{"id":"https://openalex.org/W4410527770","doi":"https://doi.org/10.7759/cureus.84426","title":"Comparison of Intravenous Carbetocin (100 Mcg) and Intravenous Oxytocin (10 IU) for the Prevention of Postpartum Hemorrhage Following Emergency Cesarean Section","display_name":"Comparison of Intravenous Carbetocin (100 Mcg) and Intravenous Oxytocin (10 IU) for the Prevention of Postpartum Hemorrhage Following Emergency Cesarean Section","publication_year":2025,"publication_date":"2025-05-19","ids":{"openalex":"https://openalex.org/W4410527770","doi":"https://doi.org/10.7759/cureus.84426","pmid":"https://pubmed.ncbi.nlm.nih.gov/40539175"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.84426","doi":"https://doi.org/10.7759/cureus.84426","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.84426","pdf_url":"https://assets.cureus.com/uploads/original_article/pdf/369965/20250520-795611-dqo9mr.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://assets.cureus.com/uploads/original_article/pdf/369965/20250520-795611-dqo9mr.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117609836","display_name":"Vadlamudi Keerthi Chowdary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123665430","display_name":"Shri BM Patil Medical College","ror":"https://ror.org/03v2nwz54","country_code":"IN","type":"education","lineage":["https://openalex.org/I123665430"]},{"id":"https://openalex.org/I4210116054","display_name":"BLDE (Deemed to be University)","ror":"https://ror.org/02bdf7k74","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210116054"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vadlamudi Keerthi Chowdary","raw_affiliation_strings":["Obstetrics and Gynaecology, Shri BM Patil Medical College and Hospital, BLDE (Deemed to be University), Vijaypura, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynaecology, Shri BM Patil Medical College and Hospital, BLDE (Deemed to be University), Vijaypura, IND","institution_ids":["https://openalex.org/I123665430","https://openalex.org/I4210116054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085943738","display_name":"Subhashchandra R Mudanur","orcid":"https://orcid.org/0000-0002-0189-2448","observed_orcids":["https://orcid.org/0000-0002-0189-2448"]},"institutions":[{"id":"https://openalex.org/I123665430","display_name":"Shri BM Patil Medical College","ror":"https://ror.org/03v2nwz54","country_code":"IN","type":"education","lineage":["https://openalex.org/I123665430"]},{"id":"https://openalex.org/I4210116054","display_name":"BLDE (Deemed to be University)","ror":"https://ror.org/02bdf7k74","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210116054"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subhashchandra R Mudanur","raw_affiliation_strings":["Obstetrics and Gynaecology, Shri BM Patil Medical College and Hospital, BLDE (Deemed to be University), Vijayapura, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynaecology, Shri BM Patil Medical College and Hospital, BLDE (Deemed to be University), Vijayapura, IND","institution_ids":["https://openalex.org/I123665430","https://openalex.org/I4210116054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078097551","display_name":"Rajasri G Yaliwal","orcid":"https://orcid.org/0000-0002-9740-6300","observed_orcids":["https://orcid.org/0000-0002-9740-6300"]},"institutions":[{"id":"https://openalex.org/I123665430","display_name":"Shri BM Patil Medical College","ror":"https://ror.org/03v2nwz54","country_code":"IN","type":"education","lineage":["https://openalex.org/I123665430"]},{"id":"https://openalex.org/I4210116054","display_name":"BLDE (Deemed to be University)","ror":"https://ror.org/02bdf7k74","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210116054"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajasri G Yaliwal","raw_affiliation_strings":["Obstetrics and Gynaecology, Shri BM Patil Medical College and Hospital, BLDE (Deemed to be University), Vijayapura, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynaecology, Shri BM Patil Medical College and Hospital, BLDE (Deemed to be University), Vijayapura, IND","institution_ids":["https://openalex.org/I123665430","https://openalex.org/I4210116054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000729141","display_name":"Shreedevi Kori","orcid":"https://orcid.org/0000-0003-2303-7685","observed_orcids":["https://orcid.org/0000-0003-2303-7685"]},"institutions":[{"id":"https://openalex.org/I123665430","display_name":"Shri BM Patil Medical College","ror":"https://ror.org/03v2nwz54","country_code":"IN","type":"education","lineage":["https://openalex.org/I123665430"]},{"id":"https://openalex.org/I4210116054","display_name":"BLDE (Deemed to be University)","ror":"https://ror.org/02bdf7k74","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210116054"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shreedevi Kori","raw_affiliation_strings":["Obstetrics and Gynaecology, Shri BM Patil Medical College and Hospital, BLDE (Deemed to be University), Vijayapura, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynaecology, Shri BM Patil Medical College and Hospital, BLDE (Deemed to be University), Vijayapura, IND","institution_ids":["https://openalex.org/I123665430","https://openalex.org/I4210116054"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ekta Chhabra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123665430","display_name":"Shri BM Patil Medical College","ror":"https://ror.org/03v2nwz54","country_code":"IN","type":"education","lineage":["https://openalex.org/I123665430"]},{"id":"https://openalex.org/I4210116054","display_name":"BLDE (Deemed to be University)","ror":"https://ror.org/02bdf7k74","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210116054"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ekta Chhabra","raw_affiliation_strings":["Obstetrics and Gynaecology, Shri BM Patil Medical College and Hospital, BLDE (Deemed to be University), Vijayapura, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynaecology, Shri BM Patil Medical College and Hospital, BLDE (Deemed to be University), Vijayapura, IND","institution_ids":["https://openalex.org/I123665430","https://openalex.org/I4210116054"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4021,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.79735671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"17","issue":"5","first_page":"e84426","last_page":"e84426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11389","display_name":"Maternal and fetal healthcare","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11389","display_name":"Maternal and fetal healthcare","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbetocin","display_name":"carbetocin","score":0.8999999761581421},{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/postpartum-hemorrhage","display_name":"postpartum hemorrhage","score":0.9229999780654907},{"id":"https://openalex.org/keywords/emergency-cesarean-section","display_name":"emergency cesarean section","score":0.9959999918937683},{"id":"https://openalex.org/keywords/uterotonic-agents","display_name":"uterotonic agents","score":0.9890000224113464},{"id":"https://openalex.org/keywords/uterine-tone","display_name":"uterine tone","score":0.7670000195503235},{"id":"https://openalex.org/keywords/intraoperative-blood-loss","display_name":"intraoperative blood loss","score":0.9350000023841858},{"id":"https://openalex.org/keywords/maternal-hemodynamic-stability","display_name":"maternal hemodynamic stability","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9909209609031677},{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.8137714266777039},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.49386173486709595},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.46369776129722595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11758369207382202}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.84426","doi":"https://doi.org/10.7759/cureus.84426","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.84426","pdf_url":"https://assets.cureus.com/uploads/original_article/pdf/369965/20250520-795611-dqo9mr.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmid:40539175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40539175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12176526","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12176526","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cureus","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7759/cureus.84426","doi":"https://doi.org/10.7759/cureus.84426","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.84426","pdf_url":"https://assets.cureus.com/uploads/original_article/pdf/369965/20250520-795611-dqo9mr.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6899999976158142}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410527770.pdf","grobid_xml":"https://content.openalex.org/works/W4410527770.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1963744473","https://openalex.org/W2023257944","https://openalex.org/W2130461169","https://openalex.org/W2808867802","https://openalex.org/W2919584157","https://openalex.org/W2990139039","https://openalex.org/W3088669528","https://openalex.org/W3200303548","https://openalex.org/W4212771519","https://openalex.org/W4220758644","https://openalex.org/W4283221120","https://openalex.org/W4306175704"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"BACKGROUND:":[0],"Postpartum":[1],"hemorrhage":[2],"(PPH)":[3],"is":[4,19,219],"a":[5,25,147,220],"leading":[6],"cause":[7],"of":[8,50,84],"maternal":[9,76],"morbidity":[10],"and":[11,39,75,109,146,169,176,214,222],"mortality,":[12],"particularly":[13],"following":[14,62],"cesarean":[15,64,89,233],"sections.":[16,234],"While":[17],"oxytocin":[18,56,101,226],"the":[20,48,70,164],"standard":[21],"uterotonic":[22,37],"agent,":[23],"carbetocin,":[24],"long-acting":[26],"synthetic":[27],"analogue,":[28],"may":[29],"offer":[30],"improved":[31,215],"efficacy":[32,198],"due":[33],"to":[34,46,94,203,225],"its":[35],"prolonged":[36],"effect":[38],"better":[40],"stability.":[41,78],"OBJECTIVE:":[42],"This":[43],"study":[44],"aimed":[45],"compare":[47],"effectiveness":[49],"intravenous":[51],"carbetocin":[52,97,165],"(100":[53],"mcg)":[54],"versus":[55],"(10":[57],"IU)":[58],"in":[59,163,191,199,231],"preventing":[60,200],"PPH":[61,201,228],"emergency":[63,88,232],"sections":[65],"by":[66],"evaluating":[67],"blood":[68,105,136,207],"loss,":[69,106,208],"need":[71,149,210],"for":[72,150,211,227],"additional":[73,151,212],"uterotonics,":[74],"hemodynamic":[77,110],"MATERIALS":[79],"AND":[80],"METHODS:":[81],"A":[82],"total":[83],"350":[85],"women":[86],"undergoing":[87],"section":[90],"were":[91,112],"randomly":[92],"assigned":[93],"receive":[95],"either":[96],"(Group":[98,102],"A)":[99],"or":[100],"B).":[103],"Intraoperative":[104],"uterine":[107,216],"tone,":[108],"parameters":[111],"measured.":[113],"Statistical":[114],"analysis":[115],"was":[116,131,161],"performed":[117],"using":[118],"IBM":[119],"SPSS":[120],"Statistics":[121],"software,":[122],"version":[123],"26":[124],"(IBM":[125],"Corp.,":[126],"Armonk,":[127],"NY).":[128],"RESULTS:":[129],"Carbetocin":[130,195,218],"associated":[132],"with":[133,187,205],"significantly":[134],"lower":[135,206],"loss":[137],"\u22651000":[138],"ml":[139],"(13(7.43%)":[140],"vs.":[141,154],"33(18.86%),":[142],"p":[143,156,177],"=":[144,157,174,178],"0.0015)":[145],"reduced":[148,209],"uterotonics":[152],"(10(5.71%)":[153],"21(12%),":[155],"0.0385).":[158],"Uterine":[159],"tone":[160],"superior":[162,197],"group":[166],"at":[167],"three":[168],"five":[170],"minutes":[171],"post-administration":[172],"(p":[173],"0.023":[175],"0.003,":[179],"respectively).":[180],"Both":[181],"drugs":[182],"had":[183],"similar":[184],"safety":[185],"profiles,":[186],"no":[188],"significant":[189],"differences":[190],"adverse":[192],"effects.":[193],"CONCLUSION:":[194],"demonstrated":[196],"compared":[202],"oxytocin,":[204],"interventions,":[213],"tone.":[217],"viable":[221],"safer":[223],"alternative":[224],"prevention,":[229],"especially":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}