{"id":"https://openalex.org/W4410051140","doi":"https://doi.org/10.1631/jzus.a2400409","title":"Recent advances in chiral drug separation membranes: design, mechanisms, challenges, and prospects","display_name":"Recent advances in chiral drug separation membranes: design, mechanisms, challenges, and prospects","publication_year":2025,"publication_date":"2025-04-01","ids":{"openalex":"https://openalex.org/W4410051140","doi":"https://doi.org/10.1631/jzus.a2400409"},"language":"en","primary_location":{"id":"doi:10.1631/jzus.a2400409","doi":"https://doi.org/10.1631/jzus.a2400409","is_oa":false,"landing_page_url":"https://doi.org/10.1631/jzus.a2400409","pdf_url":null,"source":{"id":"https://openalex.org/S4210215848","display_name":"Journal of Zhejiang University. Science A","issn_l":"1009-3095","issn":["1009-3095","1673-565X","1862-1775"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Zhejiang University-SCIENCE A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005637833","display_name":"Jianyu Wang","orcid":"https://orcid.org/0009-0009-2208-8123","observed_orcids":["https://orcid.org/0009-0009-2208-8123"]},"institutions":[{"id":"https://openalex.org/I4210119635","display_name":"Kaili University","ror":"https://ror.org/02hzqbc55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210119635"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianyu Wang","raw_affiliation_strings":["Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, China","MOE Engineering Research Center of Membrane and Water Treatment Technology, Zhejiang University, Hangzhou, China","School of Science, Kaili University, Kaili, China"],"raw_orcid":"https://orcid.org/0009-0009-2208-8123","affiliations":[{"raw_affiliation_string":"Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"MOE Engineering Research Center of Membrane and Water Treatment Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"School of Science, Kaili University, Kaili, China","institution_ids":["https://openalex.org/I4210119635"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089805583","display_name":"Qindan Chu","orcid":"https://orcid.org/0000-0002-5623-3298","observed_orcids":["https://orcid.org/0000-0002-5623-3298"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qindan Chu","raw_affiliation_strings":["Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, China","MOE Engineering Research Center of Membrane and Water Treatment Technology, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-5623-3298","affiliations":[{"raw_affiliation_string":"Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"MOE Engineering Research Center of Membrane and Water Treatment Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058348167","display_name":"Chuanjie Fang","orcid":"https://orcid.org/0000-0003-2542-3176","observed_orcids":["https://orcid.org/0000-0003-2542-3176"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuanjie Fang","raw_affiliation_strings":["Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, China","MOE Engineering Research Center of Membrane and Water Treatment Technology, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-2542-3176","affiliations":[{"raw_affiliation_string":"Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"MOE Engineering Research Center of Membrane and Water Treatment Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100684507","display_name":"Bao\u2010Ku Zhu","orcid":"https://orcid.org/0000-0002-3221-181X","observed_orcids":["https://orcid.org/0000-0002-3221-181X"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baoku Zhu","raw_affiliation_strings":["Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, China","MOE Engineering Research Center of Membrane and Water Treatment Technology, Zhejiang University, Hangzhou, China","MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-3221-181X","affiliations":[{"raw_affiliation_string":"Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"MOE Engineering Research Center of Membrane and Water Treatment Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101693423","display_name":"Liping Zhu","orcid":"https://orcid.org/0000-0002-1553-4190","observed_orcids":["https://orcid.org/0000-0002-1553-4190"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liping Zhu","raw_affiliation_strings":["Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, China","MOE Engineering Research Center of Membrane and Water Treatment Technology, Zhejiang University, Hangzhou, China","MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"MOE Engineering Research Center of Membrane and Water Treatment Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101693423"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":1.2696,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.725364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"26","issue":"4","first_page":"285","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11362","display_name":"Membrane Separation and Gas Transport","score":0.1071000024676323,"subfield":{"id":"https://openalex.org/subfields/1506","display_name":"Filtration and Separation"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chiral-drugs","display_name":"chiral drugs","score":0.871999979019165},{"id":"https://openalex.org/keywords/enantiomeric-separation","display_name":"enantiomer separation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/membrane-design","display_name":"membrane design","score":0.6209999918937683},{"id":"https://openalex.org/keywords/separation-mechanism","display_name":"separation mechanism","score":0.9300000071525574},{"id":"https://openalex.org/keywords/stereoisomerism","display_name":"stereoisomerism","score":0.7910000085830688},{"id":"https://openalex.org/keywords/chiral-recognition","display_name":"chiral recognition","score":0.5649999976158142},{"id":"https://openalex.org/keywords/pharmaceutical-separation","display_name":"drug separation","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5652879476547241},{"id":"https://openalex.org/C2776061190","wikidata":"https://www.wikidata.org/wiki/Q7451805","display_name":"Separation (statistics)","level":2,"score":0.5090886950492859},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4868268370628357},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4449875056743622},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.44342365860939026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35800448060035706},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3293089270591736},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30644863843917847},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2538319230079651},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1974518597126007},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17448526620864868},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06256318092346191},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.049007415771484375}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1631/jzus.a2400409","doi":"https://doi.org/10.1631/jzus.a2400409","is_oa":false,"landing_page_url":"https://doi.org/10.1631/jzus.a2400409","pdf_url":null,"source":{"id":"https://openalex.org/S4210215848","display_name":"Journal of Zhejiang University. Science A","issn_l":"1009-3095","issn":["1009-3095","1673-565X","1862-1775"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Zhejiang University-SCIENCE A","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W1986007184","https://openalex.org/W1997686179","https://openalex.org/W2003183631","https://openalex.org/W2004794775","https://openalex.org/W2018858346","https://openalex.org/W2033018799","https://openalex.org/W2038467903","https://openalex.org/W2058122340","https://openalex.org/W2064812226","https://openalex.org/W2079431112","https://openalex.org/W2114351096","https://openalex.org/W2118272667","https://openalex.org/W2138408758","https://openalex.org/W2152214358","https://openalex.org/W2162359733","https://openalex.org/W2332050680","https://openalex.org/W2398045272","https://openalex.org/W2485894717","https://openalex.org/W2525269373","https://openalex.org/W2569072800","https://openalex.org/W2592766538","https://openalex.org/W2605939409","https://openalex.org/W2654265455","https://openalex.org/W2730292674","https://openalex.org/W2740385597","https://openalex.org/W2742820964","https://openalex.org/W2748860189","https://openalex.org/W2757037763","https://openalex.org/W2766110589","https://openalex.org/W2785955889","https://openalex.org/W2791851526","https://openalex.org/W2792745482","https://openalex.org/W2804810650","https://openalex.org/W2899355930","https://openalex.org/W2907353969","https://openalex.org/W2908809095","https://openalex.org/W2912616597","https://openalex.org/W2921479388","https://openalex.org/W2927234297","https://openalex.org/W2962788172","https://openalex.org/W2972685126","https://openalex.org/W2979593324","https://openalex.org/W2980409492","https://openalex.org/W2991512420","https://openalex.org/W2993144011","https://openalex.org/W2997337199","https://openalex.org/W2998367360","https://openalex.org/W3008673449","https://openalex.org/W3012074333","https://openalex.org/W3016248171","https://openalex.org/W3017250543","https://openalex.org/W3019288944","https://openalex.org/W3025010324","https://openalex.org/W3034985161","https://openalex.org/W3036511994","https://openalex.org/W3044453067","https://openalex.org/W3045996286","https://openalex.org/W3080589311","https://openalex.org/W3081216902","https://openalex.org/W3086728919","https://openalex.org/W3092788725","https://openalex.org/W3111427580","https://openalex.org/W3114739964","https://openalex.org/W3129316882","https://openalex.org/W3132030216","https://openalex.org/W3133677057","https://openalex.org/W3155440464","https://openalex.org/W3160763929","https://openalex.org/W3181206485","https://openalex.org/W3182061956","https://openalex.org/W3186064446","https://openalex.org/W3195782488","https://openalex.org/W3202446932","https://openalex.org/W3204363453","https://openalex.org/W3205295404","https://openalex.org/W3206065155","https://openalex.org/W4200091175","https://openalex.org/W4200602890","https://openalex.org/W4210884372","https://openalex.org/W4224884885","https://openalex.org/W4224998203","https://openalex.org/W4226461617","https://openalex.org/W4282032713","https://openalex.org/W4283393808","https://openalex.org/W4283654610","https://openalex.org/W4285085892","https://openalex.org/W4286256865","https://openalex.org/W4286266833","https://openalex.org/W4289928711","https://openalex.org/W4290791422","https://openalex.org/W4292641125","https://openalex.org/W4296984840","https://openalex.org/W4309374103","https://openalex.org/W4309566507","https://openalex.org/W4313407817","https://openalex.org/W4313442881","https://openalex.org/W4313480506","https://openalex.org/W4318950787","https://openalex.org/W4367296638","https://openalex.org/W4372342349","https://openalex.org/W4381620465","https://openalex.org/W4386020550","https://openalex.org/W4386116691","https://openalex.org/W4386701270","https://openalex.org/W4386846113","https://openalex.org/W4394622688","https://openalex.org/W4396771957","https://openalex.org/W4400877315"],"related_works":["https://openalex.org/W4404473108","https://openalex.org/W4224903099","https://openalex.org/W4313407817","https://openalex.org/W4254951045","https://openalex.org/W4386020550","https://openalex.org/W4415787315","https://openalex.org/W3033566848","https://openalex.org/W4406012020","https://openalex.org/W2347273399","https://openalex.org/W4406566846"],"abstract_inverted_index":{"The":[0,49,133],"presence":[1],"of":[2,11,17,46,51,79,90,117,151],"chirality,":[3],"a":[4,64,88,102,106,110],"fundamental":[5],"attribute":[6],"found":[7],"in":[8,14,24,59,160],"nature,":[9],"is":[10,29,67,87],"great":[12],"significance":[13],"the":[15,39,60,77,113,126,138,149],"field":[16],"pharmaceutical":[18],"science.":[19],"Chiral":[20],"drugs":[21,53,74],"are":[22],"unique":[23],"that":[25],"their":[26],"molecular":[27],"structure":[28],"non-superimposable":[30],"on":[31,81,112],"its":[32],"mirror":[33],"image.":[34],"This":[35,93],"stereoisomerism":[36],"significantly":[37],"impacts":[38],"functionality,":[40],"metabolic":[41],"pathway,":[42],"effectiveness,":[43],"and":[44,71,115,140,158],"safety":[45],"chiral":[47,52,73,82,118,144],"medications.":[48],"enantiomers":[50],"can":[54],"exhibit":[55],"diverse":[56],"pharmacological":[57],"effects":[58],"human":[61],"body.":[62],"As":[63],"result,":[65],"it":[66,123],"essential":[68],"to":[69,96,143],"separate":[70],"purify":[72],"effectively.":[75],"Despite":[76],"abundance":[78],"reports":[80],"drug":[83,119,145],"separation":[84,120,127,146],"membranes,":[85,147],"there":[86],"dearth":[89],"comprehensive":[91],"reviews.":[92],"paper":[94,134],"aims":[95],"fill":[97],"this":[98,161],"gap":[99],"by":[100,130],"providing":[101],"thorough":[103],"review":[104],"from":[105],"materials":[107],"perspective,":[108],"with":[109,148],"focus":[111],"design":[114],"construction":[116],"membranes.":[121,132],"Furthermore,":[122],"systematically":[124],"analyzes":[125],"mechanisms":[128],"employed":[129],"these":[131],"also":[135],"delves":[136],"into":[137],"challenges":[139],"prospects":[141],"related":[142],"intention":[150],"imparting":[152],"valuable":[153],"insights":[154],"for":[155],"further":[156],"research":[157],"development":[159],"field.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-05-03T00:00:00"}