{"id":"https://openalex.org/W4410222001","doi":"https://doi.org/10.1055/s-0045-1809001","title":"Memory-like NK cell and CD19-antibody based immunotherapy combined with TKI has antitumor effects against Ph(-like) ALL","display_name":"Memory-like NK cell and CD19-antibody based immunotherapy combined with TKI has antitumor effects against Ph(-like) ALL","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4410222001","doi":"https://doi.org/10.1055/s-0045-1809001"},"language":"en","primary_location":{"id":"doi:10.1055/s-0045-1809001","doi":"https://doi.org/10.1055/s-0045-1809001","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0045-1809001","pdf_url":null,"source":{"id":"https://openalex.org/S186178718","display_name":"Klinische P\u00e4diatrie","issn_l":"0300-8630","issn":["0300-8630","1439-3824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische P\u00e4diatrie","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066612645","display_name":"Adam Lane","orcid":"https://orcid.org/0000-0002-5522-8112","observed_orcids":["https://orcid.org/0000-0002-5522-8112"]},"institutions":[{"id":"https://openalex.org/I4210108730","display_name":"Kinderkrebs-Zentrum Hamburg","ror":"https://ror.org/021924r89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210108730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Lane","raw_affiliation_strings":["Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034798152","display_name":"Nadja Kleist","orcid":"https://orcid.org/0000-0002-0409-0467","observed_orcids":["https://orcid.org/0000-0002-0409-0467"]},"institutions":[{"id":"https://openalex.org/I4210108730","display_name":"Kinderkrebs-Zentrum Hamburg","ror":"https://ror.org/021924r89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210108730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N Kleist","raw_affiliation_strings":["Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009948430","display_name":"Antonina Wrzeszcz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108730","display_name":"Kinderkrebs-Zentrum Hamburg","ror":"https://ror.org/021924r89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210108730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Wrzeszcz","raw_affiliation_strings":["Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089507510","display_name":"Julia Strau\u00df","orcid":"https://orcid.org/0009-0008-7016-8817","observed_orcids":["https://orcid.org/0009-0008-7016-8817"]},"institutions":[{"id":"https://openalex.org/I4210108730","display_name":"Kinderkrebs-Zentrum Hamburg","ror":"https://ror.org/021924r89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210108730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Strauss","raw_affiliation_strings":["Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080630441","display_name":"Stephen J. Schuster","orcid":"https://orcid.org/0000-0002-3376-8978","observed_orcids":["https://orcid.org/0000-0002-3376-8978"]},"institutions":[{"id":"https://openalex.org/I4210108730","display_name":"Kinderkrebs-Zentrum Hamburg","ror":"https://ror.org/021924r89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210108730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Schuster","raw_affiliation_strings":["Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061339000","display_name":"Richard T. Hauch","orcid":"https://orcid.org/0000-0002-1282-4803","observed_orcids":["https://orcid.org/0000-0002-1282-4803"]},"institutions":[{"id":"https://openalex.org/I4210108730","display_name":"Kinderkrebs-Zentrum Hamburg","ror":"https://ror.org/021924r89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210108730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Hauch","raw_affiliation_strings":["Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051542325","display_name":"Dorothee Winterberg","orcid":"https://orcid.org/0009-0009-9840-8074","observed_orcids":["https://orcid.org/0009-0009-9840-8074"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D Winterberg","raw_affiliation_strings":["Kiel University, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kiel University, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004327062","display_name":"Katja Klausz","orcid":"https://orcid.org/0009-0001-5626-4967","observed_orcids":["https://orcid.org/0009-0001-5626-4967"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K Klausz","raw_affiliation_strings":["Kiel University, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kiel University, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012207265","display_name":"Matthias Peipp","orcid":"https://orcid.org/0000-0002-5088-3804","observed_orcids":["https://orcid.org/0000-0002-5088-3804"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Peipp","raw_affiliation_strings":["Kiel University, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kiel University, Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102858212","display_name":"Martin A. Horstmann","orcid":"https://orcid.org/0000-0001-8559-8862","observed_orcids":["https://orcid.org/0000-0001-8559-8862"]},"institutions":[{"id":"https://openalex.org/I4210108730","display_name":"Kinderkrebs-Zentrum Hamburg","ror":"https://ror.org/021924r89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210108730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Horstmann","raw_affiliation_strings":["Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute Children&apos;s Cancer Center Hamburg, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108730"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26984127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"237","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.43650001287460327,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.43650001287460327,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.29170000553131104,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.21950000524520874,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/philadelphia-like-acute-lymphoblastic-leukemia","display_name":"Philadelphia-like acute lymphoblastic leukemia","score":0.968999981880188},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.765999972820282},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8270000219345093},{"id":"https://openalex.org/keywords/leukemia-free-survival","display_name":"leukemia-free survival","score":0.7310000061988831},{"id":"https://openalex.org/keywords/nk-cell-persistence","display_name":"NK cell persistence","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.6388874053955078},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6186738014221191},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5498143434524536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3910205066204071},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34737318754196167},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1325531303882599}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0045-1809001","doi":"https://doi.org/10.1055/s-0045-1809001","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0045-1809001","pdf_url":null,"source":{"id":"https://openalex.org/S186178718","display_name":"Klinische P\u00e4diatrie","issn_l":"0300-8630","issn":["0300-8630","1439-3824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische P\u00e4diatrie","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409078061","https://openalex.org/W4399613310","https://openalex.org/W4395068276","https://openalex.org/W3177964189","https://openalex.org/W4414444580","https://openalex.org/W4362657436","https://openalex.org/W4283370904","https://openalex.org/W2521303139","https://openalex.org/W2779029759","https://openalex.org/W2463334306"],"abstract_inverted_index":{"Philadelphia-like":[0],"acute":[1],"lymphoblastic":[2],"leukemia":[3,73,104],"(Ph-like":[4],"ALL)":[5],"is":[6],"a":[7,15,75],"molecularly":[8],"distinct":[9],"tyrosine":[10],"kinase-driven":[11,103],"entity":[12],"burdened":[13],"with":[14,41,74,93,122],"high":[16],"risk":[17,77],"of":[18,39,78,114],"relapse":[19],"and":[20,56,88,117,142],"poor":[21],"response":[22],"toward":[23],"combinatorial":[24],"chemotherapy.":[25],"Tyrosine":[26],"kinase":[27],"inhibitors":[28],"(TKI)":[29],"have":[30],"been":[31,60,69],"in":[32,98,102,110],"clinical":[33],"use":[34],"to":[35,71,147],"improve":[36],"the":[37,109],"survival":[38,145],"patients":[40],"Ph-like":[42,127],"ALL,":[43],"yet":[44],"preliminary":[45],"data":[46],"indicate":[47],"subpar":[48],"outcome.":[49],"To":[50],"advance":[51],"treatment":[52,100,112,131],"concepts":[53],"engineered":[54],"antibody":[55],"cell-based":[57],"immunotherapy":[58,91,120],"has":[59],"proposed.":[61],"Allogeneic":[62],"memory-like":[63],"natural":[64],"killer":[65],"(ML-NK)":[66],"cells":[67],"had":[68],"used":[70],"treat":[72],"low":[76],"graft-versus-host":[79],"reaction.":[80],"Previously,":[81],"we":[82,107],"demonstrated":[83],"that":[84],"optimized":[85],"ML-NK":[86,115,139],"cell":[87,116,140],"CD19":[89,118],"antibody-based":[90,119],"combined":[92,121],"selective":[94],"TKI":[95,123,148],"demonstrates":[96],"significant":[97],"vitro":[99],"efficacy":[101,113],"models.":[105],"Lately,":[106],"investigated":[108],"vivo":[111],"against":[124],"patient-derived":[125],"xenografted":[126],"ALL.":[128],"Our":[129],"proposed":[130],"approach":[132],"was":[133],"associated":[134],"with,":[135],"lower":[136],"tumor":[137],"burden,":[138],"persistence":[141],"increased":[143],"leukemia-free":[144],"compared":[146],"monotherapy.":[149],"Publication":[150],"History":[151],"Article":[152],"published":[153],"online:":[154],"09":[155],"May":[156],"2025":[157],"\u00a9":[158],"2025.":[159],"Thieme.":[160],"All":[161],"rights":[162],"reserved.":[163],"Georg":[164],"Thieme":[165],"Verlag":[166],"KG":[167],"Oswald-Hesse-Stra\u00dfe":[168],"50,":[169],"70469":[170],"Stuttgart,":[171],"Germany":[172]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-05-10T00:00:00"}
