{"id":"https://openalex.org/W4410230786","doi":"https://doi.org/10.1016/j.devcel.2025.04.013","title":"Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity","display_name":"Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity","publication_year":2025,"publication_date":"2025-05-09","ids":{"openalex":"https://openalex.org/W4410230786","doi":"https://doi.org/10.1016/j.devcel.2025.04.013","pmid":"https://pubmed.ncbi.nlm.nih.gov/40347947"},"language":"en","primary_location":{"id":"doi:10.1016/j.devcel.2025.04.013","doi":"https://doi.org/10.1016/j.devcel.2025.04.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.devcel.2025.04.013","pdf_url":null,"source":{"id":"https://openalex.org/S83804233","display_name":"Developmental Cell","issn_l":"1534-5807","issn":["1534-5807","1878-1551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.devcel.2025.04.013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068676227","display_name":"Yunyun Xu","orcid":"https://orcid.org/0000-0002-6371-054X","observed_orcids":["https://orcid.org/0000-0002-6371-054X"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210151382","display_name":"Children's Hospital of Suzhou University","ror":"https://ror.org/05a9skj35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151382"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunyun Xu","raw_affiliation_strings":["Pediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210151382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077845691","display_name":"Daohua Lou","orcid":"https://orcid.org/0000-0001-7031-998X","observed_orcids":["https://orcid.org/0000-0001-7031-998X"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Daohua Lou","raw_affiliation_strings":["Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17165, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17165, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071621068","display_name":"Ping Chen","orcid":"https://orcid.org/0000-0002-8068-1891","observed_orcids":["https://orcid.org/0000-0002-8068-1891"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Ping Chen","raw_affiliation_strings":["Department of Laboratory Medicine, Karolinska Institute, Huddinge 14157, Sweden; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsingfors 00014, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Karolinska Institute, Huddinge 14157, Sweden; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsingfors 00014, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438653","display_name":"Gang Li","orcid":"https://orcid.org/0000-0001-9585-1382","observed_orcids":["https://orcid.org/0000-0001-9585-1382"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210151382","display_name":"Children's Hospital of Suzhou University","ror":"https://ror.org/05a9skj35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151382"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Li","raw_affiliation_strings":["Pediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210151382"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dimtry Usoskin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Dimtry Usoskin","raw_affiliation_strings":["Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17165, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17165, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jian Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210151382","display_name":"Children's Hospital of Suzhou University","ror":"https://ror.org/05a9skj35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151382"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Pan","raw_affiliation_strings":["Pediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210151382"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Li","raw_affiliation_strings":["Department of Human Anatomy, Histology and Embryology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, Jiangsu 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Histology and Embryology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, Jiangsu 215000, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087301017","display_name":"Shungen Huang","orcid":"https://orcid.org/0000-0002-1978-3143","observed_orcids":["https://orcid.org/0000-0002-1978-3143"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210151382","display_name":"Children's Hospital of Suzhou University","ror":"https://ror.org/05a9skj35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151382"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shungen Huang","raw_affiliation_strings":["Department of General Surgery, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210151382"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Caroline Hess","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Caroline Hess","raw_affiliation_strings":["Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17165, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17165, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080821345","display_name":"Ruze Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210151382","display_name":"Children's Hospital of Suzhou University","ror":"https://ror.org/05a9skj35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151382"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruze Tang","raw_affiliation_strings":["Department of General Surgery, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210151382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102881806","display_name":"Xiaohan Hu","orcid":"https://orcid.org/0000-0001-5040-6023","observed_orcids":["https://orcid.org/0000-0001-5040-6023"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210151382","display_name":"Children's Hospital of Suzhou University","ror":"https://ror.org/05a9skj35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151382"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaohan Hu","raw_affiliation_strings":["Pediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210151382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102846631","display_name":"Juanjuan Yu","orcid":"https://orcid.org/0000-0002-8214-4416","observed_orcids":["https://orcid.org/0000-0002-8214-4416"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210151382","display_name":"Children's Hospital of Suzhou University","ror":"https://ror.org/05a9skj35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151382"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juanjuan Yu","raw_affiliation_strings":["Pediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210151382"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Arceo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Maria Arceo","raw_affiliation_strings":["Department of Oncology-Pathology, Karolinska Institute, Stockholm 17165, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska Institute, Stockholm 17165, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059720767","display_name":"Ronald R. de Krijger","orcid":"https://orcid.org/0000-0001-6871-1296","observed_orcids":["https://orcid.org/0000-0001-6871-1296"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210127118","display_name":"Princess M\u00e1xima Center","ror":"https://ror.org/02aj7yc53","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210127118"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ronald R. de Krijger","raw_affiliation_strings":["Princess M\u00e1xima Center for Pediatric Oncology, Utrecht 3511AB, the Netherlands; Department of Pathology, University Medical Center Utrecht, Utrecht 3511AB, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princess M\u00e1xima Center for Pediatric Oncology, Utrecht 3511AB, the Netherlands; Department of Pathology, University Medical Center Utrecht, Utrecht 3511AB, the Netherlands","institution_ids":["https://openalex.org/I3018483916","https://openalex.org/I4210127118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009606299","display_name":"Arthur S. Tischler","orcid":"https://orcid.org/0000-0002-9726-5739","observed_orcids":["https://orcid.org/0000-0002-9726-5739"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur S. Tischler","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090516986","display_name":"Susanne Schlisio","orcid":"https://orcid.org/0000-0002-2605-3771","observed_orcids":["https://orcid.org/0000-0002-2605-3771"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Susanne Schlisio","raw_affiliation_strings":["Department of Oncology-Pathology, Karolinska Institute, Stockholm 17165, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska Institute, Stockholm 17165, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004312566","display_name":"Patrik Ernfors","orcid":"https://orcid.org/0000-0002-1140-3986","observed_orcids":["https://orcid.org/0000-0002-1140-3986"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Patrik Ernfors","raw_affiliation_strings":["Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17165, Sweden. Electronic address: patrik.ernfors@ki.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17165, Sweden. Electronic address: patrik.ernfors@ki.se","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089262519","display_name":"Yizhou Hu","orcid":"https://orcid.org/0000-0002-2635-0258","observed_orcids":["https://orcid.org/0000-0002-2635-0258","https://orcid.org/0000-0003-4299-7745"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":true,"raw_author_name":"Yizhou Hu","raw_affiliation_strings":["Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17165, Sweden; Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsingfors 00014, Finland. Electronic address: yizhou.hu@ki.se"],"raw_orcid":"https://orcid.org/0000-0002-2635-0258","affiliations":[{"raw_affiliation_string":"Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17165, Sweden; Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsingfors 00014, Finland. Electronic address: yizhou.hu@ki.se","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100370590","display_name":"Jian Wang","orcid":"https://orcid.org/0000-0003-4949-4753","observed_orcids":["https://orcid.org/0000-0003-4949-4753"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210151382","display_name":"Children's Hospital of Suzhou University","ror":"https://ror.org/05a9skj35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151382"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Wang","raw_affiliation_strings":["Pediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China. Electronic address: wj196312@vip.163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China. Electronic address: wj196312@vip.163.com","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210151382"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5004312566","https://openalex.org/A5089262519","https://openalex.org/A5100370590","https://openalex.org/A5102881806"],"corresponding_institution_ids":["https://openalex.org/I133731052","https://openalex.org/I28166907","https://openalex.org/I3923682","https://openalex.org/I4210151382"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":{"value":10400,"currency":"USD","value_usd":10400},"fwci":9.5816,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.98719504,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"60","issue":"17","first_page":"2248","last_page":"2263.e11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":1.0},{"id":"https://openalex.org/keywords/developmental-plasticity","display_name":"developmental plasticity","score":0.996999979019165},{"id":"https://openalex.org/keywords/neural-crest-progenitor-cells","display_name":"neural crest progenitor cells","score":0.7390000224113464},{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.9240000247955322},{"id":"https://openalex.org/keywords/epigenetic-priming","display_name":"epigenetic priming","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8619999885559082},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.6290000081062317},{"id":"https://openalex.org/keywords/state-transitions","display_name":"state transitions","score":0.6029999852180481},{"id":"https://openalex.org/keywords/pediatric-solid-tumors","display_name":"pediatric solid tumors","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9449234008789062},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.51740562915802},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47934991121292114},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.46767744421958923},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.41065749526023865},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3067936897277832},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11877593398094177},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.111107736825943},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.devcel.2025.04.013","doi":"https://doi.org/10.1016/j.devcel.2025.04.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.devcel.2025.04.013","pdf_url":null,"source":{"id":"https://openalex.org/S83804233","display_name":"Developmental Cell","issn_l":"1534-5807","issn":["1534-5807","1878-1551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Cell","raw_type":"journal-article"},{"id":"pmid:40347947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40347947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental cell","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/466050","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/466050","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:helda.helsinki.fi:10138/600278","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/600278","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.devcel.2025.04.013","doi":"https://doi.org/10.1016/j.devcel.2025.04.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.devcel.2025.04.013","pdf_url":null,"source":{"id":"https://openalex.org/S83804233","display_name":"Developmental Cell","issn_l":"1534-5807","issn":["1534-5807","1878-1551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1631148283","display_name":null,"funder_award_id":"M2022102","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G1794404414","display_name":null,"funder_award_id":"GSWS2020048","funder_id":"https://openalex.org/F4320318555","funder_display_name":"Suzhou Municipal Health Commission"},{"id":"https://openalex.org/G2956970866","display_name":null,"funder_award_id":"Qngg2022013","funder_id":"https://openalex.org/F4320318555","funder_display_name":"Suzhou Municipal Health Commission"},{"id":"https://openalex.org/G35614304","display_name":null,"funder_award_id":"81871594","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4070628827","display_name":null,"funder_award_id":"180635","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G8872460481","display_name":null,"funder_award_id":"BK20231203","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"}],"funders":[{"id":"https://openalex.org/F4320309792","display_name":"\u00c5ke Wiberg Stiftelse","ror":"https://ror.org/03htnqd27"},{"id":"https://openalex.org/F4320318555","display_name":"Suzhou Municipal Health Commission","ror":"https://ror.org/025qxt858"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320321975","display_name":"\u00d6rebro Universitet","ror":"https://ror.org/05kytsw45"},{"id":"https://openalex.org/F4320322128","display_name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","ror":"https://ror.org/0433fd238"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323764","display_name":"Medicinska Forskningsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320325437","display_name":"Jiangsu Science and Technology Department","ror":null},{"id":"https://openalex.org/F4320330864","display_name":"Geneseeq Technology","ror":null},{"id":"https://openalex.org/F4320336376","display_name":"Uppsala Multidisciplinary Center for Advanced Computational Science","ror":"https://ror.org/0554ckj21"},{"id":"https://openalex.org/F4320336618","display_name":"Science and Technology Program of Suzhou","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1512398642","https://openalex.org/W1963501822","https://openalex.org/W1972836307","https://openalex.org/W1987468541","https://openalex.org/W1989996002","https://openalex.org/W1992258558","https://openalex.org/W2002387731","https://openalex.org/W2008496424","https://openalex.org/W2019486695","https://openalex.org/W2021690984","https://openalex.org/W2028579977","https://openalex.org/W2048861391","https://openalex.org/W2063337289","https://openalex.org/W2068767807","https://openalex.org/W2072595741","https://openalex.org/W2091514845","https://openalex.org/W2097120541","https://openalex.org/W2098282574","https://openalex.org/W2104199930","https://openalex.org/W2104320396","https://openalex.org/W2118071133","https://openalex.org/W2123954788","https://openalex.org/W2134356247","https://openalex.org/W2134374915","https://openalex.org/W2135263420","https://openalex.org/W2146275134","https://openalex.org/W2151509048","https://openalex.org/W2165684025","https://openalex.org/W2332292689","https://openalex.org/W2526356041","https://openalex.org/W2601579284","https://openalex.org/W2702680930","https://openalex.org/W2726594986","https://openalex.org/W2738563754","https://openalex.org/W2749303840","https://openalex.org/W2766437506","https://openalex.org/W2790890957","https://openalex.org/W2793601014","https://openalex.org/W2800392236","https://openalex.org/W2802963454","https://openalex.org/W2898434771","https://openalex.org/W2902592563","https://openalex.org/W2917543658","https://openalex.org/W2922545572","https://openalex.org/W2934396339","https://openalex.org/W2948517648","https://openalex.org/W2949693884","https://openalex.org/W2951673912","https://openalex.org/W2992151131","https://openalex.org/W3009684066","https://openalex.org/W3023126733","https://openalex.org/W3047141442","https://openalex.org/W3047825284","https://openalex.org/W3055581418","https://openalex.org/W3086206613","https://openalex.org/W3103797259","https://openalex.org/W3128250744","https://openalex.org/W3137366663","https://openalex.org/W3142061505","https://openalex.org/W3143387950","https://openalex.org/W3158885087","https://openalex.org/W3184057816","https://openalex.org/W3193355876","https://openalex.org/W3198669243","https://openalex.org/W3198897305","https://openalex.org/W3214730523","https://openalex.org/W4206662285","https://openalex.org/W4211147182","https://openalex.org/W4220914268","https://openalex.org/W4225598893","https://openalex.org/W4282937896","https://openalex.org/W4293703371","https://openalex.org/W4317502079","https://openalex.org/W4319296611","https://openalex.org/W4320481085","https://openalex.org/W4360999556","https://openalex.org/W4384198561","https://openalex.org/W6735680850","https://openalex.org/W6805682834","https://openalex.org/W6848692093"],"related_works":["https://openalex.org/W4416740582","https://openalex.org/W4401305376","https://openalex.org/W3023106763","https://openalex.org/W4414056261","https://openalex.org/W4404054873","https://openalex.org/W4220712627","https://openalex.org/W4280498970","https://openalex.org/W4390660975","https://openalex.org/W4220928677","https://openalex.org/W4410344211"],"abstract_inverted_index":{"Neuroblastoma,":[0],"the":[1,63,126],"most":[2],"prevalent":[3],"extracranial":[4],"pediatric":[5],"solid":[6],"tumor,":[7],"arises":[8],"from":[9,48,57],"neural":[10],"crest":[11],"progeny":[12],"cells.":[13],"It":[14],"exhibits":[15],"substantial":[16],"developmental":[17,70,76],"plasticity":[18,36],"and":[19,54,65,86,106,115],"intratumoral":[20],"heterogeneity,":[21],"leading":[22],"to":[23,61],"survival":[24],"rates":[25],"below":[26],"50%":[27],"in":[28,72,79],"high-risk":[29,80],"cases.":[30],"The":[31],"regulatory":[32,103],"mechanisms":[33],"underlying":[34],"this":[35,41],"remain":[37],"largely":[38],"elusive.":[39],"In":[40],"integrative":[42],"study,":[43],"we":[44,99],"used":[45],"single-cell":[46],"MultiOmics":[47],"a":[49],"mouse":[50],"spontaneous":[51],"tumor":[52,107],"model":[53],"spatial":[55],"transcriptomics":[56],"human":[58],"patient":[59],"samples":[60],"dissect":[62],"transcriptional":[64],"epigenetic":[66,89],"landscapes":[67],"that":[68],"govern":[69],"states":[71,78],"neuroblastoma.":[73],"We":[74],"identified":[75],"intermediate":[77],"neuroblastomas":[81],"critical":[82],"for":[83,94],"malignant":[84],"transitions":[85,114],"uncovered":[87],"extensive":[88],"priming":[90],"with":[91,120],"latent":[92],"capacity":[93],"diverse":[95],"state":[96],"transitions.":[97],"Furthermore,":[98],"mapped":[100],"enhancer":[101],"gene":[102],"networks":[104],"(eGRNs)":[105],"microenvironments":[108],"sustaining":[109],"these":[110],"aggressive":[111],"states.":[112],"State":[113],"malignancy":[116],"could":[117],"be":[118],"interfered":[119],"by":[121],"targeting":[122],"transcription":[123],"factors":[124],"controlling":[125],"eGRNs.":[127]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-05-10T00:00:00"}