{"id":"https://openalex.org/W4410766832","doi":"https://doi.org/10.1016/j.jacasi.2025.03.014","title":"Implication of the Dose of Mineralocorticoid Receptor Antagonist Following Transcatheter Edge-to-Edge Mitral Valve Repair","display_name":"Implication of the Dose of Mineralocorticoid Receptor Antagonist Following Transcatheter Edge-to-Edge Mitral Valve Repair","publication_year":2025,"publication_date":"2025-05-27","ids":{"openalex":"https://openalex.org/W4410766832","doi":"https://doi.org/10.1016/j.jacasi.2025.03.014","pmid":"https://pubmed.ncbi.nlm.nih.gov/40434334","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12426662"},"language":"en","primary_location":{"id":"doi:10.1016/j.jacasi.2025.03.014","doi":"https://doi.org/10.1016/j.jacasi.2025.03.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacasi.2025.03.014","pdf_url":null,"source":{"id":"https://openalex.org/S4210201151","display_name":"JACC Asia","issn_l":"2772-3747","issn":["2772-3747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Asia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jacasi.2025.03.014","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009215615","display_name":"Teruhiko Imamura","orcid":"https://orcid.org/0000-0002-7294-7637","observed_orcids":["https://orcid.org/0000-0002-7294-7637"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Teruhiko Imamura","raw_affiliation_strings":["Second Department of Internal Medicine, University of Toyama, Toyama, Japan. Electronic address: teimamu@med.u-toyama.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, University of Toyama, Toyama, Japan. Electronic address: teimamu@med.u-toyama.ac.jp","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103138981","display_name":"Shuhei Tanaka","orcid":"https://orcid.org/0000-0001-7551-3431","observed_orcids":["https://orcid.org/0000-0001-7551-3431"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuhei Tanaka","raw_affiliation_strings":["Second Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7551-3431","affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036988337","display_name":"Nobuyuki Fukuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Fukuda","raw_affiliation_strings":["Second Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroshi Ueno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Ueno","raw_affiliation_strings":["Second Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038275040","display_name":"Koichiro Kinugawa","orcid":"https://orcid.org/0000-0003-0009-8477","observed_orcids":["https://orcid.org/0000-0003-0009-8477"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichiro Kinugawa","raw_affiliation_strings":["Second Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104020132","display_name":"Shunsuke Kubo","orcid":"https://orcid.org/0000-0003-4794-7843","observed_orcids":["https://orcid.org/0000-0003-4794-7843"]},"institutions":[{"id":"https://openalex.org/I4210089671","display_name":"Kurashiki Central Hospital","ror":"https://ror.org/00947s692","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089671"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsuke Kubo","raw_affiliation_strings":["Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4794-7843","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan","institution_ids":["https://openalex.org/I4210089671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037640840","display_name":"Masanori Yamamoto","orcid":"https://orcid.org/0000-0001-5210-6382","observed_orcids":["https://orcid.org/0000-0001-5210-6382"]},"institutions":[{"id":"https://openalex.org/I4210126251","display_name":"Toyohashi Heart Center","ror":"https://ror.org/0331wqp96","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210126251"]},{"id":"https://openalex.org/I4210147061","display_name":"Nagoya Heart Center","ror":"https://ror.org/045r6q476","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210147061"]},{"id":"https://openalex.org/I4210155122","display_name":"Gifu Heart Center","ror":"https://ror.org/04bgfv325","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155122"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanori Yamamoto","raw_affiliation_strings":["Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan; Department of Cardiology, Nagoya Heart Center, Nagoya, Japan; Department of Cardiology, Gifu Heart Center, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan; Department of Cardiology, Nagoya Heart Center, Nagoya, Japan; Department of Cardiology, Gifu Heart Center, Gifu, Japan","institution_ids":["https://openalex.org/I4210126251","https://openalex.org/I4210147061","https://openalex.org/I4210155122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000903563","display_name":"Yuki Izumi","orcid":"https://orcid.org/0000-0002-4542-5809","observed_orcids":["https://orcid.org/0000-0002-4542-5809","https://orcid.org/0000-0003-3004-906X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuki Izumi","raw_affiliation_strings":["Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001616072","display_name":"Mike Saji","orcid":"https://orcid.org/0000-0003-2057-109X","observed_orcids":["https://orcid.org/0000-0003-2057-109X"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mike Saji","raw_affiliation_strings":["Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan; Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Faculty of Medicine, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2057-109X","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan; Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Faculty of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012537473","display_name":"Masahiko Asami","orcid":"https://orcid.org/0000-0002-2102-033X","observed_orcids":["https://orcid.org/0000-0002-2102-033X"]},"institutions":[{"id":"https://openalex.org/I4210130218","display_name":"Mitsui Memorial Hospital","ror":"https://ror.org/02qa5hr50","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210130218"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiko Asami","raw_affiliation_strings":["Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2102-033X","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4210130218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054282709","display_name":"Yusuke Enta","orcid":"https://orcid.org/0000-0003-1931-1012","observed_orcids":["https://orcid.org/0000-0003-1931-1012"]},"institutions":[{"id":"https://openalex.org/I4210166385","display_name":"Sendai Kousei Hospital","ror":"https://ror.org/05yevkn97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210166385"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Enta","raw_affiliation_strings":["Department of Cardiology, Sendai Kosei Hospital, Sendai, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1931-1012","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sendai Kosei Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210166385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101980454","display_name":"Shinichi Shirai","orcid":"https://orcid.org/0000-0002-4764-8205","observed_orcids":["https://orcid.org/0000-0002-4764-8205"]},"institutions":[{"id":"https://openalex.org/I4210161538","display_name":"Kokura Memorial Hospital","ror":"https://ror.org/056tqzr82","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161538"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichi Shirai","raw_affiliation_strings":["Division of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan","institution_ids":["https://openalex.org/I4210161538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089045646","display_name":"Masaki Izumo","orcid":"https://orcid.org/0000-0001-8597-1479","observed_orcids":["https://orcid.org/0000-0001-8597-1479"]},"institutions":[{"id":"https://openalex.org/I4405285607","display_name":"St. Marianna University Hospital","ror":"https://ror.org/05ryk9w06","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405285607"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Izumo","raw_affiliation_strings":["Division of Cardiology, St. Marianna University School of Medicine Hospital, Kawasaki, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8597-1479","affiliations":[{"raw_affiliation_string":"Division of Cardiology, St. Marianna University School of Medicine Hospital, Kawasaki, Japan","institution_ids":["https://openalex.org/I4405285607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110700491","display_name":"Shingo Mizuno","orcid":"https://orcid.org/0009-0008-2683-929X","observed_orcids":["https://orcid.org/0009-0008-2683-929X","https://orcid.org/0009-0009-6030-2418"]},"institutions":[{"id":"https://openalex.org/I4210151342","display_name":"Shonan Kamakura General Hospital","ror":"https://ror.org/03xz3hj66","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151342"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shingo Mizuno","raw_affiliation_strings":["Department of Cardiology, Shonan Kamakura General Hospital, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Shonan Kamakura General Hospital, Kanagawa, Japan","institution_ids":["https://openalex.org/I4210151342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030693549","display_name":"Yusuke Watanabe","orcid":"https://orcid.org/0000-0003-2297-5303","observed_orcids":["https://orcid.org/0000-0003-2297-5303"]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Watanabe","raw_affiliation_strings":["Department of Cardiology, Teikyo University School of Medicine, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2297-5303","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Teikyo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071736888","display_name":"Makoto Amaki","orcid":"https://orcid.org/0000-0001-5132-5129","observed_orcids":["https://orcid.org/0000-0001-5132-5129"]},"institutions":[{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Amaki","raw_affiliation_strings":["Department of Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110892230","display_name":"Kazuhisa Kodama","orcid":"https://orcid.org/0000-0002-4310-8906","observed_orcids":["https://orcid.org/0000-0002-4310-8906"]},"institutions":[{"id":"https://openalex.org/I4210096957","display_name":"Saiseikai Kumamoto Hospital","ror":"https://ror.org/00xz1cn67","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210096957"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhisa Kodama","raw_affiliation_strings":["Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan","institution_ids":["https://openalex.org/I4210096957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053229206","display_name":"Junichi Yamaguchi","orcid":"https://orcid.org/0000-0003-0967-0978","observed_orcids":["https://orcid.org/0000-0003-0967-0978","https://orcid.org/0000-0002-7194-5891"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junichi Yamaguchi","raw_affiliation_strings":["Department of Cardiology Tokyo Woman's Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology Tokyo Woman's Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Toru Naganuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094277","display_name":"New Tokyo Hospital","ror":"https://ror.org/00m44rf61","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094277"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Naganuma","raw_affiliation_strings":["Department of Cardiology, New Tokyo Hospital, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, New Tokyo Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I4210094277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021759816","display_name":"Hiroki Bota","orcid":"https://orcid.org/0009-0002-7334-8852","observed_orcids":["https://orcid.org/0009-0002-7334-8852"]},"institutions":[{"id":"https://openalex.org/I4210089947","display_name":"Sapporo Higashi Tokushukai Hospital","ror":"https://ror.org/00e81jd95","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089947"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Bota","raw_affiliation_strings":["Department of Cardiology, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210089947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015886826","display_name":"Yohei Ohno","orcid":"https://orcid.org/0000-0003-4203-7613","observed_orcids":["https://orcid.org/0000-0003-4203-7613"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]},{"id":"https://openalex.org/I4210115139","display_name":"Tokai University Hospital","ror":"https://ror.org/01gvmn480","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115139"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yohei Ohno","raw_affiliation_strings":["Department of Cardiology, Tokai University School of Medicine, Isehara, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4203-7613","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Tokai University School of Medicine, Isehara, Japan","institution_ids":["https://openalex.org/I1314466530","https://openalex.org/I4210115139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083481251","display_name":"Daisuke Hachinohe","orcid":"https://orcid.org/0000-0003-4828-1836","observed_orcids":["https://orcid.org/0000-0003-4828-1836"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daisuke Hachinohe","raw_affiliation_strings":["Department of Cardiology, Sapporo Cardiovascular Clinic, Sapporo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4828-1836","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sapporo Cardiovascular Clinic, Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101591419","display_name":"Masahiro Yamawaki","orcid":"https://orcid.org/0000-0003-4334-2441","observed_orcids":["https://orcid.org/0000-0003-4334-2441"]},"institutions":[{"id":"https://openalex.org/I4210153408","display_name":"Saiseikai Yokohama Eastern Hospital","ror":"https://ror.org/04tew3n82","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153408"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Yamawaki","raw_affiliation_strings":["Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Kanagawa, Japan","institution_ids":["https://openalex.org/I4210153408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071244315","display_name":"Kazuki Mizutani","orcid":"https://orcid.org/0000-0001-7206-4538","observed_orcids":["https://orcid.org/0000-0001-7206-4538"]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuki Mizutani","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Kinki University Faculty of Medicine, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7206-4538","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Kinki University Faculty of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048943129","display_name":"Toshiaki Otsuka","orcid":"https://orcid.org/0009-0004-7994-7594","observed_orcids":["https://orcid.org/0009-0004-7994-7594"]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Otsuka","raw_affiliation_strings":["Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048068822","display_name":"Kentaro Hayashida","orcid":"https://orcid.org/0000-0002-1750-1982","observed_orcids":["https://orcid.org/0000-0002-1750-1982"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Hayashida","raw_affiliation_strings":["Department of Cardiology, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1750-1982","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":23,"corresponding_author_ids":["https://openalex.org/A5009215615"],"corresponding_institution_ids":["https://openalex.org/I42766147"],"apc_list":{"value":4084,"currency":"USD","value_usd":4084},"apc_paid":{"value":4084,"currency":"USD","value_usd":4084},"fwci":2.9579,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.90749315,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"5","issue":"9","first_page":"1095","last_page":"1106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mineralocorticoid-receptor-antagonists","display_name":"mineralocorticoid receptor antagonists","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transcatheter-edge-to-edge-repair","display_name":"transcatheter edge-to-edge repair","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mitral-valve-repair","display_name":"mitral valve repair","score":0.796999990940094},{"id":"https://openalex.org/keywords/secondary-mitral-regurgitation","display_name":"functional mitral regurgitation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/heart-failure-with-reduced-ejection-fraction","display_name":"heart failure with reduced ejection fraction","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6290000081062317},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7070000171661377},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8970000147819519},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C189135053","wikidata":"https://www.wikidata.org/wiki/Q3454531","display_name":"Mineralocorticoid receptor","level":3,"score":0.7226581573486328},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.5280780792236328},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.525759756565094},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5197112560272217},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.5055804252624512},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4875776171684265},{"id":"https://openalex.org/C162307627","wikidata":"https://www.wikidata.org/wiki/Q204833","display_name":"Enhanced Data Rates for GSM Evolution","level":2,"score":0.4874127209186554},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36208081245422363},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3282473683357239},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.3249504566192627},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20602858066558838},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11772891879081726},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jacasi.2025.03.014","doi":"https://doi.org/10.1016/j.jacasi.2025.03.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacasi.2025.03.014","pdf_url":null,"source":{"id":"https://openalex.org/S4210201151","display_name":"JACC Asia","issn_l":"2772-3747","issn":["2772-3747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Asia","raw_type":"journal-article"},{"id":"pmid:40434334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40434334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC. Asia","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12426662","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12426662/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC Asia","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:07523:0007243836","doi":null,"is_oa":true,"landing_page_url":"https://marianna-u.repo.nii.ac.jp/records/2001592","pdf_url":"https://marianna-u.repo.nii.ac.jp/record/2001592/files/1-s2.0-S2772374725002273-main.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JACC. Asia","raw_type":"journal article"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006999123","doi":null,"is_oa":true,"landing_page_url":"https://pure.teikyo.jp/en/publications/c9be1a16-be4d-4797-9c50-4a50d78db8b8","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JACC: Asia","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1016/j.jacasi.2025.03.014","doi":"https://doi.org/10.1016/j.jacasi.2025.03.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacasi.2025.03.014","pdf_url":null,"source":{"id":"https://openalex.org/S4210201151","display_name":"JACC Asia","issn_l":"2772-3747","issn":["2772-3747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Asia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309139","display_name":"Edwards Lifesciences","ror":"https://ror.org/04jhyte11"},{"id":"https://openalex.org/F4320310567","display_name":"Boston Scientific Corporation","ror":"https://ror.org/0385es521"},{"id":"https://openalex.org/F4320334405","display_name":"Medtronic Japan","ror":"https://ror.org/031tfsa37"},{"id":"https://openalex.org/F4320334790","display_name":"Daiichi Sankyo Company","ror":"https://ror.org/027y26122"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410766832.pdf","grobid_xml":"https://content.openalex.org/works/W4410766832.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W2113698123","https://openalex.org/W2152094259","https://openalex.org/W2164705414","https://openalex.org/W2323458614","https://openalex.org/W2548066759","https://openalex.org/W2888290077","https://openalex.org/W2889688444","https://openalex.org/W2974260792","https://openalex.org/W2990806422","https://openalex.org/W3112364326","https://openalex.org/W3201722621","https://openalex.org/W4206288390","https://openalex.org/W4220837239","https://openalex.org/W4281788029","https://openalex.org/W4283833224","https://openalex.org/W4300860475","https://openalex.org/W4308426865","https://openalex.org/W4353048107","https://openalex.org/W4367042658","https://openalex.org/W4386151215","https://openalex.org/W4386241321","https://openalex.org/W4392446581"],"related_works":["https://openalex.org/W7127566326","https://openalex.org/W4390887372","https://openalex.org/W7165385089","https://openalex.org/W4283833224","https://openalex.org/W4281788029","https://openalex.org/W4306320328","https://openalex.org/W4406420379","https://openalex.org/W4294663884","https://openalex.org/W6947937351","https://openalex.org/W6891678228"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mineralocorticoid":[1],"receptor":[2],"antagonists":[3],"(MRAs)":[4],"are":[5],"integral":[6],"components":[7],"of":[8,22,50,98,108,120,144,149,155,166,175,187,200,241],"medical":[9],"therapy":[10],"for":[11,35,58,133,214],"patients":[12,27,55,66,122,210],"with":[13,16,82,160,171,193,229,234],"heart":[14,112,221],"failure":[15,113],"reduced":[17],"ejection":[18,86],"fraction.":[19],"However,":[20,238],"implication":[21],"MRA":[23,51,145,188,226,236,243],"dosing":[24,52],"in":[25,53,73,197,248,251],"older":[26,54,209],"undergoing":[28],"transcatheter":[29],"edge-to-edge":[30],"mitral":[31,37,60,91,216],"valve":[32],"repair":[33],"(TEER)":[34],"secondary":[36,59,90,215],"regurgitation":[38,92,217],"remains":[39],"uncertain.":[40],"OBJECTIVES:":[41],"The":[42,95],"authors":[43],"aimed":[44],"to":[45],"investigate":[46],"the":[47,74,104,142,167,198,201,242],"prognostic":[48],"impacts":[49],"receiving":[56],"TEER":[57,69,213],"regurgitation.":[61],"METHODS:":[62],"This":[63],"study":[64],"included":[65,130],"who":[67,211],"underwent":[68,212],"and":[70,89,111,131],"were":[71,93,115,129,189],"enrolled":[72],"OCEAN":[75],"(Optimized":[76],"CathEter":[77],"vAlvular":[78],"iNtervention)-Mitral":[79],"registry.":[80],"Patients":[81],"a":[83,134,147,161,194,224],"left":[84],"ventricular":[85],"fraction":[87],"<50%":[88],"selected.":[94],"dose-dependent":[96],"effects":[97],"MRA,":[99],"administered":[100],"at":[101,146],"discharge,":[102],"on":[103],"2-year":[105,163],"composite":[106,169],"outcome":[107,203],"all-cause":[109],"mortality":[110],"hospitalization":[114],"evaluated.":[116],"RESULTS:":[117],"A":[118],"total":[119],"2,026":[121],"(median":[123],"age":[124],"77":[125],"years;":[126],"1,287":[127],"men)":[128],"followed":[132],"median":[135],"416":[136],"days":[137],"(Q1-Q3:":[138],"294-730":[139],"days).":[140],"Post-TEER,":[141],"administration":[143],"dose":[148,244],"\u226512.5":[150],"mg/d":[151],"(ie,":[152],"any":[153],"doses":[154,186],"MRA)":[156],"was":[157,227],"independently":[158],"associated":[159,192,228],"lower":[162],"cumulative":[164],"incidence":[165],"primary":[168,202],"outcome,":[170],"an":[172],"adjusted":[173],"HR":[174],"0.83":[176],"(95%":[177],"CI:":[178],"0.69-0.99;":[179],"P":[180],"=":[181,205],"0.046).":[182],"In":[183,208],"contrast,":[184],"higher":[185],"not":[190,246],"significantly":[191],"further":[195,239],"reduction":[196],"risk":[199],"(P":[204],"0.97).":[206],"CONCLUSIONS:":[207],"caused":[218],"by":[219],"systolic":[220],"failure,":[222],"even":[223],"low-dose":[225],"improved":[230],"clinical":[231,252],"outcomes":[232],"compared":[233],"no":[235],"administration.":[237],"up-titration":[240],"did":[245],"result":[247],"additional":[249],"improvements":[250],"outcomes.":[253],"(OCEAN-Mitral":[254],"registry;":[255],"UMIN000023653).":[256]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-05-28T00:00:00"}
