{"id":"https://openalex.org/W4410830211","doi":"https://doi.org/10.1016/j.celrep.2026.117891","title":"Apoptosis inhibition reprograms alveolar myofibroblasts toward ductal myofibroblasts","display_name":"Apoptosis inhibition reprograms alveolar myofibroblasts toward ductal myofibroblasts","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W4410830211","doi":"https://doi.org/10.1016/j.celrep.2026.117891","pmid":"https://pubmed.ncbi.nlm.nih.gov/40492191","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12148055"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2026.117891","doi":"https://doi.org/10.1016/j.celrep.2026.117891","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.117891","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.celrep.2026.117891","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052805342","display_name":"Mar\u00eda Jos\u00e9 Gacha Garay","orcid":"https://orcid.org/0000-0002-9312-5237","observed_orcids":["https://orcid.org/0000-0002-9312-5237"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Jose Gacha-Garay","raw_affiliation_strings":["Department of Pulmonary Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA","Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA","Department of Pulmonary Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I919571938"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Department of Pulmonary Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hui Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Liu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA","Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086464414","display_name":"Scott E. Evans","orcid":"https://orcid.org/0000-0003-4503-0644","observed_orcids":["https://orcid.org/0000-0003-4503-0644"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott E. Evans","raw_affiliation_strings":["Department of Pulmonary Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","Department of Pulmonary Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Pulmonary Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101444919","display_name":"Tingting Mills","orcid":"https://orcid.org/0000-0002-6041-4788","observed_orcids":["https://orcid.org/0000-0002-6041-4788"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tingting W. Mills","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address: tingting.weng@uth.tmc.edu","Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address: tingting.weng@uth.tmc.edu","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020559131","display_name":"Jichao Chen","orcid":"https://orcid.org/0000-0003-2749-8550","observed_orcids":["https://orcid.org/0000-0003-2749-8550","https://orcid.org/0000-0002-9670-7486"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jichao Chen","raw_affiliation_strings":["Department of Pulmonary Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Pediatrics, Perinatal Institute Division of Pulmonary Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: jichao.chen@cchmc.org","Department of Pediatrics, Perinatal Institute Division of Pulmonary Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH 5229, USA","Department of Pulmonary Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Pediatrics, Perinatal Institute Division of Pulmonary Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: jichao.chen@cchmc.org","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I1343551460","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pediatrics, Perinatal Institute Division of Pulmonary Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH 5229, USA","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pulmonary Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020559131","https://openalex.org/A5101444919"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I1343551460","https://openalex.org/I63135867","https://openalex.org/I919571938"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00108394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"9","first_page":"117891","last_page":"117891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.11760000139474869,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.07440000027418137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/bcl-2-overexpression","display_name":"Bcl-2 overexpression","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cell-fate-plasticity","display_name":"cell fate plasticity","score":0.6039999723434448},{"id":"https://openalex.org/keywords/alveolarization","display_name":"alveolarization","score":0.7329999804496765},{"id":"https://openalex.org/keywords/airway-smooth-muscle-cells","display_name":"airway smooth muscle cells","score":0.8029999732971191},{"id":"https://openalex.org/keywords/house-dust-mite-induced-asthma","display_name":"house dust mite-induced asthma","score":0.9380000233650208},{"id":"https://openalex.org/keywords/contractile-proteins","display_name":"contractile proteins","score":0.8199999928474426},{"id":"https://openalex.org/keywords/lung-development","display_name":"lung development","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.8289531469345093},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6268661618232727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5709280967712402},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5261606574058533},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4792785346508026},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4613829255104065},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.46132558584213257},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4583122432231903},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3419908285140991},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.2688557505607605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22065028548240662},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17059865593910217},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11565259099006653},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08296474814414978}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1016/j.celrep.2026.117891","doi":"https://doi.org/10.1016/j.celrep.2026.117891","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.117891","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"doi:10.1101/2025.05.26.654588","doi":"https://doi.org/10.1101/2025.05.26.654588","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.26.654588","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40492191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40492191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42704712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42704712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13652110","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13652110/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13652110/pdf/nihms-2212242.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:40b863267b3048c2b4f26cac928b4c79","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/40b863267b3048c2b4f26cac928b4c79","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 45, Iss 9, Pp 117891- (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12148055","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12148055/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2026.117891","doi":"https://doi.org/10.1016/j.celrep.2026.117891","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.117891","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6875982916","display_name":"CFlm25 mediated alternative polyadenylation regulates fibrosis in systemic sclerosis","funder_award_id":"R01AR073284","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7363923043","display_name":"Regulation of mesenchymal cells by epithelial Wnt ligands","funder_award_id":"R01HL130129","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7545963823","display_name":"Transcriptional and epigenetic basis of lung epithelial cell fate","funder_award_id":"R01HL153511","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000857449","display_name":"Transcriptional and epigenetic mechanisms of alveologenesis and re-alveologenesis","funder_award_id":"R35HL171346","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000877237","display_name":"Macrophage NUDT21-mediated alternative polyadenylation in lung injury","funder_award_id":"R01HL168128","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410830211.pdf","grobid_xml":"https://content.openalex.org/works/W4410830211.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1487688765","https://openalex.org/W1823288226","https://openalex.org/W1976414476","https://openalex.org/W1984883254","https://openalex.org/W1987724354","https://openalex.org/W1987806865","https://openalex.org/W1995074959","https://openalex.org/W2017944609","https://openalex.org/W2019832656","https://openalex.org/W2026873116","https://openalex.org/W2040118243","https://openalex.org/W2042400521","https://openalex.org/W2050166215","https://openalex.org/W2051718122","https://openalex.org/W2052025430","https://openalex.org/W2053480920","https://openalex.org/W2055221606","https://openalex.org/W2059668731","https://openalex.org/W2085074197","https://openalex.org/W2091574626","https://openalex.org/W2104135721","https://openalex.org/W2104642638","https://openalex.org/W2114931426","https://openalex.org/W2138181097","https://openalex.org/W2159195608","https://openalex.org/W2161282017","https://openalex.org/W2167279371","https://openalex.org/W2172609591","https://openalex.org/W2175673465","https://openalex.org/W2344991207","https://openalex.org/W2345356016","https://openalex.org/W2532496207","https://openalex.org/W2617216694","https://openalex.org/W2741236035","https://openalex.org/W2759725020","https://openalex.org/W2766197806","https://openalex.org/W2800406470","https://openalex.org/W2804748573","https://openalex.org/W2808822996","https://openalex.org/W2891636773","https://openalex.org/W2964118023","https://openalex.org/W2972315524","https://openalex.org/W2988847144","https://openalex.org/W2996304902","https://openalex.org/W3002131808","https://openalex.org/W3002219094","https://openalex.org/W3016965350","https://openalex.org/W3020031087","https://openalex.org/W3099427270","https://openalex.org/W3132661792","https://openalex.org/W3175401162","https://openalex.org/W3204600913","https://openalex.org/W3210728577","https://openalex.org/W3214087492","https://openalex.org/W4200182365","https://openalex.org/W4210285434","https://openalex.org/W4221087187","https://openalex.org/W4223583090","https://openalex.org/W4292730605","https://openalex.org/W4301585281","https://openalex.org/W4301600652","https://openalex.org/W4316814311","https://openalex.org/W4322767155","https://openalex.org/W4379137350","https://openalex.org/W4388085583","https://openalex.org/W4390140129","https://openalex.org/W4391022767","https://openalex.org/W4392455137","https://openalex.org/W4393015034","https://openalex.org/W4393381524","https://openalex.org/W4394715654","https://openalex.org/W4400491625","https://openalex.org/W4407157664","https://openalex.org/W4408882813","https://openalex.org/W4410814754","https://openalex.org/W7116630415"],"related_works":["https://openalex.org/W7201931402","https://openalex.org/W7116630415","https://openalex.org/W6911301288","https://openalex.org/W4393015034","https://openalex.org/W6926050357","https://openalex.org/W2137031671","https://openalex.org/W2996304902","https://openalex.org/W6926206421","https://openalex.org/W3032273176","https://openalex.org/W7214285434"],"abstract_inverted_index":{"The":[0],"epithelial":[1,118],"tree":[2],"of":[3,31,102,112,116],"the":[4,29,99,117],"lung":[5,113],"is":[6,39],"shaped":[7],"proximo-distally":[8],"by":[9],"airway":[10],"smooth":[11],"muscle":[12],"cells":[13,85,115],"(ASMCs),":[14],"ductal":[15],"myofibroblasts":[16,21],"(DMFs),":[17],"and,":[18,74],"transiently,":[19],"alveolar":[20,70],"(AMFs).":[22],"Lineage":[23],"tracing":[24],"and":[25,59,72,82,109],"snapshot":[26],"imaging":[27],"suggest":[28],"clearance":[30,101],"AMFs":[32,66],"via":[33],"apoptosis":[34],"post-alveologenesis,":[35],"although":[36],"definitive":[37],"evidence":[38],"lacking.":[40],"Here,":[41],"we":[42,62],"generate":[43],"an":[44],"inducible":[45],"BCL2":[46],"overexpression":[47],"mouse":[48],"allele":[49],"to":[50],"inhibit":[51],"AMF":[52],"apoptosis.":[53],"Using":[54],"three":[55],"independent":[56],"Cre":[57],"drivers":[58],"single-cell":[60],"RNA-seq,":[61],"show":[63],"that":[64],"BCL2-rescued":[65],"persist":[67],"around":[68],"distal":[69],"ducts":[71],"alveoli":[73],"unexpectedly,":[75],"mature":[76],"toward":[77],"DMFs.":[78],"Both":[79],"normal":[80],"DMFs":[81],"rescued":[83],"DMF-like":[84],"upregulate":[86],"contractile":[87],"proteins":[88],"in":[89],"a":[90],"house":[91],"dust":[92],"mite-induced":[93],"asthma":[94],"model.":[95],"Our":[96],"findings":[97],"demonstrate":[98],"apoptotic":[100],"AMFs,":[103],"as":[104,106],"well":[105],"fate":[107],"plasticity":[108],"pathophysiological":[110],"convergence":[111],"mesenchymal":[114],"axis.":[119]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}