{"id":"https://openalex.org/W4410469293","doi":"https://doi.org/10.1038/s41419-025-07732-8","title":"PHGDH-mediated serine synthesis in astrocytes supports neuroinflammation by sustaining NADH level to promote histone acetylation","display_name":"PHGDH-mediated serine synthesis in astrocytes supports neuroinflammation by sustaining NADH level to promote histone acetylation","publication_year":2025,"publication_date":"2025-05-18","ids":{"openalex":"https://openalex.org/W4410469293","doi":"https://doi.org/10.1038/s41419-025-07732-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/40383841"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-025-07732-8","doi":"https://doi.org/10.1038/s41419-025-07732-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-025-07732-8","pdf_url":"https://www.nature.com/articles/s41419-025-07732-8.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-025-07732-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018994169","display_name":"Mengfei Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengfei Lv","raw_affiliation_strings":["Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao, Shandong, China","Qingdao Medical College, Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Qingdao Medical College, Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057371676","display_name":"Zhongying Duan","orcid":"https://orcid.org/0009-0000-2809-4609","observed_orcids":["https://orcid.org/0009-0000-2809-4609"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongying Duan","raw_affiliation_strings":["Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao, Shandong, China","Qingdao Medical College, Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Qingdao Medical College, Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100992142","display_name":"Tan Jinhua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhua Tan","raw_affiliation_strings":["Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao, Shandong, China","Qingdao Medical College, Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Qingdao Medical College, Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091781699","display_name":"Jiake Liu","orcid":"https://orcid.org/0009-0002-7723-7789","observed_orcids":["https://orcid.org/0009-0002-7723-7789"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiake Liu","raw_affiliation_strings":["Qingdao Medical College, Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Medical College, Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110838201","display_name":"Qinqin Wang","orcid":"https://orcid.org/0000-0002-9555-0712","observed_orcids":["https://orcid.org/0000-0002-9555-0712"]},"institutions":[{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinqin Wang","raw_affiliation_strings":["Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, Shandong, China","institution_ids":["https://openalex.org/I51185872"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Congxiao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Congxiao Wang","raw_affiliation_strings":["Department of Interventional Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031453154","display_name":"Zhaolong Zhang","orcid":"https://orcid.org/0000-0003-3145-9730","observed_orcids":["https://orcid.org/0000-0003-3145-9730"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaolong Zhang","raw_affiliation_strings":["Department of Interventional Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaona Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaona Sun","raw_affiliation_strings":["Department of Interventional Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448345","display_name":"Rui Liu","orcid":"https://orcid.org/0000-0001-6805-7263","observed_orcids":["https://orcid.org/0000-0001-6805-7263","https://orcid.org/0000-0002-2221-8057"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Liu","raw_affiliation_strings":["Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao, Shandong, China","Qingdao Medical College, Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Qingdao Medical College, Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100402032","display_name":"Yu Cui","orcid":"https://orcid.org/0000-0002-3480-0730","observed_orcids":["https://orcid.org/0000-0002-3480-0730"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu Cui","raw_affiliation_strings":["Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao, Shandong, China. cuiyu@qdu.edu.cn","Qingdao Medical College, Qingdao University, Qingdao, China. cuiyu@qdu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-3480-0730","affiliations":[{"raw_affiliation_string":"Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao, Shandong, China. cuiyu@qdu.edu.cn","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Qingdao Medical College, Qingdao University, Qingdao, China. cuiyu@qdu.edu.cn","institution_ids":["https://openalex.org/I108688024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100402032"],"corresponding_institution_ids":["https://openalex.org/I108688024"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":3.3576,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.92557652,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"16","issue":"1","first_page":"397","last_page":"397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.08259999752044678,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phgdh","display_name":"PHGDH","score":0.9620000123977661},{"id":"https://openalex.org/keywords/serine-biosynthesis","display_name":"serine biosynthesis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9649999737739563},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nadh","display_name":"NADH","score":0.8849999904632568},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":1.0},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9179999828338623},{"id":"https://openalex.org/keywords/mptp","display_name":"MPTP","score":0.6660000085830688},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.8569999933242798},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8999999761581421},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.5370000004768372},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8890933990478516},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6971506476402283},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5564440488815308},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.5224175453186035},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.4462866187095642},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.44223254919052124},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4320790767669678},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.42178159952163696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42119306325912476},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36340415477752686},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.36251550912857056},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3410756587982178},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24695664644241333},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.205323725938797},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16755148768424988},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.12760832905769348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08618134260177612},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050543","descriptor_name":"Phosphoglycerate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050543","descriptor_name":"Phosphoglycerate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050543","descriptor_name":"Phosphoglycerate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050543","descriptor_name":"Phosphoglycerate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050543","descriptor_name":"Phosphoglycerate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050543","descriptor_name":"Phosphoglycerate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050543","descriptor_name":"Phosphoglycerate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050543","descriptor_name":"Phosphoglycerate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41419-025-07732-8","doi":"https://doi.org/10.1038/s41419-025-07732-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-025-07732-8","pdf_url":"https://www.nature.com/articles/s41419-025-07732-8.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},{"id":"pmid:40383841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40383841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:10897136","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12086227","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12086227","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12086227","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ddd6e73f2fc44948b2633b52a5469e93","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ddd6e73f2fc44948b2633b52a5469e93","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease, Vol 16, Iss 1, Pp 1-13 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41419-025-07732-8","doi":"https://doi.org/10.1038/s41419-025-07732-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-025-07732-8","pdf_url":"https://www.nature.com/articles/s41419-025-07732-8.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6200000047683716,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7253698741","display_name":null,"funder_award_id":"32470984","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410469293.pdf","grobid_xml":"https://content.openalex.org/works/W4410469293.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1971001276","https://openalex.org/W1977869076","https://openalex.org/W2049876918","https://openalex.org/W2064356751","https://openalex.org/W2114413271","https://openalex.org/W2116548089","https://openalex.org/W2343452853","https://openalex.org/W2755661463","https://openalex.org/W2766957068","https://openalex.org/W2802993096","https://openalex.org/W2884432464","https://openalex.org/W2903702989","https://openalex.org/W2912827676","https://openalex.org/W2949784216","https://openalex.org/W2971770812","https://openalex.org/W2988224211","https://openalex.org/W2999641105","https://openalex.org/W3049431618","https://openalex.org/W3082361238","https://openalex.org/W3100111482","https://openalex.org/W3107395714","https://openalex.org/W3124954104","https://openalex.org/W3136113210","https://openalex.org/W3149583946","https://openalex.org/W3174749050","https://openalex.org/W3198178433","https://openalex.org/W3207237437","https://openalex.org/W4213162531","https://openalex.org/W4213415537","https://openalex.org/W4280565406","https://openalex.org/W4283796735","https://openalex.org/W4298143976","https://openalex.org/W4307770868","https://openalex.org/W4320480847","https://openalex.org/W4360609956","https://openalex.org/W4360830344","https://openalex.org/W4365515530","https://openalex.org/W4384206932","https://openalex.org/W4389451743","https://openalex.org/W4391132571","https://openalex.org/W4402878321","https://openalex.org/W4406071096"],"related_works":["https://openalex.org/W1975640329","https://openalex.org/W1572566098","https://openalex.org/W2374742110","https://openalex.org/W2387012743","https://openalex.org/W2047093218","https://openalex.org/W4390463473","https://openalex.org/W2807379694","https://openalex.org/W4221075899","https://openalex.org/W2034209754","https://openalex.org/W2374733173"],"abstract_inverted_index":{"Neuroinflammation":[0],"contributes":[1],"to":[2,89,107],"the":[3,33,41,45,61,137,147],"loss":[4],"of":[5,35,44,63,111,141,150],"dopamine":[6],"neurons":[7],"and":[8,56,123,127,139],"motor":[9],"dysfunctions":[10],"in":[11,54,65,67,78,121,129,145],"Parkinson's":[12],"disease":[13],"(PD).":[14],"How":[15],"cell":[16],"metabolism":[17],"regulates":[18],"neuroinflammation":[19,126],"by":[20,100],"modulating":[21],"epigenetic":[22],"modifications":[23],"is":[24],"largely":[25],"unknown.":[26],"In":[27],"this":[28],"study,":[29],"we":[30],"found":[31],"that":[32],"expression":[34],"phosphoglycerate":[36],"dehydrogenase":[37],"(PHGDH)":[38],"which":[39,85,152],"catalyzes":[40],"first":[42],"step":[43],"de":[46],"novo":[47],"serine":[48,143],"synthesis":[49,144],"pathway":[50],"was":[51,86],"mainly":[52],"expressed":[53],"astrocytes":[55,66,80,151],"l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine":[57],"(MPTP)":[58],"injection":[59],"triggered":[60],"upregulation":[62],"PHGDH":[64,70,95,115],"substantia":[68],"nigra.":[69],"inhibition":[71],"or":[72],"knockdown":[73],"reduced":[74],"proinflammatory":[75,97],"cytokine":[76,98,112],"production":[77],"primary":[79],"after":[81],"LPS":[82],"(lipopolysaccharide)":[83],"stimulation":[84],"not":[87],"due":[88],"suppressed":[90],"inflammatory":[91,117,148],"signaling":[92],"transduction.":[93],"Mechanistically,":[94],"promotes":[96],"transcription":[99],"sustaining":[101],"nicotinamide":[102],"adenine":[103],"dinucleotide":[104],"(NADH)":[105],"accumulation":[106],"facilitate":[108],"histone":[109],"acetylation":[110],"promoters.":[113],"Moreover,":[114],"inhibition-induced":[116],"response":[118,149],"decreased":[119],"neurotoxicity":[120,128],"vitro":[122],"alleviated":[124],"astrocytes-mediated":[125],"an":[130],"MPTP":[131],"mice":[132],"model.":[133],"This":[134],"study":[135],"reveals":[136],"role":[138],"mechanism":[140],"PHGDH-mediated":[142],"promoting":[146],"may":[153],"provide":[154],"a":[155],"potential":[156],"target":[157],"for":[158],"neurological":[159],"diseases":[160],"involving":[161],"neuroinflammation.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}
