{"id":"https://openalex.org/W4410071720","doi":"https://doi.org/10.69667/lmj.2517206","title":"The Impact of Metformin Therapy on Liver and Kidney Function in Type 2 Diabetic Patients: A Comparative Study Between Men and Women in Al-Bayda City","display_name":"The Impact of Metformin Therapy on Liver and Kidney Function in Type 2 Diabetic Patients: A Comparative Study Between Men and Women in Al-Bayda City","publication_year":2025,"publication_date":"2025-05-03","ids":{"openalex":"https://openalex.org/W4410071720","doi":"https://doi.org/10.69667/lmj.2517206"},"language":"en","primary_location":{"id":"doi:10.69667/lmj.2517206","doi":"https://doi.org/10.69667/lmj.2517206","is_oa":true,"landing_page_url":"https://doi.org/10.69667/lmj.2517206","pdf_url":"https://lmj.ly/index.php/ojs/article/download/119/101","source":{"id":"https://openalex.org/S5406976116","display_name":"Libyan Medical Journal","issn_l":"2079-1216","issn":["2079-1216","2079-1224"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Libyan Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://lmj.ly/index.php/ojs/article/download/119/101","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114709535","display_name":"Fayrouz. A. Khaled","orcid":"https://orcid.org/0000-0002-3593-6277","observed_orcids":["https://orcid.org/0000-0002-3593-6277"]},"institutions":[{"id":"https://openalex.org/I299799659","display_name":"Omar Al-Mukhtar University","ror":"https://ror.org/01wykm490","country_code":"LY","type":"education","lineage":["https://openalex.org/I299799659"]}],"countries":["LY"],"is_corresponding":true,"raw_author_name":"Fayrouz Khaled","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Omar Al-Mokhtar University, El-Beida, Libya"],"raw_orcid":"https://orcid.org/0000-0002-3593-6277","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Omar Al-Mokhtar University, El-Beida, Libya","institution_ids":["https://openalex.org/I299799659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5114709535"],"corresponding_institution_ids":["https://openalex.org/I299799659"],"apc_list":null,"apc_paid":null,"fwci":0.5087,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59667066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"164","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9089999794960022},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6620000004768372},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.6790000200271606},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.9229999780654907},{"id":"https://openalex.org/keywords/liver-function","display_name":"liver function","score":0.7020000219345093},{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.7889999747276306},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.8960000276565552},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7720000147819519},{"id":"https://openalex.org/keywords/renal-function-monitoring","display_name":"renal function monitoring","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.8768881559371948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6635637879371643},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6416679620742798},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5418556332588196},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5006275177001953},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4407760202884674},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43710771203041077},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.33367031812667847}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.69667/lmj.2517206","doi":"https://doi.org/10.69667/lmj.2517206","is_oa":true,"landing_page_url":"https://doi.org/10.69667/lmj.2517206","pdf_url":"https://lmj.ly/index.php/ojs/article/download/119/101","source":{"id":"https://openalex.org/S5406976116","display_name":"Libyan Medical Journal","issn_l":"2079-1216","issn":["2079-1216","2079-1224"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Libyan Medical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.69667/lmj.2517206","doi":"https://doi.org/10.69667/lmj.2517206","is_oa":true,"landing_page_url":"https://doi.org/10.69667/lmj.2517206","pdf_url":"https://lmj.ly/index.php/ojs/article/download/119/101","source":{"id":"https://openalex.org/S5406976116","display_name":"Libyan Medical Journal","issn_l":"2079-1216","issn":["2079-1216","2079-1224"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Libyan Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410071720.pdf","grobid_xml":"https://content.openalex.org/works/W4410071720.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7131217619","https://openalex.org/W2884337896","https://openalex.org/W2316936186","https://openalex.org/W4392349133","https://openalex.org/W7216454001","https://openalex.org/W4409038858","https://openalex.org/W3144646891","https://openalex.org/W7150175884","https://openalex.org/W3193802894","https://openalex.org/W3109526963"],"abstract_inverted_index":{"This":[0],"study":[1],"examines":[2],"the":[3,121,176,233],"impact":[4],"of":[5,151,235],"metformin":[6,210],"therapy":[7,211],"on":[8],"fasting":[9],"blood":[10],"sugar":[11],"(FBS),":[12],"renal":[13,95,125,228],"function":[14,20,66,96,131],"(urea":[15],"and":[16,18,23,27,136,157,170,185,215,220],"creatinine),":[17],"liver":[19],"(GOT,":[21],"GPT,":[22,135],"ALP)":[24],"in":[25,38,73,80,94,106,127,203,217,223,230],"male":[26,128],"female":[28],"type":[29],"2":[30],"diabetic":[31],"patients.":[32,129],"FBS":[33],"levels,":[34],"while":[35],"numerically":[36],"lower":[37],"females":[39,81,114,165],"(106.8":[40],"\u00b1":[41,48,76,83,109,116,154,160,167,172],"9.7":[42],"mg/dL)":[43,78,111],"compared":[44,112,163],"to":[45,113,164,242],"males":[46,74,107,146,231],"(119.7":[47],"19":[49],"mg/dL),":[50],"showed":[51],"no":[52,139,200],"statistically":[53,140],"significant":[54,141],"difference":[55],"(p":[56,182,196],"=":[57,87,183,187,197],"0.561),":[58],"suggesting":[59,120],"similar":[60],"glycemic":[61,219],"control":[62],"across":[63],"genders.":[64,144,225],"Renal":[65],"assessment":[67],"revealed":[68,138],"significantly":[69,104],"higher":[70,105,148,227],"urea":[71],"levels":[72,102,190],"(37.40":[75],"9.91":[77],"than":[79],"(29.37":[82],"5.02":[84],"mg/dL,":[85,118],"p":[86,186],"0.041),":[88],"potentially":[89],"indicating":[90,199],"subtle":[91],"gender-specific":[92,236],"differences":[93,142,177],"or":[97,205],"protein":[98],"metabolism.":[99,207],"Similarly,":[100],"creatinine":[101],"were":[103,191],"(0.950":[108],"0.158":[110],"(0.73":[115],"0.1636":[117],"p=0.007),":[119],"need":[122],"for":[123],"closer":[124],"monitoring":[126],"Liver":[130],"parameters,":[132],"including":[133],"GOT,":[134],"ALP,":[137],"between":[143,194],"Although":[145],"exhibited":[147],"mean":[149],"values":[150],"GOT":[152],"(40.0":[153],"74.2":[155],"U/L)":[156,162],"GPT":[158],"(31.0":[159],"18.05":[161],"(20.3":[166],"8.60":[168],"U/L":[169],"18.37":[171],"8.77":[173],"U/L,":[174],"respectively),":[175],"did":[178],"not":[179],"reach":[180],"significance":[181],"0.415":[184],"0.062).":[188],"ALP":[189],"nearly":[192],"identical":[193],"genders":[195],"0.696),":[198],"gender-based":[201],"variations":[202],"biliary":[204],"bone":[206],"In":[208],"conclusion,":[209],"demonstrates":[212],"comparable":[213],"efficacy":[214],"safety":[216],"managing":[218],"hepatic":[221],"parameters":[222],"both":[224],"However,":[226],"biomarkers":[229],"highlight":[232],"importance":[234],"monitoring.":[237],"Further":[238],"studies":[239],"are":[240],"recommended":[241],"explore":[243],"these":[244],"trends":[245],"with":[246],"larger":[247],"cohorts":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-05-05T00:00:00"}