{"id":"https://openalex.org/W4410280339","doi":"https://doi.org/10.1038/s41467-026-73099-9","title":"De novo design of peptides localizing at the interface of biomolecular condensates","display_name":"De novo design of peptides localizing at the interface of biomolecular condensates","publication_year":2026,"publication_date":"2026-05-16","ids":{"openalex":"https://openalex.org/W4410280339","doi":"https://doi.org/10.1038/s41467-026-73099-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/42143038","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13376736"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-73099-9","doi":"https://doi.org/10.1038/s41467-026-73099-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-73099-9","pdf_url":"https://www.nature.com/articles/s41467-026-73099-9.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-73099-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042831739","display_name":"Timo N. Schneider","orcid":"https://orcid.org/0000-0002-8989-1406","observed_orcids":["https://orcid.org/0000-0002-8989-1406"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257618","display_name":"Institute for Chemical and Bioengineering","ror":"https://ror.org/05fhwqj89","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257618"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Timo N. Schneider","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-8989-1406","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022742396","display_name":"Marcos Gil-Garc\u00eda","orcid":"https://orcid.org/0000-0002-7457-7860","observed_orcids":["https://orcid.org/0000-0002-7457-7860"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257618","display_name":"Institute for Chemical and Bioengineering","ror":"https://ror.org/05fhwqj89","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257618"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marcos Gil-Garcia","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-7457-7860","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257618"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marco A. B\u00fchler","orcid":"https://orcid.org/0009-0002-5323-5957","observed_orcids":["https://orcid.org/0009-0002-5323-5957"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257618","display_name":"Institute for Chemical and Bioengineering","ror":"https://ror.org/05fhwqj89","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257618"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marco A. B\u00fchler","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0009-0002-5323-5957","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081910459","display_name":"Lucas Francisco dos Santos","orcid":"https://orcid.org/0000-0001-5931-4272","observed_orcids":["https://orcid.org/0000-0001-5931-4272"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257618","display_name":"Institute for Chemical and Bioengineering","ror":"https://ror.org/05fhwqj89","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257618"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lucas F. Santos","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5931-4272","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090162992","display_name":"Lenka Faltova","orcid":"https://orcid.org/0000-0002-7274-8080","observed_orcids":["https://orcid.org/0000-0002-7274-8080"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257618","display_name":"Institute for Chemical and Bioengineering","ror":"https://ror.org/05fhwqj89","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257618"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lenka Faltova","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059336153","display_name":"Gonzalo Guill\u00e9n\u2010Gos\u00e1lbez","orcid":"https://orcid.org/0000-0001-6074-8473","observed_orcids":["https://orcid.org/0000-0001-6074-8473"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257618","display_name":"Institute for Chemical and Bioengineering","ror":"https://ror.org/05fhwqj89","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257618"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gonzalo Guill\u00e9n-Gos\u00e1lbez","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-6074-8473","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081005940","display_name":"Paolo Arosio","orcid":"https://orcid.org/0000-0002-2740-1205","observed_orcids":["https://orcid.org/0000-0002-2740-1205","https://orcid.org/0000-0003-2388-0402"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257618","display_name":"Institute for Chemical and Bioengineering","ror":"https://ror.org/05fhwqj89","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257618"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Paolo Arosio","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland. paolo.arosio@chem.ethz.ch"],"raw_orcid":"https://orcid.org/0000-0002-2740-1205","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland. paolo.arosio@chem.ethz.ch","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081005940"],"corresponding_institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257618"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":11.6837,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.98797096,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomolecular-condensates","display_name":"biomolecular condensates","score":0.9549999833106995},{"id":"https://openalex.org/keywords/peptide-design","display_name":"peptide design","score":0.8629999756813049},{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.8830000162124634},{"id":"https://openalex.org/keywords/net-charge","display_name":"net charge","score":0.5419999957084656},{"id":"https://openalex.org/keywords/electrostatic-repulsion","display_name":"electrostatic repulsion","score":0.847000002861023},{"id":"https://openalex.org/keywords/hnrnp-a1","display_name":"hnRNP A1","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ddx4","display_name":"DDX4","score":1.0},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/coarse-grained-simulation","display_name":"coarse-grained simulation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.7870000004768372},{"id":"https://openalex.org/keywords/mixed-integer-linear-programming","display_name":"mixed-integer linear programming","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.7372153997421265},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.411593496799469},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4042012691497803},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36820870637893677},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3624064326286316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26697492599487305},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.20762360095977783},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20053642988204956},{"id":"https://openalex.org/C55352822","wikidata":"https://www.wikidata.org/wiki/Q5558978","display_name":"Gibbs isotherm","level":3,"score":0.0},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091582","descriptor_name":"Biomolecular Condensates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41467-026-73099-9","doi":"https://doi.org/10.1038/s41467-026-73099-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-73099-9","pdf_url":"https://www.nature.com/articles/s41467-026-73099-9.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2025.05.09.653111","doi":"https://doi.org/10.1101/2025.05.09.653111","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.09.653111","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42143038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42143038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13376736","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13376736/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:doi:10.3929/ethz-c-000803516","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/803516","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b2a05cddd6a34c0fbe8f1d2c40c241d8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b2a05cddd6a34c0fbe8f1d2c40c241d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 17, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/803516","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/803516","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 17 (1)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-c-000803516","doi":"https://doi.org/10.3929/ethz-c-000803516","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-c-000803516","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-73099-9","doi":"https://doi.org/10.1038/s41467-026-73099-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-73099-9","pdf_url":"https://www.nature.com/articles/s41467-026-73099-9.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410280339.pdf","grobid_xml":"https://content.openalex.org/works/W4410280339.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1912455695","https://openalex.org/W1972575833","https://openalex.org/W1982534687","https://openalex.org/W1997188340","https://openalex.org/W2007898019","https://openalex.org/W2007930753","https://openalex.org/W2014574246","https://openalex.org/W2027839322","https://openalex.org/W2043876754","https://openalex.org/W2046377044","https://openalex.org/W2051276419","https://openalex.org/W2053081979","https://openalex.org/W2058971275","https://openalex.org/W2099540110","https://openalex.org/W2101234009","https://openalex.org/W2126105956","https://openalex.org/W2133425057","https://openalex.org/W2146411229","https://openalex.org/W2513709734","https://openalex.org/W2590568317","https://openalex.org/W2756821926","https://openalex.org/W2769779784","https://openalex.org/W2786469974","https://openalex.org/W2794654572","https://openalex.org/W2901816197","https://openalex.org/W2964121744","https://openalex.org/W2970971581","https://openalex.org/W3003547858","https://openalex.org/W3007812324","https://openalex.org/W3011801711","https://openalex.org/W3013626020","https://openalex.org/W3093821973","https://openalex.org/W3132347536","https://openalex.org/W3148035996","https://openalex.org/W3148042916","https://openalex.org/W3156578609","https://openalex.org/W3157810520","https://openalex.org/W3171235999","https://openalex.org/W3195840525","https://openalex.org/W3198782993","https://openalex.org/W3201073812","https://openalex.org/W3215858345","https://openalex.org/W4200346882","https://openalex.org/W4220697560","https://openalex.org/W4220989818","https://openalex.org/W4226236855","https://openalex.org/W4226523564","https://openalex.org/W4294387621","https://openalex.org/W4297779993","https://openalex.org/W4310702852","https://openalex.org/W4318070558","https://openalex.org/W4322397539","https://openalex.org/W4323350303","https://openalex.org/W4366824630","https://openalex.org/W4367309725","https://openalex.org/W4383198203","https://openalex.org/W4384819032","https://openalex.org/W4385618104","https://openalex.org/W4387025523","https://openalex.org/W4387582462","https://openalex.org/W4388376074","https://openalex.org/W4390604183","https://openalex.org/W4392705665","https://openalex.org/W4400905172","https://openalex.org/W4401295246","https://openalex.org/W4401944742","https://openalex.org/W4403069566","https://openalex.org/W4408364096","https://openalex.org/W4409409510","https://openalex.org/W4416359141","https://openalex.org/W7170601666"],"related_works":["https://openalex.org/W7130424701","https://openalex.org/W7130517704","https://openalex.org/W4318054880","https://openalex.org/W7164006706","https://openalex.org/W7164174502","https://openalex.org/W7085457423","https://openalex.org/W7130399905","https://openalex.org/W4414304679","https://openalex.org/W7203475426","https://openalex.org/W7165532875"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"interface":[2,102],"of":[3,25,50,86,103,151,175,185,198,215,219,245,251],"biomolecular":[4],"condensates":[5,37,106,142],"has":[6],"been":[7],"shown":[8],"to":[9,77],"play":[10],"an":[11,32],"important":[12],"role":[13],"in":[14,145,168],"processes":[15],"such":[16],"as":[17,31,222],"protein":[18,112],"aggregation":[19],"and":[20,38,73,95,127,161,170,248],"biochemical":[21],"reactions.":[22],"Targeted":[23],"modulation":[24],"these":[26],"interfaces":[27,54,85],"could,":[28],"therefore,":[29],"serve":[30],"effective":[33],"strategy":[34,240],"for":[35,227,241],"engineering":[36],"modifying":[39],"aberrant":[40],"behaviors.":[41],"However,":[42],"the":[43,47,84,101,125,128,132,138,141,149,152,157,163,172,176,183,189,193,207,213,216,220,242,249,252],"molecular":[44,254],"grammar":[45],"driving":[46],"preferential":[48,231],"localization":[49],"molecules":[51],"at":[52,83,100],"condensate":[53,88,126],"remains":[55],"largely":[56],"unknown.":[57],"In":[58,135,182],"this":[59,91],"study,":[60],"we":[61,93],"developed":[62],"a":[63,223,238],"computational":[64],"pipeline":[65,236],"that":[66,80,98],"combines":[67],"highthroughput":[68],"coarse-grained":[69],"simulations,":[70],"machine":[71],"learning,":[72],"mixed-integer":[74],"linear":[75],"programming":[76],"design":[78,244],"peptides":[79,97,116,229,247],"selectively":[81],"partition":[82],"specific":[87],"targets.":[89],"Using":[90],"workflow,":[92],"designed":[94],"synthesized":[96],"localize":[99],"three":[104],"distinct":[105],"formed":[107],"by":[108],"different":[109],"intrinsically":[110],"disordered":[111],"regions":[113],"(IDRs).":[114],"These":[115,210],"exhibit":[117,203],"surfactant-like":[118],"architectures,":[119],"with":[120,206,230],"one":[121],"tail":[122,139,154,165,195],"incorporated":[123],"into":[124],"other":[129],"excluded":[130,153,164,194],"from":[131],"dense":[133],"phase.":[134],"all":[136],"cases,":[137],"entering":[140],"is":[143,166],"enriched":[144,167],"aromatic":[146],"residues,":[147,201],"while":[148],"sequence":[150],"varies":[155],"among":[156],"IDRs.":[158],"For":[159],"hnRNPA1-":[160],"LAF1-IDRs,":[162],"lysines":[169],"matches":[171],"net":[173,217],"charge":[174,191,218],"condensate-forming":[177],"protein,":[178],"promoting":[179],"electrostatic":[180],"repulsion.":[181],"case":[184],"DDX4-IDR,":[186],"which":[187,202],"exhibits":[188],"lowest":[190],"density,":[192],"mainly":[196],"consists":[197],"uncharged":[199],"valine":[200],"negligible":[204],"interactions":[205],"scaffold":[208,221],"protein.":[209],"results":[211],"highlight":[212],"importance":[214],"key":[224],"physicochemical":[225],"parameter":[226],"designing":[228],"interfacial":[232],"localization.":[233],"Overall,":[234],"our":[235],"represents":[237],"promising":[239],"rational":[243],"interface-localizing":[246],"identification":[250],"corresponding":[253],"grammar.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":8}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-05-12T00:00:00"}