{"id":"https://openalex.org/W4410076620","doi":"https://doi.org/10.1002/adfm.202423340","title":"Mechanically Compliant Hydrogel Bioelectronics Promote Diabetic Skeletal Muscle Regeneration Through Immunomodulatory and Electrocoupling Effects","display_name":"Mechanically Compliant Hydrogel Bioelectronics Promote Diabetic Skeletal Muscle Regeneration Through Immunomodulatory and Electrocoupling Effects","publication_year":2025,"publication_date":"2025-05-05","ids":{"openalex":"https://openalex.org/W4410076620","doi":"https://doi.org/10.1002/adfm.202423340"},"language":"en","primary_location":{"id":"doi:10.1002/adfm.202423340","doi":"https://doi.org/10.1002/adfm.202423340","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adfm.202423340","pdf_url":null,"source":{"id":"https://openalex.org/S135204980","display_name":"Advanced Functional Materials","issn_l":"1616-301X","issn":["1616-301X","1616-3028"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-3","ki-jl-3","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Functional Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067341327","display_name":"Yeying Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yeying Lin","raw_affiliation_strings":["School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China","institution_ids":["https://openalex.org/I139024713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111032857","display_name":"Xudan Xing","orcid":"https://orcid.org/0009-0001-0468-1611","observed_orcids":["https://orcid.org/0009-0001-0468-1611"]},"institutions":[{"id":"https://openalex.org/I4210092091","display_name":"Third Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00fb35g87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092091"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xudan Xing","raw_affiliation_strings":["Guangzhou Key Laboratory of Spine Disease Prevention and Treatment Department of Orthopaedic Surgery Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangdong Provincial Clinical Medical Research Center for Obstetrics and Gynecology The Third Affiliated Hospital Guangzhou Medical University  Guangzhou 510150 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Key Laboratory of Spine Disease Prevention and Treatment Department of Orthopaedic Surgery Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangdong Provincial Clinical Medical Research Center for Obstetrics and Gynecology The Third Affiliated Hospital Guangzhou Medical University  Guangzhou 510150 P. R. China","institution_ids":["https://openalex.org/I4210092091","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076613679","display_name":"Xinchang Kang","orcid":"https://orcid.org/0000-0002-8210-9493","observed_orcids":["https://orcid.org/0000-0002-8210-9493"]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinchang Kang","raw_affiliation_strings":["School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China","institution_ids":["https://openalex.org/I139024713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112385275","display_name":"Mingjie Liu","orcid":"https://orcid.org/0000-0002-8399-2134","observed_orcids":["https://orcid.org/0000-0002-8399-2134"]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingjie Liu","raw_affiliation_strings":["School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China","institution_ids":["https://openalex.org/I139024713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044410890","display_name":"Tianhua Xiao","orcid":"https://orcid.org/0000-0002-4197-2039","observed_orcids":["https://orcid.org/0000-0002-4197-2039"]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianhua Xiao","raw_affiliation_strings":["School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China","institution_ids":["https://openalex.org/I139024713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101275892","display_name":"Yangengchen Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangengchen Zhong","raw_affiliation_strings":["School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China","institution_ids":["https://openalex.org/I139024713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101275891","display_name":"Chuyang Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuyang Xiang","raw_affiliation_strings":["School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China","institution_ids":["https://openalex.org/I139024713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044131040","display_name":"Chengyun Ning","orcid":"https://orcid.org/0000-0003-3293-4716","observed_orcids":["https://orcid.org/0000-0003-3293-4716","https://orcid.org/0000-0001-7304-5013"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengyun Ning","raw_affiliation_strings":["School of Materials Science and Engineering National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou 510641 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Materials Science and Engineering National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou 510641 P. R. China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063091376","display_name":"Yuhe Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104314","display_name":"New York Institute of Technology","ror":"https://ror.org/01bghzb51","country_code":"US","type":"education","lineage":["https://openalex.org/I4210104314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhe Jiang","raw_affiliation_strings":["New York Institute of Technology College of Osteopathic Medicine  New York NY 11568 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Institute of Technology College of Osteopathic Medicine  New York NY 11568 USA","institution_ids":["https://openalex.org/I4210104314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108406390","display_name":"Guoxin Tan","orcid":"https://orcid.org/0000-0001-8647-639X","observed_orcids":["https://orcid.org/0000-0001-8647-639X","https://orcid.org/0000-0001-7334-753X"]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guoxin Tan","raw_affiliation_strings":["School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-7334-753X","affiliations":[{"raw_affiliation_string":"School of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou 510006 P. R. China","institution_ids":["https://openalex.org/I139024713"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100325659","display_name":"Lei Zhou","orcid":"https://orcid.org/0000-0001-8056-9464","observed_orcids":["https://orcid.org/0000-0001-8056-9464"]},"institutions":[{"id":"https://openalex.org/I4210092091","display_name":"Third Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00fb35g87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092091"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Zhou","raw_affiliation_strings":["Guangzhou Key Laboratory of Spine Disease Prevention and Treatment Department of Orthopaedic Surgery Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangdong Provincial Clinical Medical Research Center for Obstetrics and Gynecology The Third Affiliated Hospital Guangzhou Medical University  Guangzhou 510150 P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-8056-9464","affiliations":[{"raw_affiliation_string":"Guangzhou Key Laboratory of Spine Disease Prevention and Treatment Department of Orthopaedic Surgery Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangdong Provincial Clinical Medical Research Center for Obstetrics and Gynecology The Third Affiliated Hospital Guangzhou Medical University  Guangzhou 510150 P. R. China","institution_ids":["https://openalex.org/I4210092091","https://openalex.org/I92039509"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100325659","https://openalex.org/A5108406390"],"corresponding_institution_ids":["https://openalex.org/I139024713","https://openalex.org/I4210092091","https://openalex.org/I92039509"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":11.1874,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.98985362,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"35","issue":"39","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.13539999723434448,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/volumetric-muscle-loss","display_name":"volumetric muscle loss","score":0.9800000190734863},{"id":"https://openalex.org/keywords/glucomannan","display_name":"glucomannan","score":0.7509999871253967},{"id":"https://openalex.org/keywords/polydopamine","display_name":"polydopamine","score":0.7509999871253967},{"id":"https://openalex.org/keywords/polypyrrole","display_name":"polypyrrole","score":0.906000018119812},{"id":"https://openalex.org/keywords/gelatin","display_name":"gelatin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/self-healing-hydrogels","display_name":"self-healing hydrogels","score":0.902999997138977},{"id":"https://openalex.org/keywords/dynamic-covalent-crosslinking","display_name":"dynamic covalent crosslinking","score":0.8360000252723694},{"id":"https://openalex.org/keywords/m2-macrophage-polarization","display_name":"M2 macrophage polarization","score":0.8130000233650208},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C60515610","wikidata":"https://www.wikidata.org/wiki/Q174502","display_name":"Bioelectronics","level":3,"score":0.9253723621368408},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.8314477205276489},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.818527340888977},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5421799421310425},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5171415209770203},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.45517754554748535},{"id":"https://openalex.org/C197525751","wikidata":"https://www.wikidata.org/wiki/Q1431093","display_name":"Neuroprosthetics","level":2,"score":0.4345892369747162},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3157848119735718},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.170536607503891},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14845409989356995},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.14320796728134155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12840896844863892},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.07938709855079651}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/adfm.202423340","doi":"https://doi.org/10.1002/adfm.202423340","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adfm.202423340","pdf_url":null,"source":{"id":"https://openalex.org/S135204980","display_name":"Advanced Functional Materials","issn_l":"1616-301X","issn":["1616-301X","1616-3028"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-3","ki-jl-3","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Functional Materials","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1991143789","display_name":"\u9aa8\u4fee\u590d\u690d\u5165\u4f53\u8868\u9762\u529b-\u7535\u54cd\u5e94\u5fae\u73af\u5883\u7684\u6784\u5efa\u53ca\u5176\u9aa8\u6574\u5408\u673a\u5236\u7814\u7a76","funder_award_id":"51932002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2959163645","display_name":null,"funder_award_id":"32471431","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3256555887","display_name":null,"funder_award_id":"202102010008","funder_id":"https://openalex.org/F4320335480","funder_display_name":"Guangzhou Municipal Science and Technology Project"},{"id":"https://openalex.org/G4321788458","display_name":null,"funder_award_id":"2023A03J0383","funder_id":"https://openalex.org/F4320335480","funder_display_name":"Guangzhou Municipal Science and Technology Project"},{"id":"https://openalex.org/G5189627797","display_name":null,"funder_award_id":"2025A1515011845","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G5733715441","display_name":null,"funder_award_id":"2023A1515011039","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335480","display_name":"Guangzhou Municipal Science and Technology Project","ror":null},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1937519362","https://openalex.org/W2124670349","https://openalex.org/W2578919874","https://openalex.org/W2770780508","https://openalex.org/W2897364906","https://openalex.org/W2900521017","https://openalex.org/W2902154203","https://openalex.org/W2915186701","https://openalex.org/W2943865557","https://openalex.org/W2945410648","https://openalex.org/W2980400481","https://openalex.org/W3002114018","https://openalex.org/W3003613881","https://openalex.org/W3046620056","https://openalex.org/W3132656047","https://openalex.org/W3135699501","https://openalex.org/W3137917562","https://openalex.org/W3164749800","https://openalex.org/W3174157635","https://openalex.org/W3182336228","https://openalex.org/W3201012220","https://openalex.org/W3212876289","https://openalex.org/W4205319637","https://openalex.org/W4224252832","https://openalex.org/W4224987903","https://openalex.org/W4226120025","https://openalex.org/W4283166621","https://openalex.org/W4310642929","https://openalex.org/W4312160065","https://openalex.org/W4318392341","https://openalex.org/W4380730618","https://openalex.org/W4384627454","https://openalex.org/W4386152858","https://openalex.org/W4387406473","https://openalex.org/W4388126490","https://openalex.org/W4388687029","https://openalex.org/W4388869923","https://openalex.org/W4390542893","https://openalex.org/W4391723176","https://openalex.org/W4391806016","https://openalex.org/W4392602447"],"related_works":["https://openalex.org/W4387433006","https://openalex.org/W4210986728","https://openalex.org/W3205892998","https://openalex.org/W4404729688","https://openalex.org/W4401200068","https://openalex.org/W4415901255","https://openalex.org/W4415785281","https://openalex.org/W4409180962","https://openalex.org/W7204845238","https://openalex.org/W7124862771"],"abstract_inverted_index":{"Abstract":[0],"Although":[1],"hydrogel\u2010based":[2,119],"therapies":[3],"have":[4],"demonstrated":[5],"promising":[6,184],"results":[7,168],"in":[8],"treating":[9],"volumetric":[10],"muscle":[11,17,72,129,159,190],"loss":[12],"(VML),":[13],"addressing":[14],"diabetic":[15,50,147,188],"skeletal":[16,189],"defects":[18],"remains":[19],"a":[20,41,146,183],"major":[21],"challenge":[22],"due":[23],"to":[24,102,140],"the":[25,67,91,152,171],"interplay":[26],"of":[27,70,99,164,173],"chronic":[28,142],"inflammation":[29],"and":[30,64,77,87,108,161,179],"impaired":[31],"regenerative":[32],"capacity":[33],"associated":[34],"with":[35,93,127,176],"diabetes":[36],"mellitus.":[37],"This":[38],"study":[39],"presents":[40],"novel":[42],"multifunctional":[43],"hydrogel":[44,92,153],"bioelectronic":[45,154],"conductor":[46,155],"designed":[47],"specifically":[48],"for":[49,187],"VML":[51,149],"repair.":[52,191],"The":[53,116],"hydrogel,":[54],"which":[55],"self\u2010assembles":[56],"from":[57],"mannose":[58],"receptor\u2010binding":[59],"glucomannan,":[60],"polydopamine\u2010functionalized":[61],"conductive":[62,118,180],"polypyrrole,":[63],"gelatin,":[65],"mimics":[66],"mechanical":[68],"properties":[69,135,181],"native":[71],"tissue":[73,95],"while":[74,131],"providing":[75],"immunomodulatory":[76,134,178],"electrocoupling":[78],"effects.":[79],"Multiple":[80],"crosslinking":[81],"mechanisms,":[82],"involving":[83],"both":[84,177],"dynamic":[85],"covalent":[86],"noncovalent":[88],"interactions,":[89],"endow":[90],"enhanced":[94],"adhesion":[96],"(adhesion":[97],"strength":[98],"69.41":[100],"kPa":[101],"soft":[103],"tissue),":[104],"elasticity":[105],"(100%":[106],"self\u2010recovery),":[107],"rapid":[109],"self\u2010healing":[110],"ability":[111],"(less":[112],"than":[113],"1":[114],"min).":[115],"electrically":[117],"elastic":[120],"bioelectronics":[121],"can":[122],"reestablish":[123],"effective":[124,157],"electrical":[125],"coupling":[126],"electroactive":[128],"tissue,":[130],"its":[132],"intrinsic":[133],"induce":[136],"M2\u2010type":[137],"macrophage":[138],"polarization":[139],"alleviate":[141],"inflammatory":[143],"response.":[144],"In":[145],"rat":[148],"defect":[150],"model,":[151],"facilitated":[156],"immunomodulation,":[158],"regeneration,":[160],"functional":[162],"recovery":[163],"injured":[165],"VML.":[166],"These":[167],"suggest":[169],"that":[170],"integration":[172],"tissue\u2010mimicking":[174],"mechanics":[175],"offers":[182],"therapeutic":[185],"approach":[186]},"counts_by_year":[{"year":2026,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-05-05T00:00:00"}