{"id":"https://openalex.org/W4410695832","doi":"https://doi.org/10.3390/ijms26115022","title":"Skin Microbiome and Radiation-Induced Skin Injury: Unraveling the Relationship, Mechanisms, and Therapeutic Implications","display_name":"Skin Microbiome and Radiation-Induced Skin Injury: Unraveling the Relationship, Mechanisms, and Therapeutic Implications","publication_year":2025,"publication_date":"2025-05-23","ids":{"openalex":"https://openalex.org/W4410695832","doi":"https://doi.org/10.3390/ijms26115022","pmid":"https://pubmed.ncbi.nlm.nih.gov/40507833","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12155174"},"language":"en","primary_location":{"id":"doi:10.3390/ijms26115022","doi":"https://doi.org/10.3390/ijms26115022","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26115022","pdf_url":"https://www.mdpi.com/1422-0067/26/11/5022/pdf?version=1747989320","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/26/11/5022/pdf?version=1747989320","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094278566","display_name":"Aleksandra Wiktoria Bratborska","orcid":"https://orcid.org/0009-0006-5288-1577","observed_orcids":["https://orcid.org/0009-0006-5288-1577"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Aleksandra Wiktoria Bratborska","raw_affiliation_strings":["Department of Dermatology and Venereology , Poznan University of Medical Sciences , 60-355 Poznan , Poland","Doctoral School, Poznan University of Medical Sciences, 61-701 Poznan, Poland"],"raw_orcid":"https://orcid.org/0009-0006-5288-1577","affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology , Poznan University of Medical Sciences , 60-355 Poznan , Poland","institution_ids":["https://openalex.org/I120230055"]},{"raw_affiliation_string":"Doctoral School, Poznan University of Medical Sciences, 61-701 Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072534905","display_name":"Pawe\u0142 G\u0142uszak","orcid":"https://orcid.org/0000-0002-5877-491X","observed_orcids":["https://orcid.org/0000-0002-5877-491X"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Pawe\u0142 G\u0142uszak","raw_affiliation_strings":["Department of Dermatology, Poznan University of Medical Sciences, 60-355 Poznan, Poland","Doctoral School , Poznan University of Medical Sciences , 61-701 Poznan , Poland"],"raw_orcid":"https://orcid.org/0000-0002-5877-491X","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Poznan University of Medical Sciences, 60-355 Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]},{"raw_affiliation_string":"Doctoral School , Poznan University of Medical Sciences , 61-701 Poznan , Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101624517","display_name":"Maria Magdalena Joks","orcid":"https://orcid.org/0009-0005-9892-6673","observed_orcids":["https://orcid.org/0009-0005-9892-6673"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Maria Joks","raw_affiliation_strings":["Department of Dermatology and Venereology, Poznan University of Medical Sciences, 60-355 Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, Poznan University of Medical Sciences, 60-355 Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000041878","display_name":"Joanna Ka\u017amierska","orcid":"https://orcid.org/0000-0001-7160-8150","observed_orcids":["https://orcid.org/0000-0001-7160-8150"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna Ka\u017amierska","raw_affiliation_strings":["Department of Radiotherapy, Poznan University of Medical Sciences, 61-866 Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Poznan University of Medical Sciences, 61-866 Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077112285","display_name":"Jakub Pazdrowski","orcid":"https://orcid.org/0000-0002-6065-6402","observed_orcids":["https://orcid.org/0000-0002-6065-6402"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jakub Pazdrowski","raw_affiliation_strings":["Department of Head and Neck Surgery, Poznan University of Medical Sciences, 61-866 Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Surgery, Poznan University of Medical Sciences, 61-866 Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071090154","display_name":"Adriana Pola\u0144ska","orcid":"https://orcid.org/0000-0001-9531-7358","observed_orcids":["https://orcid.org/0000-0001-9531-7358"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Adriana Pola\u0144ska","raw_affiliation_strings":["Department of Dermatology and Venereology, Poznan University of Medical Sciences, 60-355 Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, Poznan University of Medical Sciences, 60-355 Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110210435","display_name":"Shalini Jain","orcid":"https://orcid.org/0000-0001-5200-5928","observed_orcids":["https://orcid.org/0000-0001-5200-5928"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shalini Jain","raw_affiliation_strings":["USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015254485","display_name":"Hariom Yadav","orcid":"https://orcid.org/0000-0003-4504-1597","observed_orcids":["https://orcid.org/0000-0003-4504-1597"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hariom Yadav","raw_affiliation_strings":["USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA"],"raw_orcid":"https://orcid.org/0000-0003-4504-1597","affiliations":[{"raw_affiliation_string":"USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085220923","display_name":"Micha\u0142 M. Masternak","orcid":"https://orcid.org/0000-0002-8483-930X","observed_orcids":["https://orcid.org/0000-0002-8483-930X"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]},{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL","US"],"is_corresponding":false,"raw_author_name":"Michal M Masternak","raw_affiliation_strings":["College of Medicine , Burnett School of Biomedical Sciences , University of Central Florida , Orlando , FL 32827 USA","Department of Head and Neck Surgery, Poznan University of Medical Sciences, 61-866 Poznan, Poland","Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine , Burnett School of Biomedical Sciences , University of Central Florida , Orlando , FL 32827 USA","institution_ids":["https://openalex.org/I106165777"]},{"raw_affiliation_string":"Department of Head and Neck Surgery, Poznan University of Medical Sciences, 61-866 Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]},{"raw_affiliation_string":"Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012796989","display_name":"Aleksandra Da\u0144czak\u2010Pazdrowska","orcid":"https://orcid.org/0000-0002-8192-7013","observed_orcids":["https://orcid.org/0000-0002-8192-7013"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Aleksandra Da\u0144czak-Pazdrowska","raw_affiliation_strings":["Department of Dermatology, Poznan University of Medical Sciences, 60-355 Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Poznan University of Medical Sciences, 60-355 Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5094278566"],"corresponding_institution_ids":["https://openalex.org/I120230055"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.565,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.82162798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"26","issue":"11","first_page":"5022","last_page":"5022"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.2883000075817108,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0203000009059906,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-microbiome","display_name":"skin microbiome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/radiation-dermatitis","display_name":"radiation dermatitis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.8259999752044678},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/skin-regeneration","display_name":"skin regeneration","score":0.9470000267028809},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.784677267074585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5186387896537781},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5009801387786865},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.4310351610183716},{"id":"https://openalex.org/C2993278735","wikidata":"https://www.wikidata.org/wiki/Q275459","display_name":"Radiation injury","level":3,"score":0.4268541634082794},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3706653118133545},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.35693860054016113},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33038491010665894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2809794545173645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13572296500205994}],"mesh":[{"descriptor_ui":"D000098903","descriptor_name":"Skin Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011832","descriptor_name":"Radiation Injuries","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D011855","descriptor_name":"Radiodermatitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011855","descriptor_name":"Radiodermatitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D011855","descriptor_name":"Radiodermatitis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms26115022","doi":"https://doi.org/10.3390/ijms26115022","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26115022","pdf_url":"https://www.mdpi.com/1422-0067/26/11/5022/pdf?version=1747989320","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202504.2476.v1","doi":"https://doi.org/10.20944/preprints202504.2476.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202504.2476.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/a2a704bf005f1f414a977981605ca05a/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:12155174","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12155174","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:40507833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40507833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms26115022","doi":"https://doi.org/10.3390/ijms26115022","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26115022","pdf_url":"https://www.mdpi.com/1422-0067/26/11/5022/pdf?version=1747989320","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410695832.pdf","grobid_xml":"https://content.openalex.org/works/W4410695832.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W1489049801","https://openalex.org/W1590634572","https://openalex.org/W1975014863","https://openalex.org/W1983357763","https://openalex.org/W1988037536","https://openalex.org/W2003601710","https://openalex.org/W2010738726","https://openalex.org/W2016899305","https://openalex.org/W2017779727","https://openalex.org/W2024946942","https://openalex.org/W2047774330","https://openalex.org/W2054259512","https://openalex.org/W2060130170","https://openalex.org/W2075647502","https://openalex.org/W2082589697","https://openalex.org/W2084224801","https://openalex.org/W2095825534","https://openalex.org/W2104027193","https://openalex.org/W2125286458","https://openalex.org/W2141043078","https://openalex.org/W2143477255","https://openalex.org/W2162158108","https://openalex.org/W2180997009","https://openalex.org/W2187727368","https://openalex.org/W2194004100","https://openalex.org/W2213355316","https://openalex.org/W2307159860","https://openalex.org/W2311116156","https://openalex.org/W2328064285","https://openalex.org/W2410507602","https://openalex.org/W2419673974","https://openalex.org/W2512036091","https://openalex.org/W2560323895","https://openalex.org/W2763626562","https://openalex.org/W2780927528","https://openalex.org/W2783780088","https://openalex.org/W2787580274","https://openalex.org/W2788482126","https://openalex.org/W2789248221","https://openalex.org/W2795876858","https://openalex.org/W2840436966","https://openalex.org/W2904966986","https://openalex.org/W2911520506","https://openalex.org/W2936868735","https://openalex.org/W2972693321","https://openalex.org/W2980474875","https://openalex.org/W2983421360","https://openalex.org/W2986171356","https://openalex.org/W2990378266","https://openalex.org/W2991055117","https://openalex.org/W3003470360","https://openalex.org/W3008378263","https://openalex.org/W3020351359","https://openalex.org/W3031512451","https://openalex.org/W3038048393","https://openalex.org/W3081396975","https://openalex.org/W3086723583","https://openalex.org/W3100165832","https://openalex.org/W3105761540","https://openalex.org/W3108364418","https://openalex.org/W3109904127","https://openalex.org/W3132137273","https://openalex.org/W3134655644","https://openalex.org/W3135684373","https://openalex.org/W3159211765","https://openalex.org/W3161967602","https://openalex.org/W3164647557","https://openalex.org/W3176332101","https://openalex.org/W3196744010","https://openalex.org/W3215988482","https://openalex.org/W4207073804","https://openalex.org/W4210719890","https://openalex.org/W4220714035","https://openalex.org/W4220866002","https://openalex.org/W4220866664","https://openalex.org/W4250296856","https://openalex.org/W4281672281","https://openalex.org/W4283123669","https://openalex.org/W4283753331","https://openalex.org/W4293095080","https://openalex.org/W4294012251","https://openalex.org/W4309043084","https://openalex.org/W4313545980","https://openalex.org/W4313640810","https://openalex.org/W4315697692","https://openalex.org/W4318755043","https://openalex.org/W4323042507","https://openalex.org/W4353085779","https://openalex.org/W4360990576","https://openalex.org/W4362637521","https://openalex.org/W4368357288","https://openalex.org/W4368359999","https://openalex.org/W4382725722","https://openalex.org/W4386028530","https://openalex.org/W4386419502","https://openalex.org/W4387077756","https://openalex.org/W4387206787","https://openalex.org/W4387449576","https://openalex.org/W4391430747","https://openalex.org/W4391842017","https://openalex.org/W4391919082","https://openalex.org/W4392597466","https://openalex.org/W4392847600","https://openalex.org/W4393370949","https://openalex.org/W4396599516","https://openalex.org/W4404517584","https://openalex.org/W4408821771","https://openalex.org/W4409653045","https://openalex.org/W4410184395","https://openalex.org/W7073698835"],"related_works":["https://openalex.org/W4309043084","https://openalex.org/W7117239859","https://openalex.org/W4402786124","https://openalex.org/W7214244336","https://openalex.org/W3011831921","https://openalex.org/W3100165832","https://openalex.org/W4410208221","https://openalex.org/W3135684373","https://openalex.org/W4415997801","https://openalex.org/W7125646938"],"abstract_inverted_index":{"Radiotherapy":[0],"(RT)":[1],"is":[2,70],"a":[3,71,83],"treatment":[4],"method":[5],"commonly":[6],"used":[7],"in":[8,29,53,74],"oncology.":[9],"A":[10],"vast":[11],"majority":[12],"of":[13,63,93],"patients":[14,96],"undergoing":[15,97],"RT":[16],"suffer":[17],"from":[18,25],"radiation-induced":[19,114],"skin":[20,45,55,80,111,115],"injury":[21],"(RISI),":[22],"which":[23],"results":[24],"complex":[26],"biochemical":[27],"reactions":[28],"the":[30,54,59,79,91,107,110],"irradiated":[31],"skin.":[32],"Current":[33],"strategies":[34,124],"for":[35,42,95,125],"preventing":[36,126],"and":[37,61,113,127],"managing":[38],"RISI":[39],"are":[40],"insufficient":[41],"achieving":[43],"full":[44],"regeneration.":[46],"Multiple":[47],"studies":[48,66],"have":[49],"shown":[50],"that":[51,68,87],"alterations":[52],"microbiome":[56,112],"correlate":[57],"with":[58],"development":[60],"severity":[62],"RISI.":[64],"These":[65],"suggest":[67],"dysbiosis":[69],"crucial":[72],"factor":[73],"promoting":[75],"radiation-associated":[76],"dermatitis.":[77],"Targeting":[78],"microbiota":[81],"presents":[82],"potential":[84,122],"therapeutic":[85,123],"approach":[86],"could":[88],"significantly":[89],"improve":[90],"quality":[92],"life":[94],"RT.":[98],"This":[99],"review":[100],"aims":[101],"to":[102,120],"present":[103],"current":[104],"findings":[105],"on":[106],"interplay":[108],"between":[109],"damage":[116],"as":[117,119],"well":[118],"discuss":[121],"mitigating":[128],"this":[129],"condition.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-05-24T00:00:00"}