{"id":"https://openalex.org/W4409974256","doi":"https://doi.org/10.31083/fbl25231","title":"The Flow of Life: Convergent Approaches to Understanding Musculoskeletal Health from Molecular- to Meso-Length Scales","display_name":"The Flow of Life: Convergent Approaches to Understanding Musculoskeletal Health from Molecular- to Meso-Length Scales","publication_year":2025,"publication_date":"2025-04-18","ids":{"openalex":"https://openalex.org/W4409974256","doi":"https://doi.org/10.31083/fbl25231","pmid":"https://pubmed.ncbi.nlm.nih.gov/40302317"},"language":"en","primary_location":{"id":"doi:10.31083/fbl25231","doi":"https://doi.org/10.31083/fbl25231","is_oa":true,"landing_page_url":"https://doi.org/10.31083/fbl25231","pdf_url":"https://www.imrpress.com/journal/FBL/30/4/10.31083/FBL25231/pdf","source":{"id":"https://openalex.org/S4210236708","display_name":"Frontiers in Bioscience-Landmark","issn_l":"2768-6698","issn":["2768-6698","2768-6701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience-Landmark","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.imrpress.com/journal/FBL/30/4/10.31083/FBL25231/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004319969","display_name":"Melissa L. Knothe Tate","orcid":"https://orcid.org/0000-0002-3552-2525","observed_orcids":["https://orcid.org/0000-0002-3552-2525"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Melissa Louise Knothe Tate","raw_affiliation_strings":["Blue Mountains World Interdisciplinary Innovation Institute, Blue Mountains National Park, NSW 2782, Australia"],"raw_orcid":"https://orcid.org/0000-0002-3552-2525","affiliations":[{"raw_affiliation_string":"Blue Mountains World Interdisciplinary Innovation Institute, Blue Mountains National Park, NSW 2782, Australia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004319969"],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.1187,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.14508783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"30","issue":"4","first_page":"25231","last_page":"25231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.3693999946117401,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.3693999946117401,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14488","display_name":"Chemical and Physical Studies","score":0.20499999821186066,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/musculoskeletal-health","display_name":"musculoskeletal health","score":0.9350000023841858},{"id":"https://openalex.org/keywords/bone","display_name":"bone","score":0.4300000071525574},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8740000128746033},{"id":"https://openalex.org/keywords/molecular-transport","display_name":"molecular transport","score":0.9309999942779541},{"id":"https://openalex.org/keywords/multiphysics","display_name":"multiphysics","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cell-mechanics","display_name":"cell mechanics","score":0.3959999978542328},{"id":"https://openalex.org/keywords/environmental-health","display_name":"environmental health","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.7160722613334656},{"id":"https://openalex.org/C185874996","wikidata":"https://www.wikidata.org/wiki/Q269699","display_name":"Interdependence","level":2,"score":0.6612141728401184},{"id":"https://openalex.org/C2776184637","wikidata":"https://www.wikidata.org/wiki/Q6506039","display_name":"Living systems","level":2,"score":0.4621838331222534},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.43939894437789917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40906864404678345},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3715997338294983},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3514356017112732},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3428628444671631},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.22424104809761047},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009141","descriptor_name":"Musculoskeletal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009142","descriptor_name":"Musculoskeletal Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.31083/fbl25231","doi":"https://doi.org/10.31083/fbl25231","is_oa":true,"landing_page_url":"https://doi.org/10.31083/fbl25231","pdf_url":"https://www.imrpress.com/journal/FBL/30/4/10.31083/FBL25231/pdf","source":{"id":"https://openalex.org/S4210236708","display_name":"Frontiers in Bioscience-Landmark","issn_l":"2768-6698","issn":["2768-6698","2768-6701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience-Landmark","raw_type":"journal-article"},{"id":"pmid:40302317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40302317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioscience (Landmark edition)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1e3bbfdef01d45b9af366b5e34931615","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1e3bbfdef01d45b9af366b5e34931615","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioscience-Landmark, Vol 30, Iss 4, p 25231 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.31083/fbl25231","doi":"https://doi.org/10.31083/fbl25231","is_oa":true,"landing_page_url":"https://doi.org/10.31083/fbl25231","pdf_url":"https://www.imrpress.com/journal/FBL/30/4/10.31083/FBL25231/pdf","source":{"id":"https://openalex.org/S4210236708","display_name":"Frontiers in Bioscience-Landmark","issn_l":"2768-6698","issn":["2768-6698","2768-6701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience-Landmark","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4910970435","display_name":"Training Program in Musculoskeletal Research","funder_award_id":"T32AR007505","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G491612321","display_name":"Strength and Resorption of Biodegradable Skull Implants","funder_award_id":"R01DE013740","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G4962576690","display_name":"Mechanical Modulation of Stem Cell Shape and Fate","funder_award_id":"0826435","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5214849343","display_name":"5th Bone Fluid Flow Workshop: Organ to Cell, Lab Bench to Bedside, on Earth and in Space, Cleveland, Ohio, September 17-18, 2003","funder_award_id":"0335539","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5391000487","display_name":"Manufacture and Testing of Next Generation Orthopaedic Implants Harnessing Periosteum's Regenerative Power","funder_award_id":"1119636","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G7163049662","display_name":"ACOUSTICALLY INDUCED MICRODAMAGE TO PREVENT BONE L OSS","funder_award_id":"NCC31000","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G7281940373","display_name":null,"funder_award_id":"04-K3","funder_id":"https://openalex.org/F4320320914","funder_display_name":"AO Foundation"},{"id":"https://openalex.org/G8445650623","display_name":"5th Bone Fluid Flow Workshop","funder_award_id":"1r13ar050594-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8769902989","display_name":"The Osteoblastic Monolayer as a 'Gatekeeper'in Bone","funder_award_id":"5r21ar049351-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8935115457","display_name":"CONFOCAL AND TWO-PHOTON MICROSCOPY FOR THE ASSESSM ENT OF COUNTERMEASURES IN BONE LOSS AND IMMUNOLOG","funder_award_id":"NCC31008","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320308269","display_name":"Alexander von Humboldt-Stiftung","ror":"https://ror.org/012kf4317"},{"id":"https://openalex.org/F4320320914","display_name":"AO Foundation","ror":"https://ror.org/04v7vb598"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320320998","display_name":"Kommission f\u00fcr Technologie und Innovation","ror":"https://ror.org/012y9zp98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337391","display_name":"Division of Civil, Mechanical and Manufacturing Innovation","ror":"https://ror.org/028yd4c30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409974256.pdf","grobid_xml":"https://content.openalex.org/works/W4409974256.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W8711066","https://openalex.org/W92152433","https://openalex.org/W200876415","https://openalex.org/W1236525511","https://openalex.org/W1483393222","https://openalex.org/W1670675606","https://openalex.org/W1710973382","https://openalex.org/W1901463649","https://openalex.org/W1918886276","https://openalex.org/W1963918882","https://openalex.org/W1968323706","https://openalex.org/W1970702013","https://openalex.org/W1971322232","https://openalex.org/W1982701868","https://openalex.org/W1983061661","https://openalex.org/W1989919731","https://openalex.org/W1990178709","https://openalex.org/W1991160471","https://openalex.org/W1991570657","https://openalex.org/W1995946343","https://openalex.org/W1999173314","https://openalex.org/W2000459332","https://openalex.org/W2002938958","https://openalex.org/W2003519536","https://openalex.org/W2005400889","https://openalex.org/W2006159519","https://openalex.org/W2007289136","https://openalex.org/W2017988945","https://openalex.org/W2021236708","https://openalex.org/W2038773696","https://openalex.org/W2042006610","https://openalex.org/W2055072688","https://openalex.org/W2067181764","https://openalex.org/W2079088633","https://openalex.org/W2088282601","https://openalex.org/W2089877586","https://openalex.org/W2101056577","https://openalex.org/W2104192993","https://openalex.org/W2111601530","https://openalex.org/W2124318163","https://openalex.org/W2128431399","https://openalex.org/W2140343451","https://openalex.org/W2153057165","https://openalex.org/W2155736277","https://openalex.org/W2160073815","https://openalex.org/W2168579380","https://openalex.org/W2227199707","https://openalex.org/W2344716431","https://openalex.org/W2411441364","https://openalex.org/W2418721350","https://openalex.org/W2588534180","https://openalex.org/W2596551117","https://openalex.org/W2811092976","https://openalex.org/W2896582829","https://openalex.org/W2905227538","https://openalex.org/W3005995871","https://openalex.org/W3022092258","https://openalex.org/W3093928288","https://openalex.org/W3181573307","https://openalex.org/W4200505213","https://openalex.org/W4210338655","https://openalex.org/W4224287259","https://openalex.org/W4231129681","https://openalex.org/W4232099774","https://openalex.org/W4235847309","https://openalex.org/W4280522760","https://openalex.org/W4295779004","https://openalex.org/W4366076349","https://openalex.org/W4378808064","https://openalex.org/W4379470206","https://openalex.org/W4383425486","https://openalex.org/W4386847648","https://openalex.org/W4388928944","https://openalex.org/W4388937302","https://openalex.org/W4398146209","https://openalex.org/W4400881153"],"related_works":["https://openalex.org/W4389476575","https://openalex.org/W2561108230","https://openalex.org/W655980934","https://openalex.org/W620509543","https://openalex.org/W2009699554","https://openalex.org/W7124686564","https://openalex.org/W1865462029","https://openalex.org/W2464802075","https://openalex.org/W2075193978","https://openalex.org/W7171705293"],"abstract_inverted_index":{"In":[0,135],"the":[1,9,27,35,46,59,64,67,74,77,86,98,109,116,139,145,150,156,161,164,170,177,182,191,224,231,241],"current":[2,252],"perspective":[3],"and":[4,19,33,53,82,95,115,124,132,141,144,166,169,179,189,195,205,220,236,238],"review":[5],"article,":[6],"we":[7,22,57,72,107,137,159,212],"address":[8,58,138],"human":[10,204],"body":[11],"as":[12],"a":[13,31],"living":[14,151],"ecosystem":[15,174],"with":[16,45,85],"collecting":[17],"watersheds":[18],"draining":[20],"hydrosheds;":[21],"integrate":[23],"our":[24,227,234,245,251],"discoveries":[25],"over":[26],"past":[28],"quarter":[29],"of":[30,61,66,76,100,111,118,153,163,193,218,226,233,244],"century":[32],"pose":[34],"critical":[36],"open":[37],"research":[38],"questions":[39],"to":[40,48,88,201,214,222,240,247],"be":[41],"addressed":[42],"going":[43],"forward,":[44],"aim":[47],"improve":[49,223],"cell,":[50],"tissue,":[51],"organ":[52,128],"organismal":[54],"health.":[55],"First,":[56],"flow":[60,143],"fluid":[62,140,167],"through":[63],"tissues":[65,96,178],"musculoskeletal":[68],"system,":[69],"after":[70],"which":[71],"describe":[73,160],"interactions":[75],"fluid,":[78],"at":[79],"multiple":[80],"lengths":[81],"time":[83],"scales,":[84],"molecular":[87,125],"macroscopic":[89],"non-fluid":[90],"tissue":[91,130],"components,":[92],"discussing":[93],"bone":[94,235],"in":[97,190],"context":[99,192],"\"living\"":[101],"chromatography":[102],"and/or":[103],"electrophoresis":[104],"columns.":[105],"Thereafter,":[106],"discuss":[108],"implications":[110,147,162],"functional":[112],"barrier":[113,122],"integrity,":[114],"effects":[117],"cytokines":[119],"on":[120,173],"active":[121],"function":[123],"transport":[126],"between":[127],"systems,":[129],"compartments,":[131],"within":[133],"tissues.":[134],"addition,":[136],"its":[142],"multi-physics":[146],"thereof":[148],"for":[149],"inhabitants":[152,172],"tissues,":[154],"i.e.,":[155],"cells.":[157],"Finally,":[158],"solid":[165],"components":[168],"cellular":[171],"health,":[175],"where":[176],"organs":[180],"comprise":[181],"organism":[183],"form":[184],"interacting":[185,242],"ecosystems":[186,243],"throughout":[187],"life":[188],"health":[194,207],"disease.":[196],"By":[197],"taking":[198],"convergent":[199],"approaches":[200],"understanding":[202],"musculoskeletal,":[203],"environmental":[206],"(which":[208],"themselves":[209],"are":[210],"interdependent),":[211],"hope":[213],"pave":[215],"new":[216],"paths":[217],"innovation":[219],"discovery,":[221],"lives":[225],"worlds'":[228],"inhabitants,":[229],"from":[230],"worlds":[232,249],"joints":[237],"bodies":[239],"Earth":[246],"unknown":[248],"beyond":[250],"understanding.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-05-01T00:00:00"}
