{"id":"https://openalex.org/W4410285292","doi":"https://doi.org/10.1016/j.ejmp.2025.105002","title":"Evaluation of secondary cancers risk induction in adjuvant breast radiotherapy: creation of technique independent dose\u2013effect curves for OARs dose optimization","display_name":"Evaluation of secondary cancers risk induction in adjuvant breast radiotherapy: creation of technique independent dose\u2013effect curves for OARs dose optimization","publication_year":2025,"publication_date":"2025-05-12","ids":{"openalex":"https://openalex.org/W4410285292","doi":"https://doi.org/10.1016/j.ejmp.2025.105002","pmid":"https://pubmed.ncbi.nlm.nih.gov/40359865"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejmp.2025.105002","doi":"https://doi.org/10.1016/j.ejmp.2025.105002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmp.2025.105002","pdf_url":null,"source":{"id":"https://openalex.org/S138998826","display_name":"Physica Medica","issn_l":"1120-1797","issn":["1120-1797","1724-191X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physica Medica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Francesco Moretti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4396570469","display_name":"Azienda Socio Sanitaria Territoriale della Valle Olona","ror":"https://ror.org/023h2da51","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570469"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco Moretti","raw_affiliation_strings":["Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: francesco.moretti@asst-valleolona.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: francesco.moretti@asst-valleolona.it","institution_ids":["https://openalex.org/I4396570469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076401346","display_name":"Luca Marzoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4396570469","display_name":"Azienda Socio Sanitaria Territoriale della Valle Olona","ror":"https://ror.org/023h2da51","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570469"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luca Marzoli","raw_affiliation_strings":["Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: luca.marzoli@asst-valleolona.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: luca.marzoli@asst-valleolona.it","institution_ids":["https://openalex.org/I4396570469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057707587","display_name":"Luigi De Cicco","orcid":"https://orcid.org/0000-0003-0709-7872","observed_orcids":["https://orcid.org/0000-0003-0709-7872"]},"institutions":[{"id":"https://openalex.org/I4396570469","display_name":"Azienda Socio Sanitaria Territoriale della Valle Olona","ror":"https://ror.org/023h2da51","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570469"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luigi De Cicco","raw_affiliation_strings":["Division of Radiotherapy, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: luigi.decicco@asst-valleolona.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiotherapy, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: luigi.decicco@asst-valleolona.it","institution_ids":["https://openalex.org/I4396570469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083619983","display_name":"RITA LORUSSO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4396570469","display_name":"Azienda Socio Sanitaria Territoriale della Valle Olona","ror":"https://ror.org/023h2da51","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570469"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Rita Lorusso","raw_affiliation_strings":["Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: rita.lorusso@asst-valleolona.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: rita.lorusso@asst-valleolona.it","institution_ids":["https://openalex.org/I4396570469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012626707","display_name":"Paolo Imperiale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4396570469","display_name":"Azienda Socio Sanitaria Territoriale della Valle Olona","ror":"https://ror.org/023h2da51","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570469"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Paolo Imperiale","raw_affiliation_strings":["Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: paolo.imperiale@asst-valleolona.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: paolo.imperiale@asst-valleolona.it","institution_ids":["https://openalex.org/I4396570469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101206","display_name":"Annalisa Pepe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4396570469","display_name":"Azienda Socio Sanitaria Territoriale della Valle Olona","ror":"https://ror.org/023h2da51","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570469"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Annalisa Pepe","raw_affiliation_strings":["Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: annalisa.pepe@asst-valleolona.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: annalisa.pepe@asst-valleolona.it","institution_ids":["https://openalex.org/I4396570469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050591686","display_name":"Daniela Corletto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4396570469","display_name":"Azienda Socio Sanitaria Territoriale della Valle Olona","ror":"https://ror.org/023h2da51","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570469"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Daniela Corletto","raw_affiliation_strings":["Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: daniela.corletto@asst-valleolona.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: daniela.corletto@asst-valleolona.it","institution_ids":["https://openalex.org/I4396570469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065373956","display_name":"Barbara Bortolato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4396570469","display_name":"Azienda Socio Sanitaria Territoriale della Valle Olona","ror":"https://ror.org/023h2da51","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570469"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Barbara Bortolato","raw_affiliation_strings":["Division of Radiotherapy, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: barbara.bortolato@asst-valleolona.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiotherapy, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: barbara.bortolato@asst-valleolona.it","institution_ids":["https://openalex.org/I4396570469"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084290670","display_name":"Lorenzo Bianchi","orcid":"https://orcid.org/0000-0001-7321-1536","observed_orcids":["https://orcid.org/0000-0001-7321-1536","https://orcid.org/0009-0004-2584-707X"]},"institutions":[{"id":"https://openalex.org/I4396570469","display_name":"Azienda Socio Sanitaria Territoriale della Valle Olona","ror":"https://ror.org/023h2da51","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570469"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Lorenzo Bianchi","raw_affiliation_strings":["Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: lorenzo.bianchi@asst-valleolona.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Physics, ASST Valle Olona, Via A. da Brescia, 1, Busto Arsizio 21052 VA, Italy. Electronic address: lorenzo.bianchi@asst-valleolona.it","institution_ids":["https://openalex.org/I4396570469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012626707","https://openalex.org/A5050591686","https://openalex.org/A5057707587","https://openalex.org/A5065373956","https://openalex.org/A5076401346","https://openalex.org/A5083619983","https://openalex.org/A5084290670","https://openalex.org/A5110101206"],"corresponding_institution_ids":["https://openalex.org/I4396570469"],"apc_list":{"value":2780,"currency":"USD","value_usd":2780},"apc_paid":null,"fwci":1.0189,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.6716593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"134","issue":null,"first_page":"105002","last_page":"105002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secondary-cancer-risk","display_name":"secondary cancer risk","score":0.8450000286102295},{"id":"https://openalex.org/keywords/radiation-induced-cancer","display_name":"radiation-induced cancer","score":0.765999972820282},{"id":"https://openalex.org/keywords/adjuvant-breast-radiotherapy","display_name":"adjuvant breast radiotherapy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dose-response-curves","display_name":"dose-response curves","score":0.8019999861717224},{"id":"https://openalex.org/keywords/organs-at-risk","display_name":"organs at risk","score":0.8199999928474426},{"id":"https://openalex.org/keywords/linear-quadratic-model","display_name":"linear-quadratic model","score":0.7089999914169312},{"id":"https://openalex.org/keywords/excess-relative-risk","display_name":"excess relative risk","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lung-dose","display_name":"lung dose","score":0.5009999871253967},{"id":"https://openalex.org/keywords/contralateral-breast-dose","display_name":"contralateral breast dose","score":0.8429999947547913},{"id":"https://openalex.org/keywords/treatment-plan-optimization","display_name":"treatment planning optimization","score":0.6539999842643738},{"id":"https://openalex.org/keywords/volumetric-modulated-arc-therapy","display_name":"volumetric modulated arc therapy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/three-dimensional-conformal-radiotherapy","display_name":"3D conformal radiotherapy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/alpha-beta-ratio","display_name":"alpha/beta ratio","score":0.6119999885559082},{"id":"https://openalex.org/keywords/dose-volume-histograms","display_name":"dose-volume histograms","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6090289950370789},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6002295613288879},{"id":"https://openalex.org/C3018454096","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant radiotherapy","level":3,"score":0.5398349761962891},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5355787873268127},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4580269455909729},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.45244070887565613},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3544016480445862},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3520664870738983}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011880","descriptor_name":"Radiotherapy Planning, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020266","descriptor_name":"Radiotherapy, Conformal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D050397","descriptor_name":"Radiotherapy, Intensity-Modulated","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D058958","descriptor_name":"Organs at Risk","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejmp.2025.105002","doi":"https://doi.org/10.1016/j.ejmp.2025.105002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmp.2025.105002","pdf_url":null,"source":{"id":"https://openalex.org/S138998826","display_name":"Physica Medica","issn_l":"1120-1797","issn":["1120-1797","1724-191X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physica Medica","raw_type":"journal-article"},{"id":"pmid:40359865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40359865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W18516915","https://openalex.org/W1495036323","https://openalex.org/W1567841743","https://openalex.org/W1595611582","https://openalex.org/W1975810712","https://openalex.org/W1976420723","https://openalex.org/W1978537515","https://openalex.org/W2002793133","https://openalex.org/W2003517629","https://openalex.org/W2014973435","https://openalex.org/W2016682611","https://openalex.org/W2018240559","https://openalex.org/W2060806769","https://openalex.org/W2064291232","https://openalex.org/W2088926884","https://openalex.org/W2100025800","https://openalex.org/W2105792037","https://openalex.org/W2110998462","https://openalex.org/W2115475605","https://openalex.org/W2117285637","https://openalex.org/W2117692326","https://openalex.org/W2118553111","https://openalex.org/W2129825983","https://openalex.org/W2137986149","https://openalex.org/W2143561393","https://openalex.org/W2204498632","https://openalex.org/W2399616656","https://openalex.org/W2592466328","https://openalex.org/W2598117381","https://openalex.org/W2738090335","https://openalex.org/W3021410191","https://openalex.org/W4248142848","https://openalex.org/W4288081551","https://openalex.org/W4403996320"],"related_works":["https://openalex.org/W7128424478","https://openalex.org/W4382394850","https://openalex.org/W4386333555","https://openalex.org/W4413473525","https://openalex.org/W2740231289","https://openalex.org/W3082026032","https://openalex.org/W3214361036","https://openalex.org/W2065403406","https://openalex.org/W2472380744","https://openalex.org/W3003555090"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-05-12T00:00:00"}
