{"id":"https://openalex.org/W4410479526","doi":"https://doi.org/10.4236/jbm.2025.135008","title":"Exploring the Latest Advances in Tenecteplase in the Treatment of Acute ST-Segment Elevation Myocardial Infarction","display_name":"Exploring the Latest Advances in Tenecteplase in the Treatment of Acute ST-Segment Elevation Myocardial Infarction","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4410479526","doi":"https://doi.org/10.4236/jbm.2025.135008"},"language":"en","primary_location":{"id":"doi:10.4236/jbm.2025.135008","doi":"https://doi.org/10.4236/jbm.2025.135008","is_oa":true,"landing_page_url":"https://doi.org/10.4236/jbm.2025.135008","pdf_url":"https://www.scirp.org/pdf/jbm_2153192.pdf","source":{"id":"https://openalex.org/S2764372278","display_name":"Journal of Biosciences and Medicines","issn_l":"2327-5081","issn":["2327-5081","2327-509X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biosciences and Medicines","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scirp.org/pdf/jbm_2153192.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ni Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177739611","display_name":"Yangtze University","ror":"https://ror.org/05bhmhz54","country_code":"CN","type":"education","lineage":["https://openalex.org/I177739611"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ni Chen","raw_affiliation_strings":["Department of Cardiology , Jingzhou Hospital Affiliated to Yangtze University , Jingzhou , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology , Jingzhou Hospital Affiliated to Yangtze University , Jingzhou , China","institution_ids":["https://openalex.org/I177739611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051850388","display_name":"Jin Xie","orcid":"https://orcid.org/0000-0001-7193-8053","observed_orcids":["https://orcid.org/0000-0001-7193-8053"]},"institutions":[{"id":"https://openalex.org/I177739611","display_name":"Yangtze University","ror":"https://ror.org/05bhmhz54","country_code":"CN","type":"education","lineage":["https://openalex.org/I177739611"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin Xie","raw_affiliation_strings":["Department of Cardiology , Jingzhou Hospital Affiliated to Yangtze University , Jingzhou , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology , Jingzhou Hospital Affiliated to Yangtze University , Jingzhou , China","institution_ids":["https://openalex.org/I177739611"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051850388"],"corresponding_institution_ids":["https://openalex.org/I177739611"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17169804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"05","first_page":"100","last_page":"109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tenecteplase","display_name":"tenecteplase","score":1.0},{"id":"https://openalex.org/keywords/st-elevation-myocardial-infarction","display_name":"ST-elevation myocardial infarction","score":0.953000009059906},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.906000018119812},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.8899999856948853},{"id":"https://openalex.org/keywords/intracoronary-thrombolysis","display_name":"intracoronary thrombolysis","score":0.847000002861023},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.8840000033378601},{"id":"https://openalex.org/keywords/reperfusion-therapy","display_name":"reperfusion therapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.5630000233650208},{"id":"https://openalex.org/keywords/thrombus-burden","display_name":"thrombus burden","score":0.6710000038146973},{"id":"https://openalex.org/keywords/microvascular-blood-flow","display_name":"microvascular blood flow","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2779095551","wikidata":"https://www.wikidata.org/wiki/Q1644947","display_name":"Tenecteplase","level":4,"score":0.9684951305389404},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7116982936859131},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6598688960075378},{"id":"https://openalex.org/C37054046","wikidata":"https://www.wikidata.org/wiki/Q641888","display_name":"Elevation (ballistics)","level":2,"score":0.5761421322822571},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.569001317024231},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5590864419937134},{"id":"https://openalex.org/C2771771","wikidata":"https://www.wikidata.org/wiki/Q6576883","display_name":"ST segment","level":3,"score":0.5080897808074951},{"id":"https://openalex.org/C2910310945","wikidata":"https://www.wikidata.org/wiki/Q5357960","display_name":"Acute ST segment elevation myocardial infarction","level":4,"score":0.48328545689582825},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.15806517004966736},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.11648949980735779},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08992534875869751},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4236/jbm.2025.135008","doi":"https://doi.org/10.4236/jbm.2025.135008","is_oa":true,"landing_page_url":"https://doi.org/10.4236/jbm.2025.135008","pdf_url":"https://www.scirp.org/pdf/jbm_2153192.pdf","source":{"id":"https://openalex.org/S2764372278","display_name":"Journal of Biosciences and Medicines","issn_l":"2327-5081","issn":["2327-5081","2327-509X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biosciences and Medicines","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4236/jbm.2025.135008","doi":"https://doi.org/10.4236/jbm.2025.135008","is_oa":true,"landing_page_url":"https://doi.org/10.4236/jbm.2025.135008","pdf_url":"https://www.scirp.org/pdf/jbm_2153192.pdf","source":{"id":"https://openalex.org/S2764372278","display_name":"Journal of Biosciences and Medicines","issn_l":"2327-5081","issn":["2327-5081","2327-509X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biosciences and Medicines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410479526.pdf","grobid_xml":"https://content.openalex.org/works/W4410479526.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1972115707","https://openalex.org/W1987786332","https://openalex.org/W2005172918","https://openalex.org/W2021754784","https://openalex.org/W2043964965","https://openalex.org/W2059289792","https://openalex.org/W2092739280","https://openalex.org/W2099056054","https://openalex.org/W2104191255","https://openalex.org/W2105872403","https://openalex.org/W2113302343","https://openalex.org/W2150150721","https://openalex.org/W2155638956","https://openalex.org/W2734772485","https://openalex.org/W2747033732","https://openalex.org/W2754054868","https://openalex.org/W2901865309","https://openalex.org/W2912320077","https://openalex.org/W2939730109","https://openalex.org/W2990111125","https://openalex.org/W3092065567","https://openalex.org/W3134232206","https://openalex.org/W4224118471","https://openalex.org/W4226023370","https://openalex.org/W4236531408","https://openalex.org/W4281254155","https://openalex.org/W4286670572","https://openalex.org/W4379376075","https://openalex.org/W4396585632"],"related_works":["https://openalex.org/W4248134853","https://openalex.org/W2080137818","https://openalex.org/W4393975628","https://openalex.org/W4402736180","https://openalex.org/W2029979210","https://openalex.org/W2082020455","https://openalex.org/W2062941915","https://openalex.org/W4283526068","https://openalex.org/W2762338479","https://openalex.org/W2352918524"],"abstract_inverted_index":{"Acute":[0],"ST-segment":[1],"elevation":[2],"myocardial":[3,72],"infarction":[4],"(STEMI)":[5],"is":[6,14,116],"a":[7,21,109],"life-threatening":[8],"condition":[9],"where":[10],"rapid":[11],"reperfusion":[12],"therapy":[13],"critical":[15],"for":[16,127],"improving":[17,42],"patient":[18],"outcomes.":[19],"As":[20],"next-generation":[22],"targeted":[23],"thrombolytic":[24,51],"agent,":[25],"tenecteplase":[26,61,86,139,149,164],"optimizes":[27],"the":[28,125,160],"structure":[29],"of":[30,163],"tissue-type":[31],"plasminogen":[32],"activator":[33],"(t-PA),":[34],"significantly":[35],"extending":[36],"its":[37,134],"half-life,":[38],"enhancing":[39],"specificity,":[40],"and":[41,54,70,74,82,107,172],"resistance":[43],"to":[44,119,131],"PAI-1.":[45],"These":[46],"modifications":[47],"result":[48],"in":[49,77,94,165,169],"superior":[50],"speed,":[52],"safety,":[53],"efficacy.":[55],"Clinical":[56],"studies":[57,130],"demonstrate":[58],"that":[59],"intravenous":[60],"effectively":[62,100],"improves":[63],"cardiac":[64],"function,":[65],"increases":[66],"vascular":[67],"recanalization":[68],"rates,":[69],"reduces":[71],"damage":[73],"bleeding":[75],"risks":[76],"STEMI":[78,166],"patients,":[79],"outperforming":[80],"urokinase":[81],"streptokinase.":[83],"Additionally,":[84],"intracoronary":[85,138],"combined":[87],"with":[88,96],"emergency":[89],"PCI":[90],"shows":[91],"promising":[92],"potential":[93,162],"patients":[95],"high":[97],"thrombus":[98],"burden,":[99],"reducing":[101],"thrombotic":[102],"load,":[103],"optimizing":[104],"microcirculatory":[105],"perfusion,":[106],"maintaining":[108],"favorable":[110],"safety":[111],"profile.":[112],"However,":[113],"current":[114],"research":[115,157],"predominantly":[117],"limited":[118],"small-scale":[120],"or":[121],"single-center":[122],"trials,":[123],"highlighting":[124],"need":[126],"larger,":[128],"multicenter":[129],"further":[132],"validate":[133],"therapeutic":[135],"benefits.":[136],"While":[137],"has":[140,151],"not":[141],"been":[142],"widely":[143],"adopted":[144],"internationally,":[145],"China\u2019s":[146],"domestically":[147],"developed":[148],"(Mingfule)":[150],"achieved":[152],"positive":[153],"clinical":[154],"results.":[155],"Future":[156],"should":[158],"explore":[159],"broader":[161],"treatment,":[167],"particularly":[168],"combination":[170],"therapies":[171],"personalized":[173],"treatment":[174],"strategies.":[175]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}