{"id":"https://openalex.org/W4410340808","doi":"https://doi.org/10.1038/s41531-025-00983-4","title":"Predicting dementia in people with Parkinson\u2019s disease","display_name":"Predicting dementia in people with Parkinson\u2019s disease","publication_year":2025,"publication_date":"2025-05-13","ids":{"openalex":"https://openalex.org/W4410340808","doi":"https://doi.org/10.1038/s41531-025-00983-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/40360514","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12075756"},"language":"en","primary_location":{"id":"doi:10.1038/s41531-025-00983-4","doi":"https://doi.org/10.1038/s41531-025-00983-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41531-025-00983-4","pdf_url":"https://www.nature.com/articles/s41531-025-00983-4.pdf","source":{"id":"https://openalex.org/S2737664142","display_name":"npj Parkinson s Disease","issn_l":"2373-8057","issn":["2373-8057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Parkinson's Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41531-025-00983-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056198003","display_name":"Mohamed Aborageh","orcid":"https://orcid.org/0000-0001-8075-6999","observed_orcids":["https://orcid.org/0000-0001-8075-6999"]},"institutions":[{"id":"https://openalex.org/I4210098248","display_name":"Fraunhofer Institute for Algorithms and Scientific Computing","ror":"https://ror.org/00trw9c49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210098248","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mohamed Aborageh","raw_affiliation_strings":["Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), 53757, Sankt, Augustin, Germany. mohamed.aborageh@scai.fraunhofer.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), 53757, Sankt, Augustin, Germany. mohamed.aborageh@scai.fraunhofer.de","institution_ids":["https://openalex.org/I4210098248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027949019","display_name":"Tom H\u00e4hnel","orcid":"https://orcid.org/0000-0002-4254-2399","observed_orcids":["https://orcid.org/0000-0002-4254-2399"]},"institutions":[{"id":"https://openalex.org/I4210098248","display_name":"Fraunhofer Institute for Algorithms and Scientific Computing","ror":"https://ror.org/00trw9c49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210098248","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tom H\u00e4hnel","raw_affiliation_strings":["Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), 53757, Sankt, Augustin, Germany","Department of Neurology, University Hospital and Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), 53757, Sankt, Augustin, Germany","institution_ids":["https://openalex.org/I4210098248"]},{"raw_affiliation_string":"Department of Neurology, University Hospital and Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042842870","display_name":"Patricia Martins Conde","orcid":"https://orcid.org/0000-0003-2246-5469","observed_orcids":["https://orcid.org/0000-0003-2246-5469"]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]},{"id":"https://openalex.org/I4405257232","display_name":"Luxembourg Centre for Systems Biomedicine","ror":"https://ror.org/051tr1y59","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577","https://openalex.org/I4405257232"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Patricia Martins Conde","raw_affiliation_strings":["Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg","institution_ids":["https://openalex.org/I186903577","https://openalex.org/I4405257232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066832631","display_name":"Jochen Klucken","orcid":"https://orcid.org/0000-0001-6645-9437","observed_orcids":["https://orcid.org/0000-0001-6645-9437","https://orcid.org/0000-0002-5306-920X"]},"institutions":[{"id":"https://openalex.org/I162487826","display_name":"Centre Hospitalier de Luxembourg","ror":"https://ror.org/03xq7w797","country_code":"LU","type":"healthcare","lineage":["https://openalex.org/I162487826"]},{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]},{"id":"https://openalex.org/I4405257232","display_name":"Luxembourg Centre for Systems Biomedicine","ror":"https://ror.org/051tr1y59","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577","https://openalex.org/I4405257232"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Jochen Klucken","raw_affiliation_strings":["Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg","Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg","institution_ids":["https://openalex.org/I162487826"]},{"raw_affiliation_string":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg","institution_ids":["https://openalex.org/I186903577","https://openalex.org/I4405257232"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054001409","display_name":"Holger Fr\u00f6hlich","orcid":"https://orcid.org/0000-0002-5328-1243","observed_orcids":["https://orcid.org/0000-0002-5328-1243"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I4210098248","display_name":"Fraunhofer Institute for Algorithms and Scientific Computing","ror":"https://ror.org/00trw9c49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210098248","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I4210164149","display_name":"Bonn Aachen International Center for Information Technology","ror":"https://ror.org/054zhq066","country_code":"DE","type":"facility","lineage":["https://openalex.org/I135140700","https://openalex.org/I155417937","https://openalex.org/I4210164149","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Holger Fr\u00f6hlich","raw_affiliation_strings":["Bonn-Aachen International Center for Information Technology (B-IT), Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn, 53115, Bonn, Germany. holger.froehlich@scai.fraunhofer.de","Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), 53757, Sankt, Augustin, Germany. holger.froehlich@scai.fraunhofer.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bonn-Aachen International Center for Information Technology (B-IT), Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn, 53115, Bonn, Germany. holger.froehlich@scai.fraunhofer.de","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I4210164149"]},{"raw_affiliation_string":"Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), 53757, Sankt, Augustin, Germany. holger.froehlich@scai.fraunhofer.de","institution_ids":["https://openalex.org/I4210098248"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5054001409","https://openalex.org/A5056198003"],"corresponding_institution_ids":["https://openalex.org/I135140700","https://openalex.org/I4210098248","https://openalex.org/I4210164149"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":6.9674,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.97707925,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"126","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.14270000159740448,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease-dementia","display_name":"Parkinson's disease dementia","score":0.9359999895095825},{"id":"https://openalex.org/keywords/dementia-prediction","display_name":"dementia prediction","score":0.7149999737739563},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7710000276565552},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8050000071525574},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6930000185966492},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.781000018119812},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.7730000019073486},{"id":"https://openalex.org/keywords/dementia-prevention","display_name":"dementia prevention","score":0.777999997138977},{"id":"https://openalex.org/keywords/multimodal-data","display_name":"multimodal data","score":0.625}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.8463326692581177},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.7410709261894226},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.7134270668029785},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5647109150886536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5627918839454651},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.4821476638317108},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.4602550268173218},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4158882200717926},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.34297460317611694},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3426707983016968},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.32225432991981506},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22236698865890503},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.14241743087768555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09225630760192871},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1038/s41531-025-00983-4","doi":"https://doi.org/10.1038/s41531-025-00983-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41531-025-00983-4","pdf_url":"https://www.nature.com/articles/s41531-025-00983-4.pdf","source":{"id":"https://openalex.org/S2737664142","display_name":"npj Parkinson s Disease","issn_l":"2373-8057","issn":["2373-8057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Parkinson's Disease","raw_type":"journal-article"},{"id":"doi:10.1101/2025.01.27.25321134","doi":"https://doi.org/10.1101/2025.01.27.25321134","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.01.27.25321134","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/01/28/2025.01.27.25321134.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:40360514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40360514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Parkinson's disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12075756","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12075756/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Parkinsons Dis","raw_type":"Text"},{"id":"pmh:oai:orbilu.uni.lu:10993/65455","doi":null,"is_oa":true,"landing_page_url":"https://orbilu.uni.lu/handle/10993/65455","pdf_url":"https://orbilu.uni.lu/bitstream/10993/65455/1/s41531-025-00983-4.pdf","source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Parkinson's Disease, 11 (1), 126 (2025-05-13)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:8eee4aced01e4d68910e11d105aefbe8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8eee4aced01e4d68910e11d105aefbe8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Parkinson's Disease, Vol 11, Iss 1, Pp 1-10 (2025)","raw_type":"article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/487654","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/487654","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1038/s41531-025-00983-4","doi":"https://doi.org/10.1038/s41531-025-00983-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41531-025-00983-4","pdf_url":"https://www.nature.com/articles/s41531-025-00983-4.pdf","source":{"id":"https://openalex.org/S2737664142","display_name":"npj Parkinson s Disease","issn_l":"2373-8057","issn":["2373-8057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Parkinson's Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410340808.pdf","grobid_xml":"https://content.openalex.org/works/W4410340808.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W162979156","https://openalex.org/W1678356000","https://openalex.org/W1987003014","https://openalex.org/W1987197936","https://openalex.org/W1988494453","https://openalex.org/W1993790483","https://openalex.org/W2030090069","https://openalex.org/W2041969715","https://openalex.org/W2051719689","https://openalex.org/W2053919734","https://openalex.org/W2064972754","https://openalex.org/W2067581899","https://openalex.org/W2082704080","https://openalex.org/W2083320551","https://openalex.org/W2112298570","https://openalex.org/W2120387391","https://openalex.org/W2122825543","https://openalex.org/W2143991193","https://openalex.org/W2157979757","https://openalex.org/W2160660329","https://openalex.org/W2163144163","https://openalex.org/W2165400844","https://openalex.org/W2176431310","https://openalex.org/W2216351326","https://openalex.org/W2559809511","https://openalex.org/W2614566443","https://openalex.org/W2622509884","https://openalex.org/W2736913135","https://openalex.org/W2767297946","https://openalex.org/W2768013550","https://openalex.org/W2791863121","https://openalex.org/W2800651166","https://openalex.org/W2803072880","https://openalex.org/W2887458079","https://openalex.org/W2891478855","https://openalex.org/W2911964244","https://openalex.org/W2950598813","https://openalex.org/W2972937106","https://openalex.org/W2977839586","https://openalex.org/W2983166786","https://openalex.org/W2986932567","https://openalex.org/W2988894247","https://openalex.org/W2989855650","https://openalex.org/W3003883515","https://openalex.org/W3004888206","https://openalex.org/W3023743242","https://openalex.org/W3026805599","https://openalex.org/W3038944518","https://openalex.org/W3048245060","https://openalex.org/W3049151968","https://openalex.org/W3081492699","https://openalex.org/W3087304580","https://openalex.org/W3133637277","https://openalex.org/W3135159820","https://openalex.org/W3140403198","https://openalex.org/W3157419554","https://openalex.org/W3157584621","https://openalex.org/W3162250976","https://openalex.org/W3174664487","https://openalex.org/W3184285584","https://openalex.org/W3187490067","https://openalex.org/W3202209876","https://openalex.org/W4205088022","https://openalex.org/W4210295999","https://openalex.org/W4221086306","https://openalex.org/W4226059246","https://openalex.org/W4242665286","https://openalex.org/W4283375409","https://openalex.org/W4294763280","https://openalex.org/W4308453095","https://openalex.org/W4317390883","https://openalex.org/W4318045043","https://openalex.org/W4323349723","https://openalex.org/W4382777619","https://openalex.org/W4384945503","https://openalex.org/W4386154582","https://openalex.org/W4390541678","https://openalex.org/W4392194559","https://openalex.org/W4396572316","https://openalex.org/W4397019745","https://openalex.org/W4399128848","https://openalex.org/W4399639258","https://openalex.org/W4401164724","https://openalex.org/W4402874940","https://openalex.org/W6759073433","https://openalex.org/W6834628200"],"related_works":["https://openalex.org/W3081492699","https://openalex.org/W4402840205","https://openalex.org/W7216222982","https://openalex.org/W2072331737","https://openalex.org/W4412811167","https://openalex.org/W4382790802","https://openalex.org/W4400407020","https://openalex.org/W3091912954","https://openalex.org/W4362515136","https://openalex.org/W2382408868"],"abstract_inverted_index":{"Parkinson's":[0,52,62,130],"disease":[1],"(PD)":[2],"exhibits":[3],"a":[4,135],"variety":[5],"of":[6,11,24,51],"symptoms,":[7],"with":[8,98],"approximately":[9],"25%":[10],"patients":[12,131],"experiencing":[13],"mild":[14],"cognitive":[15],"impairment":[16],"and":[17,29,40,73,86,119,126,145],"45%":[18],"developing":[19],"dementia":[20,53],"within":[21],"ten":[22],"years":[23],"diagnosis.":[25],"Predicting":[26],"this":[27],"progression":[28],"identifying":[30],"its":[31],"causes":[32],"remains":[33],"challenging.":[34],"Our":[35],"study":[36,139],"utilizes":[37],"machine":[38],"learning":[39],"multimodal":[41],"data":[42,59],"from":[43,60,101],"the":[44,49,61,95],"UK":[45],"Biobank":[46],"to":[47,109],"explore":[48],"predictability":[50],"(PDD)":[54],"post-diagnosis,":[55],"further":[56],"validated":[57],"by":[58],"Progression":[63],"Markers":[64],"Initiative":[65],"(PPMI)":[66],"cohort.":[67],"Using":[68],"Shapley":[69],"Additive":[70],"Explanation":[71],"(SHAP)":[72],"Bayesian":[74],"Network":[75],"structure":[76],"learning,":[77],"we":[78,104],"analyzed":[79],"interactions":[80],"among":[81],"genetic":[82,92],"predisposition,":[83],"comorbidities,":[84],"lifestyle,":[85],"environmental":[87],"factors.":[88],"We":[89],"concluded":[90],"that":[91,122],"predisposition":[93],"is":[94],"dominant":[96],"factor,":[97],"significant":[99],"influence":[100],"comorbidities.":[102],"Additionally,":[103],"employed":[105],"Mendelian":[106],"randomization":[107],"(MR)":[108],"establish":[110],"potential":[111],"causal":[112],"links":[113],"between":[114],"hypertension,":[115],"type":[116],"2":[117],"diabetes,":[118],"PDD,":[120],"suggesting":[121],"managing":[123],"blood":[124],"pressure":[125],"glucose":[127],"levels":[128],"in":[129],"may":[132],"serve":[133],"as":[134],"preventive":[136],"strategy.":[137],"This":[138],"identifies":[140],"risk":[141],"factors":[142],"for":[143,148],"PDD":[144],"proposes":[146],"avenues":[147],"prevention.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-05-14T00:00:00"}