{"id":"https://openalex.org/W4410191075","doi":"https://doi.org/10.7759/cureus.83723","title":"A Comprehensive Approach to Differentiating Systemic Lupus Erythematosus From Other Autoimmune Diseases Presenting With Optic Neuritis","display_name":"A Comprehensive Approach to Differentiating Systemic Lupus Erythematosus From Other Autoimmune Diseases Presenting With Optic Neuritis","publication_year":2025,"publication_date":"2025-05-08","ids":{"openalex":"https://openalex.org/W4410191075","doi":"https://doi.org/10.7759/cureus.83723","pmid":"https://pubmed.ncbi.nlm.nih.gov/40486405","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12144925"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.83723","doi":"https://doi.org/10.7759/cureus.83723","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.83723","pdf_url":"https://assets.cureus.com/uploads/review_article/pdf/360934/20250508-232760-31zr0i.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://assets.cureus.com/uploads/review_article/pdf/360934/20250508-232760-31zr0i.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jason Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089330","display_name":"Cooper Medical School of Rowan University","ror":"https://ror.org/007evha27","country_code":"US","type":"education","lineage":["https://openalex.org/I4210089330","https://openalex.org/I4210157085","https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Peng","raw_affiliation_strings":["Medical School, Cooper Medical School of Rowan University, Camden, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, Cooper Medical School of Rowan University, Camden, USA","institution_ids":["https://openalex.org/I4210089330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064203079","display_name":"Nada Alrifai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800704349","display_name":"Cooper University Hospital","ror":"https://ror.org/049wjac82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800704349","https://openalex.org/I4210157085"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nada Alrifai","raw_affiliation_strings":["Rheumatology, Cooper University Hospital, Camden, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Cooper University Hospital, Camden, USA","institution_ids":["https://openalex.org/I2800704349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107620152","display_name":"Salvatore D DeSimone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800704349","display_name":"Cooper University Hospital","ror":"https://ror.org/049wjac82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800704349","https://openalex.org/I4210157085"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salvatore D DeSimone","raw_affiliation_strings":["Ophthalmology, Cooper University Hospital, Camden, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Cooper University Hospital, Camden, USA","institution_ids":["https://openalex.org/I2800704349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074718309","display_name":"Pietro M. Gentile","orcid":"https://orcid.org/0000-0002-0223-4260","observed_orcids":["https://orcid.org/0000-0002-0223-4260"]},"institutions":[{"id":"https://openalex.org/I2800704349","display_name":"Cooper University Hospital","ror":"https://ror.org/049wjac82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800704349","https://openalex.org/I4210157085"]},{"id":"https://openalex.org/I4210157085","display_name":"Cooper Norcross Health","ror":"https://ror.org/056nm0533","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157085"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pietro M Gentile","raw_affiliation_strings":["Bone and Joint Institute, Cooper University Hospital, Camden, USA","Orthopedic Surgery, Cooper University Health Care, Camden, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone and Joint Institute, Cooper University Hospital, Camden, USA","institution_ids":["https://openalex.org/I2800704349"]},{"raw_affiliation_string":"Orthopedic Surgery, Cooper University Health Care, Camden, USA","institution_ids":["https://openalex.org/I4210157085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030632522","display_name":"Pamela Traisak","orcid":"https://orcid.org/0000-0002-1840-8763","observed_orcids":["https://orcid.org/0000-0002-1840-8763"]},"institutions":[{"id":"https://openalex.org/I4210157085","display_name":"Cooper Norcross Health","ror":"https://ror.org/056nm0533","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157085"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela Traisak","raw_affiliation_strings":["Rheumatology, Cooper University Health Care, Camden, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Cooper University Health Care, Camden, USA","institution_ids":["https://openalex.org/I4210157085"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marisa Karpoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800704349","display_name":"Cooper University Hospital","ror":"https://ror.org/049wjac82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800704349","https://openalex.org/I4210157085"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marisa Karpoff","raw_affiliation_strings":["Rheumatology, Cooper University Hospital, Camden, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Cooper University Hospital, Camden, USA","institution_ids":["https://openalex.org/I2800704349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063317163","display_name":"David Feinstein","orcid":"https://orcid.org/0000-0003-2012-0117","observed_orcids":["https://orcid.org/0000-0003-2012-0117"]},"institutions":[{"id":"https://openalex.org/I2800704349","display_name":"Cooper University Hospital","ror":"https://ror.org/049wjac82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800704349","https://openalex.org/I4210157085"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Feinstein","raw_affiliation_strings":["Rheumatology, Cooper University Hospital, Cooper Medical School, Camden, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Cooper University Hospital, Cooper Medical School, Camden, USA","institution_ids":["https://openalex.org/I2800704349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068200684","display_name":"Hala Eid","orcid":"https://orcid.org/0000-0003-0966-2740","observed_orcids":["https://orcid.org/0000-0003-0966-2740"]},"institutions":[{"id":"https://openalex.org/I4210157085","display_name":"Cooper Norcross Health","ror":"https://ror.org/056nm0533","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157085"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hala Eid","raw_affiliation_strings":["Rheumatology, Cooper University Health Care, Camden, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Cooper University Health Care, Camden, USA","institution_ids":["https://openalex.org/I4210157085"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048684772","display_name":"Joseph D. DeSimone","orcid":"https://orcid.org/0000-0001-5770-6256","observed_orcids":["https://orcid.org/0000-0001-5770-6256"]},"institutions":[{"id":"https://openalex.org/I871049931","display_name":"Wills Eye Hospital","ror":"https://ror.org/03qygnx22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I871049931"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D DeSimone","raw_affiliation_strings":["Ophthalmology, Wills Eye Hospital, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Wills Eye Hospital, Philadelphia, USA","institution_ids":["https://openalex.org/I871049931"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074718309"],"corresponding_institution_ids":["https://openalex.org/I2800704349","https://openalex.org/I4210157085"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02548055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"5","first_page":"e83723","last_page":"e83723"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.996999979019165},{"id":"https://openalex.org/keywords/optic-neuritis","display_name":"optic neuritis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/neuromyelitis-optica-spectrum-disorder","display_name":"neuromyelitis optica spectrum disorder","score":1.0},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/visual-impairment","display_name":"visual impairment","score":0.5879999995231628},{"id":"https://openalex.org/keywords/semaphorins","display_name":"semaphorins","score":0.8960000276565552},{"id":"https://openalex.org/keywords/complement-levels","display_name":"complement levels","score":0.9139999747276306},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.5170000195503235},{"id":"https://openalex.org/keywords/ocular-manifestations","display_name":"ocular manifestations","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.979732096195221},{"id":"https://openalex.org/C2776572573","wikidata":"https://www.wikidata.org/wiki/Q972514","display_name":"Optic neuritis","level":3,"score":0.7188825607299805},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5678247213363647},{"id":"https://openalex.org/C2776028648","wikidata":"https://www.wikidata.org/wiki/Q2307256","display_name":"Neuritis","level":2,"score":0.47921067476272583},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4367712736129761},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.2990102171897888},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.05555561184883118}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.83723","doi":"https://doi.org/10.7759/cureus.83723","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.83723","pdf_url":"https://assets.cureus.com/uploads/review_article/pdf/360934/20250508-232760-31zr0i.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12144925","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12144925","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:40486405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40486405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7759/cureus.83723","doi":"https://doi.org/10.7759/cureus.83723","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.83723","pdf_url":"https://assets.cureus.com/uploads/review_article/pdf/360934/20250508-232760-31zr0i.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410191075.pdf","grobid_xml":"https://content.openalex.org/works/W4410191075.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W22214700","https://openalex.org/W1751726804","https://openalex.org/W1822820308","https://openalex.org/W1986378262","https://openalex.org/W1993761012","https://openalex.org/W2004027147","https://openalex.org/W2067561265","https://openalex.org/W2099047134","https://openalex.org/W2108798081","https://openalex.org/W2139822727","https://openalex.org/W2148991512","https://openalex.org/W2277156399","https://openalex.org/W2290544499","https://openalex.org/W2435427007","https://openalex.org/W2797502828","https://openalex.org/W2806512946","https://openalex.org/W2905645019","https://openalex.org/W2948130939","https://openalex.org/W2950431598","https://openalex.org/W2970049586","https://openalex.org/W2978571293","https://openalex.org/W2983885775","https://openalex.org/W2991065228","https://openalex.org/W3005681385","https://openalex.org/W3012812314","https://openalex.org/W3044155913","https://openalex.org/W3048007933","https://openalex.org/W3089370604","https://openalex.org/W3094125028","https://openalex.org/W3111342919","https://openalex.org/W3119121025","https://openalex.org/W3157190936","https://openalex.org/W3195042347","https://openalex.org/W4280619674","https://openalex.org/W4284958952","https://openalex.org/W4286268706","https://openalex.org/W4296902573","https://openalex.org/W4306181506","https://openalex.org/W4401982563"],"related_works":["https://openalex.org/W7118212937","https://openalex.org/W4391753807","https://openalex.org/W7135031266","https://openalex.org/W132424905","https://openalex.org/W4413297483","https://openalex.org/W2396337517","https://openalex.org/W4402098583","https://openalex.org/W2172025244","https://openalex.org/W7126238402","https://openalex.org/W2321338369"],"abstract_inverted_index":{"Systemic":[0],"lupus":[1],"erythematosus":[2],"(SLE)":[3],"is":[4,16,131,156],"a":[5,119,207],"complex":[6],"autoimmune":[7,77,105,298],"disease":[8],"with":[9,145,177],"significant":[10],"morbidity":[11],"and":[12,58,72,84,100,110,141,149,166,179,227,233,250,257,262,291],"mortality.":[13],"Early":[14],"diagnosis":[15,256,290],"crucial":[17],"for":[18,254,280],"effective":[19],"management.":[20],"Ocular":[21],"manifestations,":[22,224],"particularly":[23],"optic":[24],"neuritis":[25],"(ON),":[26],"have":[27,183],"emerged":[28],"as":[29,192,231,284],"potential":[30],"early":[31,286],"signs":[32],"of":[33,67,115,123,138,153,187,246,259,276,295],"SLE.":[34,111],"This":[35,240],"systematic":[36,60,241],"literature":[37,61,92],"review":[38,242],"analyzes":[39],"23":[40,116],"studies,":[41,45,48,51],"including":[42,203],"eight":[43],"retrospective":[44],"five":[46],"cross-sectional":[47],"two":[49],"cohort":[50],"four":[52],"case":[53],"reports,":[54],"one":[55],"narrative":[56],"review,":[57],"three":[59],"reviews,":[62],"to":[63,163,173,273],"investigate":[64],"the":[65,126,185,244,274],"use":[66],"ON":[68,130,161,165,266,283],"in":[69,136,159,195,210,267],"diagnosing":[70],"SLE":[71,139,212,281],"differentiating":[73],"it":[74],"from":[75],"other":[76],"diseases,":[78,106],"most":[79],"notably":[80],"multiple":[81,167,220],"sclerosis":[82],"(MS)":[83],"neuromyelitis":[85],"optica":[86],"spectrum":[87],"disorder":[88],"(NMOSD).":[89],"A":[90],"comprehensive":[91],"search":[93],"was":[94],"conducted":[95],"by":[96],"combining":[97],"various":[98],"keywords":[99],"MeSH":[101],"terms,":[102],"focusing":[103],"on":[104],"ON,":[107],"MS,":[108],"NMOSD,":[109,261],"The":[112],"final":[113],"selection":[114],"studies":[117,182],"reflected":[118],"methodologically":[120],"diverse":[121],"body":[122],"literature,":[124],"enhancing":[125],"review's":[127],"robustness.":[128],"SLE-associated":[129,160],"rare":[132],"but":[133],"distinctive,":[134],"occurring":[135],"1%":[137],"patients":[140,213],"often":[142],"presenting":[143],"bilaterally":[144],"severe":[146],"visual":[147,154],"impairment":[148],"intense":[150],"pain.":[151],"Recovery":[152],"acuity":[155],"less":[157],"common":[158],"compared":[162],"idiopathic":[164],"sclerosis.":[168],"Diagnostic":[169],"challenges":[170],"arise":[171],"due":[172],"overlapping":[174],"clinical":[175,268],"features":[176],"NMOSD":[178],"MS.":[180],"Various":[181],"highlighted":[184],"significance":[186],"specific":[188],"antibody":[189],"profiles,":[190],"such":[191,230],"anti-aquaporin-4":[193],"IgG,":[194],"distinguishing":[196],"between":[197],"these":[198],"conditions.":[199],"Additionally,":[200],"neuroimaging":[201],"findings,":[202],"MRI":[204],"characteristics,":[205],"play":[206],"pivotal":[208],"role":[209],"differentiation.":[211],"may":[214],"exhibit":[215],"unique":[216],"lesion":[217],"patterns":[218],"spanning":[219],"vertebral":[221],"bodies.":[222],"Dermatological":[223],"genetic":[225],"factors,":[226],"blood":[228],"biomarkers,":[229],"semaphorins":[232],"complement":[234],"levels,":[235],"also":[236],"offer":[237],"diagnostic":[238,278],"insights.":[239],"underscores":[243],"importance":[245],"integrating":[247],"clinical,":[248],"laboratory,":[249],"radiologic":[251],"imaging":[252],"data":[253],"precise":[255],"differentiation":[258],"SLE,":[260],"MS":[263],"when":[264],"encountering":[265],"practice.":[269],"These":[270],"findings":[271],"contribute":[272],"development":[275],"concrete":[277],"criteria":[279],"using":[282],"an":[285],"symptom,":[287],"facilitating":[288],"faster":[289],"more":[292],"efficient":[293],"management":[294],"this":[296],"debilitating":[297],"disease.":[299]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-05-08T00:00:00"}
