{"id":"https://openalex.org/W4409909189","doi":"https://doi.org/10.1016/j.jcyt.2025.04.007","title":"Proinflammatory cytokines sensitise mesenchymal stromal cells to intrinsic apoptosis and accelerate their in vivo clearance","display_name":"Proinflammatory cytokines sensitise mesenchymal stromal cells to intrinsic apoptosis and accelerate their in vivo clearance","publication_year":2025,"publication_date":"2025-04-30","ids":{"openalex":"https://openalex.org/W4409909189","doi":"https://doi.org/10.1016/j.jcyt.2025.04.007"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcyt.2025.04.007","doi":"https://doi.org/10.1016/j.jcyt.2025.04.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcyt.2025.04.007","pdf_url":null,"source":{"id":"https://openalex.org/S36838616","display_name":"Cytotherapy","issn_l":"1465-3249","issn":["1465-3249","1477-2566"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080769608","display_name":"Natalie L. Payne","orcid":"https://orcid.org/0000-0002-2045-2608","observed_orcids":["https://orcid.org/0000-0002-2045-2608"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"N. Payne","raw_affiliation_strings":["Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075688652","display_name":"Andrew Freeman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"A. Freeman","raw_affiliation_strings":["Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116838144","display_name":"Justin W Limar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J. Limar","raw_affiliation_strings":["Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058826754","display_name":"Dilara Ceyda Ozkocak","orcid":"https://orcid.org/0000-0003-4614-5638","observed_orcids":["https://orcid.org/0000-0003-4614-5638"]},"institutions":[{"id":"https://openalex.org/I196829312","display_name":"La Trobe University","ror":"https://ror.org/01rxfrp27","country_code":"AU","type":"education","lineage":["https://openalex.org/I196829312"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"D. Ozkocak","raw_affiliation_strings":["Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I196829312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024701701","display_name":"Ivan K. H. Poon","orcid":"https://orcid.org/0000-0002-9119-7173","observed_orcids":["https://orcid.org/0000-0002-9119-7173"]},"institutions":[{"id":"https://openalex.org/I196829312","display_name":"La Trobe University","ror":"https://ror.org/01rxfrp27","country_code":"AU","type":"education","lineage":["https://openalex.org/I196829312"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"I. Poon","raw_affiliation_strings":["Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I196829312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045759774","display_name":"Tracy S P Heng","orcid":"https://orcid.org/0000-0003-4147-8986","observed_orcids":["https://orcid.org/0000-0003-4147-8986"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"T. Heng","raw_affiliation_strings":["Australian Research Council Training Centre for Cell and Tissue Engineering Technologies, Monash University, Melbourne, VIC, Australia","Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Research Council Training Centre for Cell and Tissue Engineering Technologies, Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045759774"],"corresponding_institution_ids":["https://openalex.org/I56590836"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.3267,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45450014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"27","issue":"5","first_page":"102829","last_page":"102829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8190000057220459},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7020000219345093},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.7400000095367432},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8619999885559082},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/apoptotic-bodies","display_name":"apoptotic bodies","score":0.6589999794960022},{"id":"https://openalex.org/keywords/macrophage-clearance","display_name":"macrophage clearance","score":0.8169999718666077},{"id":"https://openalex.org/keywords/macrophage-reprogramming","display_name":"macrophage reprogramming","score":0.8999999761581421},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/adipose-derived-mscs","display_name":"adipose-derived MSCs","score":0.8740000128746033},{"id":"https://openalex.org/keywords/umbilical-cord-derived-mscs","display_name":"umbilical cord-derived MSCs","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8634476661682129},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7973724603652954},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6351888179779053},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6085270643234253},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5753263831138611},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5401429533958435},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4752254784107208},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4328669607639313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2603427767753601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24692699313163757},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2396489977836609},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.22990933060646057},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06851708889007568},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.04394218325614929}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jcyt.2025.04.007","doi":"https://doi.org/10.1016/j.jcyt.2025.04.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcyt.2025.04.007","pdf_url":null,"source":{"id":"https://openalex.org/S36838616","display_name":"Cytotherapy","issn_l":"1465-3249","issn":["1465-3249","1477-2566"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"journal-article"},{"id":"doi:10.1016/j.jcyt.2026.102829","doi":"https://doi.org/10.1016/j.jcyt.2026.102829","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcyt.2026.102829","pdf_url":null,"source":{"id":"https://openalex.org/S36838616","display_name":"Cytotherapy","issn_l":"1465-3249","issn":["1465-3249","1477-2566"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4401763349","https://openalex.org/W2950500541","https://openalex.org/W4366991250","https://openalex.org/W2941919396","https://openalex.org/W2946675900","https://openalex.org/W4381687167","https://openalex.org/W2786024057","https://openalex.org/W2089584656","https://openalex.org/W3212910602","https://openalex.org/W7223226706"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-04-30T00:00:00"}