{"id":"https://openalex.org/W4410076616","doi":"https://doi.org/10.1002/brb3.70513","title":"Causality Between Irritable Bowel Syndrome and Suicide Attempt: A Mendelian Randomization Study","display_name":"Causality Between Irritable Bowel Syndrome and Suicide Attempt: A Mendelian Randomization Study","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4410076616","doi":"https://doi.org/10.1002/brb3.70513","pmid":"https://pubmed.ncbi.nlm.nih.gov/40320944"},"language":"en","primary_location":{"id":"doi:10.1002/brb3.70513","doi":"https://doi.org/10.1002/brb3.70513","is_oa":true,"landing_page_url":"https://doi.org/10.1002/brb3.70513","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.70513","source":{"id":"https://openalex.org/S2764450051","display_name":"Brain and Behavior","issn_l":"2157-9032","issn":["2157-9032","2162-3279"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and Behavior","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.70513","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101190421","display_name":"Zhen Deng","orcid":"https://orcid.org/0009-0000-7644-3738","observed_orcids":["https://orcid.org/0009-0000-7644-3738"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Deng","raw_affiliation_strings":["Chengdu Integrated Traditional Chinese Medicine and Western Medicine Hospital  Chengdu China","Chengdu University of Traditional Chinese Medicine  Chengdu China"],"raw_orcid":"https://orcid.org/0009-0000-7644-3738","affiliations":[{"raw_affiliation_string":"Chengdu Integrated Traditional Chinese Medicine and Western Medicine Hospital  Chengdu China","institution_ids":[]},{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine  Chengdu China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kai Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Wang","raw_affiliation_strings":["Chengdu Integrated Traditional Chinese Medicine and Western Medicine Hospital  Chengdu China","Chengdu University of Traditional Chinese Medicine  Chengdu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu Integrated Traditional Chinese Medicine and Western Medicine Hospital  Chengdu China","institution_ids":[]},{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine  Chengdu China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028173848","display_name":"Tianshu Hou","orcid":"https://orcid.org/0009-0008-6922-4594","observed_orcids":["https://orcid.org/0009-0008-6922-4594"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tianshu Hou","raw_affiliation_strings":["Chengdu Integrated Traditional Chinese Medicine and Western Medicine Hospital  Chengdu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu Integrated Traditional Chinese Medicine and Western Medicine Hospital  Chengdu China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028173848"],"corresponding_institution_ids":[],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":0.541,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.60470642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"15","issue":"5","first_page":"e70513","last_page":"e70513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7163000106811523,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7163000106811523,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.12399999797344208,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10376","display_name":"Suicide and Self-Harm Studies","score":0.08139999955892563,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":1.0},{"id":"https://openalex.org/keywords/suicide-attempts","display_name":"suicide attempts","score":0.9950000047683716},{"id":"https://openalex.org/keywords/suicidal-ideation","display_name":"suicidal ideation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/causal-relationship","display_name":"causal relationship","score":0.6069999933242798},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.37700000405311584},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9990000128746033},{"id":"https://openalex.org/keywords/abdominal-pain","display_name":"abdominal pain","score":0.9760000109672546},{"id":"https://openalex.org/keywords/suicide-risk","display_name":"suicide risk","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.8713552951812744},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.5090155601501465},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49996161460876465},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4688369333744049},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.4553852081298828},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.4153309166431427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3613438606262207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17632687091827393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1575791835784912},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.14001715183258057},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.10645928978919983},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013406","descriptor_name":"Suicide, Attempted","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D013406","descriptor_name":"Suicide, Attempted","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D013406","descriptor_name":"Suicide, Attempted","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/brb3.70513","doi":"https://doi.org/10.1002/brb3.70513","is_oa":true,"landing_page_url":"https://doi.org/10.1002/brb3.70513","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.70513","source":{"id":"https://openalex.org/S2764450051","display_name":"Brain and Behavior","issn_l":"2157-9032","issn":["2157-9032","2162-3279"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and Behavior","raw_type":"journal-article"},{"id":"pmid:40320944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40320944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and behavior","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:10863178","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12050657","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12050657","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12050657","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Behav","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9a6b4126d85942f9ba2f54d72d8254e8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9a6b4126d85942f9ba2f54d72d8254e8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain and Behavior, Vol 15, Iss 5, Pp n/a-n/a (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/brb3.70513","doi":"https://doi.org/10.1002/brb3.70513","is_oa":true,"landing_page_url":"https://doi.org/10.1002/brb3.70513","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.70513","source":{"id":"https://openalex.org/S2764450051","display_name":"Brain and Behavior","issn_l":"2157-9032","issn":["2157-9032","2162-3279"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and Behavior","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410076616.pdf","grobid_xml":"https://content.openalex.org/works/W4410076616.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1902575419","https://openalex.org/W1973068418","https://openalex.org/W1977148078","https://openalex.org/W1992676701","https://openalex.org/W1995954785","https://openalex.org/W1999811423","https://openalex.org/W2007446342","https://openalex.org/W2010089686","https://openalex.org/W2017092019","https://openalex.org/W2033438673","https://openalex.org/W2035260668","https://openalex.org/W2038709220","https://openalex.org/W2041156995","https://openalex.org/W2057059418","https://openalex.org/W2062772260","https://openalex.org/W2080362587","https://openalex.org/W2082814856","https://openalex.org/W2086351101","https://openalex.org/W2086527209","https://openalex.org/W2089061405","https://openalex.org/W2095135522","https://openalex.org/W2103783427","https://openalex.org/W2113699335","https://openalex.org/W2124058583","https://openalex.org/W2126639383","https://openalex.org/W2130505437","https://openalex.org/W2131798536","https://openalex.org/W2132532937","https://openalex.org/W2134759220","https://openalex.org/W2138706910","https://openalex.org/W2144750725","https://openalex.org/W2145558296","https://openalex.org/W2164910451","https://openalex.org/W2170749787","https://openalex.org/W2244653643","https://openalex.org/W2323301622","https://openalex.org/W2324862792","https://openalex.org/W2418847259","https://openalex.org/W2488281607","https://openalex.org/W2490528887","https://openalex.org/W2507442464","https://openalex.org/W2529333592","https://openalex.org/W2533163448","https://openalex.org/W2554313249","https://openalex.org/W2741548298","https://openalex.org/W2769660358","https://openalex.org/W2803072880","https://openalex.org/W2880597845","https://openalex.org/W2889182023","https://openalex.org/W2920936885","https://openalex.org/W2942748672","https://openalex.org/W2944508046","https://openalex.org/W2981875455","https://openalex.org/W3008262075","https://openalex.org/W3012912937","https://openalex.org/W3038366553","https://openalex.org/W3159143441","https://openalex.org/W3180936710","https://openalex.org/W3197156699","https://openalex.org/W3202518185","https://openalex.org/W3210793406","https://openalex.org/W4200128442","https://openalex.org/W4210998119","https://openalex.org/W4225865892","https://openalex.org/W4237462033","https://openalex.org/W4296277377","https://openalex.org/W4313454257","https://openalex.org/W4322772341","https://openalex.org/W4324089663","https://openalex.org/W4363646188","https://openalex.org/W4382631241","https://openalex.org/W4385577954","https://openalex.org/W4389883521"],"related_works":["https://openalex.org/W2901309888","https://openalex.org/W1601684588","https://openalex.org/W2169283889","https://openalex.org/W4210703904","https://openalex.org/W2108427450","https://openalex.org/W2052821216","https://openalex.org/W4406289793","https://openalex.org/W2963192358","https://openalex.org/W4402303197","https://openalex.org/W4394745128"],"abstract_inverted_index":{"BACKGROUND:":[0],"Prior":[1],"research":[2],"has":[3],"indicated":[4],"a":[5,54,132,145,272],"correlation":[6,21],"between":[7,217,262,275],"irritable":[8],"bowel":[9],"syndrome":[10],"(IBS)":[11],"and":[12,28,40,63,78,100,112,157,165,225,251,265,277,282,305],"suicidal":[13,285,306],"behavior.":[14],"Nevertheless,":[15],"it":[16],"remains":[17],"uncertain":[18],"if":[19],"this":[20,194],"implies":[22],"causation.":[23],"METHODS:":[24],"We":[25,117,129,168,196],"used":[26,82,104,118,131],"univariate":[27],"multivariate":[29],"Mendelian":[30],"randomization.":[31],"The":[32,48,215,235],"United":[33],"Kingdom":[34],"Biobank":[35],"provided":[36],"53,400":[37],"European":[38,42],"patients":[39,289],"433,201":[41],"controls":[43,65],"for":[44,83,138,171,248,314],"the":[45,67,94,110,115,119,124,139,150,154,158,161,198,202,218,300],"IBS":[46,179,240,276,288,304],"GWAS.":[47],"outcome":[49],"variable":[50],"was":[51,81,227,244],"developed":[52],"from":[53,66],"genome-wide":[55],"association":[56],"analysis":[57,95,221,270],"of":[58,114,126,141,147,175,239],"26,590":[59],"suicide":[60,176,242,263,278,292],"attempt":[61,177,264],"cases":[62,77],"492,022":[64],"International":[68],"Suicide":[69],"Genetics":[70],"Consortium.":[71],"BioBank":[72],"Finland":[73],"GWAS":[74],"data":[75,204],"(9,771":[76],"402,410":[79],"controls)":[80],"SA":[84],"validation.":[85],"Primarily":[86],"employing":[87],"inverse":[88],"variance":[89],"weighting":[90],"(IVW),":[91],"we":[92,257],"conducted":[93],"to":[96,108,122,136,298],"establish":[97],"causality.":[98],"MR-Egger":[99,155],"weighted":[101],"median":[102],"were":[103,223],"as":[105],"complementary":[106],"methods":[107],"reinforce":[109],"robustness":[111],"validity":[113],"results.":[116],"MRlap":[120,190],"method":[121],"eliminate":[123],"effect":[125],"sample":[127],"overlap.":[128],"also":[130],"multivariable":[133],"MR":[134,269],"approach":[135],"control":[137],"influence":[140],"potential":[142],"confounders.":[143],"Using":[144],"number":[146],"approaches,":[148],"including":[149],"Cochran's":[151],"Q":[152],"test,":[153],"intercept,":[156],"MR-PRESSO":[159],"methodology,":[160],"study":[162,295],"examined":[163],"pleiotropy":[164],"heterogeneity.":[166],"RESULTS:":[167],"discovered":[169],"evidence":[170],"an":[172],"elevated":[173],"risk":[174],"with":[178,201],"(OR":[180,205],"=":[181,185,188,206,210,213],"1.67,":[182],"95%":[183,208],"CI":[184,209],"1.21-2.35,":[186],"P":[187,212],"5.52E-07).":[189],"analyses":[191],"similarly":[192],"support":[193],"result.":[195],"got":[197],"same":[199],"results":[200],"validation":[203],"1.19,":[207],"1.06-1.34,":[211],"2.46E-03).":[214],"relationships":[216],"different":[219],"sensitivity":[220],"approaches":[222],"similar,":[224],"there":[226],"no":[228,259],"indication":[229],"that":[230,302],"outliers":[231],"influenced":[232],"these":[233],"correlations.":[234],"independent":[236],"causal":[237,260,273],"impact":[238],"on":[241],"attempts":[243],"maintained":[245],"after":[246],"controlling":[247],"anxiety,":[249],"depression,":[250],"abdominal":[252],"pain.":[253],"In":[254],"reverse":[255],"MR,":[256],"found":[258],"link":[261,303],"IBS.":[266],"CONCLUSION:":[267],"Our":[268],"indicates":[271],"relationship":[274],"risk.":[279,293],"Early":[280],"detection":[281],"intervention":[283],"in":[284,287],"ideation":[286],"reduces":[290],"their":[291],"More":[294],"is":[296],"needed":[297],"understand":[299],"mechanisms":[301],"behavior,":[307],"which":[308],"may":[309],"alter":[310],"or":[311],"broaden":[312],"therapy":[313],"specific":[315],"individuals.":[316]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}