{"id":"https://openalex.org/W4410375588","doi":"https://doi.org/10.1038/s43018-025-00955-w","title":"Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma","display_name":"Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma","publication_year":2025,"publication_date":"2025-05-14","ids":{"openalex":"https://openalex.org/W4410375588","doi":"https://doi.org/10.1038/s43018-025-00955-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/37090678","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10120745"},"language":"en","primary_location":{"id":"doi:10.1038/s43018-025-00955-w","doi":"https://doi.org/10.1038/s43018-025-00955-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43018-025-00955-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210236562","display_name":"Nature Cancer","issn_l":"2662-1347","issn":["2662-1347"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1038/s43018-025-00955-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Melissa Barroux","orcid":"https://orcid.org/0000-0002-7682-0932","observed_orcids":["https://orcid.org/0000-0002-7682-0932"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"Melissa Barroux","raw_affiliation_strings":["Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK. melissa.barroux@mri.tum.de","German Cancer Consortium (DKTK) Heidelberg, Germany, Partner Site Munich, Munich, Germany. melissa.barroux@mri.tum.de","Medical Clinic and Polyclinic II, TUM University Hospital, Klinikum rechts der Isar, Munich, Germany. melissa.barroux@mri.tum.de"],"raw_orcid":"https://orcid.org/0000-0002-7682-0932","affiliations":[{"raw_affiliation_string":"Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK. melissa.barroux@mri.tum.de","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) Heidelberg, Germany, Partner Site Munich, Munich, Germany. melissa.barroux@mri.tum.de","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Medical Clinic and Polyclinic II, TUM University Hospital, Klinikum rechts der Isar, Munich, Germany. melissa.barroux@mri.tum.de","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035991292","display_name":"Jacob Househam","orcid":"https://orcid.org/0000-0003-3199-336X","observed_orcids":["https://orcid.org/0000-0003-3199-336X"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jacob Househam","raw_affiliation_strings":["Data Science Team, The Institute of Cancer Research, London, UK","Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Science Team, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068902944","display_name":"Eszter Lakatos","orcid":"https://orcid.org/0000-0002-7221-6850","observed_orcids":["https://orcid.org/0000-0002-7221-6850"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eszter Lakatos","raw_affiliation_strings":["Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-7221-6850","affiliations":[{"raw_affiliation_string":"Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087171510","display_name":"Tahel Ronel","orcid":"https://orcid.org/0000-0002-9513-9181","observed_orcids":["https://orcid.org/0000-0002-9513-9181"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tahel Ronel","raw_affiliation_strings":["Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","Division of Infection and Immunity, University College London, London, UK","Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-9513-9181","affiliations":[{"raw_affiliation_string":"Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Division of Infection and Immunity, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043279686","display_name":"Ann\u2010Marie Baker","orcid":"https://orcid.org/0000-0001-8905-9137","observed_orcids":["https://orcid.org/0000-0001-8905-9137"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ann-Marie Baker","raw_affiliation_strings":["Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-8905-9137","affiliations":[{"raw_affiliation_string":"Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043135104","display_name":"Henrike Sali\u00e9","orcid":"https://orcid.org/0000-0002-2993-3782","observed_orcids":["https://orcid.org/0000-0002-2993-3782"]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henrike Sali\u00e9","raw_affiliation_strings":["Clinic for Internal Medicine II, University Medical Center Freiburg, Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2993-3782","affiliations":[{"raw_affiliation_string":"Clinic for Internal Medicine II, University Medical Center Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076154953","display_name":"Maximilian Mossner","orcid":"https://orcid.org/0000-0001-9751-3803","observed_orcids":["https://orcid.org/0000-0001-9751-3803"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maximilian Mossner","raw_affiliation_strings":["Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044002311","display_name":"Kane Smith","orcid":"https://orcid.org/0000-0002-8661-7401","observed_orcids":["https://orcid.org/0000-0002-8661-7401"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kane Smith","raw_affiliation_strings":["Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071746453","display_name":"Christopher Kimberley","orcid":"https://orcid.org/0000-0002-9720-4434","observed_orcids":["https://orcid.org/0000-0002-9720-4434"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Kimberley","raw_affiliation_strings":["Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032072845","display_name":"Salpie Nowinski","orcid":"https://orcid.org/0000-0001-5686-3778","observed_orcids":["https://orcid.org/0000-0001-5686-3778"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Salpie Nowinski","raw_affiliation_strings":["Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082090787","display_name":"Alison Berner","orcid":"https://orcid.org/0000-0002-1132-0275","observed_orcids":["https://orcid.org/0000-0002-1132-0275"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alison Berner","raw_affiliation_strings":["Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068589782","display_name":"Vinaya Gunasri","orcid":"https://orcid.org/0000-0002-9292-6470","observed_orcids":["https://orcid.org/0000-0002-9292-6470"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vinaya Gunasri","raw_affiliation_strings":["Department of Pathology, UCL Cancer Institute, University College London, London, UK","Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, UCL Cancer Institute, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005702778","display_name":"Martin Borgmann","orcid":"https://orcid.org/0000-0002-8195-2796","observed_orcids":["https://orcid.org/0000-0002-8195-2796"]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Borgmann","raw_affiliation_strings":["Clinic for Internal Medicine II, University Medical Center Freiburg, Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8195-2796","affiliations":[{"raw_affiliation_string":"Clinic for Internal Medicine II, University Medical Center Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112660666","display_name":"Sven Thorsten Liffers","orcid":"https://orcid.org/0009-0002-7712-5920","observed_orcids":["https://orcid.org/0009-0002-7712-5920"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sven Liffers","raw_affiliation_strings":["Bridge Institute of Experimental Tumor Therapy (BIT), Division of Solid Tumor Translational Oncology (DKTK) and Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany","German Cancer Consortium (DKTK), partner site Essen, a partnership between German Cancer Research Center (DKFZ) and University Hospital Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bridge Institute of Experimental Tumor Therapy (BIT), Division of Solid Tumor Translational Oncology (DKTK) and Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), partner site Essen, a partnership between German Cancer Research Center (DKFZ) and University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083327329","display_name":"Marnix Jansen","orcid":"https://orcid.org/0000-0003-0645-564X","observed_orcids":["https://orcid.org/0000-0003-0645-564X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marnix Jansen","raw_affiliation_strings":["Department of Pathology, UCL Cancer Institute, University College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-0645-564X","affiliations":[{"raw_affiliation_string":"Department of Pathology, UCL Cancer Institute, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033643165","display_name":"Giulio Caravagna","orcid":"https://orcid.org/0000-0003-4240-3265","observed_orcids":["https://orcid.org/0000-0003-4240-3265"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulio Caravagna","raw_affiliation_strings":["Department of Mathematics, Informatics and Geosciences, University of Triest, Triest, Italy"],"raw_orcid":"https://orcid.org/0000-0003-4240-3265","affiliations":[{"raw_affiliation_string":"Department of Mathematics, Informatics and Geosciences, University of Triest, Triest, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001164379","display_name":"Katja Steiger","orcid":"https://orcid.org/0000-0002-7269-5433","observed_orcids":["https://orcid.org/0000-0002-7269-5433"]},"institutions":[{"id":"https://openalex.org/I4405259543","display_name":"Pathologisches Institut","ror":"https://ror.org/02cqe8q68","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katja Steiger","raw_affiliation_strings":["iBioTUM - Tissue, Institute of Pathology, School of Medicine, TUM, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7269-5433","affiliations":[{"raw_affiliation_string":"iBioTUM - Tissue, Institute of Pathology, School of Medicine, TUM, Munich, Germany","institution_ids":["https://openalex.org/I4405259543","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076736029","display_name":"Julia Slotta\u2010Huspenina","orcid":"https://orcid.org/0000-0003-0057-2263","observed_orcids":["https://orcid.org/0000-0003-0057-2263"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Slotta-Huspenina","raw_affiliation_strings":["Department of Nephrology, School of Medicine, Technical University Munich, Munich, Germany","Institute of Pathology, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, School of Medicine, Technical University Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Pathology, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018744564","display_name":"Wilko Weichert","orcid":"https://orcid.org/0000-0001-6139-8372","observed_orcids":["https://orcid.org/0000-0001-6139-8372"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wilko Weichert","raw_affiliation_strings":["Institute of Pathology, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Luis Zapata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Luis Zapata","raw_affiliation_strings":["Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093760607","display_name":"Eleftheria Giota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eleftheria Giota","raw_affiliation_strings":["Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000610387","display_name":"Sylvie Lorenzen","orcid":"https://orcid.org/0000-0001-7933-2507","observed_orcids":["https://orcid.org/0000-0001-7933-2507"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sylvie Lorenzen","raw_affiliation_strings":["Department of Internal Medicine III (Haematology/Medical Oncology), Technical University of Munich Hospital Rechts der Isar, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III (Haematology/Medical Oncology), Technical University of Munich Hospital Rechts der Isar, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036434076","display_name":"Markus Alberstmeier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Alberstmeier","raw_affiliation_strings":["Department of General, Visceral and Transplantation Surgery, University Hospital, Ludwig-Maximilians-Universit\u00e4t (LMU) Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University Hospital, Ludwig-Maximilians-Universit\u00e4t (LMU) Munich, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038209629","display_name":"Benny Chain","orcid":"https://orcid.org/0000-0002-7417-3970","observed_orcids":["https://orcid.org/0000-0002-7417-3970"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benny Chain","raw_affiliation_strings":["Division of Infection and Immunity, University College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-7417-3970","affiliations":[{"raw_affiliation_string":"Division of Infection and Immunity, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006574809","display_name":"Helmut Friess","orcid":"https://orcid.org/0000-0001-6029-5857","observed_orcids":["https://orcid.org/0000-0001-6029-5857"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helmut Friess","raw_affiliation_strings":["Department of Surgery, TUM University Hospital, rechts der Isar, School of Medicine and Health, Technical University Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, TUM University Hospital, rechts der Isar, School of Medicine and Health, Technical University Munich, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036331681","display_name":"Bertram Bengsch","orcid":"https://orcid.org/0000-0003-2552-740X","observed_orcids":["https://orcid.org/0000-0003-2552-740X"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bertram Bengsch","raw_affiliation_strings":["Clinic for Internal Medicine II, University Medical Center Freiburg, Freiburg, Germany","German Cancer Consortium (DKTK) Heidelberg, Germany, Partner Site Freiburg, Freiburg, Germany","Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2552-740X","affiliations":[{"raw_affiliation_string":"Clinic for Internal Medicine II, University Medical Center Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) Heidelberg, Germany, Partner Site Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101473723","display_name":"Roland Michael Schmid","orcid":"https://orcid.org/0009-0000-8976-3300","observed_orcids":["https://orcid.org/0009-0000-8976-3300","https://orcid.org/0000-0002-6945-7581","https://orcid.org/0000-0002-5751-7313"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roland M. Schmid","raw_affiliation_strings":["German Cancer Consortium (DKTK) Heidelberg, Germany, Partner Site Munich, Munich, Germany","Medical Clinic and Polyclinic II, TUM University Hospital, Klinikum rechts der Isar, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Consortium (DKTK) Heidelberg, Germany, Partner Site Munich, Munich, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Medical Clinic and Polyclinic II, TUM University Hospital, Klinikum rechts der Isar, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071888326","display_name":"Jens Thomas Siveke","orcid":"https://orcid.org/0000-0002-8772-4778","observed_orcids":["https://orcid.org/0000-0002-8772-4778"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens T. Siveke","raw_affiliation_strings":["Bridge Institute of Experimental Tumor Therapy (BIT), Division of Solid Tumor Translational Oncology (DKTK) and Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany","German Cancer Consortium (DKTK), partner site Essen, a partnership between German Cancer Research Center (DKFZ) and University Hospital Essen, Essen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8772-4778","affiliations":[{"raw_affiliation_string":"Bridge Institute of Experimental Tumor Therapy (BIT), Division of Solid Tumor Translational Oncology (DKTK) and Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), partner site Essen, a partnership between German Cancer Research Center (DKFZ) and University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040038040","display_name":"Michael Quante","orcid":"https://orcid.org/0000-0002-8497-582X","observed_orcids":["https://orcid.org/0000-0002-8497-582X"]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Quante","raw_affiliation_strings":["Clinic for Internal Medicine II, University Medical Center Freiburg, Freiburg, Germany","German Cancer Consortium (DKTK) Heidelberg, Germany, Partner Site Freiburg, Freiburg, Germany","Medical Clinic and Polyclinic II, TUM University Hospital, Klinikum rechts der Isar, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8497-582X","affiliations":[{"raw_affiliation_string":"Clinic for Internal Medicine II, University Medical Center Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) Heidelberg, Germany, Partner Site Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Medical Clinic and Polyclinic II, TUM University Hospital, Klinikum rechts der Isar, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038131018","display_name":"Trevor A. Graham","orcid":"https://orcid.org/0000-0001-9582-1597","observed_orcids":["https://orcid.org/0000-0001-9582-1597"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Trevor A. Graham","raw_affiliation_strings":["Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. trevor.graham@icr.ac.uk","Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK. trevor.graham@icr.ac.uk"],"raw_orcid":"https://orcid.org/0000-0001-9582-1597","affiliations":[{"raw_affiliation_string":"Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. trevor.graham@icr.ac.uk","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK. trevor.graham@icr.ac.uk","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5038131018"],"corresponding_institution_ids":["https://openalex.org/I142947616","https://openalex.org/I166337079","https://openalex.org/I2802619606","https://openalex.org/I4391767962","https://openalex.org/I4405264518","https://openalex.org/I62916508"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":{"value":12690,"currency":"USD","value_usd":12690},"fwci":16.753,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.99582002,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"6","issue":"5","first_page":"820","last_page":"837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.3521000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"neoadjuvant therapy","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.953000009059906},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.7960000038146973},{"id":"https://openalex.org/keywords/clonal-replacement","display_name":"clonal replacement","score":0.7419999837875366},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.593999981880188},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.746999979019165},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.5270000100135803},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.5189999938011169},{"id":"https://openalex.org/keywords/phenotypic-plasticity","display_name":"phenotypic plasticity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.44600000977516174},{"id":"https://openalex.org/keywords/imaging-mass-cytometry","display_name":"imaging mass cytometry","score":0.6579999923706055},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6530428528785706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6357954740524292},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.6175711750984192},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5886071920394897},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5272834897041321},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.5108525156974792},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5032185912132263},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4845978021621704},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4619346857070923},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.4318027198314667},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.4278010129928589},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.42288467288017273},{"id":"https://openalex.org/C2778015335","wikidata":"https://www.wikidata.org/wiki/Q17051163","display_name":"Mass cytometry","level":4,"score":0.4218497574329376},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4195517897605896},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2701209783554077},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26389122009277344},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2330552339553833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21056222915649414},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10703343152999878},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07682135701179504},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":10,"locations":[{"id":"doi:10.1038/s43018-025-00955-w","doi":"https://doi.org/10.1038/s43018-025-00955-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43018-025-00955-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210236562","display_name":"Nature Cancer","issn_l":"2662-1347","issn":["2662-1347"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cancer","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2738048/v1","doi":"https://doi.org/10.21203/rs.3.rs-2738048/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2738048/v1","pdf_url":"https://www.researchsquare.com/article/rs-2738048/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:12122370","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12122370","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Cancer","raw_type":"Text"},{"id":"pmid:37090678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37090678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Journal Article"},{"id":"pmid:40369175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40369175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10120745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10120745","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10120745/pdf/nihpp-rs2738048v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Res Sq","raw_type":"Text"},{"id":"pmh:oai:arts.units.it:11368/3139265","doi":null,"is_oa":true,"landing_page_url":"https://www.nature.com/articles/s43018-025-00955-w","pdf_url":null,"source":{"id":"https://openalex.org/S4306400480","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:bibliographie.ub.uni-due.de:ubo_mods_00231604","doi":null,"is_oa":false,"landing_page_url":"https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=105005105194","pdf_url":null,"source":{"id":"https://openalex.org/S7407055102","display_name":"Universit\u00e4tsbibliographie, Universit\u00e4t Duisburg-Essen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:freidok.uni-freiburg.de:269344","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/269344","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature cancer. - 6, 5 (2025) , 820-837, ISSN: 2662-1347","raw_type":"article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1740026","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1740026","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s43018-025-00955-w","doi":"https://doi.org/10.1038/s43018-025-00955-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43018-025-00955-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210236562","display_name":"Nature Cancer","issn_l":"2662-1347","issn":["2662-1347"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2761940787","display_name":null,"funder_award_id":"01KD2206A/SATURN3","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G2947078389","display_name":"Arizona Cancer and Evolution Center (ACE)","funder_award_id":"U54CA217376","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6165086918","display_name":null,"funder_award_id":"DFG 3772/1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6479141801","display_name":"Verbund SATURN3 - R\u00e4umliche und zeitliche Aufl\u00f6sung der intratumoralen Heterogenit\u00e4t bei den drei schwer zu behandelnden Krebsarten Brustkrebs, Darmkrebs und Bauchspeicheldr\u00fcsenkrebs, Standort Universit\u00e4t Essen-Duisburg","funder_award_id":"01KD2206A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G7288598144","display_name":null,"funder_award_id":"SI 1549/3-2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7790726129","display_name":null,"funder_award_id":"BMBF; 01KD2206A/SATURN3","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G8482385449","display_name":null,"funder_award_id":"SATURN3","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G8665684607","display_name":"KFO 337: Ph\u00e4notypische Therapie und Immunresistenz in Krebs (PhenoTImE): Pr\u00e4klinischer und translationaler Fortschritt der KFO 337","funder_award_id":"405344257","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G868862665","display_name":null,"funder_award_id":"MFAG 2020","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G9000276717","display_name":null,"funder_award_id":"CA217376","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G960497557","display_name":null,"funder_award_id":"24913","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320327569","display_name":"Deutschen Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410375588.pdf","grobid_xml":"https://content.openalex.org/works/W4410375588.grobid-xml"},"referenced_works_count":119,"referenced_works":["https://openalex.org/W1527347967","https://openalex.org/W1563750692","https://openalex.org/W1631320694","https://openalex.org/W1919257374","https://openalex.org/W1922694287","https://openalex.org/W1940241680","https://openalex.org/W1964081206","https://openalex.org/W1972189965","https://openalex.org/W1972254870","https://openalex.org/W1984068087","https://openalex.org/W1992382421","https://openalex.org/W2008255210","https://openalex.org/W2011458181","https://openalex.org/W2028433016","https://openalex.org/W2035618305","https://openalex.org/W2036685293","https://openalex.org/W2049553585","https://openalex.org/W2070555748","https://openalex.org/W2090493969","https://openalex.org/W2094122486","https://openalex.org/W2096064375","https://openalex.org/W2103441770","https://openalex.org/W2104885590","https://openalex.org/W2111281047","https://openalex.org/W2114023704","https://openalex.org/W2114104545","https://openalex.org/W2116737251","https://openalex.org/W2117801354","https://openalex.org/W2117910394","https://openalex.org/W2119180969","https://openalex.org/W2126763909","https://openalex.org/W2150056019","https://openalex.org/W2152061559","https://openalex.org/W2159707944","https://openalex.org/W2160734881","https://openalex.org/W2161395451","https://openalex.org/W2168133698","https://openalex.org/W2169456326","https://openalex.org/W2171892226","https://openalex.org/W2179438025","https://openalex.org/W2187527489","https://openalex.org/W2210453860","https://openalex.org/W2214074259","https://openalex.org/W2214699570","https://openalex.org/W2226316051","https://openalex.org/W2276335691","https://openalex.org/W2291298003","https://openalex.org/W2302137442","https://openalex.org/W2313484675","https://openalex.org/W2490318515","https://openalex.org/W2520931435","https://openalex.org/W2560367415","https://openalex.org/W2570401594","https://openalex.org/W2588009731","https://openalex.org/W2610784915","https://openalex.org/W2611387862","https://openalex.org/W2621895366","https://openalex.org/W2743787112","https://openalex.org/W2747016053","https://openalex.org/W2766209631","https://openalex.org/W2767699537","https://openalex.org/W2788142646","https://openalex.org/W2867868648","https://openalex.org/W2883970691","https://openalex.org/W2898606030","https://openalex.org/W2899145148","https://openalex.org/W2906166963","https://openalex.org/W2911880312","https://openalex.org/W2917253379","https://openalex.org/W2938774982","https://openalex.org/W2950011075","https://openalex.org/W2951144513","https://openalex.org/W2952108587","https://openalex.org/W2952935593","https://openalex.org/W2953263404","https://openalex.org/W2975634117","https://openalex.org/W2980245695","https://openalex.org/W2981545603","https://openalex.org/W2982547352","https://openalex.org/W2983330893","https://openalex.org/W2989956209","https://openalex.org/W2997046348","https://openalex.org/W2998945864","https://openalex.org/W2999445610","https://openalex.org/W3000621497","https://openalex.org/W3004480399","https://openalex.org/W3010114444","https://openalex.org/W3010398944","https://openalex.org/W3026944009","https://openalex.org/W3031036292","https://openalex.org/W3036051681","https://openalex.org/W3047825284","https://openalex.org/W3049719740","https://openalex.org/W3086062326","https://openalex.org/W3092384992","https://openalex.org/W3092607059","https://openalex.org/W3101619682","https://openalex.org/W3123367719","https://openalex.org/W3128646645","https://openalex.org/W3148827278","https://openalex.org/W3171517418","https://openalex.org/W3172231205","https://openalex.org/W3174461268","https://openalex.org/W3186098271","https://openalex.org/W3190112044","https://openalex.org/W3195935456","https://openalex.org/W3196897371","https://openalex.org/W3199874472","https://openalex.org/W3203412677","https://openalex.org/W4295759620","https://openalex.org/W4307658844","https://openalex.org/W4378907017","https://openalex.org/W4384393185","https://openalex.org/W4389938304","https://openalex.org/W4390669175","https://openalex.org/W4402553114","https://openalex.org/W4407760778","https://openalex.org/W6906520647","https://openalex.org/W6968075428"],"related_works":["https://openalex.org/W6976471533","https://openalex.org/W4362592773","https://openalex.org/W4378907017","https://openalex.org/W4306398987","https://openalex.org/W7171283972","https://openalex.org/W4297216458","https://openalex.org/W4401190491","https://openalex.org/W2999198735","https://openalex.org/W4387580705","https://openalex.org/W3089003963"],"abstract_inverted_index":{"Locally":[0],"advanced":[1],"oesophageal":[2],"adenocarcinoma":[3],"(EAC)":[4],"remains":[5],"difficult":[6],"to":[7,13,65,184],"treat":[8],"because":[9],"of":[10,39,103,145,157,171,178],"common":[11],"resistance":[12,216],"neoadjuvant":[14,92],"therapy":[15,215],"and":[16,22,57,79,90,105,108,115,148,163,175,209],"high":[17],"recurrence":[18],"rates.":[19],"The":[20,169],"ecological":[21],"evolutionary":[23],"dynamics":[24,211],"responsible":[25],"for":[26,214],"treatment":[27,100,162,187,196],"failure":[28],"are":[29],"incompletely":[30],"understood.":[31],"Here,":[32],"we":[33],"performed":[34,84,141],"a":[35,143,176],"comprehensive":[36],"multi-omic":[37],"analysis":[38],"samples":[40],"collected":[41],"from":[42],"EAC":[43,94],"patients":[44,87,147],"in":[45,53,70,142,152,166],"the":[46,158,204],"MEMORI":[47],"clinical":[48,186],"trial,":[49],"revealing":[50,155],"major":[51,96],"changes":[52,69,98,130,194],"gene":[54,128],"expression":[55,129],"profiles":[56],"immune":[58,104,172,210],"microenvironment":[59,167],"composition":[60],"that":[61,121,127,200],"did":[62],"not":[63,132],"appear":[64],"be":[66],"driven":[67],"by":[68],"clonal":[71,122,179,201],"composition.":[72,168],"Multi-region":[73],"multi-timepoint":[74],"whole":[75],"exome":[76],"(300x":[77],"depth)":[78],"paired":[80],"transcriptome":[81],"sequencing":[82,151],"was":[83,140],"on":[85],"27":[86],"pre-,":[88],"during":[89,99,161,195],"after":[91],"treatment.":[93],"showed":[95],"transcriptomic":[97],"with":[101,197,217],"upregulation":[102],"stromal":[106],"pathways":[107,110],"oncogenic":[109],"such":[111],"as":[112,212],"KRAS,":[113],"Hedgehog":[114],"WNT.":[116],"However,":[117],"genetic":[118],"data":[119],"revealed":[120],"sweeps":[123],"were":[124,131,182],"rare,":[125],"suggesting":[126,206],"clonally":[133],"driven.":[134],"Additional":[135],"longitudinal":[136],"image":[137],"mass":[138],"cytometry":[139],"subset":[144],"15":[146],"T-cell":[149,159,180],"receptor":[150],"10":[153],"patients,":[154],"remodelling":[156],"compartment":[160],"other":[164],"shifts":[165],"presence":[170],"escape":[173],"mechanisms":[174,213],"lack":[177],"expansions":[181],"linked":[183],"poor":[185],"response.":[188],"This":[189],"study":[190],"identifies":[191],"profound":[192],"transcriptional":[193],"limited":[198],"evidence":[199],"replacement":[202],"is":[203],"cause,":[205],"phenotypic":[207],"plasticity":[208],"pharmacological":[218],"relevance.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-05-15T00:00:00"}
