{"id":"https://openalex.org/W4410274891","doi":"https://doi.org/10.1164/ajrccm.2025.211.abstracts.a6376","title":"Urinary Metal Levels and Respiratory Health in the Vapescan Study","display_name":"Urinary Metal Levels and Respiratory Health in the Vapescan Study","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4410274891","doi":"https://doi.org/10.1164/ajrccm.2025.211.abstracts.a6376"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm.2025.211.abstracts.a6376","doi":"https://doi.org/10.1164/ajrccm.2025.211.abstracts.a6376","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.2025.211.abstracts.a6376","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004387533","display_name":"Christina M. Eckhardt","orcid":"https://orcid.org/0000-0002-3249-926X","observed_orcids":["https://orcid.org/0000-0002-3249-926X"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Eckhardt","raw_affiliation_strings":["Pulmonary, Allergy and Critical Care Medicine, Columbia University Irving Medical Center, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy and Critical Care Medicine, Columbia University Irving Medical Center, New York, NY, United States","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060575740","display_name":"Emilia A. Hermann","orcid":"https://orcid.org/0000-0003-3428-0728","observed_orcids":["https://orcid.org/0000-0003-3428-0728"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.A. Hermann","raw_affiliation_strings":["Internal Medicine, Columbia University Medical Center, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Columbia University Medical Center, New York, NY, United States","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061155896","display_name":"Vesna Ilievski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Ilievski","raw_affiliation_strings":["Columbia University Mailman School of Public Health, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University Mailman School of Public Health, New York, NY, United States","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037044515","display_name":"Nancy J. Lolacono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Lolacono","raw_affiliation_strings":["Columbia University Mailman School of Public Health, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University Mailman School of Public Health, New York, NY, United States","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086039689","display_name":"Galen Ziaggi","orcid":"https://orcid.org/0000-0001-6858-0986","observed_orcids":["https://orcid.org/0000-0001-6858-0986"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Ziaggi","raw_affiliation_strings":["Columbia University Irving Medical Center, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University Irving Medical Center, New York, NY, United States","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056252676","display_name":"D. Hawkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Hawkins","raw_affiliation_strings":["Columbia University Mailman School of Public Health, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University Mailman School of Public Health, New York, NY, United States","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073029210","display_name":"Daichi Shimbo","orcid":"https://orcid.org/0000-0001-6302-8834","observed_orcids":["https://orcid.org/0000-0001-6302-8834"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Shimbo","raw_affiliation_strings":["Columbia University Irving Medical Center, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University Irving Medical Center, New York, NY, United States","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081578838","display_name":"Ana Navas\u2010Aci\u00e9n","orcid":"https://orcid.org/0000-0001-9824-7797","observed_orcids":["https://orcid.org/0000-0001-9824-7797"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Navas-Acien","raw_affiliation_strings":["Columbia University Mailman School of Public Health, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University Mailman School of Public Health, New York, NY, United States","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056182924","display_name":"Elizabeth C. Oelsner","orcid":"https://orcid.org/0000-0002-7481-9671","observed_orcids":["https://orcid.org/0000-0002-7481-9671"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Oelsner","raw_affiliation_strings":["Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"211","issue":"Supplement_1","first_page":"A6376","last_page":"A6376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.0820000022649765,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urinary-metal-levels","display_name":"urinary metal levels","score":0.7480000257492065},{"id":"https://openalex.org/keywords/e-cigarette-use","display_name":"vaping","score":0.7739999890327454},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.7480000257492065},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.7459999918937683},{"id":"https://openalex.org/keywords/nickel","display_name":"nickel","score":0.44699999690055847},{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.5270000100135803},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.3160000145435333},{"id":"https://openalex.org/keywords/respiratory-health","display_name":"respiratory health","score":0.4269999861717224},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.6449999809265137},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.5820000171661377},{"id":"https://openalex.org/keywords/forced-vital-capacity","display_name":"forced vital capacity","score":0.6309999823570251},{"id":"https://openalex.org/keywords/occupational-metal-exposure","display_name":"occupational metal exposure","score":0.7120000123977661},{"id":"https://openalex.org/keywords/smoking-status","display_name":"smoking status","score":0.3779999911785126},{"id":"https://openalex.org/keywords/spirometry","display_name":"spirometry","score":0.4429999887943268},{"id":"https://openalex.org/keywords/forced-mid-expiratory-flow","display_name":"forced mid-expiratory flow","score":0.6539999842643738},{"id":"https://openalex.org/keywords/forced-expiratory-flow","display_name":"forced expiratory flow","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8925776481628418},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.6042817234992981},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5704635977745056},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4816526472568512},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.36999017000198364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2365095317363739}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm.2025.211.abstracts.a6376","doi":"https://doi.org/10.1164/ajrccm.2025.211.abstracts.a6376","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.2025.211.abstracts.a6376","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416637291","https://openalex.org/W2513352043","https://openalex.org/W7223466055","https://openalex.org/W4390994487","https://openalex.org/W4396215242","https://openalex.org/W3178542445","https://openalex.org/W4410276201","https://openalex.org/W4404097851","https://openalex.org/W4312311950","https://openalex.org/W4408505109"],"abstract_inverted_index":{"Abstract":[0],"Rationale:":[1],"Occupational":[2],"metal":[3,22,36,55,146],"exposures":[4],"have":[5,19],"been":[6],"associated":[7,235,276,313,350,368],"with":[8,44,148,159,236,277,314,351,369,380],"lung":[9,39,150,161,266,305,371,384,398],"diseases":[10],"including":[11],"asthma":[12],"and":[13,38,45,81,108,116,137,186,224,292,330,346,387],"emphysema.":[14],"However,":[15],"no":[16,95,228],"prior":[17],"studies":[18],"evaluated":[20,31],"how":[21],"levels":[23,37,111,147,240,341,375],"in":[24,41,66,114,129,301],"early":[25],"adulthood":[26],"affect":[27],"respiratory":[28],"health.":[29],"We":[30],"the":[32,125,195,394],"relationship":[33],"between":[34],"urinary":[35,238,273,310,365],"function":[40,151,162,385],"young":[42,362],"adults":[43,62],"without":[46],"history":[47],"of":[48,54,75,143,260,264,303,342,361,383,396],"e-cigarette":[49,80,92,184],"use,":[50,86,90,93,185,209,216,223],"a":[51,358,390],"known":[52],"source":[53],"exposures.":[56],"Methods:":[57],"The":[58],"VapeScan":[59,193],"Study":[60],"recruited":[61,72],"aged":[63],"18-50":[64],"years":[65],"New":[67],"York":[68],"City.":[69],"Participants":[70],"were":[71,112,152,163,175,255,348],"into":[73],"one":[74],"four":[76],"groups":[77],"based":[78],"on":[79],"cigarette":[82,89,187,215,222],"use:":[83],"dual":[84,207],"e-cigarette/cigarette":[85,96,208,229,232],"current":[87,213,220],"e-cigarette/former":[88,214],"exclusive":[91],"or":[94,354],"use":[97,233],"(controls).":[98],"Exclusion":[99],"criteria":[100],"included":[101],"physician-diagnosed":[102],"emphysema,":[103],"chronic":[104],"obstructive":[105,397],"pulmonary":[106],"disease,":[107],"bronchiectasis.":[109],"Metal":[110],"measured":[113,124],"urine":[115,119],"corrected":[117],"for":[118,170,177,393],"specific":[120],"gravity.":[121],"Pre-bronchodilator":[122],"spirometry":[123,253],"forced":[126,133,138],"expiratory":[127],"volume":[128],"1":[130],"second":[131],"(FEV1),":[132],"vital":[134],"capacity":[135],"(FVC),":[136],"mid-expiratory":[139],"flow":[140],"(FEF25-75).":[141],"Associations":[142],"baseline":[144,265],"log-transformed":[145],"cross-sectional":[149],"modeled":[153,164],"using":[154,165],"linear":[155,166],"regression,":[156],"while":[157],"associations":[158],"longitudinal":[160,304,316],"mixed-effect":[167],"models":[168,174],"adjusted":[169,176],"follow-up":[171],"time.":[172],"All":[173],"age,":[178],"sex,":[179],"race/ethnicity,":[180],"education,":[181],"height,":[182],"weight,":[183],"smoking":[188],"status.":[189],"Results:":[190],"Among":[191],"335":[192],"participants,":[194],"mean":[196],"age":[197],"was":[198,234,275,312,367],"27.9\u00b17.7":[199],"years.":[200],"In":[201,250,262,357],"total,":[202,251],"85":[203],"(25.3%)":[204],"participants":[205],"reported":[206,212,219,227],"59":[210],"(17.6%)":[211],"87":[217],"(25.9%)":[218],"e-cigarette/never":[221],"105":[225],"(31.3%)":[226],"use.":[230],"Dual":[231],"higher":[237,272,309,364],"copper":[239,274,311,366,374],"(+1.24":[241],"\u03bcg/L,":[242],"95%":[243,282,288,296,320,326,334],"CI":[244,283,289,297,321,327,335],"1.03,":[245],"1.49)":[246],"compared":[247],"to":[248],"controls.":[249],"538":[252],"measurements":[254],"obtained":[256],"over":[257],"172.6":[258],"person-years":[259],"follow-up.":[261],"analyses":[263,302],"function,":[267,306],"each":[268,307],"1-interquartile":[269],"range":[270],"(IQR)":[271],"lower":[278,315,370],"FEV1":[279,317],"(-69.71":[280],"mL,":[281,319],"-128.53,":[284],"-10.90),":[285],"FEV1/FVC":[286,324],"(-1.41,":[287],"-2.23,":[290],"-0.59),":[291],"FEF25-75":[293,331],"(-135.34":[294],"mL/s,":[295,333],"-250.33,":[298],"-20.35).":[299],"Similarly,":[300],"1-IQR":[308],"(-64.59":[318],"-119.79,":[322],"-9.48),":[323],"(-1.03,":[325],"-1.78,":[328],"-0.29),":[329],"(-116.05":[332],"-221.71,":[336],"-10.65)":[337],"(Figure":[338],"1).":[339],"Urinary":[340,373],"cadmium,":[343],"cobalt,":[344],"lead,":[345],"zinc":[347],"not":[349],"FEV1,":[352],"FEV1/FVC,":[353],"FEF25-75.":[355],"Conclusions:":[356],"prospective":[359],"cohort":[360],"adults,":[363],"function.":[372],"may":[376,388],"help":[377],"identify":[378],"individuals":[379],"increased":[381],"risk":[382],"impairment":[386],"represent":[389],"novel":[391],"target":[392],"prevention":[395],"diseases.":[399]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-05-11T00:00:00"}