{"id":"https://openalex.org/W4409909522","doi":"https://doi.org/10.1016/j.jcyt.2025.03.405","title":"Cell-derived nanoparticles generated from cell-based artificial antigen presenting cells allow for the robust and rapid manufacturing of patient T cells.","display_name":"Cell-derived nanoparticles generated from cell-based artificial antigen presenting cells allow for the robust and rapid manufacturing of patient T cells.","publication_year":2025,"publication_date":"2025-04-30","ids":{"openalex":"https://openalex.org/W4409909522","doi":"https://doi.org/10.1016/j.jcyt.2025.03.405"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcyt.2025.03.405","doi":"https://doi.org/10.1016/j.jcyt.2025.03.405","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcyt.2025.03.405","pdf_url":null,"source":{"id":"https://openalex.org/S36838616","display_name":"Cytotherapy","issn_l":"1465-3249","issn":["1465-3249","1477-2566"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. Riley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Riley","raw_affiliation_strings":["Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Deng","raw_affiliation_strings":["Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031597640","display_name":"Meizan Lai","orcid":"https://orcid.org/0009-0007-6389-1241","observed_orcids":["https://orcid.org/0009-0007-6389-1241"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Lai","raw_affiliation_strings":["Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Jiang","raw_affiliation_strings":["Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031979422","display_name":"Hui Kong","orcid":"https://orcid.org/0000-0002-8565-1691","observed_orcids":["https://orcid.org/0000-0002-8565-1691"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Kong","raw_affiliation_strings":["Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"V. Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Cooper","raw_affiliation_strings":["Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015047591","display_name":"Edgar M. Carvalho","orcid":"https://orcid.org/0000-0002-2697-8002","observed_orcids":["https://orcid.org/0000-0002-2697-8002"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Carvalho","raw_affiliation_strings":["Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Gu","raw_affiliation_strings":["Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091260928","display_name":"David Nardo","orcid":"https://orcid.org/0000-0003-3009-7686","observed_orcids":["https://orcid.org/0000-0003-3009-7686"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Nardo","raw_affiliation_strings":["Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Zhang","raw_affiliation_strings":["BlueWhale Bio, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BlueWhale Bio, Philadelphia, PA, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117370000","display_name":"C. Hanindya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Hanindya","raw_affiliation_strings":["BlueWhale Bio, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BlueWhale Bio, Philadelphia, PA, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029060744","display_name":"J. Barranco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Barranco","raw_affiliation_strings":["Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Jain","raw_affiliation_strings":["Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":null,"display_name":"M.M. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.M. Davis","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.416,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.58418671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"27","issue":"5","first_page":"S199","last_page":"S200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-antigen-presenting-cells","display_name":"artificial antigen-presenting cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/car-t-cell-manufacturing","display_name":"CAR T cell manufacturing","score":0.828000009059906},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.7979999780654907},{"id":"https://openalex.org/keywords/4-1bbl","display_name":"4-1BBL","score":0.9679999947547913},{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":0.8809999823570251},{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-expansion","display_name":"T cell expansion","score":0.8399999737739563},{"id":"https://openalex.org/keywords/costimulatory-signals","display_name":"costimulatory signals","score":0.7770000100135803},{"id":"https://openalex.org/keywords/tumor-eradication","display_name":"tumor eradication","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.6023188233375549},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5681334137916565},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5421068072319031},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46413132548332214},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3410263657569885},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.33927327394485474},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3326704502105713},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24024274945259094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19086477160453796},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10293024778366089}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jcyt.2025.03.405","doi":"https://doi.org/10.1016/j.jcyt.2025.03.405","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcyt.2025.03.405","pdf_url":null,"source":{"id":"https://openalex.org/S36838616","display_name":"Cytotherapy","issn_l":"1465-3249","issn":["1465-3249","1477-2566"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416451113","https://openalex.org/W7127318830","https://openalex.org/W4409909516","https://openalex.org/W4415900212","https://openalex.org/W7124911230","https://openalex.org/W4387855375","https://openalex.org/W2315233740","https://openalex.org/W2996753405","https://openalex.org/W4412672435","https://openalex.org/W4200147949"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-04-30T00:00:00"}