{"id":"https://openalex.org/W4410415352","doi":"https://doi.org/10.1039/d4nr05504g","title":"The application prospect of metal/metal oxide nanoparticles in the treatment of intervertebral disc degeneration","display_name":"The application prospect of metal/metal oxide nanoparticles in the treatment of intervertebral disc degeneration","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4410415352","doi":"https://doi.org/10.1039/d4nr05504g","pmid":"https://pubmed.ncbi.nlm.nih.gov/40512664"},"language":"en","primary_location":{"id":"doi:10.1039/d4nr05504g","doi":"https://doi.org/10.1039/d4nr05504g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d4nr05504g","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100363544","display_name":"Long Zhang","orcid":"https://orcid.org/0000-0002-8935-1311","observed_orcids":["https://orcid.org/0000-0002-8935-1311"]},"institutions":[{"id":"https://openalex.org/I1328775524","display_name":"Zhejiang Sci-Tech University","ror":"https://ror.org/03893we55","country_code":"CN","type":"education","lineage":["https://openalex.org/I1328775524"]},{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Long Zhang","raw_affiliation_strings":["Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China","Institute for Smart Biomedical Materials, School of Materials Science & Engineering, Zhejiang Sci-Tech University, Building 24, No. 928, No. 2 Street, Xiasha Higher Education Park, Hangzhou 310000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]},{"raw_affiliation_string":"Institute for Smart Biomedical Materials, School of Materials Science & Engineering, Zhejiang Sci-Tech University, Building 24, No. 928, No. 2 Street, Xiasha Higher Education Park, Hangzhou 310000, PR China","institution_ids":["https://openalex.org/I1328775524"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Haijiang Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haijiang Ren","raw_affiliation_strings":["Department of Orthopedics, The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310003, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310003, P. R. China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fang Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Cai","raw_affiliation_strings":["Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057247924","display_name":"Bin Ru","orcid":"https://orcid.org/0000-0003-0628-3243","observed_orcids":["https://orcid.org/0000-0003-0628-3243"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Ru","raw_affiliation_strings":["Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100693203","display_name":"Nannan Zhang","orcid":"https://orcid.org/0000-0002-0843-2401","observed_orcids":["https://orcid.org/0000-0002-0843-2401"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nannan Zhang","raw_affiliation_strings":["Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104215138","display_name":"Wenlong Liu","orcid":"https://orcid.org/0000-0001-7475-0996","observed_orcids":["https://orcid.org/0000-0001-7475-0996"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenlong Liu","raw_affiliation_strings":["Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wenjun Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjun Cai","raw_affiliation_strings":["Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101480283","display_name":"Yun Lan Xu","orcid":"https://orcid.org/0000-0002-3026-5750","observed_orcids":["https://orcid.org/0000-0002-3026-5750"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Xu","raw_affiliation_strings":["Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101492057","display_name":"Xiang Xia Wu","orcid":"https://orcid.org/0000-0001-8079-5947","observed_orcids":["https://orcid.org/0000-0001-8079-5947"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Wu","raw_affiliation_strings":["Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100738089","display_name":"Shibo Wang","orcid":"https://orcid.org/0000-0001-6621-1722","observed_orcids":["https://orcid.org/0000-0001-6621-1722"]},"institutions":[{"id":"https://openalex.org/I1328775524","display_name":"Zhejiang Sci-Tech University","ror":"https://ror.org/03893we55","country_code":"CN","type":"education","lineage":["https://openalex.org/I1328775524"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shibo Wang","raw_affiliation_strings":["Institute for Smart Biomedical Materials, School of Materials Science & Engineering, Zhejiang Sci-Tech University, Building 24, No. 928, No. 2 Street, Xiasha Higher Education Park, Hangzhou 310000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Smart Biomedical Materials, School of Materials Science & Engineering, Zhejiang Sci-Tech University, Building 24, No. 928, No. 2 Street, Xiasha Higher Education Park, Hangzhou 310000, PR China","institution_ids":["https://openalex.org/I1328775524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088303681","display_name":"Han Zhang","orcid":"https://orcid.org/0000-0002-6208-1622","observed_orcids":["https://orcid.org/0000-0002-6208-1622"]},"institutions":[{"id":"https://openalex.org/I1328775524","display_name":"Zhejiang Sci-Tech University","ror":"https://ror.org/03893we55","country_code":"CN","type":"education","lineage":["https://openalex.org/I1328775524"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Han Zhang","raw_affiliation_strings":["Institute for Smart Biomedical Materials, School of Materials Science & Engineering, Zhejiang Sci-Tech University, Building 24, No. 928, No. 2 Street, Xiasha Higher Education Park, Hangzhou 310000, PR China"],"raw_orcid":"https://orcid.org/0000-0002-6208-1622","affiliations":[{"raw_affiliation_string":"Institute for Smart Biomedical Materials, School of Materials Science & Engineering, Zhejiang Sci-Tech University, Building 24, No. 928, No. 2 Street, Xiasha Higher Education Park, Hangzhou 310000, PR China","institution_ids":["https://openalex.org/I1328775524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100442625","display_name":"Shun Li","orcid":"https://orcid.org/0000-0001-8601-2261","observed_orcids":["https://orcid.org/0000-0001-8601-2261"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shun Li","raw_affiliation_strings":["Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou 330004, Zhejiang Province, P. R. China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"last","author":{"id":null,"display_name":"Xiangdong Kong","orcid":"https://orcid.org/0000-0001-8916-7058","observed_orcids":["https://orcid.org/0000-0001-8916-7058"]},"institutions":[{"id":"https://openalex.org/I1328775524","display_name":"Zhejiang Sci-Tech University","ror":"https://ror.org/03893we55","country_code":"CN","type":"education","lineage":["https://openalex.org/I1328775524"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiangdong Kong","raw_affiliation_strings":["Institute for Smart Biomedical Materials, School of Materials Science & Engineering, Zhejiang Sci-Tech University, Building 24, No. 928, No. 2 Street, Xiasha Higher Education Park, Hangzhou 310000, PR China"],"raw_orcid":"https://orcid.org/0000-0001-8916-7058","affiliations":[{"raw_affiliation_string":"Institute for Smart Biomedical Materials, School of Materials Science & Engineering, Zhejiang Sci-Tech University, Building 24, No. 928, No. 2 Street, Xiasha Higher Education Park, Hangzhou 310000, PR China","institution_ids":["https://openalex.org/I1328775524"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5088303681","https://openalex.org/A5100442625"],"corresponding_institution_ids":["https://openalex.org/I1328775524","https://openalex.org/I4210131061","https://openalex.org/I4210165441"],"apc_list":null,"apc_paid":null,"fwci":1.0514,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.71114216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"17","issue":"26","first_page":"15605","last_page":"15616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metal-nanoparticles","display_name":"metal nanoparticles","score":0.8450000286102295},{"id":"https://openalex.org/keywords/metal-oxide-nanoparticles","display_name":"metal oxide nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/biomaterials","display_name":"biomaterials","score":0.781000018119812},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.746999979019165},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8690000176429749},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cellular-repair","display_name":"cell repair","score":0.6830000281333923},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.7919999957084656},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.7225067615509033},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.6799150705337524},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6770066022872925},{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.5714870691299438},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5458987951278687},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4792930483818054},{"id":"https://openalex.org/C2779851234","wikidata":"https://www.wikidata.org/wiki/Q50690","display_name":"Oxide","level":2,"score":0.41340962052345276},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.2596150040626526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1803983449935913},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1146324872970581},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07745331525802612}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/d4nr05504g","doi":"https://doi.org/10.1039/d4nr05504g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d4nr05504g","pdf_url":null,"source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmid:40512664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40512664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3428232013","display_name":null,"funder_award_id":"2024KY1497","funder_id":"https://openalex.org/F4320336309","funder_display_name":"Medical and Health Research Project of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320336309","display_name":"Medical and Health Research Project of Zhejiang Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W2046329142","https://openalex.org/W2053006484","https://openalex.org/W2060595910","https://openalex.org/W2106755981","https://openalex.org/W2125889054","https://openalex.org/W2310415701","https://openalex.org/W2528328022","https://openalex.org/W2614883437","https://openalex.org/W2724960832","https://openalex.org/W2805624613","https://openalex.org/W2895462470","https://openalex.org/W2912603938","https://openalex.org/W2940870186","https://openalex.org/W2969611214","https://openalex.org/W2987413771","https://openalex.org/W3155446363","https://openalex.org/W3160548291","https://openalex.org/W3179864044","https://openalex.org/W3189312346","https://openalex.org/W3194578209","https://openalex.org/W4213019636","https://openalex.org/W4214505792","https://openalex.org/W4220857325","https://openalex.org/W4288058075","https://openalex.org/W4293177554","https://openalex.org/W4294146826","https://openalex.org/W4295645131","https://openalex.org/W4296983876","https://openalex.org/W4313333039","https://openalex.org/W4315642182","https://openalex.org/W4317874802","https://openalex.org/W4321501059","https://openalex.org/W4322719615","https://openalex.org/W4360599729","https://openalex.org/W4362657208","https://openalex.org/W4362703418","https://openalex.org/W4376598535","https://openalex.org/W4378174639","https://openalex.org/W4382651524","https://openalex.org/W4382934966","https://openalex.org/W4385666618","https://openalex.org/W4386529674","https://openalex.org/W4387563773","https://openalex.org/W4388616557","https://openalex.org/W4389095760","https://openalex.org/W4391449916","https://openalex.org/W4392166241","https://openalex.org/W4392661794","https://openalex.org/W4393409940","https://openalex.org/W4400595537","https://openalex.org/W4401556484","https://openalex.org/W4401615799","https://openalex.org/W4401752595","https://openalex.org/W4403190754","https://openalex.org/W4403191046","https://openalex.org/W4404533053","https://openalex.org/W4407862114"],"related_works":["https://openalex.org/W4415958530","https://openalex.org/W4405850701","https://openalex.org/W4408121588","https://openalex.org/W7126252151","https://openalex.org/W4404168516","https://openalex.org/W7165012302","https://openalex.org/W7153067995","https://openalex.org/W4414751245","https://openalex.org/W4389462461","https://openalex.org/W7106271128"],"abstract_inverted_index":{"With":[0],"advancements":[1],"in":[2,13,101],"molecular":[3],"biology":[4],"and":[5,41,51,68,77,97,110],"tissue":[6],"engineering,":[7],"significant":[8],"progress":[9],"has":[10],"been":[11],"made":[12],"the":[14,33,56,70,93,102],"treatment":[15,103],"of":[16,35,47,58,92,95,104],"intervertebral":[17],"disc":[18],"degeneration":[19],"(IVDD).":[20],"In":[21],"recent":[22],"years,":[23],"biomaterials":[24],"have":[25],"broadened":[26],"therapeutic":[27,75,116],"options":[28],"for":[29,81],"IVDD,":[30,105],"particularly":[31],"through":[32],"incorporation":[34],"metals,":[36],"which":[37],"impart":[38],"antioxidant,":[39],"anti-inflammatory,":[40],"cellular":[42],"repair":[43],"properties.":[44],"The":[45],"combination":[46],"metal":[48,98],"ions,":[49],"nanomaterials,":[50],"bioactive":[52],"molecules":[53],"further":[54],"enhances":[55],"capacity":[57],"these":[59],"materials":[60],"to":[61,87,114],"scavenge":[62],"free":[63],"radicals,":[64],"regulate":[65],"cell":[66],"activity,":[67],"improve":[69],"microenvironment,":[71],"thereby":[72],"increasing":[73],"their":[74,115],"efficacy":[76],"providing":[78],"new":[79],"opportunities":[80],"IVDD":[82],"treatment.":[83],"This":[84],"review":[85],"aims":[86],"provide":[88],"a":[89],"comprehensive":[90],"analysis":[91],"roles":[94],"metal-based":[96],"oxide":[99],"nanoparticles":[100],"while":[106],"addressing":[107],"current":[108],"challenges":[109],"future":[111],"prospects":[112],"related":[113],"applications.":[117]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-05-16T00:00:00"}
