{"id":"https://openalex.org/W4410856431","doi":"https://doi.org/10.1016/j.hmedic.2025.100264","title":"AMPAR encephalitis in a child with short-term amnesia after COVID-19 vaccination \u2013 A case report","display_name":"AMPAR encephalitis in a child with short-term amnesia after COVID-19 vaccination \u2013 A case report","publication_year":2025,"publication_date":"2025-05-29","ids":{"openalex":"https://openalex.org/W4410856431","doi":"https://doi.org/10.1016/j.hmedic.2025.100264"},"language":"en","primary_location":{"id":"doi:10.1016/j.hmedic.2025.100264","doi":"https://doi.org/10.1016/j.hmedic.2025.100264","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hmedic.2025.100264","pdf_url":null,"source":{"id":"https://openalex.org/S4387291799","display_name":"Medical Reports","issn_l":"2949-9186","issn":["2949-9186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.hmedic.2025.100264","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092042626","display_name":"Melina Alves da Frota","orcid":"https://orcid.org/0000-0001-8405-2374","observed_orcids":["https://orcid.org/0000-0001-8405-2374"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Melina Alves da Frota","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8405-2374","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Denise Mendon\u00e7a Borges","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Denise Mendon\u00e7a Borges","raw_affiliation_strings":["Child Neurology Sector, Neurology Discipline, Department of Neurology and Neurosurgery, Paulista School of Medicine, Federal University of S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Child Neurology Sector, Neurology Discipline, Department of Neurology and Neurosurgery, Paulista School of Medicine, Federal University of S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018890082","display_name":"Caroline Corr\u00eaa Maranh\u00e3o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Caroline Corr\u00eaa Maranh\u00e3o","raw_affiliation_strings":["Child Neurology Sector, Neurology Discipline, Department of Neurology and Neurosurgery, Paulista School of Medicine, Federal University of S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Child Neurology Sector, Neurology Discipline, Department of Neurology and Neurosurgery, Paulista School of Medicine, Federal University of S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117171217","display_name":"Lidiane Indiani","orcid":"https://orcid.org/0009-0003-5719-1872","observed_orcids":["https://orcid.org/0009-0003-5719-1872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lidiane Indiani","raw_affiliation_strings":["Cl\u00ednicic Dr. Freddy Goldberg Eliaschewitz \u2013 CPCLIN, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cl\u00ednicic Dr. Freddy Goldberg Eliaschewitz \u2013 CPCLIN, SP, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090370435","display_name":"Marcelo de Melo Arag\u00e3o","orcid":"https://orcid.org/0000-0001-8877-6062","observed_orcids":["https://orcid.org/0000-0001-8877-6062"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo Melo Arag\u00e3o","raw_affiliation_strings":["Child Neurology Sector, Neurology Discipline, Department of Neurology and Neurosurgery, Paulista School of Medicine, Federal University of S\u00e3o Paulo, SP, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-8877-6062","affiliations":[{"raw_affiliation_string":"Child Neurology Sector, Neurology Discipline, Department of Neurology and Neurosurgery, Paulista School of Medicine, Federal University of S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102872828","display_name":"Ricardo Silva Pinho","orcid":"https://orcid.org/0000-0001-6626-6336","observed_orcids":["https://orcid.org/0000-0001-6626-6336"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ricardo Silva Pinho","raw_affiliation_strings":["Child Neurology Sector, Neurology Discipline, Department of Neurology and Neurosurgery, Paulista School of Medicine, Federal University of S\u00e3o Paulo, SP, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-6626-6336","affiliations":[{"raw_affiliation_string":"Child Neurology Sector, Neurology Discipline, Department of Neurology and Neurosurgery, Paulista School of Medicine, Federal University of S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5092042626"],"corresponding_institution_ids":[],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15286775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"100264","last_page":"100264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19-vaccination","display_name":"COVID-19 vaccination","score":0.6669999957084656},{"id":"https://openalex.org/keywords/pediatric-encephalitis","display_name":"pediatric encephalitis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.7440000176429749},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.8930000066757202},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.9449999928474426},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9879999756813049},{"id":"https://openalex.org/keywords/vaccine-adverse-events","display_name":"vaccine adverse events","score":0.7400000095367432},{"id":"https://openalex.org/keywords/autoimmune-encephalitis","display_name":"autoimmune encephalitis","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.7112593650817871},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.62224280834198},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.5805225372314453},{"id":"https://openalex.org/C2778615406","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Amnesia","level":2,"score":0.5651740431785583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5598635077476501},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.5253305435180664},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.48727571964263916},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.48655858635902405},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.4701937139034271},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.40091198682785034},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1431899070739746},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10320970416069031},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.10110330581665039},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.09903189539909363},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.07473263144493103},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07026606798171997},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0563521683216095},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.hmedic.2025.100264","doi":"https://doi.org/10.1016/j.hmedic.2025.100264","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hmedic.2025.100264","pdf_url":null,"source":{"id":"https://openalex.org/S4387291799","display_name":"Medical Reports","issn_l":"2949-9186","issn":["2949-9186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.hmedic.2025.100264","doi":"https://doi.org/10.1016/j.hmedic.2025.100264","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hmedic.2025.100264","pdf_url":null,"source":{"id":"https://openalex.org/S4387291799","display_name":"Medical Reports","issn_l":"2949-9186","issn":["2949-9186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1831490185","https://openalex.org/W2044031472","https://openalex.org/W2134741840","https://openalex.org/W2509143449","https://openalex.org/W2794157251","https://openalex.org/W3165607233","https://openalex.org/W4327980514","https://openalex.org/W4380324272","https://openalex.org/W4392005255","https://openalex.org/W4392817928","https://openalex.org/W6795760688"],"related_works":["https://openalex.org/W3127156785","https://openalex.org/W3009669391","https://openalex.org/W4200329650","https://openalex.org/W4205215807","https://openalex.org/W3005417802","https://openalex.org/W4205754011","https://openalex.org/W4226296940","https://openalex.org/W3028835529","https://openalex.org/W3036314732","https://openalex.org/W3134376730"],"abstract_inverted_index":{"We":[0],"report":[1],"a":[2,12,83,87,122],"12-year-old":[3],"boy":[4],"that":[5],"developed":[6],"\u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic":[7],"acid":[8],"receptors":[9],"(AMPAR)":[10],"encephalitis,":[11,93],"rare":[13],"condition":[14,118],"in":[15,44],"children,":[16],"15":[17],"days":[18,68],"after":[19],"receiving":[20],"the":[21],"Pfizer-BioNTech":[22],"COVID-19":[23],"vaccine.":[24],"Initially":[25],"presenting":[26],"with":[27,57],"short-term":[28],"amnesia,":[29],"he":[30,72],"showed":[31],"normal":[32],"results":[33],"on":[34],"EEG":[35],"and":[36,76,92,100,114],"brain":[37],"MRI.":[38],"Antibodies":[39],"against":[40],"AMPAR":[41],"were":[42,51],"found":[43],"his":[45],"cerebrospinal":[46],"fluid":[47],"(CSF).":[48],"Cancer":[49],"screenings":[50],"normal.":[52],"The":[53],"patient":[54],"was":[55],"treated":[56],"intravenous":[58],"human":[59],"immunoglobulin":[60],"(IVIG)":[61],"for":[62,121],"five":[63],"days,":[64],"but":[65],"relapsed":[66],"45":[67],"later.":[69],"Upon":[70],"relapse,":[71],"received":[73],"IVIG,":[74],"dexamethasone,":[75],"rituximab,":[77],"leading":[78],"to":[79,108],"full":[80],"recovery.":[81],"While":[82],"temporal":[84],"connection":[85],"suggests":[86],"potential":[88],"link":[89],"between":[90],"vaccination":[91],"this":[94,117],"has":[95],"not":[96],"been":[97],"previously":[98],"documented":[99],"could":[101],"be":[102],"coincidental.":[103],"Further":[104],"studies":[105],"are":[106,119],"needed":[107],"confirm":[109],"any":[110],"causation.":[111],"Early":[112],"suspicion":[113],"treatment":[115],"of":[116],"crucial":[120],"better":[123],"prognosis.":[124]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}