{"id":"https://openalex.org/W4410000804","doi":"https://doi.org/10.3390/ijms26094306","title":"Integration of Bioinformatics and Machine Learning Strategies Identifies Ferroptosis and Immune Infiltration Signatures in Peri-Implantitis","display_name":"Integration of Bioinformatics and Machine Learning Strategies Identifies Ferroptosis and Immune Infiltration Signatures in Peri-Implantitis","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4410000804","doi":"https://doi.org/10.3390/ijms26094306","pmid":"https://pubmed.ncbi.nlm.nih.gov/40362543"},"language":"en","primary_location":{"id":"doi:10.3390/ijms26094306","doi":"https://doi.org/10.3390/ijms26094306","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26094306","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms26094306","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114214215","display_name":"Jieying Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jieying Huang","raw_affiliation_strings":["Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yaokun Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaokun Zou","raw_affiliation_strings":["Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huizhi Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huizhi Deng","raw_affiliation_strings":["Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jun Zha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Zha","raw_affiliation_strings":["Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038440124","display_name":"Janak Lal. Pathak","orcid":"https://orcid.org/0000-0003-2576-443X","observed_orcids":["https://orcid.org/0000-0003-2576-443X","https://orcid.org/0009-0008-2974-6224"]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Janak Lal Pathak","raw_affiliation_strings":["Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110921787","display_name":"Yaxin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaxin Chen","raw_affiliation_strings":["Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008986224","display_name":"Qing Ge","orcid":"https://orcid.org/0000-0001-7377-9666","observed_orcids":["https://orcid.org/0000-0001-7377-9666"]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing Ge","raw_affiliation_strings":["Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"last","author":{"id":null,"display_name":"Liping Wang","orcid":"https://orcid.org/0000-0002-3750-8946","observed_orcids":["https://orcid.org/0000-0002-3750-8946"]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liping Wang","raw_affiliation_strings":["Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China"],"raw_orcid":"https://orcid.org/0000-0002-3750-8946","affiliations":[{"raw_affiliation_string":"Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China","institution_ids":["https://openalex.org/I92039509"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008986224"],"corresponding_institution_ids":["https://openalex.org/I92039509"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":4.152,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.94469362,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"26","issue":"9","first_page":"4306","last_page":"4306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.10249999910593033,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peri-implantitis","display_name":"peri-implantitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":1.0},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9240000247955322},{"id":"https://openalex.org/keywords/flt3","display_name":"FLT3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ferroptosis-biomarkers","display_name":"ferroptosis biomarkers","score":0.8679999709129333},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.7419999837875366},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.7860000133514404},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.6380000114440918},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cytokine-cytokine-receptor-interaction","display_name":"cytokine-cytokine receptor interaction","score":0.902999997138977},{"id":"https://openalex.org/keywords/ibudilast","display_name":"ibudilast","score":0.8849999904632568},{"id":"https://openalex.org/keywords/fedratinib","display_name":"fedratinib","score":1.0},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7749999761581421},{"id":"https://openalex.org/keywords/gingival-fibroblasts","display_name":"gingival fibroblasts","score":0.9419999718666077},{"id":"https://openalex.org/keywords/dental-implants","display_name":"dental implants","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.6800053715705872},{"id":"https://openalex.org/C2780802913","wikidata":"https://www.wikidata.org/wiki/Q601168","display_name":"Peri-implantitis","level":3,"score":0.6393977403640747},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6181192398071289},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3902892768383026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18677374720573425},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16849055886268616},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10537505149841309},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms26094306","doi":"https://doi.org/10.3390/ijms26094306","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26094306","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:40362543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40362543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12072437","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12072437","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms26094306","doi":"https://doi.org/10.3390/ijms26094306","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26094306","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3056702537","display_name":null,"funder_award_id":"2021A1515110988","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W1548317431","https://openalex.org/W1660934519","https://openalex.org/W1868776634","https://openalex.org/W1981852469","https://openalex.org/W1997868117","https://openalex.org/W2006617902","https://openalex.org/W2035618305","https://openalex.org/W2043248182","https://openalex.org/W2059373323","https://openalex.org/W2090357709","https://openalex.org/W2115462905","https://openalex.org/W2122291465","https://openalex.org/W2131278293","https://openalex.org/W2146454264","https://openalex.org/W2146512944","https://openalex.org/W2146737294","https://openalex.org/W2159707944","https://openalex.org/W2169353806","https://openalex.org/W2169610226","https://openalex.org/W2473926866","https://openalex.org/W2548976418","https://openalex.org/W2566072419","https://openalex.org/W2570205435","https://openalex.org/W2778455075","https://openalex.org/W2797636288","https://openalex.org/W2809593437","https://openalex.org/W2887408433","https://openalex.org/W2939322913","https://openalex.org/W2945331019","https://openalex.org/W2945668436","https://openalex.org/W2947554843","https://openalex.org/W2953881576","https://openalex.org/W2972055023","https://openalex.org/W2996628744","https://openalex.org/W3020318061","https://openalex.org/W3043251495","https://openalex.org/W3083778188","https://openalex.org/W3094220664","https://openalex.org/W3112344668","https://openalex.org/W3162305544","https://openalex.org/W3182586030","https://openalex.org/W3184622043","https://openalex.org/W4206839115","https://openalex.org/W4280556240","https://openalex.org/W4283511977","https://openalex.org/W4283819629","https://openalex.org/W4289076807","https://openalex.org/W4289939887","https://openalex.org/W4293677686","https://openalex.org/W4294541781","https://openalex.org/W4295907279","https://openalex.org/W4309842658","https://openalex.org/W4313446660","https://openalex.org/W4317910212","https://openalex.org/W4367043047","https://openalex.org/W4384665977","https://openalex.org/W4385230217","https://openalex.org/W4385707989","https://openalex.org/W4386408576","https://openalex.org/W4387326584","https://openalex.org/W4388540934","https://openalex.org/W4388631394","https://openalex.org/W4389685562","https://openalex.org/W4391320784","https://openalex.org/W4393865770","https://openalex.org/W4393900230","https://openalex.org/W4394594488","https://openalex.org/W4394691790","https://openalex.org/W4394907516","https://openalex.org/W4395670644","https://openalex.org/W4396774283","https://openalex.org/W4398238793","https://openalex.org/W4399053977","https://openalex.org/W4399299269","https://openalex.org/W4400051303","https://openalex.org/W4400942519","https://openalex.org/W4401038636","https://openalex.org/W4402047495","https://openalex.org/W4402694078","https://openalex.org/W4403255962","https://openalex.org/W4403401484","https://openalex.org/W4403459827","https://openalex.org/W4406131442","https://openalex.org/W4407605813","https://openalex.org/W4409230749","https://openalex.org/W6678379917","https://openalex.org/W6747530153","https://openalex.org/W6763087923"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"Peri-implantitis":[0],"(PI)":[1],"is":[2],"a":[3,121],"chronic":[4],"inflammatory":[5,271],"disease":[6],"that":[7,222,248],"ultimately":[8],"leads":[9],"to":[10,83,133,299],"the":[11,25,38,44,69,91,110,135,146,207,210,223,255,260,263],"dysfunction":[12],"and":[13,56,64,77,95,105,153,163,183,189,214,230,239,251,259,277,284,288],"loss":[14],"of":[15,27,41,46,176,225,257,262],"implants":[16],"with":[17,170],"established":[18],"osseointegration.":[19],"Ferroptosis":[20],"has":[21],"been":[22],"implicated":[23],"in":[24,43,198,209,236,267,293],"progression":[26],"PI,":[28,294],"but":[29],"its":[30,54],"precise":[31],"mechanisms":[32,40],"remain":[33],"unclear.":[34],"This":[35,280],"study":[36,281],"explores":[37],"molecular":[39,165],"ferroptosis":[42,196,258,287],"pathology":[45],"PI":[47,62,152,247],"through":[48],"bioinformatics,":[49],"offering":[50],"new":[51],"insights":[52],"into":[53],"diagnosis":[55],"treatment.":[57],"The":[58,72],"microarray":[59],"datasets":[60],"for":[61,160,246],"(GSE33774":[63],"GSE106090)":[65],"were":[66,81,118,179,241,273],"retrieved":[67],"from":[68],"GEO":[70],"database.":[71],"differentially":[73],"expressed":[74],"genes":[75,79],"(DEGs)":[76],"ferroptosis-related":[78],"(FRGs)":[80],"intersected":[82],"obtain":[84],"PI-Ferr-DEGs.":[85],"Using":[86],"three":[87],"machine":[88],"learning":[89,182],"algorithms,":[90],"Least":[92],"Absolute":[93],"Shrinkage":[94],"Selection":[96],"Operator":[97],"(LASSO),":[98],"Support":[99],"Vector":[100],"Machine-Recursive":[101],"Feature":[102],"Elimination":[103],"(SVM-RFE),":[104],"Boruta,":[106],"we":[107,157],"successfully":[108],"identified":[109,264,282],"most":[111],"crucial":[112],"biomarkers.":[113],"Additionally,":[114],"these":[115],"key":[116,265],"biomarkers":[117,159,197,208],"validated":[119,274],"using":[120],"verification":[122],"dataset":[123],"(GSE223924).":[124],"Gene":[125],"set":[126],"enrichment":[127,138],"analysis":[128,144,167,220],"(GSEA)":[129],"was":[130,203],"also":[131],"utilized":[132],"analyze":[134],"associated":[136],"gene":[137],"pathways.":[139],"Moreover,":[140],"immune":[141,148,289],"cell":[142,149,290],"infiltration":[143,219,291],"compared":[145],"differential":[147],"profiles":[150],"between":[151],"control":[154],"samples.":[155],"Also,":[156],"targeted":[158],"drug":[161],"prediction":[162],"conducted":[164],"docking":[166],"on":[168],"drugs":[169,245],"potential":[171,244,296],"development":[172],"value.":[173],"A":[174],"total":[175],"13":[177],"PI-Ferr-DEGs":[178],"recognized.":[180],"Machine":[181],"validation":[184],"confirmed":[185],"toll-like":[186],"receptor-4":[187],"(TLR4)":[188],"FMS-like":[190],"tyrosine":[191],"kinase":[192],"3":[193],"(FLT3)":[194],"as":[195,243,286],"PI.":[199,237,301],"In":[200],"addition,":[201],"GSEA":[202],"significantly":[204,235],"enriched":[205],"by":[206,275],"cytokine-cytokine":[211],"receptor":[212],"interaction":[213],"chemokine":[215],"signaling":[216],"pathway.":[217],"Immune":[218],"revealed":[221],"levels":[224],"B":[226],"cells,":[227],"M1":[228],"macrophages,":[229],"natural":[231],"killer":[232],"cells":[233],"differed":[234],"Ibudilast":[238],"fedratinib":[240],"predicted":[242],"target":[249],"TLR4":[250,283],"FLT3,":[252],"respectively.":[253],"Finally,":[254],"occurrence":[256],"expression":[261],"markers":[266],"gingival":[268],"fibroblasts":[269],"under":[270],"conditions":[272],"RT-qPCR":[276],"immunofluorescence":[278],"analysis.":[279],"FLT3":[285],"signatures":[292],"unraveling":[295],"novel":[297],"targets":[298],"treat":[300]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}