{"id":"https://openalex.org/W4410103220","doi":"https://doi.org/10.55214/25768484.v9i5.6806","title":"Design, synthesis and antimicrobial activity screening of new dimethyl maleimidyl heterocyclic derivatives based on 4-(N-dimethyl maleimidyl) phenyl hydrazide","display_name":"Design, synthesis and antimicrobial activity screening of new dimethyl maleimidyl heterocyclic derivatives based on 4-(N-dimethyl maleimidyl) phenyl hydrazide","publication_year":2025,"publication_date":"2025-05-03","ids":{"openalex":"https://openalex.org/W4410103220","doi":"https://doi.org/10.55214/25768484.v9i5.6806"},"language":"en","primary_location":{"id":"doi:10.55214/25768484.v9i5.6806","doi":"https://doi.org/10.55214/25768484.v9i5.6806","is_oa":true,"landing_page_url":"https://doi.org/10.55214/25768484.v9i5.6806","pdf_url":"https://learning-gate.com/index.php/2576-8484/article/download/6806/2396","source":{"id":"https://openalex.org/S4210188960","display_name":"Edelweiss Applied Science and Technology","issn_l":"2576-8484","issn":["2576-8484"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Edelweiss Applied Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://learning-gate.com/index.php/2576-8484/article/download/6806/2396","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117442960","display_name":"Zainab Majid Sadiq","orcid":"https://orcid.org/0009-0003-2834-9810","observed_orcids":["https://orcid.org/0009-0003-2834-9810"]},"institutions":[{"id":"https://openalex.org/I135120706","display_name":"University of Baghdad","ror":"https://ror.org/007f1da21","country_code":"IQ","type":"education","lineage":["https://openalex.org/I135120706"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Zainab Majid Sadiq","raw_affiliation_strings":["Department of Chemistry, College of Science, University of Baghdad, Baghdad. Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Science, University of Baghdad, Baghdad. Iraq","institution_ids":["https://openalex.org/I135120706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081068133","display_name":"Ahlam Marouf Al-Azzawi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135120706","display_name":"University of Baghdad","ror":"https://ror.org/007f1da21","country_code":"IQ","type":"education","lineage":["https://openalex.org/I135120706"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Ahlam Marouf Al-Azzawi","raw_affiliation_strings":["Department of Chemistry, College of Science, University of Baghdad, Baghdad. Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Science, University of Baghdad, Baghdad. Iraq","institution_ids":["https://openalex.org/I135120706"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135120706"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05331626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"5","first_page":"120","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.7261000275611877,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.7261000275611877,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.09059999883174896,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.07540000230073929,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schiff-base-derivatives","display_name":"Schiff base derivatives","score":0.597000002861023},{"id":"https://openalex.org/keywords/dihydroquinazolines","display_name":"dihydroquinazolines","score":0.890999972820282},{"id":"https://openalex.org/keywords/oxadiazole","display_name":"oxadiazole","score":0.8690000176429749},{"id":"https://openalex.org/keywords/pyrrole-derivatives","display_name":"pyrrole derivatives","score":0.6830000281333923},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/antibacterial-agents","display_name":"antibacterial agents","score":0.6320000290870667},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.996999979019165},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2775998212","wikidata":"https://www.wikidata.org/wiki/Q419637","display_name":"Hydrazide","level":2,"score":0.8694276809692383},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8060320615768433},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5375599265098572},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.44317278265953064},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4190168082714081}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.55214/25768484.v9i5.6806","doi":"https://doi.org/10.55214/25768484.v9i5.6806","is_oa":true,"landing_page_url":"https://doi.org/10.55214/25768484.v9i5.6806","pdf_url":"https://learning-gate.com/index.php/2576-8484/article/download/6806/2396","source":{"id":"https://openalex.org/S4210188960","display_name":"Edelweiss Applied Science and Technology","issn_l":"2576-8484","issn":["2576-8484"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Edelweiss Applied Science and Technology","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:ajp:edwast:v:9:y:2025:i:5:p:120-135:id:6806","doi":null,"is_oa":false,"landing_page_url":"https://learning-gate.com/index.php/2576-8484/article/view/6806/2396","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.55214/25768484.v9i5.6806","doi":"https://doi.org/10.55214/25768484.v9i5.6806","is_oa":true,"landing_page_url":"https://doi.org/10.55214/25768484.v9i5.6806","pdf_url":"https://learning-gate.com/index.php/2576-8484/article/download/6806/2396","source":{"id":"https://openalex.org/S4210188960","display_name":"Edelweiss Applied Science and Technology","issn_l":"2576-8484","issn":["2576-8484"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Edelweiss Applied Science and Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410103220.pdf","grobid_xml":"https://content.openalex.org/works/W4410103220.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W4283031737","https://openalex.org/W4402778000","https://openalex.org/W1986235482"],"abstract_inverted_index":{"The":[0,21,177],"research":[1,183],"involved":[2],"the":[3,32,42,62,73,110,132,156,159,164,173,180,185],"design":[4],"and":[5,193],"synthesis":[6,19,22],"of":[7,10,23,34,112,134,158,166,179,184,191],"a":[8,17,81,138,143],"collection":[9],"innovative":[11],"dimethyl":[12,35,104,125],"maleimide":[13],"heterocyclic":[14],"derivatives":[15,90],"through":[16,31],"multistep":[18],"process.":[20],"compound":[24,54,76,135,161,167,175],"[1]":[25,46],"ethyl-4-(N-dimethyl":[26],"maleimidyl)":[27],"benzoate":[28],"was":[29,47,78],"achieved":[30],"reaction":[33,83,139],"maleic":[36],"anhydride":[37,117],"with":[38,49,84,96,115,140,151,169],"ethyl-4-amino":[39],"benzoate.":[40],"In":[41,72],"second":[43],"stage,":[44],"molecule":[45],"reacted":[48,95],"hydrazine":[50,152],"hydrate":[51],"to":[52,80,98],"provide":[53],"[2]":[55,60,77,136,168],"4-(N-dimethyl":[56],"maleimidyl)phenyl":[57],"hydrazide.":[58],"Compound":[59],"is":[61,146],"crucial":[63],"precursor":[64],"from":[65],"which":[66,92],"all":[67],"objectives":[68],"compounds":[69,101,113,122,187],"were":[70,93],"produced.":[71],"third":[74],"step,":[75],"subjected":[79],"condensation":[82,165],"aromatic":[85],"aldehydes,":[86],"yielding":[87],"Schiff":[88],"base":[89],"[3-5]":[91,114],"subsequently":[94],"acid":[97],"produce":[99],"target":[100,121,160,174,186],"[6-8]":[102],"specifically":[103],"maleimides":[105,126],"featuring":[106],"dihydroquinazoline":[107],"cycles.":[108,129],"Meanwhile,":[109],"treatment":[111,150],"acetic":[116],"resulted":[118,154],"in":[119,137,142,155],"additional":[120],"[9-11]":[123],"namely":[124],"containing":[127],"oxadiazole":[128],"Furthermore":[130],",":[131],"introduction":[133],"CS2":[141],"medium":[144],"that":[145],"basic,":[147],"followed":[148],"by":[149],"hydrate,":[153],"formation":[157],"[12]":[162],"while":[163],"pyrrole":[170],"carbaldehyde":[171],"produced":[172],"[13].":[176],"results":[178],"antimicrobial":[181],"efficacy":[182],"against":[188],"four":[189],"species":[190],"bacteria":[192],"fungi":[194],"are":[195],"quite":[196],"encouraging.":[197]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}