{"id":"https://openalex.org/W4409909350","doi":"https://doi.org/10.1016/j.jcyt.2025.03.454","title":"Rapid and Accurate AAV Capsid Quantification Using Multi-Angle Dynamic Light Scattering (MADLS) for In-Process Gene Therapy Manufacturing","display_name":"Rapid and Accurate AAV Capsid Quantification Using Multi-Angle Dynamic Light Scattering (MADLS) for In-Process Gene Therapy Manufacturing","publication_year":2025,"publication_date":"2025-04-30","ids":{"openalex":"https://openalex.org/W4409909350","doi":"https://doi.org/10.1016/j.jcyt.2025.03.454"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcyt.2025.03.454","doi":"https://doi.org/10.1016/j.jcyt.2025.03.454","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcyt.2025.03.454","pdf_url":null,"source":{"id":"https://openalex.org/S36838616","display_name":"Cytotherapy","issn_l":"1465-3249","issn":["1465-3249","1477-2566"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"T. Pan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"T. Pan","raw_affiliation_strings":["PackGene Biotech, Houston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PackGene Biotech, Houston, TX, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08824337,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"5","first_page":"S222","last_page":"S222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus","display_name":"adeno-associated virus","score":0.890999972820282},{"id":"https://openalex.org/keywords/in-process-testing","display_name":"in-process testing","score":0.7680000066757202},{"id":"https://openalex.org/keywords/gene-therapy-manufacturing","display_name":"gene therapy manufacturing","score":0.9710000157356262},{"id":"https://openalex.org/keywords/particle-size-measurement","display_name":"particle size measurement","score":0.6729999780654907},{"id":"https://openalex.org/keywords/particle-aggregation","display_name":"particle aggregation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/elisa-comparison","display_name":"ELISA comparison","score":0.953000009059906},{"id":"https://openalex.org/keywords/rapid-assay-development","display_name":"rapid assay development","score":0.3630000054836273},{"id":"https://openalex.org/keywords/process-control","display_name":"process control","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.8535614609718323},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5243176221847534},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.42973455786705017},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4204799234867096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3577686548233032},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.320644736289978},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2490714192390442},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2213248908519745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1752682626247406},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.13643121719360352},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12337303161621094},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jcyt.2025.03.454","doi":"https://doi.org/10.1016/j.jcyt.2025.03.454","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcyt.2025.03.454","pdf_url":null,"source":{"id":"https://openalex.org/S36838616","display_name":"Cytotherapy","issn_l":"1465-3249","issn":["1465-3249","1477-2566"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3126192584","https://openalex.org/W4410410115","https://openalex.org/W4388153358","https://openalex.org/W4282968564","https://openalex.org/W3156409651","https://openalex.org/W4399780277","https://openalex.org/W4205267006","https://openalex.org/W4226278713","https://openalex.org/W4404499892","https://openalex.org/W4390722004"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-04-30T00:00:00"}