{"id":"https://openalex.org/W4409889709","doi":"https://doi.org/10.1038/s41598-025-94776-7","title":"Coxsackievirus A24 variant associated with acute hemorrhagic conjunctivitis outbreak in Bhutan, 2023","display_name":"Coxsackievirus A24 variant associated with acute hemorrhagic conjunctivitis outbreak in Bhutan, 2023","publication_year":2025,"publication_date":"2025-04-28","ids":{"openalex":"https://openalex.org/W4409889709","doi":"https://doi.org/10.1038/s41598-025-94776-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/40295540","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12037851"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-025-94776-7","doi":"https://doi.org/10.1038/s41598-025-94776-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-94776-7","pdf_url":"https://www.nature.com/articles/s41598-025-94776-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-025-94776-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102898525","display_name":"Sonam Gyeltshen","orcid":"https://orcid.org/0000-0003-0329-5695","observed_orcids":["https://orcid.org/0000-0003-0329-5695"]},"institutions":[{"id":"https://openalex.org/I4210107090","display_name":"Royal Centre for Disease Control","ror":"https://ror.org/00z18yv90","country_code":"BT","type":"government","lineage":["https://openalex.org/I4210094897","https://openalex.org/I4210107090"]},{"id":"https://openalex.org/I4388891770","display_name":"Royal Government of Bhutan","ror":"https://ror.org/03mv2rd02","country_code":"BT","type":"government","lineage":["https://openalex.org/I4388891770"]}],"countries":["BT"],"is_corresponding":false,"raw_author_name":"Sonam Gyeltshen","raw_affiliation_strings":["Royal Centre for Disease Control, Ministry of Health, Royal Government of Bhutan, Thimphu, Bhutan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Centre for Disease Control, Ministry of Health, Royal Government of Bhutan, Thimphu, Bhutan","institution_ids":["https://openalex.org/I4210107090","https://openalex.org/I4388891770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101740241","display_name":"Tshering Dorji","orcid":"https://orcid.org/0000-0001-7125-572X","observed_orcids":["https://orcid.org/0000-0001-7125-572X"]},"institutions":[{"id":"https://openalex.org/I4210107090","display_name":"Royal Centre for Disease Control","ror":"https://ror.org/00z18yv90","country_code":"BT","type":"government","lineage":["https://openalex.org/I4210094897","https://openalex.org/I4210107090"]},{"id":"https://openalex.org/I4388891770","display_name":"Royal Government of Bhutan","ror":"https://ror.org/03mv2rd02","country_code":"BT","type":"government","lineage":["https://openalex.org/I4388891770"]}],"countries":["BT"],"is_corresponding":true,"raw_author_name":"Tshering Dorji","raw_affiliation_strings":["Royal Centre for Disease Control, Ministry of Health, Royal Government of Bhutan, Thimphu, Bhutan. cerorziks@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Centre for Disease Control, Ministry of Health, Royal Government of Bhutan, Thimphu, Bhutan. cerorziks@gmail.com","institution_ids":["https://openalex.org/I4210107090","https://openalex.org/I4388891770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044207707","display_name":"Kunzang Dorji","orcid":"https://orcid.org/0000-0002-3876-9638","observed_orcids":["https://orcid.org/0000-0002-3876-9638"]},"institutions":[{"id":"https://openalex.org/I4210107090","display_name":"Royal Centre for Disease Control","ror":"https://ror.org/00z18yv90","country_code":"BT","type":"government","lineage":["https://openalex.org/I4210094897","https://openalex.org/I4210107090"]},{"id":"https://openalex.org/I4388891770","display_name":"Royal Government of Bhutan","ror":"https://ror.org/03mv2rd02","country_code":"BT","type":"government","lineage":["https://openalex.org/I4388891770"]}],"countries":["BT"],"is_corresponding":false,"raw_author_name":"Kunzang Dorji","raw_affiliation_strings":["Royal Centre for Disease Control, Ministry of Health, Royal Government of Bhutan, Thimphu, Bhutan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Centre for Disease Control, Ministry of Health, Royal Government of Bhutan, Thimphu, Bhutan","institution_ids":["https://openalex.org/I4210107090","https://openalex.org/I4388891770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081141758","display_name":"Sonam Wangchuk","orcid":"https://orcid.org/0009-0001-3035-5633","observed_orcids":["https://orcid.org/0009-0001-3035-5633","https://orcid.org/0009-0006-5322-6101"]},"institutions":[{"id":"https://openalex.org/I4210107090","display_name":"Royal Centre for Disease Control","ror":"https://ror.org/00z18yv90","country_code":"BT","type":"government","lineage":["https://openalex.org/I4210094897","https://openalex.org/I4210107090"]},{"id":"https://openalex.org/I4388891770","display_name":"Royal Government of Bhutan","ror":"https://ror.org/03mv2rd02","country_code":"BT","type":"government","lineage":["https://openalex.org/I4388891770"]}],"countries":["BT"],"is_corresponding":false,"raw_author_name":"Sonam Wangchuk","raw_affiliation_strings":["Royal Centre for Disease Control, Ministry of Health, Royal Government of Bhutan, Thimphu, Bhutan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Centre for Disease Control, Ministry of Health, Royal Government of Bhutan, Thimphu, Bhutan","institution_ids":["https://openalex.org/I4210107090","https://openalex.org/I4388891770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101740241","display_name":"Tshering Dorji","orcid":"https://orcid.org/0000-0001-7125-572X","observed_orcids":["https://orcid.org/0000-0001-7125-572X"]},"institutions":[{"id":"https://openalex.org/I4388891770","display_name":"Royal Government of Bhutan","ror":"https://ror.org/03mv2rd02","country_code":"BT","type":"government","lineage":["https://openalex.org/I4388891770"]}],"countries":["BT"],"is_corresponding":true,"raw_author_name":"Dorji Tshering","raw_affiliation_strings":["Phuntsholing General Hospital, National Medical Services, Royal Government of Bhutan, Phuntsholing, Bhutan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phuntsholing General Hospital, National Medical Services, Royal Government of Bhutan, Phuntsholing, Bhutan","institution_ids":["https://openalex.org/I4388891770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032952321","display_name":"Yongyuth Poolpanichupatam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112607","display_name":"Armed Forces Research Institute of Medical Science","ror":"https://ror.org/023swxh49","country_code":"TH","type":"nonprofit","lineage":["https://openalex.org/I2801080794","https://openalex.org/I4210112607","https://openalex.org/I4387156032"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Yongyuth Poolpanichupatam","raw_affiliation_strings":["Department of Virology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand","institution_ids":["https://openalex.org/I4210112607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073168144","display_name":"Piyawan Chinnawirotpisan","orcid":"https://orcid.org/0000-0001-8472-2120","observed_orcids":["https://orcid.org/0000-0001-8472-2120"]},"institutions":[{"id":"https://openalex.org/I4210112607","display_name":"Armed Forces Research Institute of Medical Science","ror":"https://ror.org/023swxh49","country_code":"TH","type":"nonprofit","lineage":["https://openalex.org/I2801080794","https://openalex.org/I4210112607","https://openalex.org/I4387156032"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Piyawan Chinnawirotpisan","raw_affiliation_strings":["Department of Virology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. PiyawanC.fsn@afrims.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. PiyawanC.fsn@afrims.org","institution_ids":["https://openalex.org/I4210112607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053422396","display_name":"Wudtichai Manasatienkij","orcid":"https://orcid.org/0000-0001-6925-9596","observed_orcids":["https://orcid.org/0000-0001-6925-9596"]},"institutions":[{"id":"https://openalex.org/I4210112607","display_name":"Armed Forces Research Institute of Medical Science","ror":"https://ror.org/023swxh49","country_code":"TH","type":"nonprofit","lineage":["https://openalex.org/I2801080794","https://openalex.org/I4210112607","https://openalex.org/I4387156032"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Wudtichai Manasatienkij","raw_affiliation_strings":["Department of Virology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand","institution_ids":["https://openalex.org/I4210112607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032268939","display_name":"Kathryn McGuckin Wuertz","orcid":"https://orcid.org/0000-0003-2658-6284","observed_orcids":["https://orcid.org/0000-0003-2658-6284"]},"institutions":[{"id":"https://openalex.org/I4210112607","display_name":"Armed Forces Research Institute of Medical Science","ror":"https://ror.org/023swxh49","country_code":"TH","type":"nonprofit","lineage":["https://openalex.org/I2801080794","https://openalex.org/I4210112607","https://openalex.org/I4387156032"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kathryn A. McGuckin Wuertz","raw_affiliation_strings":["Department of Virology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand","institution_ids":["https://openalex.org/I4210112607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030295435","display_name":"Aaron R. Farmer","orcid":"https://orcid.org/0000-0002-2115-4493","observed_orcids":["https://orcid.org/0000-0002-2115-4493"]},"institutions":[{"id":"https://openalex.org/I4210112607","display_name":"Armed Forces Research Institute of Medical Science","ror":"https://ror.org/023swxh49","country_code":"TH","type":"nonprofit","lineage":["https://openalex.org/I2801080794","https://openalex.org/I4210112607","https://openalex.org/I4387156032"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Aaron R. Farmer","raw_affiliation_strings":["Department of Virology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand","institution_ids":["https://openalex.org/I4210112607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089092921","display_name":"Chonticha Klungthong","orcid":"https://orcid.org/0000-0001-5058-8912","observed_orcids":["https://orcid.org/0000-0001-5058-8912"]},"institutions":[{"id":"https://openalex.org/I4210112607","display_name":"Armed Forces Research Institute of Medical Science","ror":"https://ror.org/023swxh49","country_code":"TH","type":"nonprofit","lineage":["https://openalex.org/I2801080794","https://openalex.org/I4210112607","https://openalex.org/I4387156032"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Chonticha Klungthong","raw_affiliation_strings":["Department of Virology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand","institution_ids":["https://openalex.org/I4210112607"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073168144","https://openalex.org/A5101740241"],"corresponding_institution_ids":["https://openalex.org/I4210107090","https://openalex.org/I4210112607","https://openalex.org/I4388891770"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.0992,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.82293305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"14864","last_page":"14864"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-hemorrhagic-conjunctivitis","display_name":"acute hemorrhagic conjunctivitis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/coxsackievirus-a24-variant","display_name":"coxsackievirus A24 variant","score":0.9860000014305115},{"id":"https://openalex.org/keywords/viral-outbreak","display_name":"viral outbreak","score":0.6930000185966492},{"id":"https://openalex.org/keywords/conjunctival-swabs","display_name":"conjunctival swabs","score":0.75},{"id":"https://openalex.org/keywords/re-emergence","display_name":"re-emergence","score":0.7960000038146973},{"id":"https://openalex.org/keywords/enterovirus","display_name":"enterovirus","score":0.6069999933242798},{"id":"https://openalex.org/keywords/bhutan","display_name":"Bhutan","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.8258823156356812},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6439929008483887},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6130899786949158},{"id":"https://openalex.org/C2776989088","wikidata":"https://www.wikidata.org/wiki/Q16364","display_name":"Throat","level":2,"score":0.6016730666160583},{"id":"https://openalex.org/C2777719358","wikidata":"https://www.wikidata.org/wiki/Q667756","display_name":"Human bocavirus","level":4,"score":0.5934051871299744},{"id":"https://openalex.org/C2779278377","wikidata":"https://www.wikidata.org/wiki/Q1351647","display_name":"Rhinovirus","level":3,"score":0.5915569067001343},{"id":"https://openalex.org/C2777888124","wikidata":"https://www.wikidata.org/wiki/Q519796","display_name":"Enterovirus","level":3,"score":0.5656682848930359},{"id":"https://openalex.org/C2779120600","wikidata":"https://www.wikidata.org/wiki/Q1138287","display_name":"Coxsackievirus","level":4,"score":0.5373818278312683},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5109735727310181},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.4968853294849396},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.48625409603118896},{"id":"https://openalex.org/C2775984611","wikidata":"https://www.wikidata.org/wiki/Q273554","display_name":"Conjunctiva","level":2,"score":0.4211186468601227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32129591703414917},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.28770706057548523},{"id":"https://openalex.org/C2776012195","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory tract infections","level":3,"score":0.21458128094673157},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20466259121894836},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19726359844207764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1380479633808136},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.13729867339134216},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.09782549738883972},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09549731016159058},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0930013358592987},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001631","descriptor_name":"Bhutan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003232","descriptor_name":"Conjunctivitis, Acute Hemorrhagic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003232","descriptor_name":"Conjunctivitis, Acute Hemorrhagic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D003384","descriptor_name":"Coxsackievirus Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003384","descriptor_name":"Coxsackievirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004196","descriptor_name":"Disease Outbreaks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030015","descriptor_name":"Enterovirus C, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D030015","descriptor_name":"Enterovirus C, Human","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-025-94776-7","doi":"https://doi.org/10.1038/s41598-025-94776-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-94776-7","pdf_url":"https://www.nature.com/articles/s41598-025-94776-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:40295540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40295540","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12037851","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12037851/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:87035baa40f346c1ab16e4cbf95b5ffc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/87035baa40f346c1ab16e4cbf95b5ffc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-025-94776-7","doi":"https://doi.org/10.1038/s41598-025-94776-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-94776-7","pdf_url":"https://www.nature.com/articles/s41598-025-94776-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6027639504","display_name":null,"funder_award_id":"P0010_23_AF","funder_id":"https://openalex.org/F4320338325","funder_display_name":"Walter Reed Army Institute of Research"}],"funders":[{"id":"https://openalex.org/F4320338325","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409889709.pdf","grobid_xml":"https://content.openalex.org/works/W4409889709.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W44421630","https://openalex.org/W1580879794","https://openalex.org/W1985684734","https://openalex.org/W2011301426","https://openalex.org/W2029488079","https://openalex.org/W2055043387","https://openalex.org/W2123265582","https://openalex.org/W2126419817","https://openalex.org/W2152207030","https://openalex.org/W2160378127","https://openalex.org/W2313863156","https://openalex.org/W2600479089","https://openalex.org/W2778474843","https://openalex.org/W2952946229","https://openalex.org/W3005235420","https://openalex.org/W3048838858","https://openalex.org/W3213566649","https://openalex.org/W4206948506","https://openalex.org/W4210362429","https://openalex.org/W4214749157","https://openalex.org/W4251751280","https://openalex.org/W4304687680","https://openalex.org/W4308318545","https://openalex.org/W4378188930","https://openalex.org/W4387581345","https://openalex.org/W4390120745","https://openalex.org/W4392462089"],"related_works":["https://openalex.org/W4399606023","https://openalex.org/W2005213185","https://openalex.org/W4405066087","https://openalex.org/W4405919466","https://openalex.org/W4405007277","https://openalex.org/W4403637692","https://openalex.org/W4396676878","https://openalex.org/W7165936665","https://openalex.org/W4409978919","https://openalex.org/W2275952528"],"abstract_inverted_index":{"In":[0],"2023,":[1],"Bhutan":[2],"detected":[3,141],"an":[4],"outbreak":[5],"of":[6,128,135,161,209,213,220],"acute":[7],"hemorrhagic":[8],"conjunctivitis":[9],"(AHC)":[10],"in":[11,21,34,99,109,131,149,168,199],"southern":[12],"and":[13,23,48,56,75],"central":[14],"regions,":[15],"coinciding":[16],"with":[17,80,153],"similar":[18],"outbreaks":[19,175,201],"reported":[20],"South":[22],"Southeast":[24],"Asia.":[25],"Laboratory":[26],"results":[27],"from":[28,51,120,156,176],"clinical":[29,43],"specimens":[30,101,111,117,151],"were":[31,54,64],"initially":[32],"inconclusive":[33],"identifying":[35,132],"the":[36,81,121,125,169,196,207,218],"etiological":[37,197],"agent.":[38],"To":[39],"address":[40],"this,":[41],"18":[42],"samples,":[44],"comprising":[45],"conjunctival":[46,110,129,157,189],"swabs":[47,50],"throat/nasal":[49,116,204],"nine":[52],"patients":[53],"collected":[55],"sent":[57],"to":[58,115,173,203],"WRAIR-AFRIMS":[59],"for":[60,194],"further":[61],"analysis.":[62],"Specimens":[63],"tested":[65],"using":[66],"multiplex":[67],"real-time":[68],"RT-PCR":[69],"(Fast-track":[70],"respiratory":[71],"21":[72],"kit,":[73],"FTD21)":[74],"hybrid-capture-based":[76],"next-generation":[77],"sequencing":[78],"(NGS)":[79],"Illumina":[82],"Viral":[83],"Surveillance":[84],"Panel.":[85],"FTD21":[86],"testing":[87],"identified":[88],"human":[89,91,97],"adenovirus,":[90],"bocavirus,":[92],"influenza":[93],"A,":[94],"enterovirus,":[95],"and/or":[96],"rhinovirus":[98],"10/18":[100],"(56%).":[102],"A":[103],"higher":[104],"detection":[105,154],"rate":[106],"was":[107],"observed":[108],"(78%,":[112],"7/9)":[113],"compared":[114,172,202],"(33%,":[118],"3/9)":[119],"same":[122],"patients,":[123],"highlighting":[124],"increased":[126],"sensitivity":[127],"samples":[130,190],"causative":[133],"agents":[134],"conjunctivitis.":[136],"Further":[137],"assessment":[138],"by":[139,181],"NGS":[140],"only":[142],"coxsackievirus":[143],"A24":[144],"variant":[145],"(CVA24v)":[146],"genotype":[147,215],"IV":[148,216],"9/17":[150],"(53%),":[152],"primarily":[155],"samples.":[158],"Phylogenetic":[159],"analyses":[160],"CVA24v":[162,214],"VP1":[163],"sequences":[164],"revealed":[165],"genetic":[166,183],"distinctions":[167],"2023":[170],"isolates":[171],"prior":[174],"2002-2017,":[177],"suggesting":[178],"re-emergence":[179],"driven":[180],"novel":[182,211],"mutations.":[184],"These":[185],"findings":[186],"suggest":[187],"that":[188],"are":[191],"more":[192],"reliable":[193],"detecting":[195],"agent":[198],"AHC":[200],"swabs.":[205],"Additionally,":[206],"identification":[208],"a":[210],"strain":[212],"underscores":[217],"importance":[219],"genomics.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-04-29T00:00:00"}