{"id":"https://openalex.org/W4409978722","doi":"https://doi.org/10.1016/j.neuron.2025.04.004","title":"Nonneuronal contributions to synaptic function","display_name":"Nonneuronal contributions to synaptic function","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4409978722","doi":"https://doi.org/10.1016/j.neuron.2025.04.004","pmid":"https://pubmed.ncbi.nlm.nih.gov/40311612"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuron.2025.04.004","doi":"https://doi.org/10.1016/j.neuron.2025.04.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuron.2025.04.004","pdf_url":null,"source":{"id":"https://openalex.org/S45757444","display_name":"Neuron","issn_l":"0896-6273","issn":["0896-6273","1097-4199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064332771","display_name":"Ritchy Hodebourg","orcid":"https://orcid.org/0000-0002-3998-6116","observed_orcids":["https://orcid.org/0000-0002-3998-6116"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritchy Hodebourg","raw_affiliation_strings":["Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067590774","display_name":"Michael D. Scofield","orcid":"https://orcid.org/0000-0002-2330-6999","observed_orcids":["https://orcid.org/0000-0002-2330-6999"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Scofield","raw_affiliation_strings":["Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Anesthesiology, Medical University of South Carolina, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Anesthesiology, Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078035590","display_name":"Peter W. Kalivas","orcid":"https://orcid.org/0000-0001-9487-0119","observed_orcids":["https://orcid.org/0000-0001-9487-0119"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter W. Kalivas","raw_affiliation_strings":["Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA; Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, SC 29401, USA. Electronic address: kalivasp@musc.edu"],"raw_orcid":"https://orcid.org/0000-0001-9487-0119","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA; Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, SC 29401, USA. Electronic address: kalivasp@musc.edu","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210132004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038823565","display_name":"Brittany N. Kuhn","orcid":"https://orcid.org/0000-0002-6240-5826","observed_orcids":["https://orcid.org/0000-0002-6240-5826"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brittany N. Kuhn","raw_affiliation_strings":["Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: kuhnb@musc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: kuhnb@musc.edu","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038823565","https://openalex.org/A5078035590"],"corresponding_institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210132004"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":2.1666,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.89628483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"113","issue":"15","first_page":"2399","last_page":"2415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synaptic-function","display_name":"synaptic function","score":0.7289999723434448},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9010000228881836},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.996999979019165},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8230000138282776},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.921999990940094},{"id":"https://openalex.org/keywords/neuropsychiatric-disorders","display_name":"neuropsychiatric disorders","score":0.7250000238418579},{"id":"https://openalex.org/keywords/drugs-of-abuse","display_name":"drugs of abuse","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cell-to-cell-communication","display_name":"cell-to-cell communication","score":0.5350000262260437},{"id":"https://openalex.org/keywords/maladaptive-behavior","display_name":"maladaptive behavior","score":0.6420000195503235},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6804901361465454},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5282905101776123},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.431901216506958},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3489171862602234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33751246333122253},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1770435869693756},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019581","descriptor_name":"Neuropil","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neuron.2025.04.004","doi":"https://doi.org/10.1016/j.neuron.2025.04.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuron.2025.04.004","pdf_url":null,"source":{"id":"https://openalex.org/S45757444","display_name":"Neuron","issn_l":"0896-6273","issn":["0896-6273","1097-4199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"journal-article"},{"id":"pmid:40311612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40311612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3045557442","display_name":null,"funder_award_id":"R01-DA054154","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3426312842","display_name":"Neurobiological mechanisms underlying resiliency and vulnerability to opioid use disorder","funder_award_id":"K99DA057390","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000901045","display_name":"Nitrergic interneurons and cue-induced cocaine seeking","funder_award_id":"5r01da054154-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F8394932145","display_name":"Intramural Research Program","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":167,"referenced_works":["https://openalex.org/W1522823711","https://openalex.org/W1542136448","https://openalex.org/W1592375995","https://openalex.org/W1789330717","https://openalex.org/W1853800668","https://openalex.org/W1964544761","https://openalex.org/W1969874929","https://openalex.org/W1971125401","https://openalex.org/W1973477241","https://openalex.org/W1977637789","https://openalex.org/W1996364982","https://openalex.org/W2001725826","https://openalex.org/W2002247284","https://openalex.org/W2007162991","https://openalex.org/W2014424306","https://openalex.org/W2017453007","https://openalex.org/W2020138925","https://openalex.org/W2021440104","https://openalex.org/W2032089725","https://openalex.org/W2039067152","https://openalex.org/W2040937016","https://openalex.org/W2044730840","https://openalex.org/W2045289070","https://openalex.org/W2056578843","https://openalex.org/W2059480421","https://openalex.org/W2059533280","https://openalex.org/W2068200390","https://openalex.org/W2071493890","https://openalex.org/W2072733897","https://openalex.org/W2073793907","https://openalex.org/W2083252150","https://openalex.org/W2088446288","https://openalex.org/W2091815849","https://openalex.org/W2092620953","https://openalex.org/W2096500024","https://openalex.org/W2104236793","https://openalex.org/W2105177783","https://openalex.org/W2109909801","https://openalex.org/W2111819027","https://openalex.org/W2115699016","https://openalex.org/W2126711746","https://openalex.org/W2129567809","https://openalex.org/W2133994038","https://openalex.org/W2143490729","https://openalex.org/W2144137250","https://openalex.org/W2144836386","https://openalex.org/W2155957566","https://openalex.org/W2157152722","https://openalex.org/W2230531921","https://openalex.org/W2239707532","https://openalex.org/W2301368457","https://openalex.org/W2333301394","https://openalex.org/W2341645163","https://openalex.org/W2366000484","https://openalex.org/W2403416022","https://openalex.org/W2403498924","https://openalex.org/W2410908538","https://openalex.org/W2411553778","https://openalex.org/W2419165202","https://openalex.org/W2467652827","https://openalex.org/W2485963787","https://openalex.org/W2559955814","https://openalex.org/W2606246034","https://openalex.org/W2608882114","https://openalex.org/W2616259342","https://openalex.org/W2626670632","https://openalex.org/W2741752826","https://openalex.org/W2747638042","https://openalex.org/W2753593979","https://openalex.org/W2759348474","https://openalex.org/W2759821008","https://openalex.org/W2763626521","https://openalex.org/W2767416879","https://openalex.org/W2781117336","https://openalex.org/W2786310594","https://openalex.org/W2787301818","https://openalex.org/W2803287932","https://openalex.org/W2886215053","https://openalex.org/W2886921828","https://openalex.org/W2893701755","https://openalex.org/W2894592121","https://openalex.org/W2894865807","https://openalex.org/W2896935109","https://openalex.org/W2900125538","https://openalex.org/W2901218988","https://openalex.org/W2903203190","https://openalex.org/W2932309265","https://openalex.org/W2937273526","https://openalex.org/W2937445301","https://openalex.org/W2939200041","https://openalex.org/W2939463158","https://openalex.org/W2945566268","https://openalex.org/W2947647528","https://openalex.org/W2948343247","https://openalex.org/W2951541013","https://openalex.org/W2952525691","https://openalex.org/W2954787410","https://openalex.org/W2954808628","https://openalex.org/W2965463326","https://openalex.org/W2970490662","https://openalex.org/W2975543744","https://openalex.org/W2979452209","https://openalex.org/W2980841692","https://openalex.org/W2983638220","https://openalex.org/W2999291880","https://openalex.org/W3004547734","https://openalex.org/W3009751543","https://openalex.org/W3013270515","https://openalex.org/W3016184834","https://openalex.org/W3025128382","https://openalex.org/W3027287313","https://openalex.org/W3031611266","https://openalex.org/W3039508055","https://openalex.org/W3040942181","https://openalex.org/W3044371294","https://openalex.org/W3044804316","https://openalex.org/W3087901293","https://openalex.org/W3089128271","https://openalex.org/W3089379338","https://openalex.org/W3092104712","https://openalex.org/W3092217721","https://openalex.org/W3095093076","https://openalex.org/W3105461634","https://openalex.org/W3112023741","https://openalex.org/W3112863450","https://openalex.org/W3132649552","https://openalex.org/W3153770000","https://openalex.org/W3158248679","https://openalex.org/W3160702355","https://openalex.org/W3165050921","https://openalex.org/W3181385353","https://openalex.org/W3194502243","https://openalex.org/W3196214717","https://openalex.org/W3196827409","https://openalex.org/W3197457389","https://openalex.org/W3212287462","https://openalex.org/W3212345080","https://openalex.org/W3212923564","https://openalex.org/W3217005254","https://openalex.org/W4205591801","https://openalex.org/W4207009271","https://openalex.org/W4210979710","https://openalex.org/W4220722512","https://openalex.org/W4220737348","https://openalex.org/W4221044970","https://openalex.org/W4280527963","https://openalex.org/W4290970536","https://openalex.org/W4294771180","https://openalex.org/W4294898454","https://openalex.org/W4302027404","https://openalex.org/W4308150510","https://openalex.org/W4311205352","https://openalex.org/W4318046453","https://openalex.org/W4321479726","https://openalex.org/W4379880258","https://openalex.org/W4383058657","https://openalex.org/W4386029768","https://openalex.org/W4387232795","https://openalex.org/W4388789578","https://openalex.org/W4389129675","https://openalex.org/W4390675197","https://openalex.org/W4400738246","https://openalex.org/W4401419925","https://openalex.org/W4406104397","https://openalex.org/W6769149232","https://openalex.org/W6849962107","https://openalex.org/W6855581081"],"related_works":["https://openalex.org/W2091393882","https://openalex.org/W3212345080","https://openalex.org/W2018689514","https://openalex.org/W2088446288","https://openalex.org/W3008431985","https://openalex.org/W7095848847","https://openalex.org/W2779381148","https://openalex.org/W2607649485","https://openalex.org/W1806509508","https://openalex.org/W2402840263"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-05-01T00:00:00"}