{"id":"https://openalex.org/W4410464310","doi":"https://doi.org/10.1007/s40120-025-00767-1","title":"Role of Immune Reconstitution Therapy with Cladribine Tablets in the Management of Relapsing Multiple Sclerosis in Older Patients","display_name":"Role of Immune Reconstitution Therapy with Cladribine Tablets in the Management of Relapsing Multiple Sclerosis in Older Patients","publication_year":2025,"publication_date":"2025-05-17","ids":{"openalex":"https://openalex.org/W4410464310","doi":"https://doi.org/10.1007/s40120-025-00767-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/40381137","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12255632"},"language":"en","primary_location":{"id":"doi:10.1007/s40120-025-00767-1","doi":"https://doi.org/10.1007/s40120-025-00767-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40120-025-00767-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40120-025-00767-1.pdf","source":{"id":"https://openalex.org/S2736361170","display_name":"Neurology and Therapy","issn_l":"2193-6536","issn":["2193-6536","2193-8253"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology and Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s40120-025-00767-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049456235","display_name":"Raed Alroughani","orcid":"https://orcid.org/0000-0001-5436-5804","observed_orcids":["https://orcid.org/0000-0001-5436-5804","https://orcid.org/0000-0002-7111-0480"]},"institutions":[{"id":"https://openalex.org/I2803040547","display_name":"Amiri Hospital","ror":"https://ror.org/04y2hdd14","country_code":"KW","type":"healthcare","lineage":["https://openalex.org/I2803040547"]}],"countries":["KW"],"is_corresponding":true,"raw_author_name":"Raed Alroughani","raw_affiliation_strings":["Division of Neurological, Department of Medicine, Amiri Hospital, Arabian Gulf Street, 13001, Sharq, Kuwait. alroughani@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurological, Department of Medicine, Amiri Hospital, Arabian Gulf Street, 13001, Sharq, Kuwait. alroughani@gmail.com","institution_ids":["https://openalex.org/I2803040547"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045037633","display_name":"Jihad Said Salim Inshasi","orcid":"https://orcid.org/0000-0001-5892-751X","observed_orcids":["https://orcid.org/0000-0001-5892-751X"]},"institutions":[{"id":"https://openalex.org/I1287366011","display_name":"Dubai Health Authority","ror":"https://ror.org/01dcrt245","country_code":"AE","type":"government","lineage":["https://openalex.org/I1287366011"]},{"id":"https://openalex.org/I2800770947","display_name":"Rashid Hospital","ror":"https://ror.org/04b2pvs09","country_code":"AE","type":"healthcare","lineage":["https://openalex.org/I1287366011","https://openalex.org/I2800770947"]},{"id":"https://openalex.org/I4210153636","display_name":"Dubai Medical College","ror":"https://ror.org/05nydfs77","country_code":"AE","type":"education","lineage":["https://openalex.org/I4210153636"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Jihad Inshasi","raw_affiliation_strings":["Department of Neurology, Rashid Hospital, Dubai, United Arab Emirates","Dubai Medical College, Dubai Health Authority, Dubai, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Rashid Hospital, Dubai, United Arab Emirates","institution_ids":["https://openalex.org/I2800770947"]},{"raw_affiliation_string":"Dubai Medical College, Dubai Health Authority, Dubai, United Arab Emirates","institution_ids":["https://openalex.org/I1287366011","https://openalex.org/I4210153636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060356455","display_name":"Samar Farouk","orcid":"https://orcid.org/0000-0002-2929-1038","observed_orcids":["https://orcid.org/0000-0002-2929-1038"]},"institutions":[{"id":"https://openalex.org/I4210150512","display_name":"Ibn Sina Hospital","ror":"https://ror.org/05359he25","country_code":"KW","type":"healthcare","lineage":["https://openalex.org/I4210150512"]},{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG","KW"],"is_corresponding":false,"raw_author_name":"Samar Farouk","raw_affiliation_strings":["Department of Neurology and Psychiatry, Minia University, Minya, Egypt","Department of Neurology, Ibn Sina Hospital, Safat, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Psychiatry, Minia University, Minya, Egypt","institution_ids":["https://openalex.org/I89466785"]},{"raw_affiliation_string":"Department of Neurology, Ibn Sina Hospital, Safat, Kuwait","institution_ids":["https://openalex.org/I4210150512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074628518","display_name":"Abdullah Rashid Al-Asmi","orcid":"https://orcid.org/0000-0002-2851-8157","observed_orcids":["https://orcid.org/0000-0002-2851-8157"]},"institutions":[{"id":"https://openalex.org/I47818738","display_name":"Sultan Qaboos University","ror":"https://ror.org/04wq8zb47","country_code":"OM","type":"education","lineage":["https://openalex.org/I47818738"]}],"countries":["OM"],"is_corresponding":false,"raw_author_name":"Abdullah Al-Asmi","raw_affiliation_strings":["Neurology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman","institution_ids":["https://openalex.org/I47818738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113831898","display_name":"Ali Hassan","orcid":"https://orcid.org/0000-0001-6485-5460","observed_orcids":["https://orcid.org/0000-0001-6485-5460"]},"institutions":[{"id":"https://openalex.org/I4210087867","display_name":"Tawam Hospital","ror":"https://ror.org/007a5h107","country_code":"AE","type":"healthcare","lineage":["https://openalex.org/I4210087867"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Ali Hassan","raw_affiliation_strings":["Neurosciences Department, Sheikh Tahnoon Medical City/Tawam Hospitals, Al Ain, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosciences Department, Sheikh Tahnoon Medical City/Tawam Hospitals, Al Ain, United Arab Emirates","institution_ids":["https://openalex.org/I4210087867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103345316","display_name":"Anu Jacob","orcid":"https://orcid.org/0000-0002-7530-6800","observed_orcids":["https://orcid.org/0000-0002-7530-6800","https://orcid.org/0000-0002-7928-9737","https://orcid.org/0009-0001-4217-2199"]},"institutions":[{"id":"https://openalex.org/I4405266839","display_name":"Cleveland Clinic Abu Dhabi","ror":"https://ror.org/00042rr39","country_code":"AE","type":"healthcare","lineage":["https://openalex.org/I4405266839"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Anu Jacob","raw_affiliation_strings":["Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates","institution_ids":["https://openalex.org/I4405266839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109999184","display_name":"Areen T. Said","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1287366011","display_name":"Dubai Health Authority","ror":"https://ror.org/01dcrt245","country_code":"AE","type":"government","lineage":["https://openalex.org/I1287366011"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Areen T. Said","raw_affiliation_strings":["Neurology Department, American Hospital, Dubai, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, American Hospital, Dubai, United Arab Emirates","institution_ids":["https://openalex.org/I1287366011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102839409","display_name":"B\u00e9atrice Benedetti","orcid":"https://orcid.org/0000-0002-5846-0507","observed_orcids":["https://orcid.org/0000-0002-5846-0507"]},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4405266839","display_name":"Cleveland Clinic Abu Dhabi","ror":"https://ror.org/00042rr39","country_code":"AE","type":"healthcare","lineage":["https://openalex.org/I4405266839"]}],"countries":["AE","US"],"is_corresponding":false,"raw_author_name":"Beatrice Benedetti","raw_affiliation_strings":["Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates","Lerner College of Medicine, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates","institution_ids":["https://openalex.org/I4405266839"]},{"raw_affiliation_string":"Lerner College of Medicine, Cleveland, OH, USA","institution_ids":["https://openalex.org/I36373038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003393259","display_name":"Dirk Deleu","orcid":"https://orcid.org/0000-0001-7495-6054","observed_orcids":["https://orcid.org/0000-0001-7495-6054"]},"institutions":[{"id":"https://openalex.org/I49828101","display_name":"Hamad Medical Corporation","ror":"https://ror.org/02zwb6n98","country_code":"QA","type":"nonprofit","lineage":["https://openalex.org/I49828101"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Dirk Deleu","raw_affiliation_strings":["Neurosciences Institute, Hamad Medical Corporation, Doha, Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosciences Institute, Hamad Medical Corporation, Doha, Qatar","institution_ids":["https://openalex.org/I49828101"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Iman Al-Lawati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1308114913","display_name":"Al Noor Hospitals","ror":"https://ror.org/00pg9d188","country_code":"AE","type":"healthcare","lineage":["https://openalex.org/I1308114913"]},{"id":"https://openalex.org/I4210120130","display_name":"Khoula Hospital","ror":"https://ror.org/02v6ptf51","country_code":"OM","type":"healthcare","lineage":["https://openalex.org/I4210120130"]},{"id":"https://openalex.org/I4210130707","display_name":"Ministry of Health","ror":"https://ror.org/0362za439","country_code":"OM","type":"government","lineage":["https://openalex.org/I4210130707"]}],"countries":["AE","OM"],"is_corresponding":false,"raw_author_name":"Iman Al-Lawati","raw_affiliation_strings":["Department of Neurology, Khoula Hospital, Ministry of Health, Minal Al Fahal, Muscat, Oman","Neurology Department, Mediclinic Al Noor Hospital, Abu Dhabi, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Khoula Hospital, Ministry of Health, Minal Al Fahal, Muscat, Oman","institution_ids":["https://openalex.org/I4210120130","https://openalex.org/I4210130707"]},{"raw_affiliation_string":"Neurology Department, Mediclinic Al Noor Hospital, Abu Dhabi, United Arab Emirates","institution_ids":["https://openalex.org/I1308114913"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065996507","display_name":"Mikl\u00f3s Sz\u00f3lics","orcid":"https://orcid.org/0000-0001-7425-4570","observed_orcids":["https://orcid.org/0000-0001-7425-4570"]},"institutions":[{"id":"https://openalex.org/I4210087867","display_name":"Tawam Hospital","ror":"https://ror.org/007a5h107","country_code":"AE","type":"healthcare","lineage":["https://openalex.org/I4210087867"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Miklos Szolics","raw_affiliation_strings":["Neurosciences Department, Sheikh Tahnoon Medical City/Tawam Hospitals, Al Ain, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosciences Department, Sheikh Tahnoon Medical City/Tawam Hospitals, Al Ain, United Arab Emirates","institution_ids":["https://openalex.org/I4210087867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106268854","display_name":"Mohammad Abouelnaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1308114913","display_name":"Al Noor Hospitals","ror":"https://ror.org/00pg9d188","country_code":"AE","type":"healthcare","lineage":["https://openalex.org/I1308114913"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Mohammad Abouelnaga","raw_affiliation_strings":["Neurology Department, Mediclinic Al Noor Hospital, Abu Dhabi, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Mediclinic Al Noor Hospital, Abu Dhabi, United Arab Emirates","institution_ids":["https://openalex.org/I1308114913"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110737599","display_name":"Mona Chetan Thakre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mona Thakre","raw_affiliation_strings":["Neurology Department, Parkview Mediclinic, Dubai, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Parkview Mediclinic, Dubai, United Arab Emirates","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023031322","display_name":"Mustafa Shakra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801466683","display_name":"Shaikh Khalifa Medical City","ror":"https://ror.org/03gd1jf50","country_code":"AE","type":"healthcare","lineage":["https://openalex.org/I2801466683"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Mustafa Shakra","raw_affiliation_strings":["Neurology Department, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates","institution_ids":["https://openalex.org/I2801466683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055993422","display_name":"Pournamy Sarathchandran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pournamy Sarathchandran","raw_affiliation_strings":["Neurology Department, Al Qassimi Hospital, EHS, Sharjah, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Al Qassimi Hospital, EHS, Sharjah, United Arab Emirates","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108677457","display_name":"Amir Boshra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amir Boshra","raw_affiliation_strings":["Merck Serono Middle East FZ-Ltd, an Affiliate of Merck KGaA, Dubai, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Serono Middle East FZ-Ltd, an Affiliate of Merck KGaA, Dubai, United Arab Emirates","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5049456235"],"corresponding_institution_ids":["https://openalex.org/I2803040547"],"apc_list":{"value":7400,"currency":"USD","value_usd":7400},"apc_paid":{"value":7400,"currency":"USD","value_usd":7400},"fwci":0.9041,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.63860485,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"14","issue":"4","first_page":"1169","last_page":"1184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relapsing-multiple-sclerosis","display_name":"relapsing multiple sclerosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cladribine-tablets","display_name":"cladribine tablets","score":0.9369999766349792},{"id":"https://openalex.org/keywords/immune-reconstitution-therapy","display_name":"immune reconstitution therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.7860000133514404},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.9679999947547913},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.9890000224113464},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7480000257492065},{"id":"https://openalex.org/keywords/treatment-withdrawal","display_name":"treatment withdrawal","score":0.4620000123977661},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C2779200787","wikidata":"https://www.wikidata.org/wiki/Q414030","display_name":"Cladribine","level":2,"score":0.9609225988388062},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8736511468887329},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8733830451965332},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.7069666981697083},{"id":"https://openalex.org/C3020694758","wikidata":"https://www.wikidata.org/wiki/Q42417392","display_name":"Relapsing remitting","level":3,"score":0.4464958906173706},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43816083669662476},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3423640727996826},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3381800055503845},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31580090522766113},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28360697627067566},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08549961447715759}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1007/s40120-025-00767-1","doi":"https://doi.org/10.1007/s40120-025-00767-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40120-025-00767-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40120-025-00767-1.pdf","source":{"id":"https://openalex.org/S2736361170","display_name":"Neurology and Therapy","issn_l":"2193-6536","issn":["2193-6536","2193-8253"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11060609","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12255632","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40381137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40381137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12255632","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12255632/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurol Ther","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:81e669625ba64b2b877a1f9462b13559","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/81e669625ba64b2b877a1f9462b13559","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurology and Therapy, Vol 14, Iss 4, Pp 1169-1184 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s40120-025-00767-1","doi":"https://doi.org/10.1007/s40120-025-00767-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40120-025-00767-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40120-025-00767-1.pdf","source":{"id":"https://openalex.org/S2736361170","display_name":"Neurology and Therapy","issn_l":"2193-6536","issn":["2193-6536","2193-8253"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410464310.pdf","grobid_xml":"https://content.openalex.org/works/W4410464310.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W37353277","https://openalex.org/W1509268069","https://openalex.org/W1967838438","https://openalex.org/W2033505817","https://openalex.org/W2044022462","https://openalex.org/W2050494572","https://openalex.org/W2093009907","https://openalex.org/W2104301864","https://openalex.org/W2117729914","https://openalex.org/W2122999365","https://openalex.org/W2127001605","https://openalex.org/W2134033939","https://openalex.org/W2139204856","https://openalex.org/W2146236437","https://openalex.org/W2150535609","https://openalex.org/W2466044324","https://openalex.org/W2565433170","https://openalex.org/W2742551220","https://openalex.org/W2751578374","https://openalex.org/W2756612472","https://openalex.org/W2790816436","https://openalex.org/W2802620527","https://openalex.org/W2804123946","https://openalex.org/W2914770914","https://openalex.org/W2919746350","https://openalex.org/W2926499529","https://openalex.org/W2943207554","https://openalex.org/W2944415869","https://openalex.org/W2971487735","https://openalex.org/W2971577153","https://openalex.org/W2972334025","https://openalex.org/W2991164179","https://openalex.org/W2999606584","https://openalex.org/W3001010350","https://openalex.org/W3006488925","https://openalex.org/W3016992643","https://openalex.org/W3030306741","https://openalex.org/W3045017175","https://openalex.org/W3045097178","https://openalex.org/W3047302551","https://openalex.org/W3115551225","https://openalex.org/W3126188775","https://openalex.org/W3135014248","https://openalex.org/W3178657798","https://openalex.org/W3187939800","https://openalex.org/W3200348962","https://openalex.org/W3205018265","https://openalex.org/W4200298634","https://openalex.org/W4206787738","https://openalex.org/W4225110271","https://openalex.org/W4280503450","https://openalex.org/W4283314461","https://openalex.org/W4286007860","https://openalex.org/W4286203377","https://openalex.org/W4288050735","https://openalex.org/W4288809028","https://openalex.org/W4292148526","https://openalex.org/W4306409647","https://openalex.org/W4308524301","https://openalex.org/W4308745030","https://openalex.org/W4311086874","https://openalex.org/W4313419594","https://openalex.org/W4317754423","https://openalex.org/W4362521630","https://openalex.org/W4376617977","https://openalex.org/W4376631082","https://openalex.org/W4379967219","https://openalex.org/W4383557708","https://openalex.org/W4385327353","https://openalex.org/W4387401172","https://openalex.org/W4387607347","https://openalex.org/W4389447972","https://openalex.org/W4389767652","https://openalex.org/W4391797146","https://openalex.org/W4392962264","https://openalex.org/W4393316104","https://openalex.org/W4394568115","https://openalex.org/W4399420665","https://openalex.org/W4399628018","https://openalex.org/W4401226031","https://openalex.org/W4401282586","https://openalex.org/W4401682185","https://openalex.org/W4401711164","https://openalex.org/W4401799246","https://openalex.org/W4402385120","https://openalex.org/W4402579782","https://openalex.org/W4403635291","https://openalex.org/W4403838134","https://openalex.org/W4404420529","https://openalex.org/W4408521843"],"related_works":["https://openalex.org/W4394568115","https://openalex.org/W4408521843","https://openalex.org/W6893297820","https://openalex.org/W7155793677","https://openalex.org/W7163134877","https://openalex.org/W7213110698","https://openalex.org/W7223103339","https://openalex.org/W7139085493","https://openalex.org/W4389639200","https://openalex.org/W4416748292"],"abstract_inverted_index":{"The":[0,44],"pathophysiology":[1],"and":[2,13,39,125,174],"presentation":[3],"of":[4,46,59,73,99,106,108,129,161],"relapsing":[5],"multiple":[6],"sclerosis":[7],"(RMS)":[8],"differ":[9],"importantly":[10],"between":[11],"younger":[12],"older":[14,87,140,177],"patients.":[15],"Older":[16],"patients":[17,192],"usually":[18],"suffer":[19],"fewer":[20],"MS":[21,100,135,143],"relapses":[22],"but":[23],"present":[24],"with":[25,32,54,89,112,142,168,171,179],"a":[26,60,153],"chronically":[27],"inflammatory":[28],"phenotype":[29],"(inflammaging)":[30],"associated":[31,167],"accelerated":[33],"age-related":[34],"changes":[35],"to":[36,52,78,122,150],"the":[37,67,97,158,202],"adaptive":[38],"innate":[40],"immune":[41,109],"systems":[42],"(immunosenescence).":[43],"efficacy":[45],"most":[47],"disease-modifying":[48],"therapies":[49],"(DMTs)":[50],"appears":[51,121],"decline":[53],"increasing":[55],"age,":[56],"likely":[57],"because":[58],"shift":[61],"away":[62],"from":[63,134],"focal":[64],"inflammation":[65],"as":[66,185],"main":[68],"driving":[69],"force":[70],"for":[71,85,138,156,176,198],"progression":[72],"MS.":[74,92],"These":[75],"observations":[76],"led":[77],"suggestions":[79],"that":[80,117],"DMT":[81,120],"may":[82,193],"be":[83,123],"withdrawn":[84],"an":[86,139,186],"person":[88],"very":[90],"stable":[91],"However,":[93],"this":[94,118,147],"approach":[95],"risks":[96],"resumption":[98],"disease":[101,136],"activity.":[102],"In":[103],"contrast,":[104],"analyses":[105],"evaluations":[107],"reconstitution":[110],"therapy":[111,197],"cladribine":[113],"tablets":[114],"(CladT)":[115],"show":[116],"high-efficacy":[119],"effective":[124],"well":[126],"tolerated":[127],"irrespective":[128],"age.":[130],"Achieving":[131],"long-term":[132],"freedom":[133],"activity":[137],"patient":[141],"is":[144,152],"feasible":[145],"using":[146],"approach.":[148],"Switching":[149],"CladT":[151],"rational":[154],"option":[155],"reducing":[157],"dual":[159],"burdens":[160],"continuous":[162,169],"treatment":[163],"(including":[164],"side":[165],"effects":[166],"immunosuppression":[170],"some":[172,191],"DMTs)":[173],"monitoring":[175],"people":[178],"RMS.":[180],"This":[181],"includes":[182],"possible":[183],"use":[184],"\"exit":[187],"therapy\",":[188],"beyond":[189],"which":[190],"not":[194],"need":[195],"pharmacological":[196],"their":[199],"RMS":[200],"in":[201],"future.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-05-18T00:00:00"}