{"id":"https://openalex.org/W4410867682","doi":"https://doi.org/10.1016/j.cdnut.2025.107372","title":"Study Protocol: Impact of a Diet in Which Digestible Carbohydrates Are Substituted by Dietary Fiber on Glycemia, Satiety, Energy Intake and the Gut Microbiome","display_name":"Study Protocol: Impact of a Diet in Which Digestible Carbohydrates Are Substituted by Dietary Fiber on Glycemia, Satiety, Energy Intake and the Gut Microbiome","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4410867682","doi":"https://doi.org/10.1016/j.cdnut.2025.107372"},"language":"en","primary_location":{"id":"doi:10.1016/j.cdnut.2025.107372","doi":"https://doi.org/10.1016/j.cdnut.2025.107372","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cdnut.2025.107372","pdf_url":null,"source":{"id":"https://openalex.org/S4210219560","display_name":"Current Developments in Nutrition","issn_l":"2475-2991","issn":["2475-2991"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Developments in Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.cdnut.2025.107372","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091851722","display_name":"Sarah Kate Walsh","orcid":"https://orcid.org/0000-0002-6783-8110","observed_orcids":["https://orcid.org/0000-0002-6783-8110"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Sarah Kate Walsh","raw_affiliation_strings":["University College Cork, School of Food and Nutritional Sciences, Ireland; APC Microbiome Ireland, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College Cork, School of Food and Nutritional Sciences, Ireland; APC Microbiome Ireland, Ireland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036833674","display_name":"A. O'Sullivan","orcid":"https://orcid.org/0000-0002-6863-1234","observed_orcids":["https://orcid.org/0000-0002-6863-1234"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Aidan F O'Sullivan","raw_affiliation_strings":["University College Cork, School of Food and Nutritional Sciences, Ireland; APC Microbiome Ireland, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College Cork, School of Food and Nutritional Sciences, Ireland; APC Microbiome Ireland, Ireland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Victoria McMahon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210141138","display_name":"APC Microbiome Institute","ror":"https://ror.org/03f2ct267","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210141138"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Victoria McMahon","raw_affiliation_strings":["APC Microbiome Ireland, University College Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APC Microbiome Ireland, University College Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210141138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092900077","display_name":"Rebecca Sempio","orcid":"https://orcid.org/0009-0003-2489-2138","observed_orcids":["https://orcid.org/0009-0003-2489-2138"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Rebecca Sempio","raw_affiliation_strings":["University College Cork, School of Food and Nutritional Sciences, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College Cork, School of Food and Nutritional Sciences, Ireland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043525874","display_name":"Elke K. Arendt","orcid":"https://orcid.org/0000-0001-8414-7701","observed_orcids":["https://orcid.org/0000-0001-8414-7701"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Elke Arendt","raw_affiliation_strings":["University College Cork, School of Food and Nutritional Sciences, Ireland; APC Microbiome Ireland, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College Cork, School of Food and Nutritional Sciences, Ireland; APC Microbiome Ireland, Ireland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005716342","display_name":"Alice J. Lucey","orcid":"https://orcid.org/0000-0002-0623-7151","observed_orcids":["https://orcid.org/0000-0002-0623-7151"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Alice Lucey","raw_affiliation_strings":["University College Cork, School of Food and Nutritional Sciences, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College Cork, School of Food and Nutritional Sciences, Ireland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073708048","display_name":"Jo\u00e3o Felipe Mota","orcid":"https://orcid.org/0000-0001-6123-7616","observed_orcids":["https://orcid.org/0000-0001-6123-7616"]},"institutions":[{"id":"https://openalex.org/I68106152","display_name":"Universidade Federal de Goi\u00e1s","ror":"https://ror.org/0039d5757","country_code":"BR","type":"education","lineage":["https://openalex.org/I68106152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Joao F Mota","raw_affiliation_strings":["Federal University of Goias, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Goias, Brazil","institution_ids":["https://openalex.org/I68106152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060648419","display_name":"Jens Walter","orcid":"https://orcid.org/0000-0003-1754-172X","observed_orcids":["https://orcid.org/0000-0003-1754-172X"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210141138","display_name":"APC Microbiome Institute","ror":"https://ror.org/03f2ct267","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210141138"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Jens Walter","raw_affiliation_strings":["APC Microbiome Ireland, University College Cork, Ireland; University College Cork, School of Microbiology, Ireland; University College Cork, Departments of Medicine, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APC Microbiome Ireland, University College Cork, Ireland; University College Cork, School of Microbiology, Ireland; University College Cork, Departments of Medicine, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210141138"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10516753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":null,"first_page":"107372","last_page":"107372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10140","display_name":"Food composition and properties","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10140","display_name":"Food composition and properties","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-fiber","display_name":"dietary fiber","score":0.949999988079071},{"id":"https://openalex.org/keywords/digestible-carbohydrates","display_name":"digestible carbohydrates","score":0.8410000205039978},{"id":"https://openalex.org/keywords/glycemia","display_name":"glycemia","score":0.753000020980835},{"id":"https://openalex.org/keywords/satiety","display_name":"satiety","score":0.9940000176429749},{"id":"https://openalex.org/keywords/energy-intake","display_name":"energy intake","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9929999709129333},{"id":"https://openalex.org/keywords/carbohydrate-substitution","display_name":"carbohydrate substitution","score":0.460999995470047},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C2992741425","wikidata":"https://www.wikidata.org/wiki/Q215210","display_name":"Dietary fiber","level":2,"score":0.7225885391235352},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.6967850923538208},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6059978008270264},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.4964035153388977},{"id":"https://openalex.org/C3020574416","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Plasma glucose","level":3,"score":0.4145020842552185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3748188614845276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3387753367424011},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2986094355583191},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.10768035054206848},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.09800112247467041}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cdnut.2025.107372","doi":"https://doi.org/10.1016/j.cdnut.2025.107372","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cdnut.2025.107372","pdf_url":null,"source":{"id":"https://openalex.org/S4210219560","display_name":"Current Developments in Nutrition","issn_l":"2475-2991","issn":["2475-2991"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Developments in Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:beaf295c59734cf9b4334762e78c002a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/beaf295c59734cf9b4334762e78c002a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Developments in Nutrition, Vol 9, Iss , Pp 107372- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.cdnut.2025.107372","doi":"https://doi.org/10.1016/j.cdnut.2025.107372","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cdnut.2025.107372","pdf_url":null,"source":{"id":"https://openalex.org/S4210219560","display_name":"Current Developments in Nutrition","issn_l":"2475-2991","issn":["2475-2991"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Developments in Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/2","score":0.5666999816894531,"display_name":"Zero hunger"}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410867898","https://openalex.org/W4400148166","https://openalex.org/W4400148164","https://openalex.org/W7162917385","https://openalex.org/W4372300895","https://openalex.org/W2161416250","https://openalex.org/W1982165907","https://openalex.org/W2915411143","https://openalex.org/W1923356426","https://openalex.org/W2883025160"],"abstract_inverted_index":{"Objectives:":[0],"Replacing":[1],"digestible":[2,41],"carbohydrates":[3,42],"with":[4,43,82],"isolated":[5],"dietary":[6,44],"fibers":[7],"in":[8,46,80],"food":[9,35],"products":[10,36],"provides":[11],"a":[12,62],"strategy":[13],"to":[14,57],"lower":[15],"the":[16,30,59],"glycemic":[17],"index":[18],"and":[19,75,78],"energy":[20,73],"density":[21],"of":[22,32,34,40,61,65],"foods":[23],"while":[24],"stimulating":[25],"gut":[26],"microbiome":[27,76],"metabolism.":[28],"However,":[29],"effects":[31],"reformulation":[33],"through":[37],"systematic":[38],"replacement":[39],"fiber":[45,67],"well-controlled":[47],"human":[48],"nutrition":[49],"trials":[50],"remain":[51],"largely":[52],"unexplored.":[53],"This":[54],"study":[55],"aims":[56],"investigate":[58],"impact":[60],"diet":[63],"composed":[64],"reformulated":[66],"rich":[68],"foods,":[69],"on":[70],"glycemia,":[71],"satiety,":[72],"intake":[74],"composition":[77],"function":[79],"adults":[81],"excess":[83],"body":[84],"weight.":[85]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-10-10T00:00:00"}