{"id":"https://openalex.org/W4410097500","doi":"https://doi.org/10.1186/s13148-025-01875-3","title":"Causal associations between epigenetic age and thromboembolism: a bi-directional two-sample Mendelian randomization study","display_name":"Causal associations between epigenetic age and thromboembolism: a bi-directional two-sample Mendelian randomization study","publication_year":2025,"publication_date":"2025-05-05","ids":{"openalex":"https://openalex.org/W4410097500","doi":"https://doi.org/10.1186/s13148-025-01875-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/40325450"},"language":"en","primary_location":{"id":"doi:10.1186/s13148-025-01875-3","doi":"https://doi.org/10.1186/s13148-025-01875-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-025-01875-3","pdf_url":"https://clinicalepigeneticsjournal.biomedcentral.com/counter/pdf/10.1186/s13148-025-01875-3","source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://clinicalepigeneticsjournal.biomedcentral.com/counter/pdf/10.1186/s13148-025-01875-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034739562","display_name":"Bowen Jin","orcid":"https://orcid.org/0000-0003-1442-6259","observed_orcids":["https://orcid.org/0000-0003-1442-6259"]},"institutions":[{"id":"https://openalex.org/I4210126156","display_name":"Wuhan Asia Heart Hospital","ror":"https://ror.org/02zzfj172","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126156"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bowen Jin","raw_affiliation_strings":["Department of Cardiovascular Surgery, Wuhan Asia Heart Hospital, Wuhan City, 430000, Hubei Province, China. 89097244@sina.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Wuhan Asia Heart Hospital, Wuhan City, 430000, Hubei Province, China. 89097244@sina.com","institution_ids":["https://openalex.org/I4210126156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008297185","display_name":"Yunyan Li","orcid":"https://orcid.org/0000-0002-1713-342X","observed_orcids":["https://orcid.org/0000-0002-1713-342X"]},"institutions":[{"id":"https://openalex.org/I4210126156","display_name":"Wuhan Asia Heart Hospital","ror":"https://ror.org/02zzfj172","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126156"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunyan Li","raw_affiliation_strings":["Department of Cardiovascular Surgery, Wuhan Asia Heart Hospital, Wuhan City, 430000, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Wuhan Asia Heart Hospital, Wuhan City, 430000, Hubei Province, China","institution_ids":["https://openalex.org/I4210126156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018860570","display_name":"Dingyang Li","orcid":"https://orcid.org/0000-0001-5072-9172","observed_orcids":["https://orcid.org/0000-0001-5072-9172"]},"institutions":[{"id":"https://openalex.org/I4210126156","display_name":"Wuhan Asia Heart Hospital","ror":"https://ror.org/02zzfj172","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126156"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dingyang Li","raw_affiliation_strings":["Department of Cardiovascular Surgery, Wuhan Asia Heart Hospital, Wuhan City, 430000, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Wuhan Asia Heart Hospital, Wuhan City, 430000, Hubei Province, China","institution_ids":["https://openalex.org/I4210126156"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chi Jing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126156","display_name":"Wuhan Asia Heart Hospital","ror":"https://ror.org/02zzfj172","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126156"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chi Jing","raw_affiliation_strings":["Department of Cardiovascular Surgery, Wuhan Asia Heart Hospital, Wuhan City, 430000, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Wuhan Asia Heart Hospital, Wuhan City, 430000, Hubei Province, China","institution_ids":["https://openalex.org/I4210126156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102644307","display_name":"Qihu Sheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126156","display_name":"Wuhan Asia Heart Hospital","ror":"https://ror.org/02zzfj172","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126156"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qunshan Sheng","raw_affiliation_strings":["Department of Cardiovascular Surgery, Wuhan Asia Heart Hospital, Wuhan City, 430000, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Wuhan Asia Heart Hospital, Wuhan City, 430000, Hubei Province, China","institution_ids":["https://openalex.org/I4210126156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034739562"],"corresponding_institution_ids":["https://openalex.org/I4210126156"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":1.069,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.73748004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"17","issue":"1","first_page":"75","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-age","display_name":"epigenetic age","score":0.8529999852180481},{"id":"https://openalex.org/keywords/thromboembolism","display_name":"thromboembolism","score":0.9700000286102295},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/arterial-embolism","display_name":"arterial embolism","score":0.8999999761581421},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.8870000243186951},{"id":"https://openalex.org/keywords/portal-vein-thrombosis","display_name":"portal vein thrombosis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.9950000047683716},{"id":"https://openalex.org/keywords/phenoage","display_name":"PhenoAge","score":0.8709999918937683},{"id":"https://openalex.org/keywords/grimage","display_name":"GrimAge","score":0.9909999966621399},{"id":"https://openalex.org/keywords/epigenetic-age-acceleration","display_name":"epigenetic age acceleration","score":0.6890000104904175},{"id":"https://openalex.org/keywords/causal-inference","display_name":"causal inference","score":0.5370000004768372},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.5220000147819519},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.5789999961853027},{"id":"https://openalex.org/keywords/heterogeneity","display_name":"heterogeneity","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9627165794372559},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.5840591788291931},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5438680052757263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48742225766181946},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.44402557611465454},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.41854605078697205},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4044235944747925},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3995684087276459},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3576904535293579},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27980178594589233},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.26552432775497437},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1663835346698761},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14309704303741455},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.09435617923736572},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s13148-025-01875-3","doi":"https://doi.org/10.1186/s13148-025-01875-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-025-01875-3","pdf_url":"https://clinicalepigeneticsjournal.biomedcentral.com/counter/pdf/10.1186/s13148-025-01875-3","source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},{"id":"pmid:40325450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40325450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical epigenetics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:10863807","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12051321","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12051321","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12051321","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clin Epigenetics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7d1cb38382564cd8a210ca079ba91ce6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7d1cb38382564cd8a210ca079ba91ce6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Epigenetics, Vol 17, Iss 1, Pp 1-30 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13148-025-01875-3","doi":"https://doi.org/10.1186/s13148-025-01875-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-025-01875-3","pdf_url":"https://clinicalepigeneticsjournal.biomedcentral.com/counter/pdf/10.1186/s13148-025-01875-3","source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.4300000071525574}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410097500.pdf","grobid_xml":"https://content.openalex.org/works/W4410097500.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1902575419","https://openalex.org/W1964184380","https://openalex.org/W1974047233","https://openalex.org/W1979414771","https://openalex.org/W2013710547","https://openalex.org/W2021837301","https://openalex.org/W2023907609","https://openalex.org/W2024601999","https://openalex.org/W2060836090","https://openalex.org/W2113699335","https://openalex.org/W2114360920","https://openalex.org/W2121091193","https://openalex.org/W2128736149","https://openalex.org/W2145748250","https://openalex.org/W2165144879","https://openalex.org/W2324862792","https://openalex.org/W2344977044","https://openalex.org/W2421283105","https://openalex.org/W2596440417","https://openalex.org/W2613603864","https://openalex.org/W2803072880","https://openalex.org/W2805983714","https://openalex.org/W2818417770","https://openalex.org/W2884117406","https://openalex.org/W2912654909","https://openalex.org/W2949100461","https://openalex.org/W2979996325","https://openalex.org/W2983762003","https://openalex.org/W3018844088","https://openalex.org/W3080229816","https://openalex.org/W3093451235","https://openalex.org/W3118367938","https://openalex.org/W3156499396","https://openalex.org/W3164615773","https://openalex.org/W3177165321","https://openalex.org/W3199797266","https://openalex.org/W3203783224","https://openalex.org/W3204811749","https://openalex.org/W3210570897","https://openalex.org/W4211103501","https://openalex.org/W4295359113","https://openalex.org/W4297997760","https://openalex.org/W4319461930","https://openalex.org/W4385298544","https://openalex.org/W4385874297"],"related_works":["https://openalex.org/W2901309888","https://openalex.org/W2169283889","https://openalex.org/W4210703904","https://openalex.org/W2052821216","https://openalex.org/W4404875725","https://openalex.org/W2036527494","https://openalex.org/W2610080820","https://openalex.org/W2979314934","https://openalex.org/W2146527561","https://openalex.org/W2770084104"],"abstract_inverted_index":{"BACKGROUND:":[0],"Thromboembolism":[1],"is":[2],"one":[3],"of":[4,72,128,146,174,196,257,290],"the":[5,11,34,70,77,91,142,170,255,281,287],"most":[6],"prevalent":[7],"cardiovascular":[8],"conditions":[9],"affecting":[10],"elder":[12],"population.":[13],"The":[14,278],"associations":[15],"between":[16,37,119,141,169,215,231,270],"epigenetic":[17,40,121,273],"aging":[18,41,274],"and":[19,43,86,103,110,124,140,150,154,176,180,191,194,219,230,234,252,261,276],"thromboembolism":[20,233],"risks":[21],"remain":[22],"incompletely":[23],"elucidated.":[24],"Through":[25],"Mendelian":[26],"randomization":[27],"(MR),":[28],"this":[29],"research":[30],"seeks":[31],"to":[32,68,89,106],"assess":[33],"causal":[35,73,92,117,268],"links":[36],"genetically":[38,143,171,271],"determined":[39,144],"factors":[42,275],"thromboembolism.":[44,277,291],"RESULTS:":[45],"Genetic":[46],"variants":[47],"were":[48,66],"extracted":[49],"from":[50],"genome-wide":[51],"association":[52,118,269],"studies":[53],"(GWAS)":[54],"under":[55],"stringent":[56],"threshold":[57],"as":[58,98],"instrumental":[59],"variables":[60],"(IVs).":[61],"Bi-directional":[62],"two-sample":[63],"MR":[64,87,113,211],"analyses":[65,96],"conducted":[67],"determine":[69],"direction":[71],"associations.":[74],"We":[75],"employed":[76],"inverse":[78],"variance":[79],"weighted":[80,82,84],"(IVW),":[81],"median,":[83],"mode":[85],"Egger":[88],"estimate":[90],"effect,":[93],"with":[94],"sensitivity":[95],"such":[97],"Cochran's":[99,248],"Q":[100,249],"tests,":[101,250],"MR-PRESSO":[102,251],"leave-one-out":[104,253],"performed":[105],"avoid":[107],"potential":[108],"heterogeneity":[109],"pleiotropy.":[111],"Our":[112,264],"analysis":[114,246],"revealed":[115],"a":[116,267],"intrinsic":[120],"age":[122],"acceleration":[123],"deep":[125],"vein":[126,217],"thrombosis":[127,155,181,195,218],"lower":[129,197],"extremities":[130],"(IVW:":[131,156,182,200,221,236],"OR":[132,157,201,222,237],"0.963,":[133],"95%":[134,159,185,203,224,239],"CI":[135,160,186,204,225,240],"0.934-0.992,":[136],"P":[137,162,188,206,227,242],"=":[138,163,189,207,228,243],"0.014),":[139],"levels":[145,173],"plasminogen":[147],"activator":[148],"inhibitor-1":[149],"other":[151,177],"arterial":[152,178,192],"embolism":[153,179,193],"1.000,":[158],"1.000-1.0005,":[161],"0.029).":[164],"Causality":[165],"was":[166],"also":[167],"identified":[168,266],"predicted":[172,272],"FGF23":[175],"OR:":[183],"1.661,":[184],"1.051-2.624,":[187],"0.029)":[190],"extremity":[198],"artery":[199],"1.68,":[202],"1.031-2.725,":[205],"0.037).":[208],"Moreover,":[209],"bi-directional":[210],"showed":[212],"reverse":[213],"effects":[214],"portal":[216],"PhenoAge":[220],"0.871,":[223],"0.765-0.992,":[226],"0.037)":[229],"venous":[232],"GrimAge":[235],"1.186,":[238],"1.048-1.341,":[241],"0.007).":[244],"Sensitivity":[245],"using":[247],"excluded":[254],"influence":[256],"heterogeneity,":[258],"horizontal":[259],"pleiotropy,":[260],"outliers.":[262],"CONCLUSION:":[263],"results":[265],"findings":[279],"highlight":[280],"necessity":[282],"for":[283],"further":[284],"exploration":[285],"into":[286],"underlying":[288],"etiology":[289]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
