"},"referenced_works_count":246,"referenced_works":["https://openalex.org/W40340874","https://openalex.org/W142954314","https://openalex.org/W149226723","https://openalex.org/W260187207","https://openalex.org/W1508109586","https://openalex.org/W1553043283","https://openalex.org/W1559837393","https://openalex.org/W1567257801","https://openalex.org/W1567615855","https://openalex.org/W1571328876","https://openalex.org/W1572775093","https://openalex.org/W1578567870","https://openalex.org/W1687596153","https://openalex.org/W1759171624","https://openalex.org/W1864822730","https://openalex.org/W1963739241","https://openalex.org/W1970125541","https://openalex.org/W1970202520","https://openalex.org/W1972947543","https://openalex.org/W1976068711","https://openalex.org/W1976787550","https://openalex.org/W1981291046","https://openalex.org/W1988209540","https://openalex.org/W1988635251","https://openalex.org/W1988975600","https://openalex.org/W1991550485","https://openalex.org/W1991672351","https://openalex.org/W1996634599","https://openalex.org/W2005396232","https://openalex.org/W2008558016","https://openalex.org/W2009686533","https://openalex.org/W2015157276","https://openalex.org/W2015783022","https://openalex.org/W2018764168","https://openalex.org/W2019759444","https://openalex.org/W2022957057","https://openalex.org/W2038693417","https://openalex.org/W2039718439","https://openalex.org/W2045389626","https://openalex.org/W2059140871","https://openalex.org/W2059635921","https://openalex.org/W2060424507","https://openalex.org/W2065686737","https://openalex.org/W2067087807","https://openalex.org/W2073030228","https://openalex.org/W2075715972","https://openalex.org/W2083499857","https://openalex.org/W2085957678","https://openalex.org/W2091746433","https://openalex.org/W2092472739","https://openalex.org/W2101795926","https://openalex.org/W2112818926","https://openalex.org/W2113154361","https://openalex.org/W2116230226","https://openalex.org/W2120227293","https://openalex.org/W2120293565","https://openalex.org/W2123647567","https://openalex.org/W2130141996","https://openalex.org/W2132810505","https://openalex.org/W2133541603","https://openalex.org/W2135953149","https://openalex.org/W2136682937","https://openalex.org/W2136901194","https://openalex.org/W2146306684","https://openalex.org/W2147268397","https://openalex.org/W2149599746","https://openalex.org/W2152246049","https://openalex.org/W2154798479","https://openalex.org/W2155412494","https://openalex.org/W2158225751","https://openalex.org/W2159888487","https://openalex.org/W2163817180","https://openalex.org/W2166191769","https://openalex.org/W2166702964","https://openalex.org/W2168111104","https://openalex.org/W2168210103","https://openalex.org/W2178946805","https://openalex.org/W2187921174","https://openalex.org/W2270498673","https://openalex.org/W2271885288","https://openalex.org/W2297962324","https://openalex.org/W2315398542","https://openalex.org/W2319957449","https://openalex.org/W2342696216","https://openalex.org/W2462159806","https://openalex.org/W2467159148","https://openalex.org/W2485683343","https://openalex.org/W2507262137","https://openalex.org/W2515541350","https://openalex.org/W2539107597","https://openalex.org/W2547330766","https://openalex.org/W2589023116","https://openalex.org/W2593043086","https://openalex.org/W2604463267","https://openalex.org/W2610210672","https://openalex.org/W2613532744","https://openalex.org/W2752069735","https://openalex.org/W2755379397","https://openalex.org/W2763205332","https://openalex.org/W2768362509","https://openalex.org/W2769391898","https://openalex.org/W2770429776","https://openalex.org/W2786697307","https://openalex.org/W2793188940","https://openalex.org/W2803070334","https://openalex.org/W2805472045","https://openalex.org/W2881279617","https://openalex.org/W2886096965","https://openalex.org/W2887114371","https://openalex.org/W2894500936","https://openalex.org/W2896293926","https://openalex.org/W2896504526","https://openalex.org/W2898319359","https://openalex.org/W2898582579","https://openalex.org/W2899070315","https://openalex.org/W2899970640","https://openalex.org/W2901132121","https://openalex.org/W2901869599","https://openalex.org/W2901894574","https://openalex.org/W2902034312","https://openalex.org/W2903612881","https://openalex.org/W2904729393","https://openalex.org/W2908652588","https://openalex.org/W2912762225","https://openalex.org/W2917259870","https://openalex.org/W2923498555","https://openalex.org/W2923697933","https://openalex.org/W2923812497","https://openalex.org/W2924867358","https://openalex.org/W2937307539","https://openalex.org/W2946055389","https://openalex.org/W2948001442","https://openalex.org/W2949447363","https://openalex.org/W2953297691","https://openalex.org/W2966313356","https://openalex.org/W2967577955","https://openalex.org/W2999978880","https://openalex.org/W3004765981","https://openalex.org/W3005953215","https://openalex.org/W3008797802","https://openalex.org/W3020935738","https://openalex.org/W3027729271","https://openalex.org/W3031984465","https://openalex.org/W3033784208","https://openalex.org/W3035378275","https://openalex.org/W3037517625","https://openalex.org/W3037975981","https://openalex.org/W3038042679","https://openalex.org/W3043158132","https://openalex.org/W3044036380","https://openalex.org/W3078481672","https://openalex.org/W3087056597","https://openalex.org/W3087259774","https://openalex.org/W3094289903","https://openalex.org/W3096332317","https://openalex.org/W3101912428","https://openalex.org/W3107035738","https://openalex.org/W3107716656","https://openalex.org/W3109746568","https://openalex.org/W3120854869","https://openalex.org/W3122067937","https://openalex.org/W3133643515","https://openalex.org/W3134274350","https://openalex.org/W3135015492","https://openalex.org/W3138073470","https://openalex.org/W3153764414","https://openalex.org/W3155245897","https://openalex.org/W3161658061","https://openalex.org/W3161802642","https://openalex.org/W3164106403","https://openalex.org/W3165802878","https://openalex.org/W3169913730","https://openalex.org/W3174972846","https://openalex.org/W3182795747","https://openalex.org/W3198310432","https://openalex.org/W3203899692","https://openalex.org/W3209376853","https://openalex.org/W3211040763","https://openalex.org/W3212898831","https://openalex.org/W4200164261","https://openalex.org/W4200196141","https://openalex.org/W4205780083","https://openalex.org/W4212875674","https://openalex.org/W4213110813","https://openalex.org/W4220835044","https://openalex.org/W4220990660","https://openalex.org/W4223903704","https://openalex.org/W4226275346","https://openalex.org/W4280498736","https://openalex.org/W4280596360","https://openalex.org/W4280632321","https://openalex.org/W4281477906","https://openalex.org/W4286602833","https://openalex.org/W4289979044","https://openalex.org/W4297995910","https://openalex.org/W4313571830","https://openalex.org/W4319294129","https://openalex.org/W4365518055","https://openalex.org/W4367322332","https://openalex.org/W4376132845","https://openalex.org/W4377227430","https://openalex.org/W4377245549","https://openalex.org/W4381598881","https://openalex.org/W4382182070","https://openalex.org/W4384035851","https://openalex.org/W4385476232","https://openalex.org/W4385546433","https://openalex.org/W4386121835","https://openalex.org/W4386832553","https://openalex.org/W4387033561","https://openalex.org/W4387330400","https://openalex.org/W4387439518","https://openalex.org/W4387501452","https://openalex.org/W4387580031","https://openalex.org/W4388035397","https://openalex.org/W4388440244","https://openalex.org/W4390062520","https://openalex.org/W4392378328","https://openalex.org/W4394674571","https://openalex.org/W4394874363","https://openalex.org/W4394995807","https://openalex.org/W4396890769","https://openalex.org/W4396907239","https://openalex.org/W4399102279","https://openalex.org/W4399564576","https://openalex.org/W4399881058","https://openalex.org/W4400580347","https://openalex.org/W4400831251","https://openalex.org/W4401699280","https://openalex.org/W4402219406","https://openalex.org/W4402354836","https://openalex.org/W4402917696","https://openalex.org/W4403348575","https://openalex.org/W4403405969","https://openalex.org/W4403513410","https://openalex.org/W4404224811","https://openalex.org/W4404252574","https://openalex.org/W4405319165","https://openalex.org/W4407029151","https://openalex.org/W4407392217","https://openalex.org/W4407660965","https://openalex.org/W4408028207","https://openalex.org/W4408854548","https://openalex.org/W4408967949","https://openalex.org/W4409176393","https://openalex.org/W4409283639"],"related_works":["https://openalex.org/W4408383413","https://openalex.org/W7172388659","https://openalex.org/W4405539690","https://openalex.org/W7167619831","https://openalex.org/W4408318614","https://openalex.org/W7213975678","https://openalex.org/W4413802661","https://openalex.org/W2954870473","https://openalex.org/W7214242805","https://openalex.org/W3135941872"],"abstract_inverted_index":{"Acute":[0],"pain":[1,68,134,145],"management":[2],"has":[3],"historically":[4],"been":[5],"dominated":[6],"by":[7,13],"opioids,":[8],"whose":[9],"efficacy":[10,44],"is":[11],"overshadowed":[12],"the":[14,23,52,73,91,99,148,151],"risks":[15],"of":[16,55,153],"addiction,":[17],"tolerance,":[18],"and":[19,45,58,75,84,98,110,128,136,155],"dependence,":[20],"culminating":[21],"in":[22,77],"global":[24],"opioid":[25],"crisis.":[26],"To":[27],"transcend":[28],"this":[29],"issue,":[30],"we":[31,115],"must":[32],"innovate":[33],"beyond":[34],"opioid-based":[35],"\u03bc":[36],"receptor":[37],"treatments,":[38],"identifying":[39],"nonopioid":[40],"analgesics":[41],"with":[42,104],"high":[43],"minimal":[46],"adverse":[47],"effects.":[48],"This":[49],"Review":[50],"navigates":[51],"multifaceted":[53],"landscape":[54],"inflammatory,":[56],"neuropathic,":[57],"nociplastic":[59],"pain,":[60,112],"emphasizing":[61],"mechanism-based":[62],"analgesic":[63],"targets":[64],"tailored":[65],"to":[66,107,143],"specific":[67],"conditions.":[69],"We":[70,88],"delve":[71],"into":[72],"challenges":[74],"breakthroughs":[76],"clinical":[78],"trials":[79],"targeting":[80],"ion":[81],"channels,":[82],"GPCRs,":[83],"other":[85],"molecular":[86],"targets.":[87],"also":[89],"highlight":[90],"intricate":[92],"crosstalk":[93],"between":[94],"different":[95],"physiological":[96],"systems":[97],"need":[100],"for":[101,131,150],"multimodal":[102],"interventions":[103],"distinct":[105],"pharmacodynamics":[106],"manage":[108],"acute":[109],"chronic":[111],"respectively.":[113],"Furthermore,":[114],"explore":[116],"emerging":[117],"strategies,":[118],"including":[119],"gene":[120],"therapy,":[121,124],"stem":[122],"cell":[123,125],"type-specific":[126],"neuromodulation,":[127],"AI-driven":[129],"techniques":[130],"objective,":[132],"unbiased":[133],"assessment":[135],"research.":[137],"These":[138],"innovative":[139],"approaches":[140],"are":[141],"poised":[142],"revolutionize":[144],"management,":[146],"paving":[147],"way":[149],"discovery":[152],"safer":[154],"more":[156],"effective":[157],"analgesics.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":9}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2025-10-10T00:00:00"}