{"id":"https://openalex.org/W4410880464","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.05.132","title":"Biomimetic nanoparticles for targeted CNS therapy: overcoming the blood-brain barrier to reduce neuroinflammation and oxidative stress","display_name":"Biomimetic nanoparticles for targeted CNS therapy: overcoming the blood-brain barrier to reduce neuroinflammation and oxidative stress","publication_year":2025,"publication_date":"2025-05-30","ids":{"openalex":"https://openalex.org/W4410880464","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.05.132"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2025.05.132","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.05.132","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2025.05.132","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009279994","display_name":"Chantalle Moulton","orcid":"https://orcid.org/0009-0002-8865-8562","observed_orcids":["https://orcid.org/0009-0002-8865-8562"]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Chantalle Moulton","raw_affiliation_strings":["Human longevity program, IRCCS San Raffaele Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human longevity program, IRCCS San Raffaele Rome, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088841287","display_name":"Eugenia Romano","orcid":"https://orcid.org/0000-0002-1500-6478","observed_orcids":["https://orcid.org/0000-0002-1500-6478"]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eugenia Romano","raw_affiliation_strings":["Human longevity program, IRCCS San Raffaele Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human longevity program, IRCCS San Raffaele Rome, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anna Baroni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Baroni","raw_affiliation_strings":["Human longevity program, IRCCS San Raffaele Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human longevity program, IRCCS San Raffaele Rome, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117737177","display_name":"Sabina Pulone","orcid":"https://orcid.org/0009-0002-4653-9098","observed_orcids":["https://orcid.org/0009-0002-4653-9098"]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabina Pulone","raw_affiliation_strings":["Human longevity program, IRCCS San Raffaele Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human longevity program, IRCCS San Raffaele Rome, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035449283","display_name":"Leonardo Lupacchini","orcid":"https://orcid.org/0000-0002-9172-7461","observed_orcids":["https://orcid.org/0000-0002-9172-7461"]},"institutions":[{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Leonardo Lupacchini","raw_affiliation_strings":["Laboratory of Molecular and Cellular Neuroscience, IRCCS San Raffaele Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Cellular Neuroscience, IRCCS San Raffaele Rome, Rome, Italy","institution_ids":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114611983","display_name":"Marta Morotti","orcid":"https://orcid.org/0000-0003-1878-0159","observed_orcids":["https://orcid.org/0000-0003-1878-0159"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Morotti","raw_affiliation_strings":["Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104167713","display_name":"Camilla Codazzi","orcid":"https://orcid.org/0009-0009-5646-3980","observed_orcids":["https://orcid.org/0009-0009-5646-3980"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Camilla Codazzi","raw_affiliation_strings":["Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lucia Leone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Leone","raw_affiliation_strings":["Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018208022","display_name":"Maria Vittoria Podda","orcid":"https://orcid.org/0000-0002-2779-8417","observed_orcids":["https://orcid.org/0000-0002-2779-8417"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Vittoria Podda","raw_affiliation_strings":["Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072404265","display_name":"Ennio Tasciotti","orcid":"https://orcid.org/0000-0003-1187-3205","observed_orcids":["https://orcid.org/0000-0003-1187-3205"]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ennio Tasciotti","raw_affiliation_strings":["Human longevity program, IRCCS San Raffaele Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human longevity program, IRCCS San Raffaele Rome, Rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009279994"],"corresponding_institution_ids":["https://openalex.org/I4387155925"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"233","issue":null,"first_page":"S36","last_page":"S37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomimetic-nanoparticles","display_name":"biomimetic nanoparticles","score":0.9919999837875366},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.902999997138977},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8009999990463257},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7670000195503235},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8960000276565552},{"id":"https://openalex.org/keywords/intranasal-administration","display_name":"intranasal administration","score":0.847000002861023},{"id":"https://openalex.org/keywords/nanoparticle-biodistribution","display_name":"nanoparticle biodistribution","score":0.7770000100135803},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.9333996772766113},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8001388311386108},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7822941541671753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4623633027076721},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4403212070465088},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.247206449508667},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22678112983703613},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17100128531455994},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.16837817430496216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1493523120880127}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2025.05.132","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.05.132","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2025.05.132","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1757271","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1757271","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220841606","https://openalex.org/W4405870471","https://openalex.org/W4410028071","https://openalex.org/W3141636208","https://openalex.org/W4411735296","https://openalex.org/W7220864339","https://openalex.org/W4364374247","https://openalex.org/W7154721488","https://openalex.org/W4399913632","https://openalex.org/W4387768734"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2025-10-10T00:00:00"}
