{"id":"https://openalex.org/W4410858629","doi":"https://doi.org/10.7554/elife.106338","title":"SVEP1 enables efficient binding of angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling","display_name":"SVEP1 enables efficient binding of angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling","publication_year":2025,"publication_date":"2025-05-29","ids":{"openalex":"https://openalex.org/W4410858629","doi":"https://doi.org/10.7554/elife.106338","pmid":"https://pubmed.ncbi.nlm.nih.gov/42960837","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722417"},"language":"en","primary_location":{"id":"doi:10.7554/elife.106338","doi":"https://doi.org/10.7554/elife.106338","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106338","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.106338","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086093489","display_name":"Katharina Uphoff","orcid":"https://orcid.org/0009-0001-4413-4698","observed_orcids":["https://orcid.org/0009-0001-4413-4698"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Uphoff","raw_affiliation_strings":["Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of M\u00fcnster","Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WU M\u00fcnster"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WU M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043287874","display_name":"Melina Hu\u00dfmann","orcid":"https://orcid.org/0000-0003-4798-7503","observed_orcids":["https://orcid.org/0000-0003-4798-7503"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Melina Hu\u00dfmann","raw_affiliation_strings":["Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of M\u00fcnster","Division of Vascular Oncology and Metastasis, German Cancer Research Center","Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WU M\u00fcnster"],"raw_orcid":"https://orcid.org/0000-0003-4798-7503","affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"Division of Vascular Oncology and Metastasis, German Cancer Research Center","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WU M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025470998","display_name":"Oliver Peters","orcid":"https://orcid.org/0000-0001-8671-6955","observed_orcids":["https://orcid.org/0000-0001-8671-6955"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA","DE"],"is_corresponding":false,"raw_author_name":"Oliver Peters","raw_affiliation_strings":["Department of Chemistry, University of Manitoba","Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WU M\u00fcnster"],"raw_orcid":"https://orcid.org/0000-0001-8671-6955","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Manitoba","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WU M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045374933","display_name":"Matthias M\u00f6rgelin","orcid":"https://orcid.org/0000-0002-6212-6990","observed_orcids":["https://orcid.org/0000-0002-6212-6990"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias M\u00f6rgelin","raw_affiliation_strings":["Colzyx AB","Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WU M\u00fcnster"],"raw_orcid":"https://orcid.org/0000-0002-6212-6990","affiliations":[{"raw_affiliation_string":"Colzyx AB","institution_ids":[]},{"raw_affiliation_string":"Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WU M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014371556","display_name":"Fabian Metzen","orcid":"https://orcid.org/0000-0002-5248-8218","observed_orcids":["https://orcid.org/0000-0002-5248-8218"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Metzen","raw_affiliation_strings":["Institute for Dental Research and Oral Musculoskeletal Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne","Colzyx AB"],"raw_orcid":"https://orcid.org/0000-0002-5248-8218","affiliations":[{"raw_affiliation_string":"Institute for Dental Research and Oral Musculoskeletal Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"Colzyx AB","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146496984","display_name":"Wolfgang MJ Obermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang MJ Obermann","raw_affiliation_strings":["Institute for Dental Research and Oral Musculoskeletal Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Dental Research and Oral Musculoskeletal Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000001503","display_name":"J. Fernando Baz\u00e1n","orcid":"https://orcid.org/0000-0002-3645-9935","observed_orcids":["https://orcid.org/0000-0002-3645-9935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando J Bazan","raw_affiliation_strings":["\u0127 bioconsulting, llc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0127 bioconsulting, llc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078791008","display_name":"J\u00f6rg Stetefeld","orcid":"https://orcid.org/0000-0003-1478-3248","observed_orcids":["https://orcid.org/0000-0003-1478-3248"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA","DE"],"is_corresponding":true,"raw_author_name":"J\u00f6rg Stetefeld","raw_affiliation_strings":["Department of Chemistry, University of Manitoba","Institute for Dental Research and Oral Musculoskeletal Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne"],"raw_orcid":"https://orcid.org/0000-0003-1478-3248","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Manitoba","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Institute for Dental Research and Oral Musculoskeletal Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067941504","display_name":"Manuel Koch","orcid":"https://orcid.org/0000-0002-2962-7814","observed_orcids":["https://orcid.org/0000-0002-2962-7814"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Manuel Koch","raw_affiliation_strings":["Institute for Dental Research and Oral Musculoskeletal Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne","Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WU M\u00fcnster"],"raw_orcid":"https://orcid.org/0000-0002-2962-7814","affiliations":[{"raw_affiliation_string":"Institute for Dental Research and Oral Musculoskeletal Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WU M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056115557","display_name":"Stefan Schulte\u2010Merker","orcid":"https://orcid.org/0000-0003-3617-8807","observed_orcids":["https://orcid.org/0000-0003-3617-8807"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan Schulte-Merker","raw_affiliation_strings":["Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of M\u00fcnster"],"raw_orcid":"https://orcid.org/0000-0003-3617-8807","affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5116752043","display_name":"D\u00f6rte Schulte-Ostermann","orcid":"https://orcid.org/0000-0003-2375-9258","observed_orcids":["https://orcid.org/0000-0003-2375-9258"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"D\u00f6rte Schulte-Ostermann","raw_affiliation_strings":["Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of M\u00fcnster"],"raw_orcid":"https://orcid.org/0000-0003-2375-9258","affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5056115557","https://openalex.org/A5067941504","https://openalex.org/A5078791008","https://openalex.org/A5116752043"],"corresponding_institution_ids":["https://openalex.org/I180923762","https://openalex.org/I22465464","https://openalex.org/I4210153755","https://openalex.org/I46247651"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/svep1","display_name":"SVEP1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":0.9549999833106995},{"id":"https://openalex.org/keywords/lymphangiogenesis","display_name":"lymphangiogenesis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/lymphatic-endothelial-cells","display_name":"lymphatic endothelial cells","score":0.824999988079071},{"id":"https://openalex.org/keywords/receptor-phosphorylation","display_name":"receptor phosphorylation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/protein-protein-binding","display_name":"protein-protein binding","score":0.6690000295639038},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/receptor-multimerization","display_name":"receptor multimerization","score":0.7120000123977661},{"id":"https://openalex.org/keywords/lymphedema","display_name":"lymphedema","score":0.7080000042915344},{"id":"https://openalex.org/keywords/lymphatic-vessels","display_name":"lymphatic vessels","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6297110319137573},{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.621826171875},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6152745485305786},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46719762682914734},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.424277126789093},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.35189288854599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2652543783187866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15752476453781128},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.07407385110855103}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042702","descriptor_name":"Angiopoietin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042810","descriptor_name":"Receptor, TIE-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.7554/elife.106338","doi":"https://doi.org/10.7554/elife.106338","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106338","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13722417","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722417/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722417/pdf/elife-106338.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:42960837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42960837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1c17333d1ec443278d19afb999ed0b3e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1c17333d1ec443278d19afb999ed0b3e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.106338","doi":"https://doi.org/10.7554/elife.106338","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106338","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4372963833","display_name":null,"funder_award_id":"CRC 1607","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4772766351","display_name":null,"funder_award_id":"KO2247/8-2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4832716505","display_name":null,"funder_award_id":"CRC 1607 project C02","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5243041098","display_name":null,"funder_award_id":"CRC 1348 project B08","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5636231247","display_name":null,"funder_award_id":"CRC 1607 project Z01","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G564582175","display_name":null,"funder_award_id":"CRC1348","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6499436294","display_name":null,"funder_award_id":"178097","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G8590398486","display_name":null,"funder_award_id":"CIHR-PJT-178097","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320322957","display_name":"Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster","ror":"https://ror.org/00pd74e08"},{"id":"https://openalex.org/F4320327553","display_name":"International Max Planck Research School for Advanced Methods in Process and Systems Engineering","ror":"https://ror.org/04hazks31"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410858629.pdf","grobid_xml":"https://content.openalex.org/works/W4410858629.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1966821227","https://openalex.org/W1970614272","https://openalex.org/W1984526317","https://openalex.org/W2009516278","https://openalex.org/W2028808241","https://openalex.org/W2078338839","https://openalex.org/W2088475623","https://openalex.org/W2109003285","https://openalex.org/W2111447897","https://openalex.org/W2116028999","https://openalex.org/W2121717631","https://openalex.org/W2155160938","https://openalex.org/W2161700314","https://openalex.org/W2163301034","https://openalex.org/W2172134293","https://openalex.org/W2470520357","https://openalex.org/W2517498730","https://openalex.org/W2586201220","https://openalex.org/W2587483777","https://openalex.org/W2606133995","https://openalex.org/W2616115829","https://openalex.org/W2772071913","https://openalex.org/W2972662355","https://openalex.org/W3031690692","https://openalex.org/W3091950429","https://openalex.org/W3177244295","https://openalex.org/W4282598310","https://openalex.org/W4283644123","https://openalex.org/W4366991586","https://openalex.org/W4399205877","https://openalex.org/W6682048127","https://openalex.org/W6683126556","https://openalex.org/W6747870160","https://openalex.org/W6782984777","https://openalex.org/W6853567511","https://openalex.org/W6855317126"],"related_works":["https://openalex.org/W2139332469","https://openalex.org/W2007326744","https://openalex.org/W4366991586","https://openalex.org/W4396896062","https://openalex.org/W2785293290","https://openalex.org/W748833376","https://openalex.org/W2028808241","https://openalex.org/W2163301034","https://openalex.org/W1473619958","https://openalex.org/W4283644123"],"abstract_inverted_index":{"The":[0],"molecular":[1],"mechanisms":[2],"that":[3,14,66,81,91],"drive":[4],"(lymph-)angiogenesis":[5],"are":[6,15],"crucial":[7],"to":[8,18,101,127,141,155],"understanding":[9],"diseases,":[10],"such":[11],"as":[12],"lymphedema,":[13],"caused":[16],"due":[17],"malformations":[19],"of":[20,57,86,94,103,120,124,150],"the":[21,28,38,67,72,148,160],"lymphatic":[22],"vasculature.":[23],"Recently,":[24],"an":[25],"interaction":[26],"between":[27],"secreted":[29],"protein":[30,63],"Svep1,":[31],"a":[32,134,156],"key":[33],"regulator":[34],"in":[35,44,52,115,136,147],"lymphangiogenesis,":[36],"and":[37,47,88,90,98,109,122,144],"transmembrane":[39],"receptor":[40,153],"Tie1":[41],"was":[42],"shown":[43],"zebrafish,":[45],"humans,":[46],"mice.":[48],"Here,":[49],"guided":[50],"by":[51,107],"silico":[53],"AlphaFold-multimer":[54],"structure":[55],"predictions":[56],"SVEP1":[58,82,97,108,128,143],"complexes,":[59],"we":[60],"assert":[61],"with":[62,96],"binding":[64,74,85],"studies":[65],"human":[68],"CCP20":[69],"domain":[70],"is":[71],"primary":[73],"site":[75],"for":[76],"TIE1.":[77,104],"We":[78,132],"further":[79],"demonstrate":[80],"mediates":[83],"strong":[84],"ANG2":[87,99,110,130],"TIE1,":[89,145],"combined":[92],"stimulation":[93],"hdLECs":[95],"leads":[100],"phosphorylation":[102,123],"TIE1":[105,152],"activation":[106],"enables":[111],"downstream":[112],"signaling":[113,166],"and,":[114],"turn,":[116],"potentiates":[117],"nuclear":[118],"exclusion":[119],"FOXO1":[121],"AKT":[125],"compared":[126],"or":[129],"alone.":[131],"present":[133],"model":[135],"which":[137],"ANG1/2":[138],"dimers":[139],"bind":[140],"both":[142],"resulting":[146],"recruitment":[149],"multiple":[151],"molecules":[154],"multimeric":[157],"complex":[158],"at":[159],"cell":[161],"membrane,":[162],"potentially":[163],"amplifying":[164],"its":[165],"capacity.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-10-10T00:00:00"}