{"id":"https://openalex.org/W4410217536","doi":"https://doi.org/10.1038/s41598-025-01287-6","title":"Metabolic mediators of the overweight\u2019s effect on infertility in women with polycystic ovary syndrome","display_name":"Metabolic mediators of the overweight\u2019s effect on infertility in women with polycystic ovary syndrome","publication_year":2025,"publication_date":"2025-05-09","ids":{"openalex":"https://openalex.org/W4410217536","doi":"https://doi.org/10.1038/s41598-025-01287-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/40346143"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-025-01287-6","doi":"https://doi.org/10.1038/s41598-025-01287-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-01287-6","pdf_url":"https://www.nature.com/articles/s41598-025-01287-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-025-01287-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002943072","display_name":"Kasra Jafari","orcid":"https://orcid.org/0009-0002-1029-1000","observed_orcids":["https://orcid.org/0009-0002-1029-1000"]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Kasra Jafari","raw_affiliation_strings":["Department of Epidemiology, School of Health, Iran University of Medical Sciences, Tehran, Iran","Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Health, Iran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I161106909"]},{"raw_affiliation_string":"Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105912674","display_name":"Nooshan Tajik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nooshan Tajik","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067526273","display_name":"Ashraf Moini","orcid":"https://orcid.org/0000-0002-7114-8331","observed_orcids":["https://orcid.org/0000-0002-7114-8331"]},"institutions":[{"id":"https://openalex.org/I202419968","display_name":"Royan Institute","ror":"https://ror.org/02exhb815","country_code":"IR","type":"nonprofit","lineage":["https://openalex.org/I202419968"]},{"id":"https://openalex.org/I4210087510","display_name":"Roointan Arash Hospital","ror":"https://ror.org/00214hk10","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210087510"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ashraf Moini","raw_affiliation_strings":["Breast Disease Research Center (BDRC), Tehran University Of Medical Sciences, Tehran, Iran","Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran","Department of Obstetrics and Gynecology, Endocrinology and Female Infertility Unit, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Disease Research Center (BDRC), Tehran University Of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]},{"raw_affiliation_string":"Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran","institution_ids":["https://openalex.org/I202419968"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Endocrinology and Female Infertility Unit, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4210087510","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051105938","display_name":"SeyedAhmad SeyedAlinaghi","orcid":"https://orcid.org/0000-0003-3210-7905","observed_orcids":["https://orcid.org/0000-0003-3210-7905"]},"institutions":[{"id":"https://openalex.org/I4403928389","display_name":"Iranian Research Center for HIV/AIDS","ror":"https://ror.org/04d9kk613","country_code":null,"type":"facility","lineage":["https://openalex.org/I4403928389","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"SeyedAhmad SeyedAlinaghi","raw_affiliation_strings":["Iranian Institute for Reduction of High-Risk Behaviors, Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran","Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iranian Institute for Reduction of High-Risk Behaviors, Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928389","https://openalex.org/I70640408"]},{"raw_affiliation_string":"Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070330890","display_name":"Amene Abiri","orcid":"https://orcid.org/0000-0002-0207-5677","observed_orcids":["https://orcid.org/0000-0002-0207-5677"]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Amene Abiri","raw_affiliation_strings":["Department of Obstetrics and Gynecology, School of Medicine, Arash Women's Hospital, Tehran University of Medical Sciences, Eastern 162th St., Baghdarnia St., Resalat Highway, Tehranpars, PO box: 1653915981, Tehran, Iran. abiri@tums.ac.ir","Department of Obstetrics and Gynecology, School of Medicine, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran. abiri@tums.ac.ir"],"raw_orcid":"https://orcid.org/0000-0002-0207-5677","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, School of Medicine, Arash Women's Hospital, Tehran University of Medical Sciences, Eastern 162th St., Baghdarnia St., Resalat Highway, Tehranpars, PO box: 1653915981, Tehran, Iran. abiri@tums.ac.ir","institution_ids":["https://openalex.org/I70640408"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, School of Medicine, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran. abiri@tums.ac.ir","institution_ids":["https://openalex.org/I70640408"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070330890"],"corresponding_institution_ids":["https://openalex.org/I70640408"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":4.089,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.93804449,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"16258","last_page":"16258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":1.0},{"id":"https://openalex.org/keywords/female-infertility","display_name":"female infertility","score":0.9430000185966492},{"id":"https://openalex.org/keywords/overweight","display_name":"overweight","score":0.8550000190734863},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9890000224113464},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8870000243186951},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9359999895095825},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8669999837875366},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.8870000243186951},{"id":"https://openalex.org/keywords/metabolic-mediators","display_name":"metabolic mediators","score":0.746999979019165},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.9641156196594238},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.814488410949707},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.7913475036621094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5656970739364624},{"id":"https://openalex.org/C2779647306","wikidata":"https://www.wikidata.org/wiki/Q648065","display_name":"Female infertility","level":4,"score":0.5380065441131592},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5239677429199219},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.49398237466812134},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.43951216340065},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42080971598625183},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.42021501064300537},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41037294268608093},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.39341554045677185},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.32830941677093506},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.30470842123031616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2726449966430664},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1573764681816101},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06267669796943665}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007492","descriptor_name":"Iran","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007492","descriptor_name":"Iran","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007492","descriptor_name":"Iran","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007492","descriptor_name":"Iran","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-025-01287-6","doi":"https://doi.org/10.1038/s41598-025-01287-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-01287-6","pdf_url":"https://www.nature.com/articles/s41598-025-01287-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:40346143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40346143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12064820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12064820","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:523c2e11b1c848e4a8d98fdf21c55c04","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/523c2e11b1c848e4a8d98fdf21c55c04","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 15, Iss 1, Pp 1-7 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-025-01287-6","doi":"https://doi.org/10.1038/s41598-025-01287-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-01287-6","pdf_url":"https://www.nature.com/articles/s41598-025-01287-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Gender equality","id":"https://metadata.un.org/sdg/5","score":0.5899999737739563}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410217536.pdf","grobid_xml":"https://content.openalex.org/works/W4410217536.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1577097214","https://openalex.org/W1582948480","https://openalex.org/W1836408129","https://openalex.org/W1849634620","https://openalex.org/W1943352132","https://openalex.org/W1970586482","https://openalex.org/W1998682109","https://openalex.org/W2001434052","https://openalex.org/W2020228466","https://openalex.org/W2029836009","https://openalex.org/W2031726677","https://openalex.org/W2056399290","https://openalex.org/W2062436615","https://openalex.org/W2089391845","https://openalex.org/W2095829298","https://openalex.org/W2110453893","https://openalex.org/W2112553362","https://openalex.org/W2128696760","https://openalex.org/W2135494941","https://openalex.org/W2170563191","https://openalex.org/W2186218348","https://openalex.org/W2398526138","https://openalex.org/W2548567961","https://openalex.org/W2559866137","https://openalex.org/W2564015027","https://openalex.org/W2576536258","https://openalex.org/W2594925855","https://openalex.org/W2751209738","https://openalex.org/W2772478311","https://openalex.org/W2793887346","https://openalex.org/W2800554476","https://openalex.org/W2884536266","https://openalex.org/W2911538911","https://openalex.org/W2972230104","https://openalex.org/W2981657781","https://openalex.org/W3005620377","https://openalex.org/W3026155818","https://openalex.org/W3154625980","https://openalex.org/W4212784858","https://openalex.org/W4220745740","https://openalex.org/W4244088697","https://openalex.org/W4384341585","https://openalex.org/W4386783847","https://openalex.org/W4387572807","https://openalex.org/W4391316306","https://openalex.org/W4399051978"],"related_works":["https://openalex.org/W2048189375","https://openalex.org/W2942270243","https://openalex.org/W2175122247","https://openalex.org/W4324129634","https://openalex.org/W2413118143","https://openalex.org/W2729095968","https://openalex.org/W2206137390","https://openalex.org/W2384785714","https://openalex.org/W4388153708","https://openalex.org/W2336733101"],"abstract_inverted_index":{"Women":[0],"with":[1,72,95,127,189],"polycystic":[2],"ovary":[3],"syndrome":[4],"(PCOS)":[5],"often":[6],"experience":[7],"infertility,":[8],"potentially":[9],"mediated":[10,161,195],"by":[11,15],"metabolic":[12,61,200],"factors":[13],"altered":[14],"elevated":[16],"body":[17],"mass":[18],"index":[19],"(BMI).":[20],"While":[21],"triglycerides":[22],"(TG),":[23],"low-density":[24],"lipoprotein":[25,28],"(LDL),":[26],"high-density":[27],"(HDL),":[29],"and":[30,91,133,135,158,169,180],"fasting":[31],"blood":[32],"sugar":[33],"(FBS)":[34],"are":[35],"known":[36],"mediators":[37,184],"in":[38,50,78,207],"the":[39,42,56,99,114,162,172,186,193],"BMI-infertility":[40,163,187],"relationship,":[41],"extent":[43],"of":[44,59,106,130,139,171,185,192],"their":[45],"mediation":[46,57],"effects":[47],"remains":[48],"unquantified":[49],"prior":[51],"studies.":[52],"This":[53],"study":[54,67,176],"quantifies":[55],"effect":[58],"these":[60,197],"factors.":[62,198],"We":[63],"conducted":[64],"a":[65,75],"cross-sectional":[66],"on":[68,86],"669":[69],"women":[70],"diagnosed":[71],"PCOS":[73],"at":[74],"tertiary":[76],"hospital":[77],"Tehran,":[79],"Iran,":[80],"from":[81],"2021":[82],"to":[83,101,146],"2023.":[84],"Data":[85],"BMI,":[87],"TG,":[88,131,156,178],"LDL,":[89,132],"HDL,":[90,137,157,179],"FBS":[92,134,159,181],"were":[93,144],"collected,":[94],"infertility":[96,205],"defined":[97],"as":[98,182],"inability":[100],"conceive":[102],"after":[103,152],"12":[104],"months":[105],"unprotected":[107],"intercourse.":[108],"Mediation":[109,148],"analysis":[110,149],"was":[111,125],"performed":[112],"using":[113],"Karlson":[115],"Holm":[116],"Breen":[117],"(KHB)":[118],"method,":[119],"adjusting":[120,153],"for":[121,142,154,166],"age.":[122],"Higher":[123],"BMI":[124],"associated":[126],"increased":[128],"levels":[129],"decreased":[136],"all":[138],"which":[140],"(except":[141],"LDL)":[143],"linked":[145],"infertility.":[147],"revealed":[150],"that":[151],"age,":[155],"significantly":[160],"association,":[164],"accounting":[165],"52.98%,":[167],"79.19%,":[168],"49.7%":[170],"effect,":[173],"respectively.":[174],"Our":[175],"identified":[177],"significant":[183],"link,":[188],"over":[190],"half":[191],"association":[194],"through":[196],"Targeting":[199],"improvements":[201],"may":[202],"help":[203],"reduce":[204],"risk":[206],"this":[208],"population.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}