{"id":"https://openalex.org/W4410248512","doi":"https://doi.org/10.3389/fneur.2025.1527302","title":"Systemic inflammation markers (SII and SIRI) as predictors of cognitive performance: evidence from NHANES 2011\u20132014","display_name":"Systemic inflammation markers (SII and SIRI) as predictors of cognitive performance: evidence from NHANES 2011\u20132014","publication_year":2025,"publication_date":"2025-05-09","ids":{"openalex":"https://openalex.org/W4410248512","doi":"https://doi.org/10.3389/fneur.2025.1527302","pmid":"https://pubmed.ncbi.nlm.nih.gov/40417122","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12098094"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2025.1527302","doi":"https://doi.org/10.3389/fneur.2025.1527302","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2025.1527302","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1527302/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1527302/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xiaoyue Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyue Wang","raw_affiliation_strings":["Public Health School, Zunyi Medical University, Zunyi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health School, Zunyi Medical University, Zunyi, China","institution_ids":["https://openalex.org/I182386381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111332313","display_name":"Qinghua Wen","orcid":"https://orcid.org/0009-0005-5800-6215","observed_orcids":["https://orcid.org/0009-0005-5800-6215"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinghua Wen","raw_affiliation_strings":["School of Nursing, Guizhou University of Traditional Chinese Medicine, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Guizhou University of Traditional Chinese Medicine, Guiyang, China","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340444","display_name":"Yujie Li","orcid":"https://orcid.org/0000-0002-2359-2673","observed_orcids":["https://orcid.org/0000-0002-2359-2673","https://orcid.org/0000-0001-8525-3987"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujie Li","raw_affiliation_strings":["School of Nursing, Guizhou University of Traditional Chinese Medicine, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Guizhou University of Traditional Chinese Medicine, Guiyang, China","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032858241","display_name":"Huanhuan Zhu","orcid":"https://orcid.org/0000-0002-2995-4911","observed_orcids":["https://orcid.org/0000-0002-2995-4911"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanhuan Zhu","raw_affiliation_strings":["School of Nursing, Guizhou University of Traditional Chinese Medicine, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Guizhou University of Traditional Chinese Medicine, Guiyang, China","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047417758","display_name":"Fengyin Zhang","orcid":"https://orcid.org/0009-0005-8581-1834","observed_orcids":["https://orcid.org/0009-0005-8581-1834"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengyin Zhang","raw_affiliation_strings":["School of Nursing, Guizhou University of Traditional Chinese Medicine, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Guizhou University of Traditional Chinese Medicine, Guiyang, China","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114260872","display_name":"Simin Li","orcid":"https://orcid.org/0009-0004-5030-3007","observed_orcids":["https://orcid.org/0009-0004-5030-3007"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Simin Li","raw_affiliation_strings":["School of Nursing, Zunyi Medical University, Zunyi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Zunyi Medical University, Zunyi, China","institution_ids":["https://openalex.org/I182386381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349216","display_name":"Zhan Lin","orcid":"https://orcid.org/0009-0002-4863-1306","observed_orcids":["https://orcid.org/0009-0002-4863-1306"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210154454","display_name":"Guizhou Provincial People's Hospital","ror":"https://ror.org/046q1bp69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154454"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Zhan","raw_affiliation_strings":["NHC Key Laboratory of Pulmonary Immune-related Diseases, Guizhou Provincial People's Hospital, Guiyang, China","Public Health School, Zunyi Medical University, Zunyi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Pulmonary Immune-related Diseases, Guizhou Provincial People's Hospital, Guiyang, China","institution_ids":["https://openalex.org/I4210154454"]},{"raw_affiliation_string":"Public Health School, Zunyi Medical University, Zunyi, China","institution_ids":["https://openalex.org/I182386381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100421030","display_name":"Juan Li","orcid":"https://orcid.org/0000-0002-5775-9355","observed_orcids":["https://orcid.org/0000-0002-5775-9355"]},"institutions":[{"id":"https://openalex.org/I4210154454","display_name":"Guizhou Provincial People's Hospital","ror":"https://ror.org/046q1bp69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154454"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Juan Li","raw_affiliation_strings":["Department of Nursing, Guizhou Provincial People's Hospital, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Guizhou Provincial People's Hospital, Guiyang, China","institution_ids":["https://openalex.org/I4210154454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100349216","https://openalex.org/A5100421030"],"corresponding_institution_ids":["https://openalex.org/I182386381","https://openalex.org/I4210154454"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":4.4223,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.95471088,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"16","issue":null,"first_page":"1527302","last_page":"1527302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.12250000238418579,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-immune-inflammation-index","display_name":"systemic immune-inflammation index","score":0.8920000195503235},{"id":"https://openalex.org/keywords/systemic-inflammatory-response-index","display_name":"systemic inflammation response index","score":0.9980000257492065},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cognitive-performance","display_name":"cognitive performance","score":0.6209999918937683},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9129999876022339},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8519999980926514},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.6819999814033508},{"id":"https://openalex.org/keywords/nhanes","display_name":"NHANES","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6695078611373901},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5738075971603394},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5290193557739258},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.527066707611084},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.513899564743042},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.5131848454475403},{"id":"https://openalex.org/C2779874844","wikidata":"https://www.wikidata.org/wiki/Q1967281","display_name":"National Health and Nutrition Examination Survey","level":3,"score":0.5051339268684387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4627954959869385},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4626989960670471},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3593810796737671},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.31841811537742615},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.15915051102638245},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1142900288105011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fneur.2025.1527302","doi":"https://doi.org/10.3389/fneur.2025.1527302","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2025.1527302","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1527302/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmid:40417122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40417122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12098094","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12098094/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:32a89201d31046f1a4aaf773cfb15bc0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/32a89201d31046f1a4aaf773cfb15bc0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2025.1527302","doi":"https://doi.org/10.3389/fneur.2025.1527302","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2025.1527302","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1527302/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2866965719","display_name":null,"funder_award_id":"72364005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4374850233","display_name":null,"funder_award_id":"82160633","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410248512.pdf","grobid_xml":"https://content.openalex.org/works/W4410248512.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1859980654","https://openalex.org/W1991375558","https://openalex.org/W2107934474","https://openalex.org/W2132322340","https://openalex.org/W2187470459","https://openalex.org/W2307324788","https://openalex.org/W2345885627","https://openalex.org/W2346648910","https://openalex.org/W2769340459","https://openalex.org/W2792672107","https://openalex.org/W2807873759","https://openalex.org/W2917958408","https://openalex.org/W2941020388","https://openalex.org/W2993168892","https://openalex.org/W2993908729","https://openalex.org/W2994871395","https://openalex.org/W3024876690","https://openalex.org/W3085706776","https://openalex.org/W3123354432","https://openalex.org/W3134361662","https://openalex.org/W3138652291","https://openalex.org/W3138956554","https://openalex.org/W3164455019","https://openalex.org/W3167095362","https://openalex.org/W3199467955","https://openalex.org/W4200380390","https://openalex.org/W4220814924","https://openalex.org/W4223451421","https://openalex.org/W4284973433","https://openalex.org/W4285724617","https://openalex.org/W4296099146","https://openalex.org/W4303961992","https://openalex.org/W4311045164","https://openalex.org/W4311631252","https://openalex.org/W4315498378","https://openalex.org/W4315620635","https://openalex.org/W4318219753","https://openalex.org/W4318833910","https://openalex.org/W4319298595","https://openalex.org/W4320490550","https://openalex.org/W4323659997","https://openalex.org/W4381848696","https://openalex.org/W4385498418","https://openalex.org/W4386574661","https://openalex.org/W4387357186","https://openalex.org/W4392163619","https://openalex.org/W4399052229","https://openalex.org/W4399799531","https://openalex.org/W4403995197","https://openalex.org/W4404029017"],"related_works":["https://openalex.org/W4388783695","https://openalex.org/W2204247355","https://openalex.org/W7155217150","https://openalex.org/W7162068907","https://openalex.org/W4321458650","https://openalex.org/W4402563435","https://openalex.org/W4282580408","https://openalex.org/W7162186055","https://openalex.org/W4223434619","https://openalex.org/W4392805317"],"abstract_inverted_index":{"Background":[0],"Neuroinflammation":[1],"is":[2],"linked":[3],"to":[4,79,207],"cognitive":[5,31,42,84,102,157,164,227,250],"function.":[6],"However,":[7],"epidemiological":[8],"research":[9],"on":[10],"two":[11],"emerging":[12],"inflammation":[13,22,87],"markers\u2014the":[14],"systemic":[15,21],"immune-inflammation":[16],"index":[17,24],"(SII)":[18],"and":[19,41,59,72,86,91,115,141,186,226],"the":[20,28,36,55,81,172,239],"response":[23],"(SIRI)\u2014remains":[25],"limited":[26],"in":[27,44],"context":[29],"of":[30,107,118,132,155,163,241],"performance.":[32],"This":[33,48,217],"study":[34,218],"investigates":[35],"relationship":[37,199,233],"between":[38,83,223],"SII,":[39,224],"SIRI,":[40,225],"performance":[43,85],"older":[45],"adults.":[46],"Methods":[47],"cross-sectional":[49],"analysis":[50,177,194],"included":[51],"2,194":[52],"participants":[53,99],"from":[54],"2011\u20132014":[56],"National":[57],"Health":[58],"Nutrition":[60],"Examination":[61],"Survey":[62],"(NHANES)":[63],"who":[64],"met":[65],"eligibility":[66],"criteria.":[67],"Logistic":[68],"regression,":[69],"subgroup":[70],"analysis,":[71],"restricted":[73],"cubic":[74],"spline":[75],"modeling":[76],"were":[77,149],"used":[78],"assess":[80],"associations":[82,181],"markers,":[88],"specifically":[89],"SII":[90,106,134,190,208],"SIRI.":[92,235],"Results":[93],"After":[94],"adjusting":[95],"for":[96,182,200,234,248],"population":[97],"weights,":[98],"with":[100,152,229],"low":[101],"function":[103],"had":[104],"an":[105,116,160],"541.54":[108],"(95%":[109,120],"CI:":[110,121,139,147],"360.00\u2013796.50,":[111],"p":[112,123,203,210],"=":[113,124,136,144,204,211],"0.037)":[114],"SIRI":[117,142,183,201,242],"1.28":[119],"0.82\u20132.18,":[122],"0.031).":[125],"In":[126],"fully":[127],"adjusted":[128],"models,":[129],"higher":[130],"levels":[131],"both":[133],"(OR":[135,143],"0.858,":[137],"95%":[138,146],"0.856\u20130.859)":[140],"0.891,":[145],"0.889\u20130.892)":[148],"significantly":[150],"associated":[151],"lower":[153],"odds":[154],"normal":[156],"function,":[158,228],"indicating":[159],"increased":[161],"risk":[162],"impairment.":[165],"Neutrophil-related":[166],"markers":[167],"(NC,":[168],"NLR,":[169],"SIRI)":[170],"exhibited":[171],"strongest":[173],"inverse":[174],"associations.":[175],"Subgroup":[176],"showed":[178],"more":[179,231],"consistent":[180],"across":[184],"demographic":[185],"behavioral":[187],"factors,":[188],"while":[189],"displayed":[191],"fewer.":[192],"RCS":[193],"indicated":[195],"a":[196,220,230,244],"stronger":[197],"non-linear":[198],"(":[202,209],"0.005)":[205],"compared":[206],"0.018)":[212],"after":[213],"full":[214],"adjustment.":[215],"Conclusion":[216],"suggests":[219],"positive":[221],"association":[222],"pronounced":[232],"These":[236],"findings":[237],"highlight":[238],"potential":[240],"as":[243],"novel,":[245],"accessible":[246],"marker":[247],"predicting":[249],"impairment":[251],"risk.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-05-10T00:00:00"}