{"id":"https://openalex.org/W4410313580","doi":"https://doi.org/10.1002/dad2.70107","title":"Cross\u2010sectional study of plasma phosphorylated tau 217 in persons without dementia","display_name":"Cross\u2010sectional study of plasma phosphorylated tau 217 in persons without dementia","publication_year":2025,"publication_date":"2025-04-01","ids":{"openalex":"https://openalex.org/W4410313580","doi":"https://doi.org/10.1002/dad2.70107","pmid":"https://pubmed.ncbi.nlm.nih.gov/40352683","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12064337"},"language":"en","primary_location":{"id":"doi:10.1002/dad2.70107","doi":"https://doi.org/10.1002/dad2.70107","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dad2.70107","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.70107","source":{"id":"https://openalex.org/S2898482455","display_name":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","issn_l":"2352-8729","issn":["2352-8729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-2","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.70107","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069350743","display_name":"Toni Tapani Saari","orcid":"https://orcid.org/0000-0001-7721-3336","observed_orcids":["https://orcid.org/0000-0001-7721-3336"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Toni T. Saari","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055296565","display_name":"Teemu Palviainen","orcid":"https://orcid.org/0000-0002-7847-8384","observed_orcids":["https://orcid.org/0000-0002-7847-8384"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Teemu Palviainen","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082600086","display_name":"Mikko O. Hiltunen","orcid":"https://orcid.org/0000-0003-3566-4096","observed_orcids":["https://orcid.org/0000-0003-3566-4096"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mikko Hiltunen","raw_affiliation_strings":["Institute of Biomedicine University of Eastern Finland  Kuopio Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine University of Eastern Finland  Kuopio Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056012003","display_name":"Sanna\u2010Kaisa Herukka","orcid":"https://orcid.org/0000-0003-3308-8662","observed_orcids":["https://orcid.org/0000-0003-3308-8662"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sanna\u2010Kaisa Herukka","raw_affiliation_strings":["Department of Neurology Neurocenter Kuopio University Hospital  Kuopio Finland","Institute of Clinical Medicine/Neurology University of Eastern Finland  Kuopio Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Neurocenter Kuopio University Hospital  Kuopio Finland","institution_ids":["https://openalex.org/I4210092991"]},{"raw_affiliation_string":"Institute of Clinical Medicine/Neurology University of Eastern Finland  Kuopio Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059442267","display_name":"Tarja Kokkola","orcid":"https://orcid.org/0000-0002-3303-3912","observed_orcids":["https://orcid.org/0000-0002-3303-3912"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tarja Kokkola","raw_affiliation_strings":["Institute of Clinical Medicine/Neurology University of Eastern Finland  Kuopio Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Medicine/Neurology University of Eastern Finland  Kuopio Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034212138","display_name":"Sari K\u00e4rkk\u00e4inen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sari K\u00e4rkk\u00e4inen","raw_affiliation_strings":["Institute of Clinical Medicine/Neurology University of Eastern Finland  Kuopio Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Medicine/Neurology University of Eastern Finland  Kuopio Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025305192","display_name":"Mia Urjansson","orcid":"https://orcid.org/0009-0003-5084-3831","observed_orcids":["https://orcid.org/0009-0003-5084-3831"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mia Urjansson","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063356239","display_name":"Aino Aaltonen","orcid":"https://orcid.org/0009-0000-4543-8645","observed_orcids":["https://orcid.org/0009-0000-4543-8645"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Aino Aaltonen","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085708490","display_name":"Aarno V. Palotie","orcid":"https://orcid.org/0000-0002-2527-5874","observed_orcids":["https://orcid.org/0000-0002-2527-5874"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]},{"id":"https://openalex.org/I4392738323","display_name":"Stanley Center for Psychiatric Research","ror":"https://ror.org/01tm9b530","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Aarno Palotie","raw_affiliation_strings":["Analytic and Translational Genetics Unit Department of Medicine Department of Neurology and Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA","Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland","The Stanley Center for Psychiatric Research and Program in Medical and Population Genetics The Broad Institute of MIT and Harvard  Cambridge Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytic and Translational Genetics Unit Department of Medicine Department of Neurology and Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"The Stanley Center for Psychiatric Research and Program in Medical and Population Genetics The Broad Institute of MIT and Harvard  Cambridge Massachusetts USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089969264","display_name":"Heiko Runz","orcid":"https://orcid.org/0000-0002-2133-7345","observed_orcids":["https://orcid.org/0000-0002-2133-7345","https://orcid.org/0000-0002-3716-2455"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["DE","FI"],"is_corresponding":false,"raw_author_name":"Heiko Runz","raw_affiliation_strings":["European Molecular Biological Laboratories (EMBL)  Heidelberg Germany","Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biological Laboratories (EMBL)  Heidelberg Germany","institution_ids":["https://openalex.org/I4210138560"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002275174","display_name":"Jaakko A. Kaprio","orcid":"https://orcid.org/0000-0002-3716-2455","observed_orcids":["https://orcid.org/0000-0002-3716-2455","https://orcid.org/0000-0002-2527-5874","https://orcid.org/0000-0003-2838-3085"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jaakko Kaprio","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042850649","display_name":"Valtteri Julkunen","orcid":"https://orcid.org/0000-0002-8727-8536","observed_orcids":["https://orcid.org/0000-0002-8727-8536","https://orcid.org/0000-0002-2133-7345"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Valtteri Julkunen","raw_affiliation_strings":["Department of Neurology Neurocenter Kuopio University Hospital  Kuopio Finland","Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland","Institute of Clinical Medicine/Neurology University of Eastern Finland  Kuopio Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Neurocenter Kuopio University Hospital  Kuopio Finland","institution_ids":["https://openalex.org/I4210092991"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Institute of Clinical Medicine/Neurology University of Eastern Finland  Kuopio Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018060788","display_name":"Eero Vuoksimaa","orcid":"https://orcid.org/0000-0002-6534-3667","observed_orcids":["https://orcid.org/0000-0002-6534-3667"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Eero Vuoksimaa","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland"],"raw_orcid":"https://orcid.org/0000-0002-6534-3667","affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science University of Helsinki  Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"last","author":{"id":null,"display_name":"for FinnGen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for FinnGen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5018060788"],"corresponding_institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"],"apc_list":{"value":2540,"currency":"USD","value_usd":2540},"apc_paid":{"value":2540,"currency":"USD","value_usd":2540},"fwci":6.5037,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.97389688,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"17","issue":"2","first_page":"e70107","last_page":"e70107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.3330000042915344,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphorylated-tau-217","display_name":"phosphorylated tau217","score":0.9549999833106995},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.8230000138282776},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8399999737739563},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.8510000109672546},{"id":"https://openalex.org/keywords/genetic-risk","display_name":"genetic risk","score":0.6940000057220459},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8659999966621399},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5370000004768372},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.5989999771118164},{"id":"https://openalex.org/keywords/twins","display_name":"twins","score":0.5849999785423279},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7242732048034668},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5261390209197998},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46834084391593933},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46776172518730164},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.4552861154079437},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40500766038894653},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37793028354644775},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3336558938026428},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2776460647583008},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21474289894104004},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1661393642425537},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12466257810592651}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1002/dad2.70107","doi":"https://doi.org/10.1002/dad2.70107","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dad2.70107","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.70107","source":{"id":"https://openalex.org/S2898482455","display_name":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","issn_l":"2352-8729","issn":["2352-8729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-2","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring","raw_type":"journal-article"},{"id":"doi:10.1101/2024.05.17.24307528","doi":"https://doi.org/10.1101/2024.05.17.24307528","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.05.17.24307528","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:12064337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12064337","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimers Dement (Amst)","raw_type":"Text"},{"id":"pmid:40352683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40352683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & dementia (Amsterdam, Netherlands)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e77285dda47a45d2832423d07086af27","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e77285dda47a45d2832423d07086af27","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimer\u2019s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 17, Iss 2, Pp n/a-n/a (2025)","raw_type":"article"},{"id":"pmh:oai:helda.helsinki.fi:10138/596584","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/596584","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1002/dad2.70107","doi":"https://doi.org/10.1002/dad2.70107","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dad2.70107","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.70107","source":{"id":"https://openalex.org/S2898482455","display_name":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","issn_l":"2352-8729","issn":["2352-8729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-2","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1569838456","display_name":null,"funder_award_id":"263\u2009278","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G2433343305","display_name":null,"funder_award_id":"265\u2009240","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G279455444","display_name":null,"funder_award_id":"264\u2009146","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G4764960795","display_name":"Genome Center of Eastern Finland","funder_award_id":"353053","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G4928701027","display_name":null,"funder_award_id":"314639","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G7799623451","display_name":null,"funder_award_id":"345988","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"}],"funders":[{"id":"https://openalex.org/F4320306257","display_name":"Boehringer Ingelheim","ror":"https://ror.org/05kffp613"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307778","display_name":"Novartis","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320319538","display_name":"Maze Therapeutics","ror":"https://ror.org/030sdfc18"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320323760","display_name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00ckakm23"},{"id":"https://openalex.org/F4320328501","display_name":"Business Finland","ror":"https://ror.org/05bgf9v38"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410313580.pdf","grobid_xml":"https://content.openalex.org/works/W4410313580.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1918432791","https://openalex.org/W1951724000","https://openalex.org/W1986286400","https://openalex.org/W2033151532","https://openalex.org/W2043601400","https://openalex.org/W2109349396","https://openalex.org/W2115779804","https://openalex.org/W2152885121","https://openalex.org/W2168357345","https://openalex.org/W2510973425","https://openalex.org/W2511515754","https://openalex.org/W2529241974","https://openalex.org/W2798054687","https://openalex.org/W2801534945","https://openalex.org/W2962898942","https://openalex.org/W2970011713","https://openalex.org/W2991212521","https://openalex.org/W3001668805","https://openalex.org/W3005602364","https://openalex.org/W3102892253","https://openalex.org/W3138513807","https://openalex.org/W3161336068","https://openalex.org/W3168489639","https://openalex.org/W3172294552","https://openalex.org/W3197290161","https://openalex.org/W3199337605","https://openalex.org/W4206038508","https://openalex.org/W4210650500","https://openalex.org/W4223470668","https://openalex.org/W4223591189","https://openalex.org/W4225681755","https://openalex.org/W4280619985","https://openalex.org/W4281558685","https://openalex.org/W4294762973","https://openalex.org/W4296954210","https://openalex.org/W4323832104","https://openalex.org/W4361999839","https://openalex.org/W4386151109","https://openalex.org/W4386170974","https://openalex.org/W4386413214","https://openalex.org/W4391101037","https://openalex.org/W4399539887","https://openalex.org/W4399561322","https://openalex.org/W4399584049","https://openalex.org/W4400089962","https://openalex.org/W4400126480","https://openalex.org/W4400388912","https://openalex.org/W4403854232","https://openalex.org/W4405527832","https://openalex.org/W4406501668"],"related_works":["https://openalex.org/W4416186776","https://openalex.org/W3168489639","https://openalex.org/W7134250164","https://openalex.org/W4405582789","https://openalex.org/W7134811457","https://openalex.org/W7219412047","https://openalex.org/W4220894208","https://openalex.org/W7079913881","https://openalex.org/W7126246673","https://openalex.org/W7212043567"],"abstract_inverted_index":{"Abstract":[0],"INTRODUCTION":[1],"Little":[2],"is":[3,182],"known":[4],"about":[5],"plasma":[6,25,174,192,227],"phosphorylated":[7,178],"tau":[8,179],"217":[9,180],"(p\u2010tau217)":[10,181],"in":[11,94,151,194],"individuals":[12],"without":[13,161],"a":[14,39,152,162,183,195,206,235],"clinical":[15,163,207],"diagnosis":[16,164,208],"of":[17,24,50,85,149,165,186,198,209,230],"Alzheimer's":[18,187],"disease":[19,188],"(AD).":[20,189],"We":[21,155,190,202],"studied":[22,191],"associations":[23,148],"p\u2010tau217":[26,81,150,193,231],"with":[27,72,98,205,225],"age,":[28],"sex,":[29],"education,":[30],"and":[31,37,83,101,119,146,213,234],"genetic":[32,147],"risk;":[33],"estimated":[34],"the":[35,137,144,243],"heritability;":[36],"conducted":[38],"genome\u2010wide":[40,236],"association":[41,237],"study":[42,49,238],"(GWAS).":[43],"METHODS":[44],"A":[45],"population\u2010based":[46,153,196],"biobank":[47],"recall":[48],"65\u2010":[51,158,199],"to":[52,159,167,200],"85\u2010year\u2010old":[53],"twins":[54],"(":[55,106,127,218],"N":[56],"=":[57],"697,":[58],"mean":[59],"[SD]":[60],"age":[61,100,212],"76.2":[62],"[4.6]":[63],"years;":[64],"53%":[65],"women,":[66],"154":[67],"full":[68],"pairs)":[69],"excluding":[70],"those":[71,204],"AD":[73,86,166,169],"based":[74,172],"on":[75,173],"health":[76],"registry":[77],"data.":[78],"RESULTS":[79],"Higher":[80],"level":[82],"likelihood":[84],"neuropathologic":[87,170],"change":[88,171],"(p\u2010tau217":[89],">":[90],"0.42":[91],"pg/mL;":[92],"evident":[93],"39%)":[95],"were":[96,223],"associated":[97,224],"higher":[99,226],"having":[102,214],"an":[103,215],"apolipoprotein":[104,216],"E":[105,217],"APOE":[107,138,219,244],")":[108,134,220],"\u03b54":[109,221],"allele.":[110],"Heritability":[111,229],"was":[112,232],"0.56":[113],"(95%":[114],"confidence":[115],"interval":[116],"[CI]:":[117],"0.36\u20130.79)":[118],"GWAS":[120],"indicated":[121],"45":[122],"single":[123],"nucleotide":[124],"polymorphisms":[125],"(SNPs)":[126],"p":[128],"<":[129],"5":[130],"\u00d7":[131],"10":[132],"\u221208":[133],"centered":[135],"around":[136,242],"locus.":[139],"DISCUSSION":[140],"Our":[141],"results":[142],"elucidate":[143],"characteristics":[145],"setting.":[154],"found":[156],"many":[157],"85\u2010year\u2010olds":[160],"have":[168],"p\u2010tau217.":[175,228],"Highlights":[176],"Plasma":[177],"promising":[184],"biomarker":[185],"sample":[197],"\u201085\u2010year\u2010olds.":[201],"excluded":[203],"AD.":[210],"Older":[211],"allele":[222],"56%":[233],"(GWAS)":[239],"implicated":[240],"genes":[241],"region.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2025-05-13T00:00:00"}