{"id":"https://openalex.org/W4410020249","doi":"https://doi.org/10.1016/j.jot.2025.04.009","title":"Scleraxis-expressing progenitor cells are critical for the maturation of the annulus fibrosus and demonstrate therapeutic potential","display_name":"Scleraxis-expressing progenitor cells are critical for the maturation of the annulus fibrosus and demonstrate therapeutic potential","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4410020249","doi":"https://doi.org/10.1016/j.jot.2025.04.009","pmid":"https://pubmed.ncbi.nlm.nih.gov/40421145"},"language":"en","primary_location":{"id":"doi:10.1016/j.jot.2025.04.009","doi":"https://doi.org/10.1016/j.jot.2025.04.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jot.2025.04.009","pdf_url":null,"source":{"id":"https://openalex.org/S2764689464","display_name":"Journal of Orthopaedic Translation","issn_l":"2214-031X","issn":["2214-031X","2214-0328"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Translation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jot.2025.04.009","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102942921","display_name":"Hongtao Jia","orcid":"https://orcid.org/0000-0001-7275-8580","observed_orcids":["https://orcid.org/0000-0001-7275-8580"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongtao Jia","raw_affiliation_strings":["Department of Rheumatology & Immunology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology & Immunology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101736127","display_name":"Shuqin Chen","orcid":"https://orcid.org/0000-0001-6388-4235","observed_orcids":["https://orcid.org/0000-0001-6388-4235"]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuqin Chen","raw_affiliation_strings":["Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, 571199, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, 571199, China","institution_ids":["https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037098948","display_name":"Xuye Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuye Hu","raw_affiliation_strings":["Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China","institution_ids":["https://openalex.org/I4210121447","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111966030","display_name":"Jiajun Wang","orcid":"https://orcid.org/0000-0003-0909-9943","observed_orcids":["https://orcid.org/0000-0003-0909-9943"]},"institutions":[{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajun Wang","raw_affiliation_strings":["Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China","institution_ids":["https://openalex.org/I4210121447","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002457770","display_name":"Jinlong Suo","orcid":"https://orcid.org/0000-0003-3389-3776","observed_orcids":["https://orcid.org/0000-0003-3389-3776"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinlong Suo","raw_affiliation_strings":["Institute of Microsurgery on Extremities, and Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microsurgery on Extremities, and Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010955332","display_name":"Sheng\u2010Ming Dai","orcid":"https://orcid.org/0000-0001-8876-4205","observed_orcids":["https://orcid.org/0000-0001-8876-4205"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Sheng-Ming Dai","raw_affiliation_strings":["Department of Rheumatology & Immunology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China"],"raw_orcid":"https://orcid.org/0000-0001-8876-4205","affiliations":[{"raw_affiliation_string":"Department of Rheumatology & Immunology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022404028","display_name":"Weiguo Zou","orcid":"https://orcid.org/0000-0003-2516-0302","observed_orcids":["https://orcid.org/0000-0003-2516-0302"]},"institutions":[{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weiguo Zou","raw_affiliation_strings":["Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, 571199, China","Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, 571199, China","institution_ids":["https://openalex.org/I79731167"]},{"raw_affiliation_string":"Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China","institution_ids":["https://openalex.org/I4210121447","https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023575427","display_name":"Heng Feng","orcid":"https://orcid.org/0000-0001-6830-4607","observed_orcids":["https://orcid.org/0000-0001-6830-4607"]},"institutions":[{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Heng Feng","raw_affiliation_strings":["Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China"],"raw_orcid":"https://orcid.org/0000-0001-6830-4607","affiliations":[{"raw_affiliation_string":"Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China","institution_ids":["https://openalex.org/I4210121447","https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5010955332","https://openalex.org/A5022404028","https://openalex.org/A5023575427"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210121447","https://openalex.org/I4210144482","https://openalex.org/I4210165038","https://openalex.org/I79731167"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":1.1967,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.77156141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"52","issue":null,"first_page":"301","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/annulus-fibrosus","display_name":"annulus fibrosus","score":0.9589999914169312},{"id":"https://openalex.org/keywords/scleraxis","display_name":"scleraxis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/intervertebral-disc","display_name":"intervertebral disc","score":0.8119999766349792},{"id":"https://openalex.org/keywords/progenitor-cells","display_name":"progenitor cells","score":0.828000009059906},{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.7200000286102295},{"id":"https://openalex.org/keywords/disc-regeneration","display_name":"disc regeneration","score":0.4490000009536743},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.7559999823570251},{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.8960000276565552},{"id":"https://openalex.org/keywords/lineage-tracing","display_name":"lineage tracing","score":0.800000011920929},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cell-ablation","display_name":"cell ablation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/intervertebral-disc-injury","display_name":"intervertebral disc injury","score":0.6710000038146973},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7658530473709106},{"id":"https://openalex.org/C150936888","wikidata":"https://www.wikidata.org/wiki/Q4769748","display_name":"Annulus (botany)","level":2,"score":0.7303392291069031},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.5110765695571899},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3952488303184509},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37122100591659546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3598940968513489},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3535239100456238},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3339334726333618},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2838422656059265},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jot.2025.04.009","doi":"https://doi.org/10.1016/j.jot.2025.04.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jot.2025.04.009","pdf_url":null,"source":{"id":"https://openalex.org/S2764689464","display_name":"Journal of Orthopaedic Translation","issn_l":"2214-031X","issn":["2214-031X","2214-0328"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Translation","raw_type":"journal-article"},{"id":"pmid:40421145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40421145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic translation","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:10914022","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12104688","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12104688","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12104688","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Orthop Translat","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:00d5e4f5d9604fd3b0a9aff10e0abf54","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/00d5e4f5d9604fd3b0a9aff10e0abf54","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Orthopaedic Translation, Vol 52, Iss , Pp 301-312 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jot.2025.04.009","doi":"https://doi.org/10.1016/j.jot.2025.04.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jot.2025.04.009","pdf_url":null,"source":{"id":"https://openalex.org/S2764689464","display_name":"Journal of Orthopaedic Translation","issn_l":"2214-031X","issn":["2214-031X","2214-0328"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Translation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5899999737739563,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1290736299","display_name":null,"funder_award_id":"BX2021309","funder_id":"https://openalex.org/F4320335768","funder_display_name":"National Postdoctoral Program for Innovative Talents"},{"id":"https://openalex.org/G2348463415","display_name":null,"funder_award_id":"82472450","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4201799465","display_name":null,"funder_award_id":"82071809","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5392882238","display_name":null,"funder_award_id":"XDB19000000","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G8240586027","display_name":null,"funder_award_id":"82102569","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320335768","display_name":"National Postdoctoral Program for Innovative Talents","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1970044252","https://openalex.org/W1973070057","https://openalex.org/W1977245294","https://openalex.org/W2000156083","https://openalex.org/W2000603949","https://openalex.org/W2040220737","https://openalex.org/W2062121465","https://openalex.org/W2074972079","https://openalex.org/W2095144717","https://openalex.org/W2095327623","https://openalex.org/W2135245708","https://openalex.org/W2136186538","https://openalex.org/W2157826907","https://openalex.org/W2160709087","https://openalex.org/W2196644438","https://openalex.org/W2345228995","https://openalex.org/W2417524891","https://openalex.org/W2582453508","https://openalex.org/W2622625947","https://openalex.org/W2756641402","https://openalex.org/W2762300204","https://openalex.org/W2793994394","https://openalex.org/W2798204211","https://openalex.org/W2806312038","https://openalex.org/W2883501038","https://openalex.org/W2891318069","https://openalex.org/W2912664379","https://openalex.org/W2946475042","https://openalex.org/W2995488520","https://openalex.org/W3045067536","https://openalex.org/W3081151586","https://openalex.org/W3111578302","https://openalex.org/W3122679803","https://openalex.org/W3130345333","https://openalex.org/W3198491511","https://openalex.org/W4205766845","https://openalex.org/W4210484126","https://openalex.org/W4211136641","https://openalex.org/W4285616690","https://openalex.org/W4311086494","https://openalex.org/W4317475702","https://openalex.org/W4362657208","https://openalex.org/W4377691601","https://openalex.org/W4377944072","https://openalex.org/W4393935123","https://openalex.org/W4394894573","https://openalex.org/W6642664033","https://openalex.org/W6660605282","https://openalex.org/W6674117657","https://openalex.org/W6753821543","https://openalex.org/W6807368661","https://openalex.org/W6839578767","https://openalex.org/W6852296195","https://openalex.org/W6863362607"],"related_works":["https://openalex.org/W4393375503","https://openalex.org/W2084533426","https://openalex.org/W2043337239","https://openalex.org/W2019260118","https://openalex.org/W2026748421","https://openalex.org/W2762443209","https://openalex.org/W2578732716","https://openalex.org/W2966060845","https://openalex.org/W2057870358","https://openalex.org/W2889893284"],"abstract_inverted_index":{"Annulus":[0],"fibrosus":[1],"(AF)":[2],"is":[3],"an":[4],"important":[5,230],"part":[6],"of":[7,32,38,80,91,96,117,140,170,178,191,217,232,246],"the":[8,28,33,36,51,56,78,89,97,103,118,164,176,205,215,229],"intervertebral":[9,98],"disc":[10],"(IVD)":[11],"and":[12,19,30,54,73,86,154,160,219,237,239],"its":[13],"injury":[14],"leads":[15],"to":[16,132,195],"back":[17],"pain":[18],"impaired":[20],"mobility.":[21],"The":[22,143,168,180],"stem/progenitor":[23,40,151],"cells":[24,41,49,83,128,147,174,184,194,211,234],"are":[25,148,185,212],"essential":[26],"for":[27,150,187,214,223,243],"maturation":[29,85,177,216,236],"repair":[31,238],"AF,":[34],"however,":[35],"identity":[37],"AF":[39,81,127,146,173,183,197,206,218,224,247],"remain":[42],"elusive.":[43],"In":[44],"this":[45],"study,":[46],"we":[47,76,100],"sorted":[48],"from":[50],"murine":[52],"IVDs":[53],"performed":[55],"single-cell":[57,61,92],"RNA":[58],"sequencing.":[59],"Using":[60],"transcriptomics,":[62],"genetic":[63],"lineage":[64,122],"tracing,":[65],"in":[66,84,235],"vitro":[67],"stem":[68,233],"cell":[69,74,115,152],"experiment,":[70],"ablation":[71,169],"models":[72],"transplantation,":[75],"elucidate":[77],"role":[79,231],"progenitor":[82,114,210],"injury.":[87],"On":[88],"basis":[90],"RNA-sequencing":[93],"(scRNA-seq)":[94],"analysis":[95],"disc,":[99],"found":[101],"that":[102],"transcription":[104],"factor":[105,202],"Scleraxis":[106,208],"(":[107],"Scx":[108,125,144,165,171,181,192],")":[109],"can":[110],"specifically":[111],"label":[112],"a":[113,156],"population":[116],"outer":[119],"AF.":[120,179],"By":[121],"tracing":[123],"assay,":[124],"-lineage":[126,193],"proliferate":[129,137],"mainly":[130],"prior":[131],"sexual":[133],"maturity,":[134],"but":[135],"barely":[136],"after":[138],"age":[139],"8":[141],"weeks.":[142],"-expressing":[145,172,209],"enriched":[149,186],"markers":[153],"show":[155],"higher":[157],"proliferative":[158],"capacity":[159],"differentiation":[161],"potential":[162,222],"than":[163],"\u2212":[166],"cells.":[167],"impairs":[175],"+":[182],"TGF\u03b2":[188],"signaling.":[189],"Transplantation":[190],"injured":[196],"with":[198],"Connective":[199],"tissue":[200],"growth":[201],"(CTGF)":[203],"improved":[204],"healing.":[207],"critical":[213],"demonstrate":[220],"therapeutic":[221],"regeneration.":[225],"These":[226],"findings":[227],"expand":[228],"provide":[240],"new":[241],"strategy":[242],"cellular":[244],"therapy":[245],"repair.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-10-10T00:00:00"}