{"id":"https://openalex.org/W4410875412","doi":"https://doi.org/10.1364/ol.560869","title":"Focus-tunable two-photon fiberscope enabling in vivo imaging at selected depths","display_name":"Focus-tunable two-photon fiberscope enabling in vivo imaging at selected depths","publication_year":2025,"publication_date":"2025-05-30","ids":{"openalex":"https://openalex.org/W4410875412","doi":"https://doi.org/10.1364/ol.560869","pmid":"https://pubmed.ncbi.nlm.nih.gov/40591278","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12981939"},"language":"en","primary_location":{"id":"doi:10.1364/ol.560869","doi":"https://doi.org/10.1364/ol.560869","is_oa":false,"landing_page_url":"https://doi.org/10.1364/ol.560869","pdf_url":null,"source":{"id":"https://openalex.org/S134390580","display_name":"Optics Letters","issn_l":"0146-9592","issn":["0146-9592","1071-2763","1539-4794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315679","host_organization_name":"Optica Publishing Group","host_organization_lineage":["https://openalex.org/P4310315679"],"host_organization_lineage_names":["Optica Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Optics Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2025.02.26.640465","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102724265","display_name":"Yuehan Liu","orcid":"https://orcid.org/0000-0002-8751-448X","observed_orcids":["https://orcid.org/0000-0002-8751-448X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuehan Liu","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Johns Hopkins University, Maryland 21218, USA"],"raw_orcid":"https://orcid.org/0000-0002-8751-448X","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Johns Hopkins University, Maryland 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025390354","display_name":"J. Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiayun L. Huang","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Maryland 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Maryland 21205, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014330564","display_name":"Xingde D. Li","orcid":"https://orcid.org/0000-0002-4725-3297","observed_orcids":["https://orcid.org/0000-0002-4725-3297"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xingde Li","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Maryland 21205, USA","Department of Electrical and Computer Engineering, Johns Hopkins University, Maryland 21218, USA"],"raw_orcid":"https://orcid.org/0000-0002-4725-3297","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Maryland 21205, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Johns Hopkins University, Maryland 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014330564"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":0.3751,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.51415094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"50","issue":"13","first_page":"4194","last_page":"4194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11996","display_name":"Random lasers and scattering media","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/3102","display_name":"Acoustics and Ultrasonics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11788","display_name":"Nonlinear Optical Materials Studies","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/two-photon-imaging","display_name":"two-photon imaging","score":0.8870000243186951},{"id":"https://openalex.org/keywords/fiberscope","display_name":"fiberscope","score":0.9210000038146973},{"id":"https://openalex.org/keywords/electrowetting","display_name":"electrowetting","score":0.847000002861023},{"id":"https://openalex.org/keywords/volumetric-imaging","display_name":"volumetric imaging","score":0.6930000185966492},{"id":"https://openalex.org/keywords/in-vivo-calcium-imaging","display_name":"in vivo calcium imaging","score":0.7229999899864197},{"id":"https://openalex.org/keywords/gcamp","display_name":"GCaMP","score":0.972000002861023},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.925000011920929},{"id":"https://openalex.org/keywords/mouse-brain","display_name":"mouse brain","score":0.41999998688697815},{"id":"https://openalex.org/keywords/convallaria","display_name":"Convallaria","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2780495800","wikidata":"https://www.wikidata.org/wiki/Q2566090","display_name":"Fiberscope","level":2,"score":0.8339064717292786},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.827610969543457},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.6522879004478455},{"id":"https://openalex.org/C2781402376","wikidata":"https://www.wikidata.org/wiki/Q17126172","display_name":"Photon counting","level":3,"score":0.47490179538726807},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.45697081089019775},{"id":"https://openalex.org/C159317903","wikidata":"https://www.wikidata.org/wiki/Q3198","display_name":"Photon","level":2,"score":0.4527365267276764},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3351289927959442}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017785","descriptor_name":"Photons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1364/ol.560869","doi":"https://doi.org/10.1364/ol.560869","is_oa":false,"landing_page_url":"https://doi.org/10.1364/ol.560869","pdf_url":null,"source":{"id":"https://openalex.org/S134390580","display_name":"Optics Letters","issn_l":"0146-9592","issn":["0146-9592","1071-2763","1539-4794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315679","host_organization_name":"Optica Publishing Group","host_organization_lineage":["https://openalex.org/P4310315679"],"host_organization_lineage_names":["Optica Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Optics Letters","raw_type":"journal-article"},{"id":"doi:10.1101/2025.02.26.640465","doi":"https://doi.org/10.1101/2025.02.26.640465","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.02.26.640465","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40591278","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40591278","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Optics letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12981939","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40591278/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Opt Lett","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.02.26.640465","doi":"https://doi.org/10.1101/2025.02.26.640465","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.02.26.640465","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000864629","display_name":"Advancing Thyroid Cancer Diagnostics with AI-enhanced Multimodal Optical Histopathology","funder_award_id":"R01CA288613","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000877082","display_name":"Simultaneous two-photon imaging and two-photon manipulation of neural activity in freely behaving mice","funder_award_id":"R21EB035306","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000920670","display_name":"3D Scanning Two-photon Fiberscope Technology for Simultaneous Multi-region Multi-cell-type Imaging in Freely-moving Rodents","funder_award_id":"R01EB033364","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1018693578","https://openalex.org/W1970834779","https://openalex.org/W1973002110","https://openalex.org/W1980816332","https://openalex.org/W1987382181","https://openalex.org/W1997763677","https://openalex.org/W2003429530","https://openalex.org/W2007822613","https://openalex.org/W2013209722","https://openalex.org/W2028307628","https://openalex.org/W2061464631","https://openalex.org/W2062054522","https://openalex.org/W2106519300","https://openalex.org/W2141206945","https://openalex.org/W2147607085","https://openalex.org/W2167460696","https://openalex.org/W2606284136","https://openalex.org/W2765381890","https://openalex.org/W2804355830","https://openalex.org/W2805271873","https://openalex.org/W2884254575","https://openalex.org/W2888531590","https://openalex.org/W3031290078","https://openalex.org/W3049349502","https://openalex.org/W3093980361","https://openalex.org/W3120126666","https://openalex.org/W3161971069","https://openalex.org/W4220982034","https://openalex.org/W4221044755","https://openalex.org/W4388909108","https://openalex.org/W6929844528"],"related_works":["https://openalex.org/W7133538488","https://openalex.org/W2804355830","https://openalex.org/W2136537123","https://openalex.org/W2790047345","https://openalex.org/W4390918544","https://openalex.org/W2005160345","https://openalex.org/W6929844528","https://openalex.org/W6889607630","https://openalex.org/W7096412644","https://openalex.org/W2070737749"],"abstract_inverted_index":{"Miniaturized":[0],"two-photon":[1],"(2P)":[2],"imaging":[3,12,31,49,103,121],"devices":[4],"enable":[5],"real-time":[6],"in":[7,10,116,125],"vivo":[8,102,117],"and":[9,21,59,108],"situ":[11],"at":[13,32],"subcellular":[14],"resolution,":[15],"highly":[16],"valuable":[17],"for":[18],"clinical":[19],"applications":[20],"basic":[22],"research":[23],"(such":[24],"as":[25,113,115],"neuroscience).":[26],"However,":[27],"achieving":[28],"high-quality":[29],"volumetric":[30],"varying":[33],"depths":[34],"remains":[35],"challenging.":[36],"In":[37],"this":[38],"study,":[39],"we":[40],"demonstrated":[41,99],"a":[42,51,55,60,70,77],"2P":[43,81],"fiberscope":[44,97],"capable":[45],"of":[46,54,95,104,122],"three-dimensional":[47],"(3D)":[48],"over":[50],"cylindrical":[52],"volume":[53],"350":[56],"\u03bcm":[57,62],"diameter":[58],"400":[61],"depth.":[63],"Depth":[64],"scanning":[65,80],"was":[66,85,98],"achieved":[67],"by":[68,87,100],"incorporating":[69],"miniature":[71],"electrowetting-based":[72],"varioptic":[73],"lens":[74],"(VL)":[75],"into":[76],"two-dimensional":[78],"(2D)":[79],"fiberscope,":[82],"whose":[83],"focus":[84],"tuned":[86],"modulating":[88],"the":[89,96],"VL":[90],"drive":[91],"voltage.":[92],"The":[93],"performance":[94],"ex":[101],"fluorescently":[105],"stained":[106],"convallaria":[107],"GFP":[109],"mouse":[110],"brain":[111],"sections,":[112],"well":[114],"dynamic":[118],"GCaMP-based":[119],"calcium":[120],"cortical":[123],"neurons":[124],"an":[126],"awake":[127],"mouse.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-05-30T00:00:00"}
